JP2017502257A5 - - Google Patents

Download PDF

Info

Publication number
JP2017502257A5
JP2017502257A5 JP2016525565A JP2016525565A JP2017502257A5 JP 2017502257 A5 JP2017502257 A5 JP 2017502257A5 JP 2016525565 A JP2016525565 A JP 2016525565A JP 2016525565 A JP2016525565 A JP 2016525565A JP 2017502257 A5 JP2017502257 A5 JP 2017502257A5
Authority
JP
Japan
Prior art keywords
objects
micro
microfluidic device
enclosure
capture micro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016525565A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017502257A (ja
JP6465878B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from US14/520,510 external-priority patent/US9617145B2/en
Publication of JP2017502257A publication Critical patent/JP2017502257A/ja
Publication of JP2017502257A5 publication Critical patent/JP2017502257A5/ja
Application granted granted Critical
Publication of JP6465878B2 publication Critical patent/JP6465878B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016525565A 2013-10-22 2014-10-22 生体アクティビティをアッセイするための微少流体デバイス Active JP6465878B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201361996962P 2013-10-22 2013-10-22
US201361996973P 2013-10-22 2013-10-22
US201361996969P 2013-10-22 2013-10-22
US61/996,962 2013-10-22
US61/996,969 2013-10-22
US61/996,973 2013-10-22
US201462058658P 2014-10-01 2014-10-01
US62/058,658 2014-10-01
US14/520,510 US9617145B2 (en) 2013-10-22 2014-10-22 Exporting a selected group of micro-objects from a micro-fluidic device
PCT/US2014/061848 WO2015061506A1 (en) 2013-10-22 2014-10-22 Micro-fluidic devices for assaying biological activity
US14/520,510 2014-10-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019001195A Division JP6709299B2 (ja) 2013-10-22 2019-01-08 生体アクティビティをアッセイするための微少流体デバイス

Publications (3)

Publication Number Publication Date
JP2017502257A JP2017502257A (ja) 2017-01-19
JP2017502257A5 true JP2017502257A5 (https=) 2017-11-30
JP6465878B2 JP6465878B2 (ja) 2019-02-06

Family

ID=52993527

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016525565A Active JP6465878B2 (ja) 2013-10-22 2014-10-22 生体アクティビティをアッセイするための微少流体デバイス
JP2019001195A Active JP6709299B2 (ja) 2013-10-22 2019-01-08 生体アクティビティをアッセイするための微少流体デバイス

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019001195A Active JP6709299B2 (ja) 2013-10-22 2019-01-08 生体アクティビティをアッセイするための微少流体デバイス

Country Status (9)

Country Link
US (3) US9617145B2 (https=)
EP (2) EP3783094B1 (https=)
JP (2) JP6465878B2 (https=)
KR (1) KR102113990B1 (https=)
AU (2) AU2014340098B2 (https=)
CA (1) CA2925326C (https=)
IL (2) IL245253B (https=)
SG (2) SG11201602336UA (https=)
WO (1) WO2015061506A1 (https=)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9889445B2 (en) 2013-10-22 2018-02-13 Berkeley Lights, Inc. Micro-fluidic devices for assaying biological activity
EP3760703A1 (en) 2013-10-22 2021-01-06 Berkeley Lights, Inc. Microfluidic devices having isolation pens and methods of testing biological micro-objects with same
US11192107B2 (en) 2014-04-25 2021-12-07 Berkeley Lights, Inc. DEP force control and electrowetting control in different sections of the same microfluidic apparatus
WO2015188171A1 (en) 2014-06-06 2015-12-10 Berkeley Lights, Inc. Isolating microfluidic structures and trapping bubbles
EP3229961B1 (en) 2014-12-08 2019-11-13 Berkeley Lights, Inc. Actuated microfluidic structures for directed flow in a microfluidic device and methods of use thereof
DK3229958T3 (da) 2014-12-08 2020-11-30 Berkeley Lights Inc Mikrofluidanordning, der omfatter laterale/vertikale transistorstrukturer, samt fremgangsmåde til fremstilling og anvendelse heraf
CN107223208B (zh) 2014-12-09 2021-04-09 伯克利之光生命科技公司 微流体装置中微物体的自动检测和重新定位
EP3230718B1 (en) 2014-12-09 2022-03-02 Berkeley Lights, Inc. Automated detection of assay-positive areas or of analyte quantities in microfluidic devices
US10751715B1 (en) 2015-04-22 2020-08-25 Berkeley Lights, Inc. Microfluidic reporter cell assay methods and kits thereof
US10101250B2 (en) 2015-04-22 2018-10-16 Berkeley Lights, Inc. Manipulation of cell nuclei in a micro-fluidic device
SG11201708429WA (en) 2015-04-22 2017-11-29 Berkeley Lights Inc Microfluidic cell culture
CN107810059B (zh) 2015-04-22 2021-03-23 伯克利之光生命科技公司 在微流体装置上冷冻和存档细胞
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
CN108495712A (zh) 2015-11-23 2018-09-04 伯克利之光生命科技公司 原位生成的微流体隔离结构、试剂盒及其使用方法
US10705082B2 (en) * 2015-12-08 2020-07-07 Berkeley Lights, Inc. In situ-generated microfluidic assay structures, related kits, and methods of use thereof
CA3009073C (en) 2015-12-30 2024-11-12 Berkeley Lights, Inc. MICROFLUID DEVICES FOR OPTICALLY CONTROLLED CONVECTION AND MOVEMENT, KITS AND ASSOCIATED PROCESSES
WO2017117521A1 (en) 2015-12-31 2017-07-06 Berkeley Lights, Inc. Tumor infilitrating cells engineered to express a pro-inflammatory polypeptide
EP3889176A1 (en) 2016-01-15 2021-10-06 Berkeley Lights, Inc. Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor
CN109922885B (zh) * 2016-03-16 2022-05-10 伯克利之光生命科技公司 用于基因组编辑克隆的选择和传代的方法、系统和装置
US11285478B2 (en) * 2016-04-04 2022-03-29 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
US10675625B2 (en) 2016-04-15 2020-06-09 Berkeley Lights, Inc Light sequencing and patterns for dielectrophoretic transport
EP4684881A3 (en) 2016-04-15 2026-03-18 Bruker Cellular Analysis, Inc. Methods, systems, computer program and non-transitory computer-readable medium for in-pen assays
CN115678773A (zh) 2016-05-26 2023-02-03 伯克利之光生命科技公司 共价修饰的表面、试剂盒及制备方法和用途
AU2017298545B2 (en) 2016-07-21 2022-10-27 Berkeley Lights, Inc. Sorting of T lymphocytes in a microfluidic device
CA3045333A1 (en) * 2016-12-01 2018-06-07 Berkeley Lights, Inc. Automated detection and repositioning of micro-objects in microfluidic devices
US11473081B2 (en) 2016-12-12 2022-10-18 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
CN110546495B (zh) * 2016-12-30 2022-11-01 加利福尼亚州立大学董事会 用于基因组编辑t细胞的选择和传代的方法
JP7208902B2 (ja) 2016-12-30 2023-01-19 エクセラ・バイオサイエンシーズ・インコーポレイテッド マルチステージサンプル回収システム
WO2018226900A2 (en) 2017-06-06 2018-12-13 Zymergen Inc. A htp genomic engineering platform for improving fungal strains
EP3721209B1 (en) 2017-10-15 2024-02-07 Berkeley Lights, Inc. Methods for in-pen assays
EP3765838A4 (en) * 2018-03-15 2021-11-03 Massachusetts Institute of Technology CHEMORESISTIVE SENSOR AND DETECTION METHODS
WO2019236848A1 (en) 2018-06-06 2019-12-12 Zymergen Inc. Manipulation of genes involved in signal transduction to control fungal morphology during fermentation and production
CN108728359B (zh) * 2018-06-08 2022-03-11 天晴干细胞股份有限公司 一种空间站细胞培养瓶及其辅助装置的应用
EP3849705A4 (en) * 2018-09-14 2022-06-01 Berkeley Lights, Inc. Methods for assaying binding affinity
CN109410726B (zh) * 2018-09-17 2020-11-03 中国石油大学(华东) 一种交互式压汞毛管力曲线虚拟仿真测试教学系统及其运行方法
US11993766B2 (en) 2018-09-21 2024-05-28 Bruker Cellular Analysis, Inc. Functionalized well plate, methods of preparation and use thereof
WO2020077274A1 (en) 2018-10-11 2020-04-16 Berkeley Lights, Inc. Systems and methods for identification of optimized protein production and kits therefor
CN113366312A (zh) 2018-11-01 2021-09-07 伯克利之光生命科技公司 在微流体环境中测定生物细胞的方法
SG11202104544WA (en) 2018-11-19 2021-06-29 Berkeley Lights Inc Microfluidic device with programmable switching elements
EP3890876B1 (en) 2018-12-06 2024-05-01 Xcella Biosciences, Inc. Lateral loading of microcapillary arrays
WO2020168258A1 (en) 2019-02-15 2020-08-20 Berkeley Lights, Inc. Laser-assisted repositioning of a micro-object and culturing of an attachment-dependent cell in a microfluidic environment
PT3501658T (pt) 2019-03-19 2021-06-02 Ace Medical Tech Co Ltd Dispositivo para classificar bio-partículas utilizando uma força gerada a partir de dieletroforese induzida por luz e seu método de operação
WO2020223555A1 (en) 2019-04-30 2020-11-05 Berkeley Lights, Inc. Methods for encapsulating and assaying cells
CN110538680B (zh) * 2019-08-19 2024-08-06 昆山汇先医药技术有限公司 一种微流控样品处理设备
JP7403549B2 (ja) * 2019-09-26 2023-12-22 京セラ株式会社 細胞検出装置および細胞検出方法
CN110935568B (zh) * 2019-11-15 2022-01-04 Tcl华星光电技术有限公司 粒子分离装置和粒子分离方法
AU2020385015A1 (en) 2019-11-17 2022-06-09 Berkeley Lights, Inc. Systems and methods for analyses of biological samples
US11479779B2 (en) 2020-07-31 2022-10-25 Zymergen Inc. Systems and methods for high-throughput automated strain generation for non-sporulating fungi
WO2023038630A1 (en) * 2021-09-10 2023-03-16 Hewlett-Packard Development Company, L.P. Interface devices with electrodes for digital microfluidics
DE102021211549A1 (de) 2021-10-13 2023-04-13 Robert Bosch Gesellschaft mit beschränkter Haftung Vorrichtung, insbesondere mikrofluidische Kartusche, und Verfahren mit Entnahmekammer und entfernbarer Abdeckung

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2255599C (en) 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US6942776B2 (en) 1999-05-18 2005-09-13 Silicon Biosystems S.R.L. Method and apparatus for the manipulation of particles by means of dielectrophoresis
US7601270B1 (en) 1999-06-28 2009-10-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US20030007894A1 (en) 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
AU3053002A (en) * 2000-11-28 2002-06-11 Univ California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
ITTO20010411A1 (it) 2001-05-02 2002-11-02 Silicon Biosystems S R L Metodo e dispositivo per l'esecuzione di test e saggi ad alta processivita' ed alto valore biologico su cellule e/o composti.
AU2003224817B2 (en) 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US6958132B2 (en) 2002-05-31 2005-10-25 The Regents Of The University Of California Systems and methods for optical actuation of microfluidics based on opto-electrowetting
US7790443B2 (en) * 2002-08-27 2010-09-07 Vanderbilt University Bioreactors with substance injection capacity
JP4328168B2 (ja) 2003-10-02 2009-09-09 ソニー株式会社 毛細管現象を利用する物質間の相互作用検出部と該検出部を用いる方法及びバイオアッセイ用基板
US7425253B2 (en) 2004-01-29 2008-09-16 Massachusetts Institute Of Technology Microscale sorting cytometer
WO2005080606A1 (en) 2004-02-18 2005-09-01 Xiaochuan Zhou Fluidic devices and methods for multiplex chemical and biochemical reactions
KR100597870B1 (ko) * 2004-04-01 2006-07-06 한국과학기술원 고속 스크리닝 또는 고속 분석을 위한 미소 유체 칩
WO2005100541A2 (en) 2004-04-12 2005-10-27 The Regents Of The University Of California Optoelectronic tweezers for microparticle and cell manipulation
US20060091015A1 (en) 2004-11-01 2006-05-04 Applera Corporation Surface modification for non-specific adsorption of biological material
GB2420850A (en) * 2004-12-03 2006-06-07 Orion Diagnostica Oy Particle based binding assay
EP3029135B1 (en) * 2005-07-07 2021-03-17 The Regents of the University of California Apparatus for cell culture array
WO2007024701A2 (en) 2005-08-19 2007-03-01 The Regents Of The University Of California Microfluidic methods for diagnostics and cellular analysis
WO2007102839A2 (en) 2005-10-27 2007-09-13 Applera Corporation Optoelectronic separation of biomolecules
US8124015B2 (en) 2006-02-03 2012-02-28 Institute For Systems Biology Multiplexed, microfluidic molecular assay device and assay method
WO2008119066A1 (en) 2007-03-28 2008-10-02 The Regents Of The University Of California Single-sided lateral-field and phototransistor-based optoelectronic tweezers
US20080302732A1 (en) 2007-05-24 2008-12-11 Hyongsok Soh Integrated fluidics devices with magnetic sorting
AU2008280932B8 (en) 2007-07-24 2011-02-24 Panasonic Electric Works Co., Ltd. Charging monitor
US8961877B2 (en) 2007-08-09 2015-02-24 Massachusetts Institute Of Technology High-throughput, whole-animal screening system
EP2078958A1 (en) 2007-10-25 2009-07-15 Koninklijke Philips Electronics N.V. A reconfigurable microfluidic filter based on eletric fields
JP2011516867A (ja) 2008-04-03 2011-05-26 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア 細胞、小胞、ナノ粒子およびバイオマーカーを分離および単離するためのエキソビボの多次元システム
US20110117634A1 (en) * 2008-04-21 2011-05-19 Asaf Halamish Flat cell carriers with cell traps
KR20100000822A (ko) 2008-06-25 2010-01-06 엘지디스플레이 주식회사 유기전계발광표시장치와 이의 제조방법
WO2010005593A1 (en) * 2008-07-11 2010-01-14 President And Fellows Of Harvard College Systems and methods of droplet-based selection
GB2464300A (en) * 2008-10-10 2010-04-14 Univ Dublin City Microfluidic multiplexed cellular and molecular analysis device and method
WO2010115167A2 (en) 2009-04-03 2010-10-07 The Regents Of The University Of California Methods and devices for sorting cells and other biological particulates
US20100273681A1 (en) 2009-04-27 2010-10-28 Wisconsin Alumni Research Foundation Combinatorial chemistry reaction cell with optical tweezers
JP2011000079A (ja) 2009-06-19 2011-01-06 Univ Of Tokyo 粒子を操作する方法及びマイクロ流体装置
WO2011149032A1 (ja) * 2010-05-26 2011-12-01 東ソー株式会社 生体試料固定装置
CN101947124B (zh) 2010-06-25 2012-07-04 博奥生物有限公司 一种集成式微流控芯片装置及其使用方法
CN103261436B (zh) 2010-09-14 2015-03-25 加利福尼亚大学董事会 利用微流体截留涡流从异质溶液中分离细胞的方法
WO2012050981A1 (en) 2010-09-29 2012-04-19 Massachusetts Institute Of Technology Device for high throughput investigations of cellular interactions
US20140178854A1 (en) * 2010-10-31 2014-06-26 Tocagen Inc. Antisera assays for mlv related viruses in humans and other mammals
US10571475B2 (en) 2010-12-03 2020-02-25 Cellply S.R.L. Rapid screening of monoclonal antibodies
EP2646798B1 (en) * 2010-12-03 2017-06-28 Cellply S.R.L. Microanalysis of cellular function
US8765455B2 (en) * 2011-01-27 2014-07-01 Lawrence Livermore National Security, Llc Chip-based droplet sorting
US9227200B2 (en) 2011-06-03 2016-01-05 The Regents Of The University Of California Microfluidic devices with flexible optically transparent electrodes
CN103998394B (zh) 2011-08-01 2016-08-17 德诺弗科学公司 细胞捕获系统和使用方法
US9050593B2 (en) 2011-11-23 2015-06-09 Wisconsin Alumni Research Foundation Self-loading microfluidic device and methods of use
CA2868261C (en) * 2012-03-27 2020-07-14 The Regents Of The University Of California Continuous whole-chip 3-dimensional dep cell sorter and related fabrication method
US9857333B2 (en) * 2012-10-31 2018-01-02 Berkeley Lights, Inc. Pens for biological micro-objects
US9403172B2 (en) 2012-11-08 2016-08-02 Berkeley Lights, Inc. Circuit based optoelectronic tweezers
KR102257305B1 (ko) 2013-03-28 2021-05-28 더 유니버시티 오브 브리티쉬 콜롬비아 미세유동 장치 및 분비물의 다세포 검정법에서의 그의 사용 방법

Similar Documents

Publication Publication Date Title
JP2017502257A5 (https=)
JP6465878B2 (ja) 生体アクティビティをアッセイするための微少流体デバイス
US20220388003A1 (en) Micro-Fluidic Devices for Assaying Biological Activity
US10802014B2 (en) Apparatus for improved disease detection
US9408565B2 (en) Apparatus for detecting tumor cells
US20130236882A1 (en) Micro-Devices for Improved Disease Detection
WO2020123305A3 (en) Generating capture probes for spatial analysis
WO2017181030A2 (en) Analyte detection methods and apparatus using dielectrophoresis and electroosmosis
CA2831223A1 (en) Micro-devices for disease detection
US6991906B1 (en) Method and device for measuring, calibrating and using laser tweezers
ATE339687T1 (de) Immunologische verfahren, vorrichtungen und reagenzien
JP6363078B2 (ja) センサデバイス及びサンプリングする方法
KR20150101651A (ko) 부유미생물 측정장치 및 그 측정방법
James et al. High-efficiency magnetic particle focusing using dielectrophoresis and magnetophoresis in a microfluidic device
PL3591403T3 (pl) Sposób zautomatyzowanego wykrywania przeciwciał w ciekłej próbce biologicznej z zastosowaniem chipu antygenowego
US20170113223A1 (en) Biosensor for the detection of target components in a sample
US20160320373A1 (en) Re-Usable Analyte Detector and Methods
HK40002833A (en) Micro-fluidic devices for assaying biological activity
JP2012254048A (ja) 分離装置および分離方法
KR20160013647A (ko) 부유미생물 측정장치 및 그 측정방법
De La Fuente Short paper: Design of a dielectrophoresis-based portable device for monitoring pollution in water deposits
JP2008232927A (ja) タンパク質濃縮装置及びタンパク質測定装置、これらを用いた空気調整機