JP2017500301A - シンナムアルデヒドを使用したエネルギー消費を増大するための方法及び組成物 - Google Patents
シンナムアルデヒドを使用したエネルギー消費を増大するための方法及び組成物 Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Abstract
Description
[0057]以下の非限定的実施例は、シンナムアルデヒドを投与して、許容できない味覚又は胃腸作用を与えることなく、エネルギー消費、交感神経系活性、又は脂肪酸化のうちの少なくとも1つを増大するという概念を発展及び支持する臨床科学的データを示す。
[0059]ヒト被験者に、プラシーボ、清涼香味剤、カプサイシン又はシンナムアルデヒドを投与した。エネルギー消費を、摂取後80分間測定した。図3は、エネルギー消費を、種々の化合物の摂取後の経過時間の関数として示すグラフである。図4は、種々の化合物の摂取後のAUCに基づくエネルギー消費を示すグラフである。図3及び4は、シンナムアルデヒド摂取後に、プラシーボと比較して、エネルギー消費が増大することを示す。
[0065]ヒト被験者に、4.8ppmのカプサイシン又は350ppmのシンナムアルデヒドを含む組成物を投与した。図9は、比較味覚試験結果のグラフを示す。参加者の87.9%が、カプサイシン強度を非常に強いと判定したのに対し、シンナムアルデヒドに関しては、わずか20.5%であった。カプサイシン及びシンナムアルデヒドの脂肪酸化に対する類似の効果を達成するため、カプサイシンの用量は、香味剤として使用できる最大量(Fenaroli’s Handbookにより、7ppm)の約1.5分の1であり、シンナムアルデヒドの用量は、香味剤として使用できる最大量(Fenaroli’s Handbookにより、6191.0ppm)の約17.5分の1である。
Claims (15)
- 体重維持の方法であって、それを必要とする哺乳類にシンナムアルデヒドを含む組成物を投与する工程を含む、方法。
- 前記シンナムアルデヒドは、約1.25mg/kg体重/日の量で投与される、請求項1に記載の方法。
- 前記シンナムアルデヒドは、17.48ppm〜6191.0ppmの濃度で前記組成物中に存在する、請求項1に記載の方法。
- 前記シンナムアルデヒドを含む組成物は、1日1回投与される、請求項1に記載の方法。
- 前記組成物は、前記シンナムアルデヒドの少なくとも一部をもたらすシナモン精油抽出物を含む、請求項1に記載の方法。
- 前記シンナムアルデヒドの少なくとも一部は、単離シンナムアルデヒド及び合成シンナムアルデヒドからなる群から選択される、請求項1に記載の方法。
- 体重減少を促進する方法であって、それを必要とする哺乳類にシンナムアルデヒドを含む組成物を投与する工程を含む、方法。
- 肥満又は体重過多を予防する方法であって、そのリスクのある哺乳類にシンナムアルデヒドを含む組成物を投与する工程を含む、方法。
- 肥満又は体重過多を治療する方法であって、それを必要とする哺乳類にシンナムアルデヒドを含む組成物を投与する工程を含む、方法。
- シンナムアルデヒドを、経口的に耐容可能な量であって、エネルギー消費、交感神経系活性、及び脂肪酸化からなる群から選択される少なくとも1つの特徴を増大するのに有効な量で含む組成物。
- 前記組成物は、前記シンナムアルデヒドが17.48ppm〜6191.0ppmの濃度でその中に存在する食料製品である、請求項10に記載の組成物。
- 前記組成物は、タンパク質、炭水化物、脂肪、及びこれらの組み合わせからなる群から選択される成分を含む食料製品である、請求項10に記載の組成物。
- 前記組成物は、薬剤、食料製品、及び食料製品に対する栄養補助剤からなる群から選択される、請求項10に記載の組成物。
- 前記組成物は、追加成分を、体重維持又は体重減少を促進するために治療的に有効な量で更に含む、請求項10に記載の組成物。
- 減量プログラムを実施中の個体にシンナムアルデヒドを含む組成物を投与する工程を含む、体重減少を促進する方法。
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PCT/EP2014/077544 WO2015086811A1 (en) | 2013-12-12 | 2014-12-12 | Methods and compositions for increasing energy expenditure using cinnamaldehyde |
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JP2006199647A (ja) * | 2005-01-21 | 2006-08-03 | Japan Health Science Foundation | 脂肪細胞分化制御剤 |
JP2007535576A (ja) * | 2004-04-30 | 2007-12-06 | ニュー・エイチ・シー・フォーミュレーションズ・リミテッド | 迅速な体重減少を促進し、カロリーを燃焼させ、熱発生を増大させ、エネルギー代謝を補助し、且つ/または食欲を抑制する栄養組成物 |
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CN1320438A (zh) * | 2000-04-26 | 2001-11-07 | 萧湘 | 药物的制备方法 |
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JP2010083787A (ja) * | 2008-09-30 | 2010-04-15 | Kirin Holdings Co Ltd | Cb1受容体アンタゴニストとしての桂皮アルデヒドおよび桂皮抽出物 |
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US10159653B2 (en) | 2018-12-25 |
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CN105792819A (zh) | 2016-07-20 |
AU2014363403A1 (en) | 2016-05-05 |
BR112016012233A2 (pt) | 2017-08-08 |
AU2024200698A1 (en) | 2024-02-22 |
CA2929067A1 (en) | 2015-06-18 |
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