JP2017509640A - 嚥下を改善するためシンナムアルデヒド及び亜鉛を含む組成物 - Google Patents
嚥下を改善するためシンナムアルデヒド及び亜鉛を含む組成物 Download PDFInfo
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- JP2017509640A JP2017509640A JP2016557636A JP2016557636A JP2017509640A JP 2017509640 A JP2017509640 A JP 2017509640A JP 2016557636 A JP2016557636 A JP 2016557636A JP 2016557636 A JP2016557636 A JP 2016557636A JP 2017509640 A JP2017509640 A JP 2017509640A
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- Prior art keywords
- cinnamaldehyde
- composition
- zinc
- swallowing
- patient
- Prior art date
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Classifications
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Abstract
Description
アルコール飲料:最大で498.8ppm、例えば、約435.6ppmなど
焼成食品:最大で367.4ppm、例えば、約273.8ppmなど
チューインガム:最大で6191.0ppm、例えば、約1533.0ppmなど
香辛料又は風味量:最大で31.87ppm、例えば、約17.48ppmなど
冷凍乳製品:最大で77.96ppm、例えば、約72.98ppmなど
フルーツアイス:最大で900.0ppm、例えば、900.0ppmなど
ゼラチン又はプディング:最大で109.4ppm、例えば、約100.3ppmなど
グレービー:最大で800.0ppm、例えば、約640.0ppmなど
ハードキャンディ:最大で1003.0ppm、例えば、約792.2ppmなど
肉製品:最大で39.09ppm、例えば、約6.97ppmなど
非アルコール飲料:最大で67.82ppm、例えば、約52.71ppmなど
ソフトキャンディ:最大で370.0ppm、例えば、370.0ppmなど。
[0058]以下の非限定例は、許容できない味又は胃腸管作用を付与することなくTRPA1を相乗的に活性化して、嚥下反射を促進するための、シンナムアルデヒド及び亜鉛の併用投与の概念を展開し、かつ支持する、試験管内での科学的データを示す。
[0060]10μMシンナムアルデヒド、及び0.3μM亜鉛のそれぞれ、並びにこれらの併用について、CHO細胞において発現したhTRPA1の試験管内活性を測定した。結果を図2に示し、シンナムアルデヒド及び亜鉛を併用したときの相乗効果を示す(シンナムアルデヒド+亜鉛)。C+は、この試験に関し実験上の陽性対照を表し、50mMのシンナムアルデヒドである。C+は用量応答曲線によると最大効果を与える。
Claims (15)
- シンナムアルデヒド及び亜鉛を含む組成物を、嚥下反射を促進する必要のある患者に投与することを含む、嚥下反射を促進する方法。
- 前記シンナムアルデヒドが、摂取するのに忍容可能な量であり、かつ前記亜鉛と組み合わせて前記患者における嚥下反射を促進するのに有効な量で、前記組成物中に存在する、請求項1に記載の方法。
- 前記嚥下反射の促進が、前記嚥下反射の惹起、前記患者の嚥下能の向上、前記嚥下反射の効率の向上、嚥下遅延の低減、及びこれらの組み合わせからなる群から選択される効果を含む、請求項2に記載の方法。
- 前記組成物が、前記シンナムアルデヒドの少なくとも一部をもたらすシナモン精油抽出物を含む、請求項1に記載の方法。
- 前記シンナムアルデヒドの少なくとも一部が、単離シンナムアルデヒド及び合成シンナムアルデヒドからなる群から選択される、請求項1に記載の方法。
- 前記亜鉛の少なくとも一部が、塩化亜鉛、硫酸亜鉛、乳酸亜鉛、クエン酸亜鉛、及びこれらの組み合わせからなる群から選択される、請求項1に記載の方法。
- 嚥下困難を有する患者にシンナムアルデヒド及び亜鉛を含む組成物を投与することを含む、嚥下困難の治療方法。
- 前記嚥下困難が、癌、癌化学療法、癌放射線療法、口腔癌手術、咽喉癌手術、脳卒中、脳損傷、進行性神経筋疾患、神経変性疾患、患者が高齢であること、及びこれらの組み合わせからなる群から選択された状態に関連する、口腔咽頭嚥下困難である、請求項7に記載の方法。
- 嚥下困難による誤嚥性肺炎の危険性のある患者に、シンナムアルデヒド及び亜鉛を含む組成物を投与することを含む、嚥下困難による誤嚥性肺炎の予防方法。
- 前記シンナムアルデヒドが、摂取するのに忍容可能な量であり、かつ前記亜鉛と組み合わせて前記患者における嚥下反射を促進するのに有効な量で、前記組成物中に存在する、請求項9に記載の方法。
- シンナムアルデヒド及び亜鉛を含む組成物。
- 前記シンナムアルデヒドが、経口的に忍容可能な量であり、前記組成物の前記亜鉛と組み合わせて嚥下反射を促進するのに有効な量で、前記組成物中に存在する、請求項11に記載の組成物。
- 前記組成物が、前記シンナムアルデヒドが約100ppmの濃度で存在する食品製品である、請求項11に記載の組成物。
- 前記組成物が、前記シンナムアルデヒド:亜鉛比が1:0.5〜1:0.005の食品製品である、請求項11に記載の組成物。
- 前記組成物が、タンパク質、炭水化物、脂質、及びこれらの組み合わせからなる群から選択される成分を含む食品製品である、請求項11に記載の組成物。
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PCT/EP2015/055479 WO2015140124A1 (en) | 2014-03-20 | 2015-03-17 | Composition comprising cinnamaldehyde and zinc to improve swallowing |
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CN106102727A (zh) | 2016-11-09 |
AU2015233634A1 (en) | 2016-07-28 |
WO2015140124A1 (en) | 2015-09-24 |
US20230201255A1 (en) | 2023-06-29 |
US20190125793A1 (en) | 2019-05-02 |
CA2939846A1 (en) | 2015-09-24 |
CN106102727B (zh) | 2021-07-02 |
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BR112016018009A2 (pt) | 2017-08-08 |
CA2939846C (en) | 2022-07-26 |
ES2672798T3 (es) | 2018-06-18 |
AU2015233634B2 (en) | 2020-01-30 |
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EP3119385B2 (en) | 2020-11-11 |
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DK3119385T4 (da) | 2021-02-15 |
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