JP6869286B2 - 桂皮アルデヒド及び亜鉛を含む組成物並びにかかる組成物の使用方法 - Google Patents
桂皮アルデヒド及び亜鉛を含む組成物並びにかかる組成物の使用方法 Download PDFInfo
- Publication number
- JP6869286B2 JP6869286B2 JP2019084115A JP2019084115A JP6869286B2 JP 6869286 B2 JP6869286 B2 JP 6869286B2 JP 2019084115 A JP2019084115 A JP 2019084115A JP 2019084115 A JP2019084115 A JP 2019084115A JP 6869286 B2 JP6869286 B2 JP 6869286B2
- Authority
- JP
- Japan
- Prior art keywords
- cinnamaldehyde
- zinc
- composition
- ppm
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 title claims description 90
- 229940117916 cinnamic aldehyde Drugs 0.000 title claims description 90
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 title claims description 90
- 239000000203 mixture Substances 0.000 title claims description 74
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title claims description 54
- 239000011701 zinc Substances 0.000 title claims description 53
- 229910052725 zinc Inorganic materials 0.000 title claims description 53
- 235000013305 food Nutrition 0.000 claims description 36
- 206010022489 Insulin Resistance Diseases 0.000 claims description 33
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 32
- 239000008103 glucose Substances 0.000 claims description 32
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 18
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 15
- 235000017803 cinnamon Nutrition 0.000 claims description 13
- 150000001299 aldehydes Chemical class 0.000 claims description 12
- 102000004877 Insulin Human genes 0.000 claims description 9
- 108090001061 Insulin Proteins 0.000 claims description 9
- 239000003925 fat Substances 0.000 claims description 9
- 229940125396 insulin Drugs 0.000 claims description 9
- 150000001720 carbohydrates Chemical class 0.000 claims description 8
- 235000014633 carbohydrates Nutrition 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 208000002705 Glucose Intolerance Diseases 0.000 claims description 6
- 201000009104 prediabetes syndrome Diseases 0.000 claims description 6
- 239000000341 volatile oil Substances 0.000 claims description 5
- 208000001362 Fetal Growth Retardation Diseases 0.000 claims description 4
- 206010070531 Foetal growth restriction Diseases 0.000 claims description 4
- 208000030941 fetal growth restriction Diseases 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 235000000346 sugar Nutrition 0.000 claims description 4
- 208000004104 gestational diabetes Diseases 0.000 claims description 3
- 241000723347 Cinnamomum Species 0.000 claims 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 48
- 230000000694 effects Effects 0.000 description 32
- 150000001875 compounds Chemical class 0.000 description 26
- 229960002504 capsaicin Drugs 0.000 description 24
- 235000017663 capsaicin Nutrition 0.000 description 24
- 230000037406 food intake Effects 0.000 description 24
- 230000008901 benefit Effects 0.000 description 23
- 238000005265 energy consumption Methods 0.000 description 22
- 230000036651 mood Effects 0.000 description 21
- 230000001965 increasing effect Effects 0.000 description 20
- 238000000034 method Methods 0.000 description 20
- 230000004580 weight loss Effects 0.000 description 20
- 230000019771 cognition Effects 0.000 description 16
- 230000015654 memory Effects 0.000 description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 15
- 235000005911 diet Nutrition 0.000 description 14
- 238000011282 treatment Methods 0.000 description 14
- 210000002820 sympathetic nervous system Anatomy 0.000 description 13
- 230000037213 diet Effects 0.000 description 12
- 201000010099 disease Diseases 0.000 description 12
- 239000000796 flavoring agent Substances 0.000 description 12
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 11
- 239000008280 blood Substances 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 9
- 230000020477 pH reduction Effects 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 241000282414 Homo sapiens Species 0.000 description 8
- 241000124008 Mammalia Species 0.000 description 8
- 208000008589 Obesity Diseases 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 8
- 208000010877 cognitive disease Diseases 0.000 description 8
- 235000020824 obesity Nutrition 0.000 description 8
- 230000002195 synergetic effect Effects 0.000 description 8
- 235000014113 dietary fatty acids Nutrition 0.000 description 7
- 235000015872 dietary supplement Nutrition 0.000 description 7
- 235000019197 fats Nutrition 0.000 description 7
- 239000000194 fatty acid Substances 0.000 description 7
- 229930195729 fatty acid Natural products 0.000 description 7
- 150000004665 fatty acids Chemical class 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 206010033307 Overweight Diseases 0.000 description 6
- -1 addition to Chemical compound 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000003930 cognitive ability Effects 0.000 description 6
- 230000001976 improved effect Effects 0.000 description 6
- 235000016709 nutrition Nutrition 0.000 description 6
- 230000000291 postprandial effect Effects 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- 230000035807 sensation Effects 0.000 description 6
- 235000019615 sensations Nutrition 0.000 description 6
- 241000282412 Homo Species 0.000 description 5
- 235000013355 food flavoring agent Nutrition 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 235000018102 proteins Nutrition 0.000 description 5
- 208000000044 Amnesia Diseases 0.000 description 4
- 235000003130 Arctium lappa Nutrition 0.000 description 4
- 244000294263 Arctium minus Species 0.000 description 4
- 235000008078 Arctium minus Nutrition 0.000 description 4
- 235000013361 beverage Nutrition 0.000 description 4
- 230000006999 cognitive decline Effects 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 238000012423 maintenance Methods 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 235000013599 spices Nutrition 0.000 description 4
- 235000019640 taste Nutrition 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000012549 training Methods 0.000 description 4
- 230000037221 weight management Effects 0.000 description 4
- 241000723438 Cercidiphyllum japonicum Species 0.000 description 3
- 206010061818 Disease progression Diseases 0.000 description 3
- 208000026139 Memory disease Diseases 0.000 description 3
- 208000019022 Mood disease Diseases 0.000 description 3
- 244000203593 Piper nigrum Species 0.000 description 3
- 235000008184 Piper nigrum Nutrition 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229940112822 chewing gum Drugs 0.000 description 3
- 235000015218 chewing gum Nutrition 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 230000005750 disease progression Effects 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 235000011194 food seasoning agent Nutrition 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 235000015263 low fat diet Nutrition 0.000 description 3
- 230000006984 memory degeneration Effects 0.000 description 3
- 208000023060 memory loss Diseases 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 210000000496 pancreas Anatomy 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 239000000902 placebo Substances 0.000 description 3
- 229940068196 placebo Drugs 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 230000002889 sympathetic effect Effects 0.000 description 3
- 230000001052 transient effect Effects 0.000 description 3
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 2
- 240000003291 Armoracia rusticana Species 0.000 description 2
- 235000011330 Armoracia rusticana Nutrition 0.000 description 2
- 244000056139 Brassica cretica Species 0.000 description 2
- 235000003351 Brassica cretica Nutrition 0.000 description 2
- 235000003343 Brassica rupestris Nutrition 0.000 description 2
- 206010006784 Burning sensation Diseases 0.000 description 2
- 206010012289 Dementia Diseases 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 244000273928 Zingiber officinale Species 0.000 description 2
- 235000006886 Zingiber officinale Nutrition 0.000 description 2
- 239000000556 agonist Substances 0.000 description 2
- 238000002266 amputation Methods 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 2
- 235000013614 black pepper Nutrition 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 235000019577 caloric intake Nutrition 0.000 description 2
- 150000003943 catecholamines Chemical class 0.000 description 2
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 2
- 230000001149 cognitive effect Effects 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 235000013365 dairy product Nutrition 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 235000005686 eating Nutrition 0.000 description 2
- 230000008451 emotion Effects 0.000 description 2
- 230000002996 emotional effect Effects 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 235000013373 food additive Nutrition 0.000 description 2
- 239000002778 food additive Substances 0.000 description 2
- 235000013350 formula milk Nutrition 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 235000008397 ginger Nutrition 0.000 description 2
- 235000009200 high fat diet Nutrition 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 235000020845 low-calorie diet Nutrition 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 208000027061 mild cognitive impairment Diseases 0.000 description 2
- 235000010460 mustard Nutrition 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 235000006180 nutrition needs Nutrition 0.000 description 2
- 238000007410 oral glucose tolerance test Methods 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 230000001502 supplementing effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000005062 synaptic transmission Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000001331 thermoregulatory effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 231100000167 toxic agent Toxicity 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 230000003936 working memory Effects 0.000 description 2
- 235000013618 yogurt Nutrition 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 244000080208 Canella winterana Species 0.000 description 1
- 235000008499 Canella winterana Nutrition 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 240000004160 Capsicum annuum Species 0.000 description 1
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 1
- 235000007862 Capsicum baccatum Nutrition 0.000 description 1
- 108091005462 Cation channels Proteins 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 208000028698 Cognitive impairment Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010012689 Diabetic retinopathy Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 102000003746 Insulin Receptor Human genes 0.000 description 1
- 108010001127 Insulin Receptor Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010028817 Nausea and vomiting symptoms Diseases 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 206010048636 Self-induced vomiting Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 229940123223 TRPA1 agonist Drugs 0.000 description 1
- 102000003610 TRPM8 Human genes 0.000 description 1
- 101150111302 Trpm8 gene Proteins 0.000 description 1
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000016571 aggressive behavior Effects 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- 238000005882 aldol condensation reaction Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000003935 attention Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- 230000037237 body shape Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 235000015496 breakfast cereal Nutrition 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000001728 capsicum frutescens Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000021074 carbohydrate intake Nutrition 0.000 description 1
- 235000012182 cereal bars Nutrition 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 229940017545 cinnamon bark Drugs 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007278 cognition impairment Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 235000014510 cooky Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000012495 crackers Nutrition 0.000 description 1
- 235000015140 cultured milk Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 235000021196 dietary intervention Nutrition 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000009982 effect on human Effects 0.000 description 1
- 239000008393 encapsulating agent Substances 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 235000013882 gravy Nutrition 0.000 description 1
- 230000010370 hearing loss Effects 0.000 description 1
- 231100000888 hearing loss Toxicity 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000008449 language Effects 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 235000020855 low-carbohydrate diet Nutrition 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 235000020879 medical diet Nutrition 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000003924 mental process Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000020166 milkshake Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000009456 molecular mechanism Effects 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 235000019520 non-alcoholic beverage Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000036314 physical performance Effects 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 235000011962 puddings Nutrition 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 235000019685 rice crackers Nutrition 0.000 description 1
- 239000011257 shell material Substances 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 235000013570 smoothie Nutrition 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000005496 tempering Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 235000008924 yoghurt drink Nutrition 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 229960001939 zinc chloride Drugs 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Description
[0086]アルコール飲料:最高498.8ppm、例えば、約435.6ppm
[0087]焼成製品:最高367.4ppm、例えば、約273.8ppm
[0088]チューインガム:最高6191.0ppm、例えば、約1533.0ppm
[0089]調味料又は香辛料:最高31.87ppm、例えば、約17.48ppm
[0090]凍結した乳製品(frozendairy product):最高77.96ppm、例えば、約72.98ppm
[0091]フルーツアイス:最高900.0ppm、例えば、900.0ppm
[0092]ゼラチン又はプディング:最高109.4ppm、例えば、約100.3ppm
[0093]グレイビー:最高800.0ppm、例えば、約640.0ppm
[0094]ハードキャンディ:最高1003.0ppm、例えば、約792.2ppm
[0095]肉製品:最高39.09ppm、例えば、約6.97ppm
[0096]ノンアルコール飲料:最高67.82ppm、例えば、約52.71ppm
[0097]ソフトキャンディ:最高370.0ppm、例えば、370.0ppm
[0112]以下の非限定例は、不愉快な味わい又は胃腸に対する許容不能な影響をもたらすことなく、TRPA1を相乗的に活性化させて、エネルギー消費、交感神経系の活動、若しくは脂肪酸化のうちの少なくとも1つを向上させ、かつ/又はインスリン感受性、耐糖能、認知能力、認知、気分、若しくは記憶力のうちの少なくとも1つを改善させるという、桂皮アルデヒド及び亜鉛の組み合わせた投与の概念を発展させ、かつ支持する科学的なデータを示す。
[0114]ヒト被験者に、プラシーボ、清涼香味剤、カプサイシン又は桂皮アルデヒドを投与した。エネルギー消費を、摂取後80分間測定した。図3は、エネルギー消費を、種々の化合物の摂取後の経過時間の関数として示すグラフである。図4は、種々の化合物の摂取後のAUCに基づくエネルギー消費を示すグラフである。図3及び4は、桂皮アルデヒド摂取後に、プラシーボと比較してエネルギー消費が増大することを示す。
[0120]ヒト被験者に、4.8ppmのカプサイシン又は350ppmの桂皮アルデヒドを含む組成物を投与した。図9は、比較味覚試験結果のグラフを示す。参加者の87.9%が、カプサイシン強度を非常に強いと判定したのに対し、桂皮アルデヒドに関しては、わずか20.5%であった。カプサイシン及び桂皮アルデヒドに関し、脂肪酸化に対し同様の効果を達成するため、カプサイシンの投与量は、着香剤として使用可能な最高量の約1.5分の1とし(Fenaroli’s Handbook;Burdock,2010によると7ppm)、及び桂皮アルデヒドの投与量は、着香剤として使用可能な最高量の約17.5分の1とする(Fenaroli’s Handbook;Burdock,2010によると6191.0ppm)。
[0122]CHO細胞において、それぞれ10μM桂皮アルデヒド及び0.3μM亜鉛、並びにこれらの組み合わせにより発現したhTRPA1のin vitro活性を測定した。結果を図10に示し、かつ、桂皮アルデヒド及び亜鉛を組み合わせたとき(Cin+Zinc)の相乗効果を示す。C+は、本試験の実施上の陽性対照を表し、用量反応曲線による最大反応を与える50mM桂皮アルデヒドである。
Claims (8)
- 桂皮アルデヒド及び亜鉛を含み、前記桂皮アルデヒドが31.87ppm〜6191ppmの香味付与濃度で存在し、前記桂皮アルデヒド:亜鉛の比が1:0.5〜1:0.03である食品製品である、インスリン感受性及び耐糖能からなる群から選択される少なくとも1つを改善するための組成物。
- 前記桂皮アルデヒドが、安全で摂取するのに許容可能な量であり、かつ前記亜鉛と組み合わせて、インスリン感受性及び耐糖能からなる群から選択される少なくとも1つを改善するのに有効な量で、前記組成物に存在する、請求項1に記載の組成物。
- 早産児、子宮内胎児発育遅延を経験した幼児、妊娠性糖尿病に罹患している妊婦、インスリン感受性に罹患しているヒト、耐糖能障害に罹患しているヒト、及びII型糖尿病に罹患しているヒトからなる群から選択される個体のための、請求項1又は2に記載の組成物。
- 前記組成物が、前記桂皮アルデヒドの少なくとも一部をもたらすシナモン精油抽出物を含む、請求項1〜3のいずれか一項に記載の組成物。
- 前記桂皮アルデヒドの少なくとも一部が、単離桂皮アルデヒド及び合成桂皮アルデヒドからなる群から選択される、請求項1〜4のいずれか一項に記載の組成物。
- 少なくとも一週間にわたって、少なくとも1日1回、個体に投与される、請求項1〜5のいずれか一項に記載の組成物。
- タンパク質、炭水化物、脂肪、及びこれらの組み合わせからなる群から選択される構成成分を含む食品製品である、請求項1〜6のいずれか一項に記載の組成物。
- 請求項1〜7のいずれか一項に記載の組成物を、タンパク質、炭水化物、脂肪、及びこれらの組み合わせからなる群から選択される構成成分に添加することを含む、食品の製造方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462026157P | 2014-07-18 | 2014-07-18 | |
US62/026,157 | 2014-07-18 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017501660A Division JP2017526643A (ja) | 2014-07-18 | 2015-06-08 | 桂皮アルデヒド及び亜鉛を含む組成物並びにかかる組成物の使用方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019142940A JP2019142940A (ja) | 2019-08-29 |
JP6869286B2 true JP6869286B2 (ja) | 2021-05-12 |
Family
ID=53366030
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017501660A Pending JP2017526643A (ja) | 2014-07-18 | 2015-06-08 | 桂皮アルデヒド及び亜鉛を含む組成物並びにかかる組成物の使用方法 |
JP2019084115A Active JP6869286B2 (ja) | 2014-07-18 | 2019-04-25 | 桂皮アルデヒド及び亜鉛を含む組成物並びにかかる組成物の使用方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017501660A Pending JP2017526643A (ja) | 2014-07-18 | 2015-06-08 | 桂皮アルデヒド及び亜鉛を含む組成物並びにかかる組成物の使用方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US10092028B2 (ja) |
EP (2) | EP3756475A1 (ja) |
JP (2) | JP2017526643A (ja) |
CN (1) | CN106470691B (ja) |
AU (1) | AU2015291442B2 (ja) |
BR (1) | BR112016029749B1 (ja) |
CA (2) | CA2951090A1 (ja) |
ES (1) | ES2822524T3 (ja) |
WO (1) | WO2016008642A2 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10188678B2 (en) * | 2014-03-20 | 2019-01-29 | Nestec S.A. | Composition comprising cinnamaldehyde and zinc to improve swallowing |
CA2985564A1 (en) * | 2015-06-05 | 2016-12-08 | Nestec S.A. | Compositions comprising cinnamaldehyde and zinc and methods of using such compositions |
US20180125795A1 (en) * | 2017-01-03 | 2018-05-10 | Thermolife International, Llc | Cinnamaldehyde compositions and methods |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4469674A (en) * | 1981-09-03 | 1984-09-04 | Richardson-Vicks Inc. | Stable oral compositions containing zinc and fluoride compounds |
AU1094301A (en) * | 1999-10-19 | 2001-04-30 | Nutrasweet Company, The | Personal care products using n-(n-(3,3-dimethylbutyl)-1-alpha-aspartyl)-l-phenylalanine methyl ester |
DE202004017113U1 (de) * | 2004-11-05 | 2004-12-30 | Salus-Haus Gmbh & Co. Kg | Momordica charantia-Zimt-Zubereitung |
KR20120122597A (ko) * | 2011-04-29 | 2012-11-07 | 영남대학교 산학협력단 | 계피 추출물을 유효성분으로 함유하는 대사증후군의 예방 및 치료용 조성물 |
JP6669665B2 (ja) * | 2014-03-20 | 2020-03-18 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 体重管理にシンナムアルデヒド及び亜鉛を用いるための方法及び組成物 |
-
2015
- 2015-06-08 AU AU2015291442A patent/AU2015291442B2/en active Active
- 2015-06-08 JP JP2017501660A patent/JP2017526643A/ja active Pending
- 2015-06-08 ES ES15727655T patent/ES2822524T3/es active Active
- 2015-06-08 WO PCT/EP2015/062696 patent/WO2016008642A2/en active Application Filing
- 2015-06-08 BR BR112016029749-0A patent/BR112016029749B1/pt active IP Right Grant
- 2015-06-08 US US15/327,108 patent/US10092028B2/en active Active
- 2015-06-08 CA CA2951090A patent/CA2951090A1/en active Pending
- 2015-06-08 CA CA3132696A patent/CA3132696C/en active Active
- 2015-06-08 CN CN201580034856.3A patent/CN106470691B/zh active Active
- 2015-06-08 EP EP20184577.3A patent/EP3756475A1/en active Pending
- 2015-06-08 EP EP15727655.1A patent/EP3169170B1/en active Active
-
2019
- 2019-04-25 JP JP2019084115A patent/JP6869286B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
JP2017526643A (ja) | 2017-09-14 |
ES2822524T3 (es) | 2021-05-04 |
CN106470691A (zh) | 2017-03-01 |
AU2015291442B2 (en) | 2019-04-11 |
BR112016029749A2 (pt) | 2017-08-22 |
WO2016008642A2 (en) | 2016-01-21 |
EP3756475A1 (en) | 2020-12-30 |
EP3169170B1 (en) | 2020-07-08 |
WO2016008642A3 (en) | 2016-03-17 |
CA3132696A1 (en) | 2016-01-21 |
BR112016029749A8 (pt) | 2021-03-16 |
CN106470691B (zh) | 2020-04-03 |
US20170164648A1 (en) | 2017-06-15 |
EP3169170A2 (en) | 2017-05-24 |
JP2019142940A (ja) | 2019-08-29 |
CA3132696C (en) | 2023-10-10 |
CA2951090A1 (en) | 2016-01-21 |
AU2015291442A1 (en) | 2016-12-08 |
US10092028B2 (en) | 2018-10-09 |
BR112016029749B1 (pt) | 2021-10-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7163460B2 (ja) | 桂皮アルデヒド及び亜鉛を含む組成物並びにかかる組成物の使用方法 | |
JP6869286B2 (ja) | 桂皮アルデヒド及び亜鉛を含む組成物並びにかかる組成物の使用方法 | |
US20220133782A1 (en) | Methods and compositions for using cinnamaldehyde and zinc for weight management | |
JP6629732B2 (ja) | シンナムアルデヒドを使用したエネルギー消費を増大するための方法及び組成物 | |
JP6360172B2 (ja) | チグリンアルデヒドを使用する組成物及び方法 | |
JP6513103B2 (ja) | 嚥下を改善するためシンナムアルデヒド及び亜鉛を含む組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190509 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A712 Effective date: 20190614 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200414 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20200709 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201013 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20201104 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210303 |
|
C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20210303 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20210311 |
|
C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20210316 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210406 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210413 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6869286 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |