JP2017218449A5 - - Google Patents
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- Publication number
- JP2017218449A5 JP2017218449A5 JP2017111066A JP2017111066A JP2017218449A5 JP 2017218449 A5 JP2017218449 A5 JP 2017218449A5 JP 2017111066 A JP2017111066 A JP 2017111066A JP 2017111066 A JP2017111066 A JP 2017111066A JP 2017218449 A5 JP2017218449 A5 JP 2017218449A5
- Authority
- JP
- Japan
- Prior art keywords
- fluoro
- imidazol
- pyridinyl
- chloro
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- AIMDYPMHNJACAF-UHFFFAOYSA-N Cc1nc(F)c(-c(cc2)ccc2N)[nH]1 Chemical compound Cc1nc(F)c(-c(cc2)ccc2N)[nH]1 AIMDYPMHNJACAF-UHFFFAOYSA-N 0.000 description 4
- 0 CC(CCCC(CCC1)[C@](CCC2=*C(c3cc(N)ccc3C3CCCCCCCC3)=C3)*2C3=O)C1C1CCCC(*N)CCC1 Chemical compound CC(CCCC(CCC1)[C@](CCC2=*C(c3cc(N)ccc3C3CCCCCCCC3)=C3)*2C3=O)C1C1CCCC(*N)CCC1 0.000 description 3
- CTUSCHMWIYXOOL-UHFFFAOYSA-N C[n]1nnc(C#N)c1 Chemical compound C[n]1nnc(C#N)c1 CTUSCHMWIYXOOL-UHFFFAOYSA-N 0.000 description 3
- OMAFFHIGWTVZOH-UHFFFAOYSA-N C[n]1nnnc1 Chemical compound C[n]1nnnc1 OMAFFHIGWTVZOH-UHFFFAOYSA-N 0.000 description 3
- KKCPSPNBLCXVHJ-UHFFFAOYSA-N Cc([nH]c(C(C=C1)=C(F)[I]=C1N)n1)c1F Chemical compound Cc([nH]c(C(C=C1)=C(F)[I]=C1N)n1)c1F KKCPSPNBLCXVHJ-UHFFFAOYSA-N 0.000 description 2
- KGICUHLUBDERQN-UHFFFAOYSA-N Cc([nH]c(-c(ccc(N)n1)c1F)n1)c1F Chemical compound Cc([nH]c(-c(ccc(N)n1)c1F)n1)c1F KGICUHLUBDERQN-UHFFFAOYSA-N 0.000 description 1
- JLSBKUUDUWIJAA-UHFFFAOYSA-N Cc1nc(F)c(-c2ccc(N)nc2F)[nH]1 Chemical compound Cc1nc(F)c(-c2ccc(N)nc2F)[nH]1 JLSBKUUDUWIJAA-UHFFFAOYSA-N 0.000 description 1
- BQECPFRSFBNCPY-UHFFFAOYSA-N Cc1nc(F)c(C(C=C2)=C(F)[I]=C2N)[nH]1 Chemical compound Cc1nc(F)c(C(C=C2)=C(F)[I]=C2N)[nH]1 BQECPFRSFBNCPY-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016112327 | 2016-06-06 | ||
| JP2016112327 | 2016-06-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017218449A JP2017218449A (ja) | 2017-12-14 |
| JP2017218449A5 true JP2017218449A5 (enExample) | 2020-07-09 |
| JP6992284B2 JP6992284B2 (ja) | 2022-01-13 |
Family
ID=60658375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017111066A Expired - Fee Related JP6992284B2 (ja) | 2016-06-06 | 2017-06-05 | ジヒドロインドリジノン誘導体を含有する医薬組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6992284B2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI826599B (zh) * | 2018-11-30 | 2023-12-21 | 日商小野藥品工業股份有限公司 | （３ｓ）－３－［２－（６－胺－２－氟吡啶－３－基）－４－氟－１ｈ－咪唑－５－基］－７－［５－氯－２－（１ｈ－四唑－１－基）苯基］－２，３－二氫吲嗪－５（１ｈ）－酮的新穎結晶 |
| CN114026087B (zh) * | 2019-06-28 | 2023-07-18 | 上海济煜医药科技有限公司 | 三并环类化合物及其制备方法和用途 |
| JP2023534704A (ja) * | 2020-07-22 | 2023-08-10 | ヤンセン ファーマシューティカ エヌ．ベー． | 第ｘｉａ因子阻害剤として有用な化合物 |
| JP2024125436A (ja) * | 2021-07-20 | 2024-09-19 | 小野薬品工業株式会社 | イミダゾール化合物の製造方法 |
| WO2023179624A1 (zh) * | 2022-03-21 | 2023-09-28 | 上海济煜医药科技有限公司 | 三并环类化合物制备方法及其中间体 |
| WO2023205463A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9732085B2 (en) * | 2011-12-21 | 2017-08-15 | Ono Pharmaceutical Co., Ltd. | Pyridinone and pyrimidinone derivatives as factor Xia |
| BR112017012146B1 (pt) * | 2014-12-10 | 2023-11-21 | Ono Pharmaceutical Co., Ltd | Composto derivado de di-hidroindolizinona, seu uso, composição farmacêutica e inibidor de fxia |
-
2017
- 2017-06-05 JP JP2017111066A patent/JP6992284B2/ja not_active Expired - Fee Related
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