JP2017210488A5 - - Google Patents
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- Publication number
- JP2017210488A5 JP2017210488A5 JP2017168227A JP2017168227A JP2017210488A5 JP 2017210488 A5 JP2017210488 A5 JP 2017210488A5 JP 2017168227 A JP2017168227 A JP 2017168227A JP 2017168227 A JP2017168227 A JP 2017168227A JP 2017210488 A5 JP2017210488 A5 JP 2017210488A5
- Authority
- JP
- Japan
- Prior art keywords
- suspension
- temperature
- heating
- cooling
- cyclosporin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000725 suspension Substances 0.000 claims 25
- 238000000034 method Methods 0.000 claims 23
- 238000001816 cooling Methods 0.000 claims 14
- 238000010438 heat treatment Methods 0.000 claims 14
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical group CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 11
- 239000002904 solvent Substances 0.000 claims 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 11
- 238000003756 stirring Methods 0.000 claims 8
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 6
- 229930105110 Cyclosporin A Natural products 0.000 claims 6
- 108010036949 Cyclosporine Proteins 0.000 claims 6
- 229960001265 ciclosporin Drugs 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 2
- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
- RNHDAKUGFHSZEV-UHFFFAOYSA-N 1,4-dioxane;hydrate Chemical compound O.C1COCCO1 RNHDAKUGFHSZEV-UHFFFAOYSA-N 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- 206010040026 Sensory disturbance Diseases 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 206010069664 atopic keratoconjunctivitis Diseases 0.000 claims 1
- 208000010217 blepharitis Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000004175 meibomian gland Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000018464 vernal keratoconjunctivitis Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161559830P | 2011-11-15 | 2011-11-15 | |
| US61/559,830 | 2011-11-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014542396A Division JP6204921B2 (ja) | 2011-11-15 | 2012-11-14 | シクロスポリンａの形態２およびその作製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017210488A JP2017210488A (ja) | 2017-11-30 |
| JP2017210488A5 true JP2017210488A5 (cg-RX-API-DMAC7.html) | 2018-01-18 |
| JP6513755B2 JP6513755B2 (ja) | 2019-05-15 |
Family
ID=47222337
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014542396A Expired - Fee Related JP6204921B2 (ja) | 2011-11-15 | 2012-11-14 | シクロスポリンａの形態２およびその作製方法 |
| JP2017168227A Active JP6513755B2 (ja) | 2011-11-15 | 2017-09-01 | シクロスポリンａの形態２およびその作製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014542396A Expired - Fee Related JP6204921B2 (ja) | 2011-11-15 | 2012-11-14 | シクロスポリンａの形態２およびその作製方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US8796221B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2780358B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6204921B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102072252B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN104039813B (cg-RX-API-DMAC7.html) |
| AU (3) | AU2012339693B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112014011768A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2856034C (cg-RX-API-DMAC7.html) |
| ES (2) | ES2578154T3 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2635547C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013074608A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014011768A2 (pt) * | 2011-11-15 | 2017-05-09 | Allergan Inc | forma 2 de ciclosporina a e método de produção da mesma |
| AU2013267435B2 (en) | 2012-06-01 | 2017-11-09 | Allergan, Inc. | Cyclosporin A analogs |
| US10780048B2 (en) | 2014-07-18 | 2020-09-22 | Allergan, Inc. | Suspension compositions of cyclosporin A for subconjunctival and periocular injection |
| TW201639873A (zh) | 2015-01-08 | 2016-11-16 | 歐樂根公司 | Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物 |
| CN113117359B (zh) * | 2021-03-05 | 2022-08-26 | 湘雅生物医药(湖州)有限公司 | 一种用于胶原蛋白提取用的无菌式蒸馏瓶 |
| EP4585605A1 (en) | 2022-10-20 | 2025-07-16 | Chugai Seiyaku Kabushiki Kaisha | Method for producing cyclic peptide crystals |
| TW202502802A (zh) | 2023-03-20 | 2025-01-16 | 日商中外製藥股份有限公司 | 環狀胜肽共晶體的製造方法 |
| CN116879437A (zh) * | 2023-07-11 | 2023-10-13 | 苏州欧康维视生物科技有限公司 | 一种检测眼用植入剂的体外释放的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0391909B1 (en) | 1987-09-03 | 1994-08-17 | The University Of Georgia Research Foundation, Inc. | Ocular cyclosporin composition |
| HU203564B (en) | 1987-12-21 | 1991-08-28 | Sandoz Ag | Process for producing new orthorombos cyclosporin without solvatation |
| GB8916901D0 (en) * | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
| GB9105705D0 (en) * | 1991-03-18 | 1991-05-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5382714A (en) * | 1994-03-17 | 1995-01-17 | The Catholic University Of America | Process for isolation, purification, and recrystallization of lutein from saponified marigold oleoresin and uses thereof |
| ES2177652T3 (es) * | 1994-11-03 | 2002-12-16 | Novartis Ag | Nuevas formas de preparacion de ciclosporina para la aplicacion oral con composicion simple y alta biodisponibilidad, y procedimiento para su obtencion. |
| TW581681B (en) * | 1998-02-20 | 2004-04-01 | Nektar Therapeutics | Liquid crystal forms of cyclosporin |
| JP4208281B2 (ja) * | 1998-02-26 | 2009-01-14 | キヤノン株式会社 | 積層型光起電力素子 |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| DE602005011928D1 (de) | 2004-01-20 | 2009-02-05 | Allergan Inc | Zusammensetzungen für die lokalisierte therapie des auges, vorzugsweise enthaltend triamcinolon-acetonid und hyaluronsäure |
| US10137083B2 (en) | 2006-03-07 | 2018-11-27 | SGN Nanopharma Inc | Ophthalmic preparations |
| EP3521302A1 (en) * | 2011-05-27 | 2019-08-07 | Allergan, Inc. | A new crystalline form of cyclosporine a, methods of preparation, and methods for use thereof |
| BR112014011768A2 (pt) * | 2011-11-15 | 2017-05-09 | Allergan Inc | forma 2 de ciclosporina a e método de produção da mesma |
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2012
- 2012-11-14 BR BR112014011768A patent/BR112014011768A2/pt not_active Application Discontinuation
- 2012-11-14 JP JP2014542396A patent/JP6204921B2/ja not_active Expired - Fee Related
- 2012-11-14 WO PCT/US2012/064985 patent/WO2013074608A1/en not_active Ceased
- 2012-11-14 CA CA2856034A patent/CA2856034C/en active Active
- 2012-11-14 AU AU2012339693A patent/AU2012339693B2/en not_active Ceased
- 2012-11-14 RU RU2014123468A patent/RU2635547C2/ru active
- 2012-11-14 KR KR1020147016151A patent/KR102072252B1/ko not_active Expired - Fee Related
- 2012-11-14 EP EP12791059.4A patent/EP2780358B1/en active Active
- 2012-11-14 ES ES12791059.4T patent/ES2578154T3/es active Active
- 2012-11-14 US US13/676,339 patent/US8796221B2/en active Active
- 2012-11-14 EP EP16156092.5A patent/EP3067363B1/en active Active
- 2012-11-14 CN CN201280066581.8A patent/CN104039813B/zh not_active Expired - Fee Related
- 2012-11-14 ES ES16156092.5T patent/ES2666191T3/es active Active
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2014
- 2014-06-19 US US14/309,547 patent/US9352014B2/en active Active
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2016
- 2016-05-26 US US15/165,997 patent/US10017541B2/en active Active
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2017
- 2017-09-01 JP JP2017168227A patent/JP6513755B2/ja active Active
- 2017-12-06 AU AU2017272197A patent/AU2017272197A1/en not_active Abandoned
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2018
- 2018-07-06 US US16/028,956 patent/US20180312543A1/en not_active Abandoned
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2019
- 2019-06-28 AU AU2019204591A patent/AU2019204591B2/en not_active Ceased