JP2017190308A - Composition for suppressing increase in blood neutral fat - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition that dramatically improves the action of inhibiting an increase in blood neutral fat.SOLUTION: According to the present invention, a composition comprises a terminalia-processed substance, which is a plant of Cyperaceae family, and composition comprising at least one selected from the following (a) to (h): (a) at least one green leaf selected from barley young leaves and sweet potato leaves; (b) an antioxidant, which is astaxanthin; (c) a polysaccharide, which is chitosan; (d) at least one selected from capsicum, hydrangea, and black ginger; (e) at least one fungus selected from lactic acid bacteria and yeast; (f) at least one fermented product selected from cereal fermented products and black vinegar; (g) at least vitamin B group selected from vitamin B12, vitamin B5, vitamin B2, and vitamin B1; and (h) a plant extract extracted from at least one plant selected from pine bark, kudzu flower, gymnema, ginger, and salacia.SELECTED DRAWING: None

Description

  The present invention relates to a composition for suppressing blood triglyceride elevation, and specifically relates to a composition for inhibiting blood triglyceride elevation containing terminaria and specific other components.

  Terminalia (Terminalia) is a plant belonging to the family Sequimidae and is used as a medicine in India. Its fruits have been mainly used to prevent diarrhea and ripe fruits as an antidiarrheal agent.

In recent years, this terminaria has been found to have an effect of preventing vascular fibrosis and has been found to be used as a preventive or therapeutic agent for vascular fibrosis (see, for example, Patent Document 1). However, there is not enough research on other effects of terminaria.
JP 2004-75584 A

  The inventors of the present invention have confirmed the blood neutral fat increase inhibitory action by combining terminaria and a wide variety of other components, and in a specific combination, blood triglyceride of terminaria alone or a specific other component alone. It has been found that the blood neutral fat elevation-inhibiting ability is remarkably improved as compared with the increase-inhibiting ability, and the present invention has been completed. That is, it was found that the ability to suppress blood neutral fat elevation can be synergistically improved by combining terminaria and other specific components. The subject of this invention is providing the composition which the blood neutral fat rise inhibitory action improved greatly.

  The present inventors tested combinations of terminaria with a variety of other components, and conducted extensive research and research on blood triglyceride-inhibiting action. As a result, certain combinations showed blood triglyceride-inhibiting action. It has been found that it can be dramatically improved and the present invention has been completed. That is, by combining a specific other component with little or no effect on blood triglyceride increase with terminaria, it can be compared with the terminaria alone or specific other component alone. It has been found that the effect of suppressing the increase in sex fat can be dramatically improved.

That is, the present invention is as follows.
(1) A composition comprising a treated product of terminaria and at least one component selected from the group consisting of the following (a) to (h).
(A) at least one green leaf selected from barley young leaves and sweet potato young leaves (b) an antioxidant that is astaxanthin (c) a polysaccharide that is chitosan (d) at least one spice selected from chili pepper, hihatsu and black ginger (E) at least one fungus selected from lactic acid bacteria and yeast (f) at least one fermented product selected from cereal fermented products and black vinegar (g) at least selected from vitamin B12, vitamin B5, vitamin B2 and vitamin B1 Vitamin B group (h) A plant extract extracted from at least one plant selected from pine bark, kuzu flower, gymnema, ginger and Salacia (2) consisting of a processed terminaria and the following (a) to (h) A composition for inhibiting blood neutral fat elevation, comprising at least one component selected from the group.
(A) at least one green leaf selected from barley young leaves and sweet potato young leaves (b) an antioxidant that is astaxanthin (c) a polysaccharide that is chitosan (d) at least one spice selected from chili pepper, hihatsu and black ginger (E) at least one fungus selected from lactic acid bacteria and yeast (f) at least one fermented product selected from cereal fermented products and black vinegar (g) at least selected from vitamin B12, vitamin B5, vitamin B2 and vitamin B1 Vitamin B group (h) A plant extract extracted from at least one plant selected from pine bark, kuzunohana, gymnema, ginger and salacia (3) selected from the group consisting of terminaria and (a) to (h) (1) or (2), wherein the blending mass ratio with at least one component is in the range of 0.5: 1 to 70: 1 ).
(4) The composition according to any one of (1) to (3), which is liquid, powder or granule.
(5) The composition according to any one of (1) to (4), which is an instant powder beverage or an instant granule beverage.
(6) The composition according to (5), which is a packaging composition containing 3 to 10 g of instant powder beverage or instant granule beverage.
(7) The composition according to any one of (1) to (4), which is a packaged beverage.
(8) A blood neutral fat elevation inhibitor comprising a treated product of terminaria and at least one component selected from the group consisting of the following (a) to (h).
(A) at least one green leaf selected from barley young leaves and sweet potato young leaves (b) an antioxidant that is astaxanthin (c) a polysaccharide that is chitosan (d) at least one spice selected from chili pepper, hihatsu and black ginger (E) at least one fungus selected from lactic acid bacteria and yeast (f) at least one fermented product selected from cereal fermented products and black vinegar (g) at least selected from vitamin B12, vitamin B5, vitamin B2 and vitamin B1 Vitamin B group (h) A plant extract extracted from at least one plant selected from pine bark, kuzu flower, gymnema, ginger and salacia

  According to the composition for inhibiting blood triglyceride elevation according to the present invention, the blood triglyceride elevation inhibiting action can be drastically improved as compared with the case of terminaria alone or specific other components alone.

  The composition for suppressing blood neutral fat elevation of the present invention is characterized by containing terminaria and at least one selected from specific other components.

[Terminalia]
The terminaria used in the composition for inhibiting blood triglyceride elevation according to the present invention is not particularly limited as long as it is a plant belonging to the genus Terminaria, and examples thereof include: Terminaria belliarica, Terminalia bellerica, Terminaria catapapalina, Tenaminaria tenmenta, Terminaria tenta, , Terminalia coplandii, Terminalia brassi, Terminalia ivorensis, Terminalia superba, Terminalia arjuna, Terminalia chebula and the like. In the present invention, Terminaria berylica is preferably used.

  The processed product obtained from the terminaria used in the present invention (hereinafter sometimes referred to simply as “processed product”) is a dried product, paste, squeezed from a part such as a leaf, bark, root, flower, xylem, fruit or seed. Examples include juices and extracts. In addition, although any site | part may be used for the terminaria of this invention, the site | part except a seed is preferable, and the site | part (fruit skin or flesh part) except a fruit seed is used most preferably.

  The method for obtaining a dried product which is an embodiment of the processed product in the present invention is not particularly limited, and may be any one that is dried by, for example, sun drying, half sun drying, shade drying, heat drying, room temperature drying, freeze drying, If necessary, it may be pulverized using a ball mill, a hammer mill or the like.

  In addition, the paste or squeeze, which is an embodiment of the processed product of the present invention, can be obtained, for example, by crushing the terminaria fruit with a mascolloider without drying, and further filtering or centrifuging the paste. By separating, it can be made into juice. It is also possible to squeeze the Terminaria fruit into juice. Of course, the obtained extract can be used as it is, or once dried to obtain an extract powder. Moreover, when obtaining an extract from a dried product, it can be obtained by squeezing or filtering after the dried product is hydrated. The amount of hydration is not particularly limited, but is about 1 to 50 parts by mass with respect to 1 part by mass of the dry powder.

  Furthermore, the extract which is an embodiment of the processed product of the present invention may be extracted, for example, by adding water or an organic solvent as it is to the terminaria fruit, or may be extracted from a ground product, It may be extracted from once dried. In particular, it is preferable to extract the fruit after pulverizing it into a paste or dry powder.

  Examples of the solvent used for extraction include water, an organic solvent, or a mixed solution of water and an organic solvent, and examples of the organic solvent include methanol, ethanol, n-propanol, n-butanol, acetone, hexane, cyclohexane, propylene glycol, and ethyl. Examples include methyl ketone, glycerin, methyl acetate, ethyl acetate, diethyl ether, dichloromethane, edible fats and oils, 1,1,1,2-tetrafluoroethane, and 1,1,2-trichloroethene. Preferred are polar organic solvents, more preferred are ethanol, n-butanol, methanol, acetone, propylene glycol, ethyl acetate, and most preferred is ethanol.

  The amount of the solvent used for extraction is not particularly limited as long as it is a sufficient amount of solvent to be extracted. 50 mass parts is preferable, and when it is not a dry substance, it is preferable that it is 0.1-30 mass parts. Further, the extraction temperature is not particularly limited and is changed depending on the boiling point of the solvent to be used. In the case of efficient extraction, the lower limit of the extraction temperature is 10 ° C. or higher, preferably 20 ° C. or higher, and the upper limit of the extraction temperature. The value is preferably 120 ° C. or lower, but the upper limit of the extraction temperature is preferably lower than the boiling point of the solvent used.

  The extraction time varies depending on the amount of extraction solvent or the extraction temperature, but the lower limit of the extraction time is 30 minutes or more, preferably 1 hour or more, and the upper limit is 72 hours or less, preferably 48 hours or less. It is. In this way, an extract can be obtained from the terminaria. The obtained extract may be used as it is, but if necessary, it can be concentrated by a method commonly used by those skilled in the art to obtain a liquid, paste, or powder extract. For concentration, heating to dryness, vacuum concentration to dryness, lyophilization, or the like is used. In order to suppress denaturation of components in the extract, it is preferably vacuum concentration to dryness or freeze drying.

  Furthermore, in order to make the obtained extract more active, this extract is synthesized with a synthetic adsorbent (Diaion HP20, Sephabies SP825, Amberlite XAD4, MCIgelCHP20P, etc.) or dextran resin (Sephadex LH-20, etc.). ) To further fractionate and concentrate the components. Since the processed product of terminaria obtained in this way exhibits an excellent effect, it can be used in the present invention.

[Other ingredients]
The composition for suppressing blood triglyceride elevation of the present invention comprises terminaria and a specific other component, and the specific other component has little ability to suppress blood triglyceride elevation, Although it will not be limited if it is a component which can synergistically improve the blood neutral fat rise suppression ability by combining other components with small ability with terminaria, it describes below (a)-(h) And at least one component selected from the group consisting of:

(A) Green leaf In the composition for suppressing blood neutral fat elevation of the present invention, it is preferable to use at least one green leaf selected from barley young leaves and sweet potato young leaves as a specific other component together with terminaria. When these other components are combined with terminaria, not only a synergistic blood neutral fat increase-inhibiting action can be obtained, but also the taste such as stimulating taste and miscellaneous taste of terminaria can be improved. Moreover, the unique flavor of terminaria can be improved, and the flavor can be enhanced and the flavor can be improved. Furthermore, it is excellent in color and dispersibility, compared with the case where only terminaria is dissolved in water.

  These green leaves may be any part of the plant, but usually parts such as leaves and stems are preferred, and the plant material itself (including dry matter), its pulverized product, juice, extract, extract, etc. Can be used. Examples of the pulverized product include powder and granules. The squeezed juice or extract may be liquid, but can also be used as a paste or dry powder. The extract can be obtained by extraction using an appropriate solvent. As the solvent, for example, water, ethanol, or hydrous ethanol can be used.

The barley young leaves are barley ( Hordeum vulgare L. ) native to Central Asia and are annual or perennial herbs belonging to the family Gramineae. There is no particular limitation. The barley young leaves only need to contain barley leaves, and may contain other parts such as stems and roots in addition to the barley leaves. The barley young leaves used in the present invention are not particularly limited as long as they are usually available, and any barley young leaves such as Nijo barley and Rojo barley may be used. Any kind of barley young leaves may be used.

The sweet potato young leaf refers to a plant belonging to the family Convolvulaceae, and is not particularly limited as long as it is generally called sweet potato. The variety of sweet potato is not particularly limited. For example, varieties such as Suiou, Joy White, Koganesengan, Shiroyutaka, Satsuma Musti, Ayamurasaki and the like can be mentioned. Of these, it is preferable to use a high polyphenol content. The sweet potato may be used as a whole or in any part, but the foliage is preferable, the tip part of the foliage (the young foliage) is more preferable, and the young foliage in a state of holding a yellowish green is further included preferable.

(B) Antioxidant In the composition for inhibiting blood neutral fat elevation of the present invention, it is preferable to use an antioxidant that is astaxanthin as a specific other component together with terminaria. When this other component is combined with terminaria, not only a synergistic blood neutral fat increase-inhibiting action can be obtained, but also the taste such as the stimulating taste and miscellaneous taste of terminaria can be improved. Moreover, the unique flavor of terminaria can be improved, and the flavor can be enhanced and the flavor can be improved. Furthermore, it is excellent in color and dispersibility, compared with the case where only terminaria is dissolved in water.

  Astaxanthin is a kind of carotenoid, and is said to have an antioxidant action 1000 times that of vitamin E, and may be derived from natural products or obtained by synthesis. Examples of those derived from natural products include astaxanthin obtained from algae such as Haematococcus algae, crustaceans such as shrimp and crab, and fishes such as salmon and Thailand. Naturally derived extracts and chemically synthesized products are commercially available, and these commercially available products can be used.

(C) Polysaccharides In the composition for inhibiting blood neutral fat elevation of the present invention, it is preferable to use a polysaccharide that is chitosan as a specific other component together with terminaria. When this other component is combined with terminaria, not only a synergistic blood neutral fat increase-inhibiting action can be obtained, but also the taste such as the stimulating taste and miscellaneous taste of terminaria can be improved. Moreover, the unique flavor of terminaria can be improved, and the flavor can be enhanced and the flavor can be improved. Furthermore, it is excellent in color and dispersibility, compared with the case where only terminaria is dissolved in water.

Examples of the chitosan include those made from shells such as crabs, shrimps and insects, and those made from cell walls such as mushrooms and filamentous fungi. In particular, it is preferable to use one made from crab, shrimp or the like. As a manufacturing method of chitosan or a chitosan derivative, the following methods are mentioned, for example. First, crab shells, shrimp shells, and the like are crushed, and the crushed shells are treated with an acid (for example, hydrochloric acid) to decalcify them. Next, if it processes with an alkali (for example, caustic soda etc.) and protein is removed, chitin will be obtained. Further, if this is treated with an alkali (for example, caustic soda), chitosan can be obtained. Examples of chitosan derivatives include water-soluble chitosan obtained by further reducing the molecular weight of chitosan, and salts thereof. Among them, the average molecular weight is 500,000 or more, and the degree of deacetylation is 70% or more, preferably about 80 to 90%. The particle size is 32 mesh or less, preferably 48 mesh or less, but 85% or more is preferable.

(D) Spices In the composition for inhibiting blood neutral fat elevation of the present invention, it is preferable to use at least one spice selected from red pepper, hihatsu and black ginger as the specific other component together with terminaria. In the present invention, these components only need to be blended, and may not be blended for the purpose of exhibiting the function of a so-called spice such as giving out a fragrance or a pungent taste. When these other components are combined with terminaria, not only a synergistic collagenase inhibitory action can be obtained, but also the taste such as stimulating taste and miscellaneous taste of terminaria can be improved. Moreover, the unique flavor of terminaria can be improved, and the flavor can be enhanced and the flavor can be improved. Furthermore, it is excellent in color and dispersibility, compared with the case where only terminaria is dissolved in water.

These spices may be any part of the plant such as seeds, berries, flowers, leaves, stems, roots, etc., but the parts usually used as spices are preferred, and the plant material itself (including dry matter), its A pulverized product, juice, extract, extract and the like can be used. Examples of the pulverized product include powder and granules. The squeezed juice or extract may be liquid, but can also be used as a paste or dry powder. The extract can be obtained by extraction using an appropriate solvent. As the solvent, for example, water, ethanol, or hydrous ethanol can be used.

The pepper is not particularly limited as long as it is a plant belonging to the genus Capsicum. Both varieties having a pungent taste and varieties having no pungent taste can be used, but it is preferable to use a variety having a pungent taste.

The Hibatsu is a plant belonging to the family Pepperaceae and has the scientific name Piper longum L. It is preferable to use the fruit of the plant which is.

The black ginger is a plant belonging to the genus Banturcum, and the scientific name is Kaempferia parviflora. The black ginger used in the present invention is not particularly limited. For example, regardless of the production area such as domestic production and foreign production, examples of the foreign production include Thai production and Laos production. Examples include Okinawa. Moreover, as a site | part of the black ginger used for this invention, although it does not specifically limit, It is preferable to use a rhizome.

(D) Fungi In the composition for inhibiting blood neutral fat elevation according to the present invention, it is preferable to use at least one fungus selected from lactic acid bacteria and yeast as specific other components together with terminaria. When these other components are combined with terminaria, not only synergistic blood neutral fat increase suppression can be obtained, but also the taste such as stimulating taste and miscellaneous taste of terminaria can be improved. Moreover, the unique flavor of terminaria can be improved, and the flavor can be enhanced and the flavor can be improved. Furthermore, it is excellent in color and dispersibility, compared with the case where only terminaria is dissolved in water.

The form of the fungus used in the present invention is not particularly limited, and it may be used as it is after it has been dried and powdered, or may be used in the form of a culture obtained by culturing the fungus according to a conventional method. The product may be used in the form of a residue obtained by subjecting the product to a solid / liquid separation treatment such as centrifugation or filtration. In addition, dry powders and extracts of fungi are commercially available, and these commercially available products can be used.

As the lactic acid bacteria, those conventionally known can be used, but are not particularly limited. Examples of such lactic acid bacteria include Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium lactis, Bifidobacterium longum, Bifidobacterium adolescentis, Bifidobacterium mongoliense, Lactbacillus brevis, Lactbacillus gasseri, Lactobacillus acidophilus, Lactobacillus bactibacterium Lactobacillus crispatus, Lactobacillus curvatus, Lactobacillus halivaticus, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacilus paracasei, Lact
obacillus rhamnosus, Lactobacillus salivarius, Lactobacillus sporogenes, Lactobacillus sakei, Lactobacillus fructivorans, Lactobacillus hilgardii, Lactobacillus reuteri, Lactobacillus fermentum, Enterococcus faecalis (also known as Streptococcus faecalis) ), Streptococcus thermophilus, Lactococcus lactis (sometimes referred to as Streptococcus lactis), Leuconostoc mesenteroides, Leuconostoc oenos, Pediococcus acidilactici, Pediococcus pentosaceus, Staphylococcus carnosus, Staphylococcus xylos, Staphylococcus xylos , Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Lactbacillus gasseri, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum, Lactobacilus paracasei, Lactobacillus plantarum, Lactobacillus fermentum, Lactobacilus paracasei Preferred are occus faecalis (Streptococcus faecalis), Enterococcus faesium (Streptococcus faesium), Streptococcus thermophilus, Lactococcus lactis (Streptococcus lactis), Bacillus coagulans, and Bacillus mesentericus. The properties of these lactic acid bacteria are not particularly limited, and can be appropriately selected according to the dosage form and quality of the composition for inhibiting blood neutral fat elevation of the present invention, for example, heat resistance, acid resistance, Examples include sugar resistance, salt resistance, and spore resistance. The method for obtaining lactic acid bacteria is not particularly limited, and for example, lactic acid bacteria isolated from foods such as yogurt and vegetables or commercially available products may be used.

A conventionally known yeast can be used as the yeast, but it is not particularly limited. Examples of such yeast include the genus Saccharomyces such as Saccharomyces cerevisiae, the genus Candida such as Candida lipolytica, and the genus Candida such as Candida lipolytica. (Toululaspora), Kluyveromyces thermotolerans and other yeasts such as Kluyveromyces genus (Kluyveromyces) and Pichia membranaefaciens (Pichia membranaefaciens) Good Preferably, it belongs to the genus Saccharomyces.

(E) Fermented product In the composition for inhibiting blood neutral fat elevation of the present invention, it is preferable to use at least one fermented product selected from cereal fermented product and black vinegar as the specific other component together with terminaria. When these other components are combined with terminaria, not only a synergistic blood neutral fat increase-inhibiting action can be obtained, but also the taste such as stimulating taste and miscellaneous taste of terminaria can be improved. Moreover, the unique flavor of terminaria can be improved, and the flavor can be enhanced and the flavor can be improved. Furthermore, it is excellent in color and dispersibility, compared with the case where only terminaria is dissolved in water.

  These fermented products are not particularly limited, but fermented products may be used as they are, or fermented products may be dried and pulverized. Moreover, what was extracted from fermented material may be sufficient and an extract can also be grind | pulverized and used as it is. Examples of the pulverized product include powder and granules. The extract may be liquid, but can also be used as a paste or a dry powder. The extract can be obtained by extraction using an appropriate solvent. As the solvent, for example, water, ethanol, or hydrous ethanol can be used.

As the cereal fermented product, those obtained by fermenting the seeds of gramineous plants and legumes can be used, but are not particularly limited. Examples of the seeds of the grass family include rice, corn, barley, wheat, rye, oats, oats, pearl barley, millet, millet, millet, sorghum, etc., and the seeds of the legumes include soybean, azuki bean, mung bean, Examples include cowpeas, kidney beans, groundnuts, peas, broad beans, lentils, chickpeas, lentils and jujube. Fermentation may be any part of the seed such as whole grain, pericarp, seed coat, endosperm, cotyledon, hypocotyl, etc. However, it is usually preferable to use straw that is produced when grain is refined. As the microbial cells used for fermentation, microbial cells usually used for fermentation such as Neisseria gonorrhoeae, yeast, lactic acid bacteria, acetic acid bacteria, Bacillus subtilis and the like can be used. Two or more kinds may be used. In the present invention, gonococcus is particularly preferably used because grains can be decomposed by various enzymes.

As the black vinegar, only rice, a product obtained by adding barley or wheat to rice, or fermented using only barley as a raw material and turned brown or black brown by fermentation or aging can be used, but is not particularly limited. Grains used for fermentation may be those that have not been whitened, but may be whitened. As the cells used for fermentation, cells usually used for fermentation such as koji molds, yeasts, lactic acid bacteria, acetic acid bacteria, Bacillus subtilis, etc. can be used. Is preferably used.

(G) Vitamin B group In the composition for suppressing blood neutral fat elevation of the present invention, at least a vitamin B group selected from vitamin B12, vitamin B5, vitamin B2, and vitamin B1 is used as a specific other component together with terminaria. It is preferable. When these other components are combined with terminaria, not only a synergistic blood neutral fat increase-inhibiting action can be obtained, but also the taste such as stimulating taste and miscellaneous taste of terminaria can be improved. Moreover, the unique flavor of terminaria can be improved, and the flavor can be enhanced and the flavor can be improved. Furthermore, it is excellent in color and dispersibility, compared with the case where only terminaria is dissolved in water.

(H) Plant extract In the composition for inhibiting blood triglyceride elevation of the present invention, at least one plant selected from pine bark, kuzunohana, gymnema, ginger and salacia as specific other components together with terminaria. It is preferable to use a plant extract extracted from. When these other components are combined with terminaria, not only a synergistic blood neutral fat increase-inhibiting action can be obtained, but also the taste such as stimulating taste and miscellaneous taste of terminaria can be improved. Moreover, the unique flavor of terminaria can be improved, and the flavor can be enhanced and the flavor can be improved. Furthermore, it is excellent in color and dispersibility, compared with the case where only terminaria is dissolved in water.

Examples of the pine bark extract include extracts of bark such as French maritime pine (Pinus Martina), larch, black pine, Japanese red pine, etc. Among them, French maritime pine (Pinus Martima) rich in proanthocyanidins. ) Bark extract is preferred.

  As the kuzu flower, a flower belonging to the genus Leguminosae is used. Kuzu is a perennial plant of the leguminous genus Kudzu. As a site | part used as a plant raw material of this invention, a flower and a root are preferable and a flower is especially preferable. As Kuzuhana, what was collected in any process from the bud to the fully-opened flower may be used, and what was collected in each process can also be mixed and used. Although there is no restriction | limiting in particular as a kind of kuzu, Pueraria thomsonii (Pueraria tomsonii), Pueraria Roberta (Pueraria robota), Pueraria thumbergiana (Pueraria thumbergiana) etc. can be illustrated.

As the above-mentioned Gymnema, Gymnema is a vine plant belonging to the Oleander family that originates from India and Sri Lanka, and for example, Gymnema sylvestre (Gymnema sylvestre) can be mentioned. As a site | part used in this invention, a stem and a leaf are preferable.

  The ginger is not particularly limited as long as it is a plant belonging to the family Ginger, such as Sanshu ginger, Omi ginger, Yanaka ginger, Kinki ginger, Shizuoka No. 4, yellow ginger, dough ginger, otafuku ginger Various ginger can be mentioned. As a form of the ginger family raw material used by this invention, besides using a rhizome as it is, it can be used as a slice, a pulverized material, squeezed, a mash, an extract, etc. Examples of the pulverized product include powder and granules. The squeezed juice or extract may be liquid, but can also be used as a paste or dry powder. The extract can be obtained by extraction using an appropriate solvent. As the solvent, for example, water, ethanol, or hydrous ethanol can be used. Although the solvent to be used is not particularly limited, it is preferable to use a solution containing ethanol. For example, an extract can be obtained by adding ethanol or hydrous ethanol to a ginger plant having a finer rootstock.

  Examples of the Salacia include plants belonging to the genus Salacia, which naturally grow in Sri Lanka, India, and Southeast Asia. Examples include Salacia reticulata, Salacia oblonga, Salacia fimbrisala, Salacia mamba, Salacia mamba, Salacia Salacia reticulata is particularly preferred. The site used in the present invention is preferably a root.

[Composition for inhibiting blood neutral fat elevation]
The composition for suppressing blood triglyceride elevation according to the present invention is preferably a food for inhibiting blood triglyceride elevation to be used for inhibiting blood triglyceride elevation, and such blood triglyceride elevation inhibiting composition. The food for use is not particularly limited as long as it contains terminaria and other specific ingredients and can be used to suppress the increase in blood neutral fat, as long as it can be distinguished from other products. For example, the display of the fact that any of the main body, packaging, instructions, and promotional material of the product according to the present invention has a function of suppressing blood neutral fat elevation is included in the scope of the present invention. For example, mention may be made of so-called health foods such as functional foods for which the indication of efficacy has been approved by a prescribed organization such as foods for specified health use, functional indication foods, etc. Reduce (reduce, reduce) "," suppress the rise of blood neutral fat "," suppress neutral fat that rises after meals "," moderate the rise of blood neutral fat after meals ", Examples of the display include “suppressing absorption of dietary fat” and “helping the health of those with higher neutral fat”.

  Examples of the form of the composition for inhibiting blood neutral fat elevation of the present invention include, for example, liquid, powder, granule, tablet, capsule, granule, rod, plate, block, solid, round, Examples include paste, cream, caplet, gel, chewable, and stick. Among these, liquid, powder, and granular forms are particularly preferable. Specific examples include container-packed beverages filled in PET bottles, cans, bottles, and instant powder beverages or instant granule beverages for dissolving and drinking in water (hot water), milk, fruit juice, green juice, etc. be able to. These are preferable in that they can be easily taken at the time of eating and the like, and can enhance palatability.

  The blending mass ratio of the terminaria and the specific other material is preferably in the range of 0.5: 1 to 80: 1 in terms of dry mass, and preferably in the range of 0.75: 1 to 70: 1. More preferably, it is in the range of 1: 1 to 60: 1, more preferably in the range of 1: 1 to 50: 1. When the compounding ratio of the terminaria and the specific other material is within the above range, the effect of the present invention can be more effectively exhibited.

  The content of terminaria and specific other material in the composition for inhibiting blood triglyceride elevation of the present invention may be appropriately contained within the range where the effect is exerted, and terminaria is used as an active ingredient, and (a) to (a) to It is good also as containing at least 1 sort (s) of ingredients chosen from the group which consists of (h), and also as containing at least 1 sort of ingredients chosen from the group which consists of Terminaria and (a)-(h) as an active ingredient. Good. When terminaria is used as an active ingredient and further contains at least one component selected from the group consisting of (a) to (h), a specific other component may be contained as an accelerator for action by terminaria. . In general, the content is preferably 0.01 to 100% by mass, more preferably 0.1 to 97% by mass, in terms of dry mass, of terminaria and specific other materials. It is more preferable that 0.5 to 95% by mass is further included.

  When the composition for suppressing blood neutral fat elevation of the present invention is a tablet or a capsule, it contains 0.01 to 100% by mass of terminaria and specific other materials in terms of dry mass. Is preferable, 0.1 to 90 mass% is more preferable, and 0.5 to 80 mass% is further more preferable.

  When the composition for suppressing blood neutral fat elevation of the present invention is an instant powder beverage or an instant granule beverage, 1 to 100% by mass of terminaria and specific other materials are contained in terms of dry mass. It is preferable that 3-90 mass% is contained, It is more preferable that 5-80 mass% is contained.

  When the composition for suppressing blood neutral fat elevation according to the present invention is a container-packed beverage, it may contain 0.1 to 10% by mass of terminaria and specific other materials in terms of dry mass. Preferably, 0.3 to 6% by mass is contained, more preferably 0.5 to 4% by mass.

  Although there is no restriction | limiting in particular as an intake of the composition for blood triglyceride rise suppression of this invention, From a viewpoint of exhibiting the effect of this invention more notably, the terminaria per meal and a specific other material The intake is preferably 50 mg / dose or more, more preferably 100 mg / dose or more, more preferably 150 mg / dose or more, more preferably 200 mg / dose. It is particularly preferable to take it so that it is more than once. The food having an inhibitory effect on blood triglyceride elevation of the present invention may be a single dose or a daily dose in one container, or, for example, a plurality of 2-3 It can be divided into containers and accommodated as one day. For example, 3-10 g of the instant powder beverage or instant granule beverage can be packaged.

  Moreover, you may mix | blend components other than terminaria and a specific other raw material as needed for the composition for blood triglyceride rise suppression of this invention. Examples of components other than terminaria and specific other materials include water-soluble vitamins (vitamins B1, B2, B3, B5, B6, B12, B13, B15, B17, biotin, choline, folic acid, inositol, PABA, vitamin C, Vitamin P), vitamins such as oil-soluble vitamins (vitamins A, D, E, K); minerals such as calcium, magnesium, phosphorus, iron; sulfur-containing compounds contained in taurine, garlic, etc .; hesperidin, quercetin, etc. Flavanoids or flavonoids; proteins such as collagen; peptides; amino acids; animal fats and oils; vegetable oils and fats; pulverized or extracted animal or plant, calcium stearate, silicon dioxide, sucrose fatty acid ester, glycerin fatty acid ester, maltose, reduced Maltose, reduced palatinose, cellulose, hydro Excipients such sheet cellulose can be mentioned.

  Moreover, as a composition for blood neutral fat rise suppression of this invention, the foodstuff which added terminaria and a specific other raw material can be mentioned. Examples of such foods include beverages such as carbonated drinks, nutrient drinks, fruit drinks, lactic acid drinks, and green juice; frozen desserts such as ice cream, ice sherbet and shaved ice; noodles such as soba, udon, harusame, Chinese noodles, and instant noodles ; Confectionery such as candy, candy, gum, chocolate, tablet confectionery, snacks, biscuits, jelly, jam, cream, baked confectionery, bread; fishery and livestock processed foods such as kamaboko, ham, sausage; processed milk, fermented milk, Dairy products such as yogurt; salad oil, tempura oil, margarine, mayonnaise, shortening, whipped cream, dressing and other fats and processed foods; seasonings such as sauces, soy sauce; curry, stew, parent and child rice cake, rice bowl, miso, Chinese Salmon, bonito, tempura, beef salmon, hayashi rice, omelet rice, oden, mabodorf, gyoza, shumai, Nbagu, mention may be made of meat balls, a variety of sources, retort pouch foods such as various soups and the like. It should be noted that the properties, blending amount, intake amount, other components, etc. of Terminaria and specific other materials are the same as described above.

Hereinafter, the present invention will be described based on examples.
Example 1 Lipase Inhibition Test Each test substance suspension was formulated in an Eppendorf tube with 0.1M PBS as a solvent and treated with terminaria and certain other components as follows. For terminaria, powder obtained by drying a hot water extract of the pulp of Terminaria berylica was used. For barley young leaves, “Barley young leaf powder” manufactured by Toyo Shinyaku was used. For the sweet potato young leaves, Toyo Shinyaku Co., Ltd. “sweet potato young leaf powder” was used.
Astaxanthin used was a commercially available synthetic product. Commercially available chitosan was used. As the chili pepper, a commercially available strawberry chili powder was used. Hihatsu used a commercially available dried powder of fruit spikelets. As the black ginger, a dry powder of the ethanol extract of the rhizome of Kaempferia parviflora was used. As the lactic acid bacteria, commercially available E. coli Enterococcus faecalis (dead bacteria) derived from human intestine was used. As the yeast, commercially available dry brewer's yeast powder (dead bacteria) with reduced bitterness was used. As a cereal fermented product, commercially available wheat bran koji mold fermented extract powder was used. As the black vinegar, a commercially available black vinegar extract was used. Vitamins used were all commercially available and vitamin B1 was hydrochloride. As the pine bark, “Flavandenol” manufactured by Toyo Shinyaku was used. Kuzunohana used “Kuzunohana Extract” manufactured by Toyo Shinyaku. As the Gymnema, an extract powder extracted from the leaves of a commercially available Gymnema sylvestre was used. As the ginger, commercially available ginger extract powder was used. As Salacia, commercially available Salacia reticulata root extract powder was used.

5 μL of 0.08 mg / mL lipase, 4 μL of elastase inhibitor, and 200 μL of color developing solution were added to each of the mixed sample solutions, and pre-incubated for 5 minutes at 30 ± 1 ° C. in the dark. After adding 20 μL of substrate solution and incubating at 30 ± 1 ° C. for 30 minutes, 400 μL of stop solution was added. For the blank, the substrate solution was added after the reaction stop solution was added. 300 μL of the reaction solution was transferred to a 96-well plate, and the absorbance at 412 nm was measured with a microplate reader. Using the measured absorbance, the lipase inhibition rate was calculated by the following formula.
Inhibition rate (% of control) = (1-[(Sample ^test- Sample ^blank ) / Control ^test- Control ^blank ]]) × 100

  Table 2 shows the results of the lipase inhibition test measured in Example 1. Numerical values other than the inhibition rate in Table 2 indicate the final concentration of the sample, and the inhibition rate indicates the relative inhibition rate of each group when the inhibition rate of the treated terminaria alone group is 100%.

  As shown in Table 2, it can be seen that even when the lipase inhibitory action of the specific other component itself is considerably low, the lipase inhibitory action is dramatically improved by combining terminaria. Since the combination of the processed terminaria of the present invention and a specific other material has an excellent lipase inhibitory action, inhibiting lipase can suppress the decomposition of fat in the digestive tract and suppress fat absorption from the intestinal tract. Be expected.

(Comparative Examples 22-23)
For mulberry leaf powder (Comparative Example 22) and vitamin B6 (Comparative Example 23), the same test as in Example 1 was performed, and the change value of terminaria and the change value of either mulberry leaf powder or vitamin B6 were summed. Occasionally, the change value of the test group of the combination was less than 1.2 times, and the lipase inhibitory action was not confirmed.

Since the food of the present invention has an effect of suppressing an increase in blood neutral fat, it is highly industrially useful.

Claims (2)

A composition comprising a treated product of terminia and at least one component selected from the group consisting of the following (a) to (h).
(A) at least one green leaf selected from barley young leaves and sweet potato young leaves (b) an antioxidant that is astaxanthin (c) a polysaccharide that is chitosan (d) at least one spice selected from chili pepper, hihatsu and black ginger (E) at least one fungus selected from lactic acid bacteria and yeast (f) at least one fermented product selected from cereal fermented products and black vinegar (g) at least selected from vitamin B12, vitamin B5, vitamin B2 and vitamin B1 Vitamin B group (h) A plant extract extracted from at least one plant selected from pine bark, kuzu flower, gymnema, ginger and salacia A composition for suppressing blood neutral fat elevation, comprising a processed terminaria and at least one component selected from the group consisting of (a) to (h).
(A) at least one green leaf selected from barley young leaves and sweet potato young leaves (b) an antioxidant that is astaxanthin (c) a polysaccharide that is chitosan (d) at least one spice selected from capsicum, hihatsu and black ginger (E) at least one fungus selected from lactic acid bacteria and yeast (f) at least one fermented product selected from cereal fermented products and black vinegar (g) at least selected from vitamin B12, vitamin B5, vitamin B2 and vitamin B1 Vitamin B group (h) A plant extract extracted from at least one plant selected from pine bark, kuzu flower, gymnema, ginger and salacia