JP2017173334A5 - - Google Patents
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- Publication number
- JP2017173334A5 JP2017173334A5 JP2017092161A JP2017092161A JP2017173334A5 JP 2017173334 A5 JP2017173334 A5 JP 2017173334A5 JP 2017092161 A JP2017092161 A JP 2017092161A JP 2017092161 A JP2017092161 A JP 2017092161A JP 2017173334 A5 JP2017173334 A5 JP 2017173334A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- fluorouracil
- specimen
- cancer
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 10
- 239000011780 sodium chloride Substances 0.000 claims 10
- ZROHGHOFXNOHSO-BNTLRKBRSA-L (1R,2R)-cyclohexane-1,2-diamine;oxalate;platinum(2+) Chemical compound [H][N]([C@@H]1CCCC[C@H]1[N]1([H])[H])([H])[Pt]11OC(=O)C(=O)O1 ZROHGHOFXNOHSO-BNTLRKBRSA-L 0.000 claims 5
- GHASVSINZRGABV-UHFFFAOYSA-N 5-flurouricil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 5
- 229960002949 Fluorouracil Drugs 0.000 claims 5
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- 229960001756 oxaliplatin Drugs 0.000 claims 5
- 239000012472 biological sample Substances 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 230000035945 sensitivity Effects 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims 1
- 229940029575 Guanosine Drugs 0.000 claims 1
- NYHBQMYGNKIUIF-PXMDKTAGSA-N Guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1[C@H]1O[C@@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-PXMDKTAGSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- OYIFNHCXNCRBQI-UHFFFAOYSA-N α-Aminoadipic acid Chemical compound OC(=O)C(N)CCCC(O)=O OYIFNHCXNCRBQI-UHFFFAOYSA-N 0.000 claims 1
Claims (8)
- Ｃｙｓｔｅｉｎｅ−ｇｌｕｔａｔｈｉｏｎｅ、２−Ａｍｉｎｏａｄｉｐｉｃ ａｃｉｄ及びＧｕａｎｏｓｉｎｅから選ばれる１以上の分子からなる、オキサリプラチン又はその塩とフルオロウラシル又はその塩を含む抗がん剤の感受性判定マーカー。
- オキサリプラチン又はその塩とフルオロウラシル又はその塩を含む抗がん剤の感受性を判定する目的で、検体中の請求項１記載の物質を測定する方法。
- 検体が、がんを有する被験者由来の生体試料である請求項２記載の方法。
- 検体が、オキサリプラチン又はその塩とフルオロウラシル又はその塩を含む抗がん剤を投与された、がんを有する被験者由来の生体試料である請求項２又は３記載の方法。
- 検体中の請求項１記載の物質を測定するためのプロトコールを含むことを特徴とする請求項２〜４のいずれか１項記載の方法を実施するためのキット。
- 検体が、がんを有する被験者由来の生体試料である請求項５記載のキット。
- 検体が、オキサリプラチン又はその塩とフルオロウラシル又はその塩を含む抗がん剤を投与された、がんを有する被験者由来の生体試料である請求項５又は６記載のキット。
- 請求項１記載の物質の発現変動を指標とするオキサリプラチン又はその塩とフルオロウラシル又はその塩を含む抗がん剤に対する感受性亢進剤のスクリーニング方法。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012037448 | 2012-02-23 | ||
| JP2012037448 | 2012-02-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014500945A Division JP6141824B2 (ja) | 2012-02-23 | 2013-02-22 | 併用抗がん剤の感受性判定マーカー |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018140929A Division JP2018169409A (ja) | 2012-02-23 | 2018-07-27 | 併用抗がん剤の感受性判定マーカー |
| JP2018140928A Division JP6527994B2 (ja) | 2012-02-23 | 2018-07-27 | 併用抗がん剤の感受性判定マーカー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017173334A JP2017173334A (ja) | 2017-09-28 |
| JP2017173334A5 true JP2017173334A5 (ja) | 2017-11-16 |
| JP6381735B2 JP6381735B2 (ja) | 2018-08-29 |
Family
ID=49005852
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014500945A Expired - Fee Related JP6141824B2 (ja) | 2012-02-23 | 2013-02-22 | 併用抗がん剤の感受性判定マーカー |
| JP2017092161A Expired - Fee Related JP6381735B2 (ja) | 2012-02-23 | 2017-05-08 | 併用抗がん剤の感受性判定マーカー |
| JP2018140928A Expired - Fee Related JP6527994B2 (ja) | 2012-02-23 | 2018-07-27 | 併用抗がん剤の感受性判定マーカー |
| JP2018140929A Ceased JP2018169409A (ja) | 2012-02-23 | 2018-07-27 | 併用抗がん剤の感受性判定マーカー |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014500945A Expired - Fee Related JP6141824B2 (ja) | 2012-02-23 | 2013-02-22 | 併用抗がん剤の感受性判定マーカー |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018140928A Expired - Fee Related JP6527994B2 (ja) | 2012-02-23 | 2018-07-27 | 併用抗がん剤の感受性判定マーカー |
| JP2018140929A Ceased JP2018169409A (ja) | 2012-02-23 | 2018-07-27 | 併用抗がん剤の感受性判定マーカー |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9733256B2 (ja) |
| EP (3) | EP3326632B1 (ja) |
| JP (4) | JP6141824B2 (ja) |
| CN (2) | CN108508168B (ja) |
| WO (1) | WO2013125675A1 (ja) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107252428B (zh) * | 2011-03-24 | 2020-04-14 | 学校法人庆应义塾 | 抗癌剂感受性的判定标记 |
| CN108508168B (zh) | 2012-02-23 | 2021-08-17 | 学校法人庆应义塾 | 并用抗癌剂的感受性判定标记 |
| WO2018181759A1 (ja) | 2017-03-31 | 2018-10-04 | 学校法人慶應義塾 | 併用抗がん剤の感受性の判定マーカー |
| CN111919120A (zh) * | 2018-03-29 | 2020-11-10 | 学校法人庆应义塾 | 包含伊立替康的抗癌剂疗法的敏感性判定标志物 |
| EP3858344A4 (en) * | 2018-09-28 | 2022-07-06 | Keio University | MARKER TO EVALUATE SENSITIVITY TO A COMBINATION OF ANTICANCER DRUGS |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100569288C (zh) * | 2005-04-06 | 2009-12-16 | 山东蓝金生物工程有限公司 | 一种抗实体肿瘤药物组合物 |
| DE102005051976B4 (de) * | 2005-10-31 | 2009-04-30 | Forschungszentrum Borstel Zentrum für Medizin und Biowissenschaften | Kit für hoch-sensitive Nachweisassays |
| WO2008036691A2 (en) * | 2006-09-19 | 2008-03-27 | Metabolon, Inc. | Biomarkers for prostate cancer and methods using the same |
| CN104784706A (zh) * | 2008-01-31 | 2015-07-22 | 学校法人庆应义塾 | 抗癌剂感受性的判定方法 |
| SG192544A1 (en) * | 2008-01-31 | 2013-08-30 | Univ Keio | Marker for determination of sensitivity to anti-cancer agent |
| JP2010038796A (ja) * | 2008-08-06 | 2010-02-18 | Human Metabolome Technologies Inc | 疾患マーカー、および、疾患マーカーの測定方法 |
| CN102597762B (zh) * | 2009-10-30 | 2016-08-03 | 学校法人庆应义塾 | 抗癌剂感受性判定标记 |
| CN105699638B (zh) * | 2009-10-30 | 2018-05-22 | 学校法人庆应义塾 | 抗癌剂感受性的判定方法 |
| US20110151497A1 (en) * | 2009-12-22 | 2011-06-23 | The Regents Of The University Of Michigan | Metabolomic profiling of prostate cancer |
| CN108508168B (zh) | 2012-02-23 | 2021-08-17 | 学校法人庆应义塾 | 并用抗癌剂的感受性判定标记 |
-
2013
- 2013-02-22 CN CN201810228371.3A patent/CN108508168B/zh active Active
- 2013-02-22 JP JP2014500945A patent/JP6141824B2/ja not_active Expired - Fee Related
- 2013-02-22 EP EP17202053.9A patent/EP3326632B1/en active Active
- 2013-02-22 CN CN201380010388.7A patent/CN104169721A/zh active Pending
- 2013-02-22 US US14/379,945 patent/US9733256B2/en active Active
- 2013-02-22 EP EP20214606.4A patent/EP3812009A1/en not_active Withdrawn
- 2013-02-22 EP EP13752246.2A patent/EP2818870A4/en not_active Withdrawn
- 2013-02-22 WO PCT/JP2013/054488 patent/WO2013125675A1/ja active Application Filing
-
2017
- 2017-05-08 JP JP2017092161A patent/JP6381735B2/ja not_active Expired - Fee Related
- 2017-06-28 US US15/635,293 patent/US10481160B2/en active Active
-
2018
- 2018-07-27 JP JP2018140928A patent/JP6527994B2/ja not_active Expired - Fee Related
- 2018-07-27 JP JP2018140929A patent/JP2018169409A/ja not_active Ceased
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