JP2017160149A - 美容組成物 - Google Patents
美容組成物 Download PDFInfo
- Publication number
- JP2017160149A JP2017160149A JP2016044887A JP2016044887A JP2017160149A JP 2017160149 A JP2017160149 A JP 2017160149A JP 2016044887 A JP2016044887 A JP 2016044887A JP 2016044887 A JP2016044887 A JP 2016044887A JP 2017160149 A JP2017160149 A JP 2017160149A
- Authority
- JP
- Japan
- Prior art keywords
- cosmetic composition
- fulvic acid
- composition according
- acid
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- FCYKAQOGGFGCMD-UHFFFAOYSA-N Fulvic acid Natural products O1C2=CC(O)=C(O)C(C(O)=O)=C2C(=O)C2=C1CC(C)(O)OC2 FCYKAQOGGFGCMD-UHFFFAOYSA-N 0.000 claims abstract description 64
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Abstract
紫外線照射時のMMP−1産生抑制に加えて、細胞生存率も向上させることにより、総合的に皮膚の光老化を防止する物質を探索し、その用途を提供する。
【解決手段】
本発明は、FT−IR法における赤外線吸収スペクトルにおいて波数3362,2875,1675,1559,1360,1200,1047及び835cm−1に赤外線吸収ピークを有するフルボ酸を含有する腐植抽出物、並びに化粧品学的、皮膚病学的及び/又は薬学的に許容される添加剤を含む美容組成物である。
【選択図】図1
Description
(1)3次元分光蛍光光度法
ヒューミクルの4%水溶液の3次元励起−蛍光スペクトル(測定装置JASCO FP−8200)を図3に示す。比較のため、愛知県段戸森林土壌から抽出精製されたフルボ酸及びフミン酸(いずれも、日本腐植物質学会から「日本腐植物質学会 標準資料」として頒布されている、以下、それぞれ、段戸産フルボ酸及び段戸産フミン酸という)の3次元蛍光スペクトルを図4に示す。ヒューミクル及び段戸産フルボ酸の3次元励起−蛍光スペクトルには、フルボ酸由来の蛍光の特徴である、励起250nm付近−蛍光430nm付近のピーク及び、励起320nm付近−蛍光430nm付近のピークが出現している。
GPC−UV/TC分析法は、水中溶存有機物を分子の大きさや排除の程度によって高速に分離し、分離した溶存分子をUV検出器及びTC検出器(Total Carbon Analyzer)でモニタリングする手法である。以下GPC−TC装置:
GPC:Shodex GPC SYSTEM 21
分離カラム TOSO HW−50S
溶離液 30mM Na2HPO4
UV吸収(220nm)検出器:GL7450(GL サイエンス製)
TC検出器:LCT−100(東レエンジニアリング製)
を用いて、ヒューミクル及び段戸産フルボ酸の分子量を測定した。
前記フルボ酸分画のATR法(Attenuated Total Reflection、全反射吸収法)にて赤外線吸収スペクトルを取得した。具体的には、前記フルボ酸分画をDax−8樹脂(Spelco社製)に施用し、そこに吸着した有機物をアルカリ性溶液で脱着した。脱着した有機物を、さらにイオン交換樹脂に通して不要な塩類を取り除いた。得られた試料をATR法に基づくFT−IR分光分析(PerkinElmer Spectrum 65)に供した。
[配合例1]化粧水
〔実施例1〕
皮膚3次元モデルに紫外線を照射する試験において、腐植抽出物がMMP−1の産生を抑制するか否か、そしてMMP−1の産生抑制効果が細胞生存率の挙動に実際に影響するか否かを調べた。なお、実験は、n=3にて実施した。
実施例1として、米国ユタ産の腐植の水性抽出物を乾固した製品である腐植抽出物(製品名:ヒューミクル、株式会社スタイルアンドバリュージャパン製)を水に0.1重量%又は0.01重量%溶解することにより、本発明の美容組成物を調製した。比較のため、日本腐植物質学会より入手した腐植標準物質である段戸産フルボ酸(比較例1)及び琵琶湖産フルボ酸(比較例2)を、それぞれ、水に0.1重量%に溶解し、比較例の美容組成物を調製した。
ヒトの皮膚と近似した構造を有し、化粧品等の動物実験代替モデルとなる皮膚3次元モデル(製品名EPI−200、(株)クラボウ製)を入手し、18時間の前培養した。このモデルの上部に、各試料を100μL添加し、さらに48時間培養した。その後、PBS(−)にて、モデル上部を洗浄した。
培養終了後の培地上清を回収し、MMP−1アッセイに供した。MMP−1アッセイは、ELISAキット(フナコシ株式会社製)により実施した。各試料のMMP−1産生量を表5に示す。
紫外線照射後の細胞生存率を測定するため、3次元皮膚モデルをMTTアッセイに供した。MTTアッセイは、下記の手法により実施した。すなわち、培養終了後、MTT(3−(4,5−di−methylthiazol−2−yl)−2,5−diphenyltetrazolium bromide, yellow tetrazole)を1mg/mL含有するアッセイ培地(上記皮膚モデルに付属の物)を0.8mL含有する培地に交換し、さらに2時間培養した。培養後、イソプロパノール2mLを入れた24ウェルプレートに皮膚モデルを移し、4℃にて24時間静置し、静置後、300rpmのシェーカーにて10分間振盪後、イソプロパノール層に抽出されたホルマザン色素を540nmの波長で測光した。細胞生存率は、試験品無添加かつUVB無照射を100%として計算した。細胞生存率の測定結果を表5に示す。
Claims (10)
- FT−IR法における赤外線吸収スペクトルにおいて波数3362,2875,1675,1559,1360,1200,1047及び835cm−1に赤外線吸収ピークを有するフルボ酸を含有する腐植抽出物、並びに化粧品学的、皮膚病学的及び/又は薬学的に許容される添加剤あるいは食品添加物を含む美容組成物。
- 前記腐植抽出物は、図1に示す赤外線吸収スペクトルを示すフルボ酸を含有する、請求項1に記載の美容組成物。
- 前記腐植抽出物は、ナフタレン環構造を有さないことを特徴とする、請求項1又は2に記載の美容組成物。
- 前記腐植抽出物中のフルボ酸の平均分子量は、4,000よりも小さい、請求項1〜8のいずれか一項に記載の美容組成物。
- 皮膚の光老化防止用である、請求項1〜3のいずれか一項に記載の美容組成物。
- 前記光老化防止は、MMP−1の産生を抑制し、かつ皮膚細胞の細胞生存率を向上させることを特徴とする、請求項1〜5のいずれか一項に記載の美容組成物。
- 経皮投与用である、請求項1〜6のいずれか一項に記載の美容組成物。
- 水剤、液剤、乳剤、乳液、エマルション、クリーム又は粉体の形態である、請求項7に記載の美容組成物。
- 経口投与用である、請求項1〜6のいずれか一項に記載の美容組成物。
- 散剤、顆粒剤、カプセル剤、丸剤、錠剤、チュアブル錠、ドロップ、水剤又はシロップの形態である、請求項9に記載の美容組成物。
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JP2006087393A (ja) * | 2004-09-27 | 2006-04-06 | Global Science:Kk | 健康食品及び薬剤 |
JP2007308673A (ja) * | 2006-05-22 | 2007-11-29 | Masakazu Shirakawa | ミネラル入り石鹸及びミネラル入り石鹸の製造法 |
JP4040077B1 (ja) * | 2006-06-20 | 2008-01-30 | 株式会社ピュアハート | 飲料水の製造方法及び装置 |
JP2011063563A (ja) * | 2009-09-18 | 2011-03-31 | Fuji Chem Ind Co Ltd | しわ改善組成物 |
JP2012171937A (ja) * | 2011-02-23 | 2012-09-10 | Kose Corp | 一重項酸素消去剤 |
JP2013107857A (ja) * | 2011-11-22 | 2013-06-06 | Funao Kurosawa | 皮膚外用剤 |
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