JP2017133918A - Body fluid viscosity measurement device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a body fluid viscosity measurement device with which it is possible to obtain, by one session of measurement operation, the measured values of electrical conductivity and viscosity obtainable by multiple sessions of measurement operation.SOLUTION: Provided is a body fluid viscosity measurement device 10 for measuring the electrical conductivity and viscosity of a body fluid F flowing in a flow channel 11, the device comprising: first conductive parts 12-14 provided in the flow channel 11 and connected to an external AC power supply V; second conductive parts 15-18 provided in the flow channel 11 and electrically connected to the first conductive parts 12-14 via the body fluid F in the flow channel 11; and computation means 44 for calculating the electrical conductivity and viscosity of the body fluid F from the magnitude of an electric signal outputted from an output terminal 19 connected to the second conductive parts 15-18. The first and second conductive parts 12-18 are available for at least three in total, each coming in contact with the body fluid F at different positions in the flow channel 11 along the flow of the body fluid F.SELECTED DRAWING: Figure 1

Description

The present invention relates to a bodily fluid viscosity measuring apparatus that measures the viscosity of bodily fluids.

Measuring the viscosity of bodily fluids is effective in knowing the health condition. For example, in the case of a person, it has been confirmed that the viscosity of blood rises when it is dehydrated or suffers from myocardial infarction, cerebral infarction, or the like.
There are various methods for measuring the viscosity of a body fluid, and specific examples thereof are described in Patent Documents 1 and 2, for example. In Patent Document 1, a reference fluid having a reference viscosity and a fluid to be measured to be measured are injected from both sides of the tube, and among the plurality of counting channels connected to the tube at regular intervals, the fluid to be measured Has disclosed a method for measuring the viscosity of a fluid to be measured based on the number of the flowed fluids. Patent Document 2 discloses a method for determining the viscosity of an electrolyte solution from electrical conductivity measurement.

Special table 2013-520676 gazette Japanese Patent Laying-Open No. 2015-132510

However, in the methods described in Patent Documents 1 and 2, since there is only one viscosity value derived by one measurement operation, in order to obtain the viscosity in consideration of the measurement error, the viscosity is determined multiple times. It was necessary to measure. Therefore, in order to accurately measure the viscosity of the body fluid, there is a problem that it is necessary to repeat the viscosity measurement a plurality of times and to prepare an amount of the body fluid that can be measured a plurality of times.
The present invention has been made in view of such circumstances, and it is possible to obtain measured values of electrical conductivity and viscosity obtained by a plurality of independent measurement operations by a single measurement operation using a small amount of sample. An object of the present invention is to provide a body fluid viscosity measuring device.

The bodily fluid viscosity measuring device according to the present invention that meets the above object is a bodily fluid viscosity measuring device that measures electrical conductivity and viscosity of a bodily fluid flowing through a flow path, and is provided in the flow path and connected to an external AC power source. A first conductive part, a second conductive part provided in the flow path and electrically connected to the first conductive part via the body fluid in the flow path, and the second conductive Computing means for calculating the electrical conductivity and viscosity of the bodily fluid from the magnitude of the electrical signal output from the output terminal connected to the part, wherein the first and second conductive parts are at least three in total. Thus, each body fluid comes into contact with the body fluid at a different position along the flow of the body fluid.

In the bodily fluid viscosity measuring apparatus according to the present invention, it is preferable that the first and second conductive portions are alternately arranged along the flow of the bodily fluid.

In the bodily fluid viscosity measuring device according to the present invention, it is preferable that the arrangement pitch of the first and second conductive portions is constant.

In the bodily fluid viscosity measuring device according to the present invention, it is preferable that the width of the flow path is a size in which the bodily fluid flows by capillary action.

In the body fluid viscosity measurement device according to the present invention, it is preferable that there are a plurality of the second conductive parts, and the plurality of second conductive parts are connected to one output terminal.

In the bodily fluid viscosity measuring device according to the present invention, a reagent solution is merged with the bodily fluid on the downstream side of the arrangement region of the first and second conductive portions of the flow path, and the mixed solution of the bodily fluid and the reagent solution It is preferable to further include a liquid supply mechanism that adjusts the viscosity of the liquid mixture to a predetermined value and a concentration derivation unit that measures the electrical conductivity and the electrolyte concentration of the mixed liquid.

In the bodily fluid viscosity measuring apparatus according to the present invention, it is preferable that the calculating means calculates the viscosity of the bodily fluid using the electrolyte concentration of the mixed liquid measured by the concentration deriving means.

In the bodily fluid viscosity measuring device according to the present invention, electrode units P and Q each having at least three of the first and second conductive portions and the output terminal are provided. The exit side of the flow path is connected to the entrance side of the flow path of the electrode unit Q via a trap that removes a specific substance from the body fluid, and the computing means flows through the electrode units P and Q. It is preferable to calculate the electrical conductivity and viscosity of the body fluid, respectively.

In the bodily fluid viscosity measuring device according to the present invention, the flow path and a chip having at least three first and second conductive parts in total, and a mounted body to which the chip is mounted, are provided, and the mounted body The body includes a first circuit for connecting the first conductive portion of the mounted chip to the AC power source, and a second circuit for connecting the second conductive portion of the mounted chip to the output terminal. The circuit is preferably provided.

In the body fluid viscosity measuring device according to the present invention, the flow path, the electrode unit R having at least three of the first and second conductive portions and the output terminal, and the electrode unit S having the same structure as the electrode unit R, The calculation means is configured to flow the body fluid of the electrode unit R based on the viscosity of the standard sample solution calculated by flowing a standard sample solution whose viscosity is known through the flow path of the electrode unit S. It is preferable to correct the viscosity of the bodily fluid calculated through the flow path.

The bodily fluid viscosity measuring device according to the present invention includes a first conductive part provided in the flow path and a first conductive part provided in the flow path and electrically connected to the first conductive part via the body fluid in the flow path. Two conductive parts, and there are at least three first and second conductive parts in total, each contacting the body fluid at a different position along the flow of the body fluid, so that the body fluid passes through the flow path. As the signal travels, the magnitude of the electrical signal output from the output terminal changes. Therefore, it is possible to calculate the electrical conductivity and viscosity of body fluids with electrical signals of different magnitudes, and to measure the electrical conductivity and viscosity values obtained by multiple independent measurement operations in a single measurement operation. It is possible to obtain.

It is explanatory drawing of the bodily fluid viscosity measuring apparatus which concerns on one embodiment of this invention. It is explanatory drawing of the electrode unit of the same body liquid viscosity measuring apparatus. (A), (B), (C) is the fragmentary sectional view of the chip | tip of a homogeneous liquid viscosity measuring apparatus, respectively, and the fragmentary sectional view of the chip | tip concerning the 1st, 2nd modification. It is explanatory drawing which shows the connection of a some electrode unit and a trap. It is explanatory drawing which shows the connection of a some electrode unit and a liquid supply mechanism. It is explanatory drawing which shows the power supply units R and S used in order to correct | amend electrical conductivity and viscosity using a standard sample liquid. It is a graph which shows the change of the output electric current value by progress of time. It is the graph which expanded a part of graph of FIG.

Next, embodiments of the present invention will be described with reference to the accompanying drawings for understanding of the present invention.
As shown in FIGS. 1, 2, and 3 (A), a bodily fluid viscosity measuring apparatus 10 according to an embodiment of the present invention is provided in a flow path 11 and is connected to an external AC power source V via an input terminal 40. Connected to the first conductive parts 12, 13, 14, the second conductive parts 15, 16, 17, 18 provided in the flow path 11, and the second conductive parts 15, 16, 17, 18. This is a device for measuring the electrical conductivity and viscosity (hereinafter the same) of the body fluid F flowing through the flow path 11 from the magnitude of the electrical signal output from the connected output terminal 19. Details will be described below.

The body fluid F that is a viscosity measurement target is an electrolyte solution, such as human blood, spinal fluid, sweat, saliva, and tears.
The bodily fluid viscosity measuring device 10 includes an electrode unit 21 connected to an AC power source V via a switch 20 as shown in FIGS. As shown in FIGS. 1, 2, and 3 (A), the electrode unit 21 is provided with a flow path 11, and includes first conductive portions 12, 13, 14 and second conductive portions 15, 16, 17, A chip 22 having 18 and a mounted body 23 to which the chip 22 is mounted.

As shown in FIGS. 2 and 3A, the chip 22 includes a rectangular plate member 24 that is long in the front and rear directions, and a long plate-like base member 25 that is fixed in the front and rear directions.
In the plate member 24, a recess 26 is formed on the bottom side along the longitudinal direction of the plate member 24, an opening 27 formed from the upper surface of the plate member 24 to one side of the recess 26, and the other side of the recess 26 from the upper surface of the plate member 24. An opening 28 formed over the top is provided. In the present embodiment, the opening 27 is an inlet for the body fluid F and the opening 28 is the outlet for the body fluid F. However, the opening 28 is used as the inlet for the body fluid F and the opening 27 is used as the outlet for the body fluid F. May be.

The flow path 11 of the chip 22 is formed by closing the opening of the concave portion 26 of the plate member 24 with the upper surface of the base member 25 by fixing the bottom surface of the plate member 24 in contact with the upper surface of the base member 25. The flow path 11 has hydrophilicity, and the width of the flow path 11 is such a size that the bodily fluid F can move in the flow path 11 by capillary action, for example, in the range of 10 μm to 500 μm. For this reason, when the body fluid F is introduced from the opening 27, the body fluid F travels in the flow path 11 from the opening 27 side (one side) to the opening 28 side (the other side) by capillary action, A laminar flow occurs from one side to the other.

In the present embodiment, the plate member 24 is formed by PDMS (dimethylpolysiloxane) containing Silwet and the hydrophilicity of the flow path 11 is ensured, but the hydrophilic treatment is limited to this. It is not a thing.

Conductive wires 32, 33, and 34 having first conductive portions 12, 13, and 14, and conductive wires 35, 36, 37, and second conductive portions 15, 16, 17, and 18, respectively, on the upper surface of the base member 25. 38 is provided. In addition, in this Embodiment, although the base member 25 is formed with glass, it is not limited to this.

And the conducting wire 35 (same also about conducting wires 32-34, 36-38), as shown to FIG. 2, FIG. 3 (A), about the 2nd electroconductive part 15 (about conducting wires 32-34, 36-38, Each of the first conductive portions 12 to 14 and the second conductive portions 16 to 18) may be disposed in the flow path 11 and extends from the left end to the right end of the base member 25 as in the present embodiment. The entire conductive wire 35 does not need to be in close contact with the upper surface of the base member 25.
For example, as shown in FIG. 3B, the second conductive portion 15 may be fixed to the upper side of the flow path 11 and the conductive wire 35 may be wired away from the base member 25. Alternatively, as shown in FIG. ), The conductive wire 35 may be wired so that one end is disposed in the flow path 11. These are the same for the conductive wires 32 to 34 and 36 to 38.

In the flow path 11, as shown in FIGS. 1 and 2, along the flow of the body fluid F, the second conductive portion 15, the first conductive portion 12, the second conductive portion 16, and the first conductive portion. 13, the second conductive portion 17, the first conductive portion 14, and the second conductive portion 18 are arranged in order (that is, the first conductive portion and the second conductive portion are arranged along the flow of body fluid. Alternately arranged).
Therefore, the bodily fluid F introduced into the opening 27 travels through the flow path 11 while the second conductive portion 15, the first conductive portion 12, the second conductive portion 16, the first conductive portion 13, Two conductive parts 17, the first conductive part 14 and the second conductive part 18 in order, and the first conductive parts 12, 13, 14 and the second conductive parts 15, 16, 17, 18 The body fluid F is contacted at different positions of the flow path 11 along the flow of F.

The second conductive portion 15, the first conductive portion 12, the second conductive portion 16, the first conductive portion 13, the second conductive portion 17, the first conductive portion 14, and the second conductive portion 18. The arrangement pitch of is constant. Therefore, the bodily fluid F introduced from the opening 27 has the second conductive portion 15, the first conductive portion 12, the second conductive portion 16, the first conductive portion 13, and the second conductive portion at regular time intervals. The conductive portion 17, the first conductive portion 14, and the second conductive portion 18 are sequentially reached.

Since the bodily fluid F has electrical conductivity, the bodily fluid F introduced from the opening 27 passes through the second conductive portion 15 and reaches the first conductive portion 12, and then reaches the first conductive portion 12 from the opening 27 of the flow path 11. When the body fluid F exists in the entire region up to the conductive portion 12, the second conductive portion 15 is electrically connected to the first conductive portion 12 via the body fluid F in the flow path 11. The Thereafter, when the body fluid F reaches the second conductive portion 16, the second conductive portion 16 is electrically connected to the first conductive portion 12 and the second conductive portion 15 via the body fluid F. Is done. When the body fluid F reaches the second conductive part 18, all the first conductive parts 12, 13, 14 and the second conductive parts 15, 16, 17, 18 are passed through the body fluid F. Electrically connected.

As shown in FIGS. 1 and 2, the mounted body 23 includes a frame portion 39 into which the chip 22 is fitted. The frame portion 39 is provided with an input terminal 40 connected to the AC power source V and a circuit 41 (first circuit) having a conducting wire branched into three from the input terminal 40 on the left side, the output terminal 19, A circuit 42 (second circuit) having four conductive wires branched from the output terminal 19 is provided on the right side.
When the chip 22 is fitted inside the frame portion 39 (that is, the chip 22 is mounted on the mounted body 23), the chip 22 has the first conductive portions 12, 13, and 14 via the circuit 41. The second conductive portions 15, 16, 17, and 18 are connected to the output terminal 19 through the circuit 42.

That is, the plurality of second conductive portions 15, 16, 17, and 18 are connected to the circuit 42, and the circuit 42 connects the second conductive portions 15, 16, 17, and 18 to one output terminal 19. Hereinafter, the chip 22 is assumed to be mounted on the mounted body 23 unless otherwise specified.
As shown in FIG. 1, the output terminal 19 is connected with a calculation means 44 via a switch 43. The computing means 44 calculates the viscosity of the body fluid F from the value of the current (an example of an electrical signal) output from the output terminal 19. As shown in FIG. 1, the switch 43 can switch the connection destination of the calculation means 44 from the output terminal 19 of the electrode unit 21 to a reference resistor 44 a for calibration (calibration).

The calculation means 44 obtains the impedance (in this embodiment, the combined resistance value) between the input terminal 40 and the output terminal 19 from the current value from the output terminal 19 and derives the electrical conductivity and viscosity of the body fluid F. The electrical conductivity and viscosity of the body fluid F calculated by the calculation means 44 are stored in a storage medium (not shown).
The magnitude of the impedance between the input terminal 40 and the output terminal 19 depends on the electrical conductivity and viscosity of the body fluid F flowing in the flow path 11, the first conductive parts 12, 13, 14 and the second conductive parts 15, 16. , 17 and 18 are determined by the connection state via the body fluid F.

Therefore, if the connection state of the first conductive parts 12, 13, 14 and the second conductive parts 15, 16, 17, 18 through the body fluid F is known, the body fluid F can be determined from the impedance between the input terminal 40 and the output terminal 19. Can be obtained. The fact that there is a correlation between the impedance between the input terminal 40 and the output terminal 19 and the viscosity of the body fluid F is known, for example, from the Walden rule.

As the leading portion of the body fluid F introduced into the opening 27 and traveling along the flow path 11 proceeds toward the opening 28, the leading portion of the body fluid F becomes the second conductive portion 15, the first conductive portion 12, and the second conductive portion 15. Through the conductive portion 16, the first conductive portion 13, the second conductive portion 17, the first conductive portion 14, and the second conductive portion 18, and the impedance between the input terminal 40 and the output terminal 19 is stepwise. The current value output from the output terminal 19 (hereinafter also simply referred to as “output current value”) increases stepwise.

The stepwise increase in the output current value is caused by the first portion of the body fluid F being the first conductive portion 12, the second conductive portion 16, the first conductive portion 13, the second conductive portion 17, and the first conductive portion. 14 and the second conductive part 18, meaning that the connection state of the first conductive parts 12, 13, 14 and the second conductive parts 15, 16, 17, 18 through the body fluid F changes. To do.
Since the calculating means 44 can detect an increase in the output current value, the first conductive portions 12, 13, 14 and the second conductive portions 15, 16, 17, The connection state via 18 body fluids F can be detected. Therefore, the calculation means 44 can determine the electrical conductivity and viscosity of the body fluid F from the impedance between the input terminal 40 and the output terminal 19.

Here, the calculation means 44 calculates the electrical conductivity and viscosity of the body fluid F based on the output current value every time the output current value increases stepwise. Therefore, the body fluid F of a predetermined amount (amount in which all of the first conductive portions 12, 13, 14 and the second conductive portions 15, 16, 17, 18 are electrically connected by the body fluid F in the flow path 11). Is introduced from the opening 27, the calculation means 44 can calculate the electrical conductivity and viscosity of the body fluid F a plurality of times.

Then, the calculation means 44 obtains the final viscosity value of the body fluid F based on the calculated plurality of viscosity values (in this embodiment, the viscosity coefficient). For example, the average of a plurality of calculated viscosity values can be used as the final viscosity value. When there is a difference greater than or equal to the calculated viscosity value or when the output current value does not increase step by step at a predetermined time interval, the calculation means 44 outputs a signal indicating that there is an abnormality. Designed.
In the present embodiment, since the output current value rises six times stepwise, the calculation means 44 calculates the electrical conductivity and viscosity of the body fluid F six times.

In the present embodiment, as shown in FIG. 1, the calculation means 44 is mainly configured by two electric circuits 45 and 46, but the number of electric circuits is not necessarily two.
In the present embodiment, the first conductive portions 12, 13, 14 and the second conductive portions 15, 16, 17, 18 are seven in total, but the first and second conductive portions are combined. There should be at least three. This means that if there are at least three first and second conductive parts in total, the output current value increases stepwise, and the electrical conductivity and viscosity value of the body fluid are calculated from at least two different output current values. It is because it can do.

In the present embodiment, only one electrode unit 21 is provided. However, as shown in FIG. 4, two electrode units 48 and 49 (electrode units P and Q) may be provided. Each of the electrode units 48 and 49 has basically the same structure as the electrode unit 21, and includes the flow path 11 and a total of seven (that is, at least three) first conductive portions 12, 13, 14, and Second conductive parts 15, 16, 17, 18 and an output terminal 19 are provided.

The exit side (the other side) of the flow path 11 of the electrode unit 48 is connected to the entrance side (one side) of the flow path 11 of the electrode unit 49 from the body fluid F to a specific substance (for example, when the body fluid F is blood). The substance is connected via a trap 50 that removes blood cells). In addition, in the electrode units 48 and 49, about the structure similar to the electrode unit 21, the same code | symbol is attached | subjected and detailed description is abbreviate | omitted (hereinafter the same).

Therefore, the bodily fluid F introduced from the opening 27 of the electrode unit 48 passes through the flow path 11 of the electrode unit 48 and flows through the flow path 11 of the electrode unit 49 after a specific substance is removed by the trap 50. Therefore, the calculation means (not shown) calculates the viscosity of the body fluid F from which the specific substance has not been removed based on the output current value from the output terminal 19 of the electrode unit 48, and outputs it from the output terminal 19 of the electrode unit 49. Based on the current value, the electrical conductivity and viscosity of body fluid F from which a specific substance has been removed (for example, blood including plasma from which blood cells have been removed) are calculated.

Further, as shown in FIG. 5, the reagent solution is applied to the body fluid F on the downstream side of the arrangement region of the first conductive parts 12, 13, 14 and the second conductive parts 15, 16, 17, 18 of the flow path 11. A liquid supply mechanism 52 that adjusts the viscosity of the mixed liquid of the body fluid F and the reagent liquid to a predetermined value may be provided.
In the example shown in FIG. 5, an electrode unit 51 is provided on the downstream side of the electrode unit 49, and the entrance side of the flow channel 11 is connected to the exit side of the flow channel 11 of the electrode unit 49. A liquid supply mechanism 52 is connected to a connection region of the flow path 11 of the electrode unit 51 through a pipe.

The electrode unit 51 basically has the same structure as the electrode unit 21, and the liquid supply mechanism 52 can be configured to include, for example, a pump and an electromagnetic valve.
For example, the liquid supply mechanism 52 joins the body fluid F between the electrode units 49 and 51 with distilled water (an example of a reagent solution, hereinafter, also simply referred to as “water”) approximately 20 times the body fluid F in volume ratio. The viscosity of the mixture of body fluid F and water is set to the same level as water. The output terminal 19 of the electrode unit 51 is connected to a concentration derivation unit (not shown) that measures the electrolyte concentration of the mixed liquid flowing through the flow path 11 of the electrode unit 51 based on the output current value from the output terminal 19. The concentration deriving means can be configured by, for example, an electronic computer in which a software program is installed.

The calculation means can acquire the electrolyte concentration measured by the concentration derivation means from the concentration derivation means, and calculates the viscosity of the body fluid F using the electrolyte concentration of the mixed liquid measured by the concentration derivation means.
Here, the calculation formula for calculating the viscosity of the body fluid based on the impedance requires the electrolyte concentration of the body fluid. In this regard, the value of the electrolyte concentration of the body fluid is within a certain range for each type of body fluid, and variation is small. Therefore, by substituting a predetermined value of the electrolyte concentration into the calculation formula, the viscosity of the target body fluid can be calculated without measuring the electrolyte concentration. However, from the viewpoint of calculating the electrolyte concentration more accurately, it is preferable to calculate the viscosity by substituting the measured electrolyte concentration into the calculation formula.

In addition, as shown in FIG. 6, two electrode units 53 and 54 (electrode units R and S) having the same structure as the electrode unit 21 are provided, and body fluid F is caused to flow through the flow path 11 of the electrode unit 53, It is also possible to correct the calculated viscosity of the body fluid F by flowing a standard sample liquid whose viscosity is known in the flow path 11.
The calculation means calculates the viscosity of the standard sample liquid that has flowed through the flow path 11 of the electrode unit 54 and the viscosity of the body fluid F that has flowed through the flow path 11 of the electrode unit 53, respectively. Corrects the calculated viscosity of the body fluid F based on the difference between the calculated viscosity of the standard sample liquid and the viscosity of the standard sample liquid whose viscosity has been found. It is conceivable that some errors occur in the viscosity of the calculated body fluid F due to environmental differences such as the temperature at the time of measurement. Therefore, the calculated viscosity of the body fluid F is corrected based on the viscosity of the standard sample solution. It is suitable for obtaining a more accurate viscosity. Further, for example, a temperature measuring means such as a thermistor element can be installed on the electrode unit to record the temperature at the time of measurement, so that it can be more accurate.

Next, an experiment conducted for confirming the effect of the present invention will be described.
In this experiment, an electrode unit having a total of seven first and second conductive portions was adopted, and a saline solution (hereinafter also simply referred to as “saline solution”) whose viscosity was increased by adding sucrose to the flow path. Shed. 7 and 8 show the transition of the measured output current with respect to the time axis. The graph of FIG. 8 is an enlarged view of a part of the graph of FIG. 7, and FIG. 8 shows the value of the combined resistance corresponding to each of the output currents that increase stepwise.
From FIG. 7 and FIG. 8, it was confirmed that each increase value of the output current that increases stepwise is substantially the same, and that the output current increased stepwise at intervals of 5 to 6 seconds. As a result, it can be seen that the electric conductivity and viscosity can be calculated from each of the output currents that increase in stages.
In FIG. 7, D indicates a point in time when the saline solution is introduced, and W indicates a point in time when the salt solution is washed away by flowing water through the flow path.

Although the embodiments of the present invention have been described above, the present invention is not limited to the above-described embodiments, and all changes in conditions and the like that do not depart from the gist are within the scope of the present invention.
For example, instead of a flow path in which body fluid travels by capillary action, a flow path in which body fluid travels by a pump or gravity may be employed. However, when a flow path through which body fluid proceeds by capillary action is employed, the amount of body fluid required to measure viscosity can be reduced.

In the present embodiment, the frequency of the AC voltage applied from the AC power source to the input terminal is single and constant, but a plurality of AC voltages having different frequencies can also be applied to the input terminal. When an AC voltage having a different frequency is applied to the input terminal, the calculation means calculates the impedance of each frequency and calculates the viscosity of the body fluid.
If the impedance changes as the body fluid flows, the first and second conductive parts do not need to be arranged alternately along the body fluid flow. Furthermore, the arrangement pitch of the first and second conductive portions may not be constant.
In addition, when there are a plurality of second conductive portions, the plurality of second conductive portions do not need to be connected to one output terminal, and may be connected to separate output terminals. When connecting a plurality of second conductive parts to separate output terminals, separate viscosities are calculated based on output current values from the respective output terminals.

10: body fluid viscosity measuring device, 11: flow path, 12-14: first conductive part, 15-18: second conductive part, 19: output terminal, 20: switch, 21: electrode unit, 22: chip, 23: Mounted object, 24: Plate material, 25: Base member, 26: Recessed part, 27, 28: Opening part, 32-38: Conductor, 39: Frame part, 40: Input terminal, 41, 42: Circuit, 43: Switch, 44: Calculation means, 44a: Reference resistance, 45, 46: Electric circuit, 48, 49: Electrode unit, 50: Trap, 51: Electrode unit, 52: Liquid supply mechanism, 53, 54: Electrode unit, F: Body fluid, V: AC power supply

Claims (10)

A bodily fluid viscosity measuring device for measuring electrical conductivity and viscosity of bodily fluid flowing through a flow path,
A first conductive portion provided in the flow path and connected to an external AC power source;
A second conductive portion provided in the flow path and electrically connected to the first conductive section via the body fluid in the flow path;
Calculating means for calculating the electrical conductivity and viscosity of the body fluid from the magnitude of the electrical signal output from the output terminal connected to the second conductive part,
There are at least three of the first and second conductive portions in total, and each body fluid viscosity measuring device is in contact with the body fluid at a different position of the flow path along the flow of the body fluid. The bodily fluid viscosity measuring apparatus according to claim 1, wherein the first and second conductive portions are alternately arranged along the flow of the bodily fluid. 3. The body fluid viscosity measuring apparatus according to claim 1, wherein the arrangement pitch of the first and second conductive parts is constant. The bodily fluid viscosity measuring apparatus according to any one of claims 1 to 3, wherein the width of the flow path is a size in which the bodily fluid flows by capillary action. 5. The body fluid viscosity measuring device according to claim 1, wherein there are a plurality of the second conductive portions, and the plurality of second conductive portions are connected to one of the output terminals. Body fluid viscosity measuring device. The bodily fluid viscosity measuring device according to any one of claims 1 to 5, wherein a reagent solution is joined to the bodily fluid on the downstream side of the arrangement region of the first and second conductive portions of the flow path, The body fluid viscosity further comprising: a liquid supply mechanism that adjusts the viscosity of the mixture of the body fluid and the reagent solution to a predetermined value; and a concentration derivation unit that measures the electrical conductivity and the electrolyte concentration of the mixture. measuring device. 7. The body fluid viscosity measuring apparatus according to claim 6, wherein the calculation means calculates the viscosity of the body fluid using the electrolyte concentration of the mixed liquid measured by the concentration derivation means. The body fluid viscosity measuring device according to any one of claims 1 to 7, wherein each of the electrode units P and Q includes at least three of the first and second conductive portions and the output terminal in combination with the flow path. The outlet side of the flow path of the electrode unit P is connected to the inlet side of the flow path of the electrode unit Q via a trap that removes a specific substance from the body fluid, An apparatus for measuring body fluid viscosity, which calculates the electrical conductivity and viscosity of the body fluid flowing through the electrode units P and Q, respectively. The body fluid viscosity measuring device according to any one of claims 1 to 7, wherein the flow path and a chip having at least three of the first and second conductive parts in total, and a mounting to which the chip is mounted A first circuit for connecting the first conductive portion of the mounted chip to the AC power source, and the second conductive portion of the mounted chip. And a second circuit for connecting the output to the output terminal. The body fluid viscosity measuring device according to any one of claims 1 to 7, wherein the electrode unit R and the electrode unit each include the flow path, the first and second conductive portions, and the output terminal. The electrode unit S having the same structure as R is provided, and the calculation means is based on the viscosity of the standard sample liquid calculated by flowing a standard sample liquid whose viscosity is known through the flow path of the electrode unit S. The bodily fluid viscosity measuring apparatus, wherein the bodily fluid viscosity corrected by flowing the bodily fluid through the flow path of the electrode unit R is corrected.

Images