JP2017125203A5 - - Google Patents
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- Publication number
- JP2017125203A5 JP2017125203A5 JP2017043621A JP2017043621A JP2017125203A5 JP 2017125203 A5 JP2017125203 A5 JP 2017125203A5 JP 2017043621 A JP2017043621 A JP 2017043621A JP 2017043621 A JP2017043621 A JP 2017043621A JP 2017125203 A5 JP2017125203 A5 JP 2017125203A5
- Authority
- JP
- Japan
- Prior art keywords
- molar equivalent
- water
- chondroitin sulfate
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001412 amines Chemical class 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 5
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 5
- 229940059329 chondroitin sulfate Drugs 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000004132 cross linking Methods 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- 239000012046 mixed solvent Substances 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 claims 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 claims 1
- RJNUXEDAPIKMDE-UHFFFAOYSA-M 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium;chloride;hydrate Chemical group O.[Cl-].COC1=NC(OC)=NC([N+]2(C)CCOCC2)=N1 RJNUXEDAPIKMDE-UHFFFAOYSA-M 0.000 claims 1
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims 1
- 238000006065 biodegradation reaction Methods 0.000 claims 1
- 150000004985 diamines Chemical class 0.000 claims 1
- 125000000600 disaccharide group Chemical group 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015007072 | 2015-01-16 | ||
| JP2015007072 | 2015-01-16 | ||
| JP2015150976 | 2015-07-30 | ||
| JP2015150976 | 2015-07-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533212A Division JP6110037B2 (ja) | 2015-01-16 | 2016-01-15 | コンドロイチン硫酸架橋体、並びにこれを含有する組成物、及び眼疾患処置剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017125203A JP2017125203A (ja) | 2017-07-20 |
| JP2017125203A5 true JP2017125203A5 (enExample) | 2019-07-25 |
| JP6715201B2 JP6715201B2 (ja) | 2020-07-01 |
Family
ID=56405937
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533212A Active JP6110037B2 (ja) | 2015-01-16 | 2016-01-15 | コンドロイチン硫酸架橋体、並びにこれを含有する組成物、及び眼疾患処置剤 |
| JP2017043621A Active JP6715201B2 (ja) | 2015-01-16 | 2017-03-08 | コンドロイチン硫酸架橋体、並びにこれを含有する組成物、及び眼疾患処置剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533212A Active JP6110037B2 (ja) | 2015-01-16 | 2016-01-15 | コンドロイチン硫酸架橋体、並びにこれを含有する組成物、及び眼疾患処置剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US10420796B2 (enExample) |
| EP (2) | EP3246037A4 (enExample) |
| JP (2) | JP6110037B2 (enExample) |
| ES (1) | ES2938482T3 (enExample) |
| WO (1) | WO2016114397A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11766421B2 (en) | 2017-09-25 | 2023-09-26 | Surface Ophthalmics, Inc. | Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease |
| KR20210141448A (ko) | 2018-12-27 | 2021-11-23 | 서피스 아프샐믹스 인코포레이티드 | 안구 표면 질환을 치료하기 위한 안과용 약학 조성물 및 방법 |
| WO2021188882A1 (en) * | 2020-03-19 | 2021-09-23 | Glycologix, Llc | Sulfated glycosaminoglycan biomaterials as proteoglycan mimics |
| US12310981B2 (en) | 2021-05-10 | 2025-05-27 | Surface Ophthalmics, Inc. | Use of chondroitin sulfate for relieving ocular pain |
| US12440510B2 (en) | 2021-05-10 | 2025-10-14 | Surface Ophthalmics, Inc. | Use of chondroitin sulfate for relieving ocular pain |
| CN116687959B (zh) * | 2022-05-18 | 2024-10-22 | 朱小丰 | 一种硫酸软骨素生物多胺复合物、其制备方法及用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4863907A (en) * | 1984-06-29 | 1989-09-05 | Seikagaku Kogyo Co., Ltd. | Crosslinked glycosaminoglycans and their use |
| US5527893A (en) | 1987-09-18 | 1996-06-18 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
| DE69131688T2 (de) | 1990-05-04 | 2000-05-25 | Perio Products Ltd., Hahotzvim | System zur arzneistoffabgabe im colon |
| IL98087A (en) | 1990-05-04 | 1996-11-14 | Perio Prod Ltd | Preparation for dispensing drugs in the colon |
| JP2855307B2 (ja) | 1992-02-05 | 1999-02-10 | 生化学工業株式会社 | 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法 |
| JPH07223966A (ja) * | 1994-02-08 | 1995-08-22 | Seiko Epson Corp | 眼科用人工涙液 |
| JP3059092B2 (ja) | 1995-11-15 | 2000-07-04 | 田辺製薬株式会社 | ドライアイおよびドライアイを原因とする疾患の予防・治療剤 |
| IT1303738B1 (it) * | 1998-11-11 | 2001-02-23 | Aquisitio S P A | Processo di reticolazione di polisaccaridi carbossilati. |
| JP3903475B2 (ja) * | 1999-04-30 | 2007-04-11 | ニプロ株式会社 | 乾性角膜症治療剤 |
| RU2486907C2 (ru) | 2006-12-04 | 2013-07-10 | Джонс Хопкинс Юниверсити | Имидированный биополимерный адгезив и гидрогель |
| WO2016107834A1 (en) * | 2014-12-29 | 2016-07-07 | Galderma S.A. | Carboxyl cross-linked chondroitin hydrogels and their use for soft tissue applications |
| EP3040117A1 (en) * | 2014-12-29 | 2016-07-06 | Galderma S.A. | Ether cross-linked chondroitin sulfate hydrogels and their use for soft tissue applications |
-
2016
- 2016-01-15 JP JP2016533212A patent/JP6110037B2/ja active Active
- 2016-01-15 WO PCT/JP2016/051176 patent/WO2016114397A1/ja not_active Ceased
- 2016-01-15 EP EP16737468.5A patent/EP3246037A4/en not_active Withdrawn
- 2016-01-15 EP EP21150701.7A patent/EP3831394B1/en active Active
- 2016-01-15 ES ES21150701T patent/ES2938482T3/es active Active
- 2016-01-15 US US15/543,748 patent/US10420796B2/en active Active
-
2017
- 2017-03-08 JP JP2017043621A patent/JP6715201B2/ja active Active
-
2019
- 2019-08-09 US US16/536,779 patent/US10716804B2/en active Active
-
2020
- 2020-06-09 US US16/896,823 patent/US11207345B2/en active Active
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