JP2017124996A - Antibacterial and antiviral composition and lubricant comprising the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an antibacterial and antiviral composition that has excellent an antibacterial and antiviral effect, and resists discoloration even when stored for the long term.SOLUTION: An antibacterial and antiviral composition has amino acid silver, amino acid zinc and copper ions.SELECTED DRAWING: None

Description

  The present invention relates to an antibacterial / antiviral composition and a lubricant containing the same.

  2. Description of the Related Art Lubricants (lotions) that have lubricity and viscosity and are intended to reduce the burden on the skin during massage and to reduce frictional pain during intercourse have been known. As such a lubricant, for example, a lubricant whose antibacterial property has been improved by blending catechin into an aqueous solution of polyacrylate as a main component has been proposed (Patent Document 1). In addition, additives such as glycerin, guar gum, alginic acid, collagen, polysaccharides, and disaccharides may be added to such lubricants.

  On the other hand, antibacterial and antiviral compositions containing fine metal particles such as silver and zinc are also known (for example, Patent Documents 2 to 7).

JP 2005-28984 A JP 2004-2227 A Special table 2008-520570 gazette JP 2010-70571 A JP-T-2004-528389 JP 2014-208606 A Special table 2013-503124 gazette

  However, in the case of the lubricant of Patent Document 1, antibacterial and antiviral effects are not sufficient. In particular, when the lubricant contains various additives, there is a risk that bacteria, microorganisms and the like may grow using this as a nutrient source. In addition, if the anti-viral effect of the lubricant is insufficient, human immunodeficiency virus (HIV), herpes simplex virus (HSV), human papilloma virus (HPV), etc. are infected when the lubricant is used, and AIDS, genital herpes It can also cause diseases such as pointed condylome.

  In addition, for example, it is conceivable to add methylparaben used as an antibacterial agent and preservative to a conventional lubricant such as Patent Document 1, but since methylparaben dissolves with alcohol, alcohol allergies and skin diseases are considered. It may have an adverse effect. Furthermore, since methylparaben has weak antiviral properties, virus infection cannot be suppressed at normal concentrations.

  On the other hand, in the case of the antibacterial / antiviral composition of Patent Documents 2 to 5, the color is likely to change due to halogenation or change with time when stored for a long period of time. For this reason, when using conventional antibacterial and antiviral compositions such as Patent Documents 2 to 5 as lubricants, it is necessary to limit the amount of metal added to suppress discoloration, and as a result, sufficient There is a problem that the antibacterial and antiviral effects cannot be exhibited. Therefore, these antibacterial and antiviral compositions are not widely used as lubricant materials.

  The present invention has been made in view of the above circumstances, and provides an antibacterial / antiviral composition that is excellent in antibacterial / antiviral effects and has suppressed discoloration even after long-term storage. Is an issue.

  In order to solve the above problems, the antibacterial and antiviral composition of the present invention is characterized by containing amino acid silver, amino acid zinc and copper ion.

  In this antibacterial / antiviral composition, the amino acids silver and zinc are preferably L-pyrrolidonecarboxylic acid.

  In this antibacterial / antiviral composition, the copper ion is preferably derived from copper pyrrolidone carboxylate.

  The antibacterial / antiviral composition preferably further contains sulfuric acid.

  The antibacterial / antiviral composition preferably further contains N-long chain acylamino acid potassium.

  The lubricant of the present invention contains the antibacterial / antiviral composition described above.

  The antibacterial / antiviral composition of the present invention contains amino acid silver, amino acid zinc and copper ion in water as a solvent. In the antibacterial / antiviral composition of the present invention, at least a part of the blended amino acid silver and amino acid zinc, silver and zinc are present in an ionized state.

  Examples of amino acids in the amino acid silver and the amino acid zinc include glycine, alanine, valine, leucine, phenylalanine, tyrosine, threonine, tryptophan, methionine, aspartic acid, lysine, arginine, histidine pidolic acid, L-glutamic acid, and L-glutamic acid. , L-glutamic acid, L-glutamic acid lactam, L-glutiminic acid, L-pyrrolidonecarboxylic acid, L-pyroglutamic acid and oxoproline. Among these, since L-pyrrolidone carboxylic acid is excellent in antibacterial and antiviral effects, an antibacterial agent can be obtained by blending silver pyrrolidone carboxylate and zinc pyrrolidone carboxylate into the antibacterial and antiviral composition of the present invention.・ The antiviral effect can be increased with certainty.

  The compounding amount of amino acid silver and amino acid zinc can be appropriately designed. For example, the total of silver ions and zinc ions with respect to 1000 ml of water is preferably 15000 mg / L or more, and practically, silver ions with respect to 1000 ml of water. The total of zinc ions is more preferably in the range of about 15000 mg / L to 100000 mg / L.

  The copper ions contained in the antibacterial / antiviral composition of the present invention may be due to various copper compounds, specifically, for example, copper nitrate, copper chloride, copper sulfate, copper oxide, copper sulfate, Examples thereof include copper iodide, copper carbonate, copper citrate, and amino acid copper. Among them, amino acid copper is preferable.

  The amino acid copper amino acid is, for example, glycine, alanine, valine, leucine, phenylalanine, tyrosine, threonine, tryptophan, methionine, aspartic acid, lysine, arginine, histidine pidolic acid, L-glutamic acid, as well as amino acid silver and amino acid zinc. , L-glutamic acid, L-glutamic acid, L-glutamic acid lactam, L-glutiminic acid, L-pyrrolidone carboxylic acid, L-pyroglutamic acid, oxoproline, or one or more of them can be exemplified. Among these, since L-pyrrolidone carboxylic acid is excellent in antibacterial and antiviral effects, antibacterial and antiviral effects can be obtained by adding copper pyrrolidone carboxylate to the antibacterial and antiviral composition of the present invention. It can certainly be increased.

  The compounding amount of amino acid copper can be appropriately designed. For example, the copper ion with respect to 1000 ml of water is preferably 100 mg / L or more. In practice, the total of silver ions and zinc ions with respect to 1000 ml of water is 100 mg. More preferably, it is in the range of about / L to 500 mg / L.

  In addition, the antibacterial / antiviral composition of the present invention may appropriately include other metals such as nickel, magnesium, iron, and titanium.

  Furthermore, the antibacterial and antiviral composition of the present invention preferably contains potassium N-long complex acylamino acid as a surfactant. Unlike the conventional sodium type, potassium N-long complex acylamino acid is easily changed to a stable binding state by easily replacing potassium ions with silver ions, zinc ions and copper ions of the antiviral composition. For this reason, N-long complex acylamino acid potassium has a role of retaining an antiviral component, can impart a surfactant effect, and can enhance the detergency.

  The mixing ratio of the antibacterial / antiviral composition of the present invention and potassium N-long complex acylamino acid can be appropriately set according to the use, purpose, etc., for example, for the antibacterial / antiviral composition, Examples are in the range of 0.005 wt% to 10 wt%. When the N-long complex acylamino acid potassium compounding ratio is within this range, the above-described effect is reliably exhibited.

  Further, when the concentration of the surfactant such as potassium N-long complex acylamino acid is in the range of 0.1% to 1%, it is suitable for cleaning of instruments and toys, and in the range of 5% to 12.5%. If it is, it is suitable for face washing or shaving, and if it is 7.5% to 15%, it is suitable for cleaning agents such as hands, feet, body and hair.

  Since the antibacterial / antiviral composition of the present invention contains amino acid silver, amino acid zinc and copper ions, it is excellent in antibacterial / antiviral effect and suppresses the occurrence of discoloration even after long-term storage. For this reason, the antibacterial / antiviral composition of the present invention can maintain the quality for a long period of time. For example, body cleansing agents, lubricants for massage, etc. Mucosal protective agents (cleaning agents), cleaning agents such as toys and sanitary products, cosmetic creams, lotions, cosmetics, facial cleansing agents, textile products such as sheet materials and masks for wiping the face and body, pet goods, etc. Can be preferably used.

  The antibacterial / antiviral composition of the present invention can be blended with various other additives in consideration of use, handling properties, storage stability, and the like. For example, compounding agents usually used in preparations such as surfactants, oils, alcohols, moisturizers, thickeners, preservatives, antioxidants, chelating agents, pH adjusters, fragrances, pigments, vitamins, herbal medicines Moreover, a plant extract etc. can also be mix | blended. Moreover, pH can also be adjusted using acids, such as zinc sulfate heptahydrate and copper sulfate pentahydrate, sodium hydroxide, etc.

  More specifically, when the antibacterial / antiviral composition of the present invention is used as a lubricant, a conventionally known polymer cellulose acetate butylate of polyacrylates, polyacrylamides, polyethylene oxysides is used. , Methylcellulose, ethylcellulose, methoxycellulose, propylene glycol, hydroxypropylcellulose water-soluble fiber derivatives, starch, modified starch, alginates, silicone oil, glycerins, polysaccharides, disaccharides, hyaluronic acid, collagen, isoborabone, citric acid, etc. The antibacterial and antiviral composition of the present invention can be blended with a lubricant containing

  Among them, polyacrylic acid is preferable because it has a carboxyl group in the basic skeleton and thus has high hydrophilicity and is easily handled in an aqueous system. The weight average molecular weight of the polyacrylic acid is preferably 500 to 2000, and more preferably about 2000. By blending this polyacrylic acid, it is possible to incorporate silver ions, zinc ions, copper ions, etc. in the amino acid metal dispersed in water to crosslink and disperse, so that the antibacterial / antiviral composition of Dispersibility can be increased.

  Moreover, when using the antibacterial and antiviral composition of the present invention as a lubricant, it is preferable to add an appropriate amount of sulfuric acid. Since the generation of precipitates can be suppressed by adding sulfuric acid, the quality is further improved.

  When the antibacterial / antiviral composition of the present invention is used as a lubricant, the blending ratio of the antibacterial / antiviral composition can be appropriately set, but is 0.01% to 0.00% with respect to the total amount. By adding 1% or more, antiviral properties, antibacterial properties, and deodorizing properties can be ensured, so that they are inexpensive.

  Moreover, since the antibacterial and antiviral composition of the present invention also exhibits a deodorizing effect, for example, the odor of the lubricant can be suppressed, so that the quality can be further improved.

  The antibacterial / antiviral composition of the present invention is not limited to the above embodiment.

Hereinafter, the antibacterial / antiviral composition of the present invention will be described together with examples, but the antibacterial / antiviral composition of the present invention is not limited to the following examples.
<Example 1> Preparation of antibacterial / antiviral composition An antibacterial / antiviral composition was prepared by the following procedure.
(1) To 1000 ml of pure water, 0.1 mol of silver nitrate and 0.1 mol of sodium hydrogen carbonate were added, and the mixture was stirred for 10 minutes after addition in a room protected from light at room temperature.
(2) It dehydrated using a filter paper and washed with 1000 ml of pure water.
(3) A paste corresponding to 6.75 g of dry weight obtained in the above (2) and 6.96 g of L-pyrrolidonecarboxylic acid are added to 1000 ml of pure water and heated to react to give 1000 mg / silver pyrrolidonecarboxylate. L was obtained.
(4) Similarly to the above (1), (2) and (3), zinc nitrate is used as a material and reacted with L-pyrrolidone carboxylic acid to produce zinc pyrrolidone carboxylate (zinc: 82%, pyrrolidone carboxylic acid compound: 18%) 16.5 g (dry weight) was obtained.
(5) Silver pyrrolidone carboxylate, zinc L-pyrrolidone carboxylate, and copper sulfate pentahydrate were blended as follows to prepare an antibacterial / antiviral composition.

Formulation in 1000 ml of water Silver pyrrolidone carboxylate as described above 100 mg / L
Zinc L-pyrrolidonecarboxylate 16500mg / L
Copper sulfate pentahydrate 2400mg / L
In addition, it was confirmed that this composition does not discolor even if it passes for a long time.

<Example 2> Antiviral property of composition The antiviral property of the composition obtained in Example 1 was examined by the following method.
(Antiviral test summary)
(1) The virus test was carried out on the fiber which had been diluted 100 times, infiltrated into the fiber at a weight ratio of 1: 1 with the fiber, and dried at 60 ° C. for 2 hours.
Testing organization: Boken Quality Evaluation Organization Testing method: ISO18184 Textiles-Determination of antivirial activity of textile products.
Test virus: Influenza virus (H3N2)
ATCC VR-1679 virus infectivity titration method: Plaque assay
Test establishment conditions: 14.3.1 (a) to (c) were satisfied.
(2) The results are shown in Table 1.

  As shown in Table 1, it was confirmed that the fiber infiltrated with the composition of Example 1 had excellent antiviral properties.

<Example 3> Antibacterial property 1 of composition
(1) The antibacterial properties of the composition obtained in Example 1 were examined by the following method.
Antibacterial activity test: The composition obtained in Example 1 was diluted 100 times and adhered to the fiber, and the test was carried out after drying at 60 ° C.
Test method: JSL1902: 2008 Quantitative test (bacterial solution absorption method).
Method for measuring the number of viable bacteria: Pour plate culture test strain: Staphylococcus Aureus NBRC 12732
(2) The results are shown in Table 2.

  As shown in Tables 2 and 3, it was confirmed that the composition obtained in Example 1 had excellent antibacterial properties.

<Example 4> Antibacterial property 2 of the composition
(1) The antibacterial properties of the composition obtained in Example 1 were examined by the following method.
Antibacterial activity test: The composition obtained in Example 1 was diluted 100 times and adhered to the fiber, and the test was carried out after drying at 60 ° C.
Test method: JSL1902: 2008 Quantitative test (bacterial liquid absorption method)
Method for measuring the number of viable bacteria: Pouch plate culture method Test strain: Escherichia coli NBRC 3301
(2) The results are shown in Table 4.

  As shown in Table 4, it was confirmed that the composition obtained in Example 1 has excellent antibacterial properties.

  Moreover, as a result of having diluted the composition obtained in Example 1 200 times and performing the same test, it was also confirmed that the antibacterial activity value is 2 or more.

<Example 5> Deodorizing effect of composition (1) The deodorizing effect of the composition obtained in Example 1 was examined by the following method.
(A) Testing organization: (one company) Textile Evaluation Technology Council Deodorization test (100-fold dilution): Detector tube method, gas chromatograph gas initial concentration ammonia 100 ppm (detector tube)
Acetic acid 30ppm (detector tube)
Isovaleric acid 38ppm (gas chromatograph)
Test sample Detector tube method 100m2
Gas chromatograph 50m2
Measurement time 2 hours (B) Test organization: In-house deodorization test (200-fold dilution) detector tube method, gas chromatograph gas initial concentration ammonia 100 ppm (detector tube)
Acetic acid 30ppm (detector tube)
Test sample Detector tube method 100m2
Measurement time 2 hours (2) The results are shown in Table 5.

  As shown in Table 5, it was confirmed that the composition obtained in Example 1 has a deodorizing effect.

<Example 6> Dilution rate of composition The test similar to Examples 2-5 was done by changing the dilution rate of the composition obtained in Example 1 (0 to 200 times).

  As shown in Table 6, even when the dilution rate of the composition obtained in Example 1 was changed by 0 to 200 times, it was confirmed that excellent antiviral properties, antibacterial properties, and deodorizing properties were exhibited. In addition, it was confirmed that the composition obtained in Example 1 maintained antiviral properties, antibacterial properties, and deodorizing properties even when added to a dry state, fiber, or other solvent.

<Example 7> Use 1 of the composition obtained in Example 1 as a lubricant (lotion)
The test was carried out by adding the composition obtained in Example 1 to a commercially available lubricant (manufactured by Nakajima Chemical Co., Ltd .: trade name Pepe) mainly composed of sodium polyacrylate.

  Specifically, the composition obtained in Example 1 was diluted 25 to 100 times, and each concentration of N-long complex acylamino acid potassium surfactant (0.1, 0.5, 1, 5, 7.5). 10, 12.5, 15%) were added, and the antibacterial properties, antiviral properties, and deodorizing properties were tested.

  The results are shown in Table 7.

  As shown in Table 7, even when the composition obtained in Example 1 was added to a commercially available lubricant, the antiviral properties, antibacterial properties, and deodorizing properties of the composition were not inhibited, and sufficient effects were exhibited. Confirmed to do. Further, it was confirmed that the lubricant to which the composition obtained in Example 1 was added did not cause discoloration even after a long period of time.

<Example 8> Use of the composition obtained in Example 1 as a lubricant (lotion) 2
Commercially available lubricants contain alcohol as a solvent and methylparaben, which is a preservative, but tend to be alkaline and often cause mold growth.

(1) Lubricant 1
And sodium polyacrylate 1 wt% to Isoborabon 1000 mg / L containing lubricant 9 ml, those of the antiviral composition is added 1% by weight to the lubricant prepare each 100 ml, respectively, E. coli 2.7 × 10 ⁵ 1 ml was added, 100 μml was smeared on a potato dextrose agar medium, and cultured in a thermostat at 37 ° C. for 24 hours.

  The results are shown in Table 8.

  As shown in Table 8, it was confirmed that the composition obtained in Example 1 exhibited excellent antiviral properties by adding 1% by weight to the lubricant.

(2) Lubricant 2
100 ml each of 9 ml of a lubricant containing 1000 mg / L of isoborabone in 2% by weight of sodium alginate and 1% by weight of the antiviral composition added to the lubricant was prepared, and 1 ml of 2.7 × 10 ⁵ Escherichia coli was added to each. In addition, 100 μml was smeared on a potato dextrose agar medium and cultured in a 37 ° C. incubator for 24 hours.

  The results are shown in Table 9.

  As shown in Table 9, it was confirmed that the composition obtained in Example 1 exhibited excellent antiviral properties by adding 1% by weight to the lubricant.

(3) Lubricant 3
A lubricant was prepared by adding 25 parts by weight of propylene glycol to 50 parts by weight of 5% by weight of carboxymethyl cellulose (CMC) and further adding 25 parts by weight of sorbitol to 100 parts by weight as a whole.

100 ml each of 9 ml of this lubricant and 1% by weight of the antiviral composition added to this lubricant, and 1 ml of 2.7 × 10 ⁵ Escherichia coli were added to each, and 100 μml was smeared on potato dextrose agar medium. The cells were cultured for 24 hours in a 37 ° C. incubator.

  The results are shown in Table 10.

  As shown in Table 9, it was confirmed that the composition obtained in Example 1 exhibited excellent antiviral properties by adding 1% by weight to the lubricant.

(4) Lubricant 4
A lubricant was prepared by adding 0.1 parts by weight of fibroin sulfate to 99.8 parts by weight of sodium polyacrylate (0.1% by weight) to make 100 parts by weight as a whole.

100 ml each of 9 ml of this lubricant and 1% by weight of the antiviral composition added to this lubricant, and 1 ml of 2.7 × 10 ⁵ Escherichia coli were added to each, and 100 μml was smeared on potato dextrose agar medium. The cells were cultured for 24 hours in a 37 ° C. incubator.

  The results are shown in Table 11.

  As shown in Table 11, it was confirmed that the composition obtained in Example 1 exhibited excellent antiviral properties when added to a lubricant at 1% by weight.

<Example 9> Component ratio at dilution of antibacterial / antiviral composition An antiviral composition was prepared with the formulation shown in Table 12 below, which is different from Example 1.

  This antibacterial / antiviral composition was confirmed to exhibit antiviral properties, antibacterial properties, and deodorizing properties equivalent to or higher than the composition obtained in Example 1. Moreover, it was confirmed that this antibacterial / antiviral composition exhibits antiviral properties, antibacterial properties, and deodorizing properties even when added to the lubricant in an amount of 0.01% to 0.1%.

  Table 12 shows a guide for effective concentration of each component. Within this concentration range, antiviral properties, antibacterial properties, and deodorizing properties can be reliably exhibited.

  In addition, as a more preferable blending ratio, silver pyrrolidonecarboxylate 100 mg / L to 10 mg / L, zinc pyrrolidonecarboxylate 500 mg / L to 110 mg / L, 500 mg / L to 150 mg / L as copper sulfate, glutamic acid 20 mg / L to 5 mg / L, citric acid 1000 mg / L to 100 mg / L, N-long chain acylamino acid potassium 2000 mg / L to 400 mg / L.

Claims (6)

  An antibacterial / antiviral composition comprising amino acid silver, amino acid zinc and copper ion.   The antibacterial and antiviral composition according to claim 1, wherein the amino acid silver and amino acid zinc are L-pyrrolidone carboxylic acids.   The antibacterial / antiviral composition according to claim 1 or 2, wherein the copper ion is derived from copper pyrrolidonecarboxylate.   The antibacterial / antiviral composition according to claim 1, further comprising sulfuric acid.   The antibacterial / antiviral composition according to any one of claims 1 to 4, further comprising potassium N-long chain acylamino acid.   A lubricant comprising the antibacterial and antiviral composition according to any one of claims 1 to 5.