JP2020019746A - Viscous antibacterial agent - Google Patents

Abstract

To provide antibacterial agents that have low skin irritation and exert high antibacterial effect, not only for a few hours immediately after attaching to a user's hand or finger, but also even after for longer time, for viscous antibacterial agents containing ethanol.SOLUTION: Provided is a viscous antibacterial agent containing a silver carrier, ethanol, and a thickening compound, characterized by having a viscosity at 25°C of 0.05 to 100 Pa s, the viscous antibacterial agent containing 0.01 to 2.0% by weight of the silver carrier, 30 to 75% by weight of the ethanol, and 0.15 to 2.0% by weight of the thickening compound.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a viscous antibacterial agent for killing bacteria, molds, viruses, and the like attached to a user's hand or finger.

  BACKGROUND ART Viscous antibacterial agents containing ethanol as an active ingredient in order to kill bacteria, molds, viruses, and the like attached to the hands and fingers of users have been known.

  For example, Patent Document 1 discloses a disinfectant having a viscosity of 20,000 centipoise, which contains benzalkonium chloride, local ethanol, carboxyvinyl polymer, hydroxypropylmethylcellulose, and the like.

JP-A-6-199700

  However, the disinfectant of Patent Literature 1 has an antibacterial effect of suppressing bacterial growth because ethanol is sufficiently contained immediately after use, but the ethanol gradually evaporates due to the user's body temperature or external temperature. Then, there was a problem that its antibacterial effect gradually decreased. In addition, benzalkonium chloride also has an antibacterial effect. However, although the antibacterial effect lasts longer than ethanol, the effect lasts for only a few hours, so that the antibacterial effect gradually decreases gradually. In addition, there is a concern that if the user repeatedly coats the hands and fingers, the antibacterial component benzalkonium chloride will be concentrated, and it will cause skin rash accompanied by pruritus, vesicles accompanied by redness, and the like.

  Therefore, in the present invention, the viscous antibacterial agent containing ethanol has a skin irritancy not only several hours immediately after being attached to the user's hand or finger, but also after a further time has passed. An object of the present invention is to provide an antibacterial agent having a low and high antibacterial effect.

  [1] That is, a viscous antibacterial agent containing a silver carrier, ethanol, and a thickening compound, wherein the viscosity at 25 ° C. is 0.05 to 100 Pa · s. Agent.

  [2] And, the silver carrier is 0.01 to 2.0% by weight, the ethanol is 30 to 75% by weight, and the thickening compound is 0.15 to 2.0% by weight. The viscous antibacterial agent according to the above [1].

  [3] The viscous antibacterial agent according to [1] or [2], wherein the thickening compound is an acrylic acid compound or a polysaccharide.

  [4] The viscous antibacterial agent according to any one of [1] to [3], wherein the thickening compound is a carboxyvinyl polymer.

  [5] The viscous antibacterial agent according to any of [1] to [4], wherein the silver carrier is calcium phosphate having metallic silver supported on the surface.

  According to the present invention, the viscous antibacterial agent containing ethanol has a high antibacterial property not only immediately after being attached to a user's hand or finger, but also after the time for which the ethanol evaporates. The effect can be achieved. This also has the effect of preventing infectious diseases and food poisoning by suppressing various pathogenic bacteria, such as Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli, which are supposed to be transmitted through fingers.

It is a figure which shows the test result of the persistence of the effect of the composition of Examples 1-3 of this invention. It is a figure which shows the test result of the persistence of the effect of the composition of Examples 4-6 of this invention. It is a figure which shows the test result of the persistence of the effect of the composition of Examples 7-9 of this invention. It is a figure which shows the test result of the persistence of the effect of the composition of the comparative examples 1 and 3 of this invention.

  Hereinafter, embodiments of the viscous antibacterial agent of the present invention will be described in detail. In addition, when there is a notation indicating the range in the description, it includes the upper limit and the lower limit.

  The silver carrier in the present invention is a compound that supports silver atoms such as metallic silver, silver ions, and silver salts, and the eluted silver ions enter the cells of bacteria, molds and viruses and inhibit the function of enzymes. It is an active ingredient that exerts an antibacterial effect by inactivating or inactivating it.

  Examples of the silver salt include silver acetate, silver acetylacetonate, silver azide, silver acetylide, silver arsenate, silver benzoate, silver hydrogen fluoride, silver bromate, silver bromide, silver carbonate, silver chloride, and chloric acid. Silver, silver chromate, silver citrate, silver cyanate, silver cyanide, silver (cis, cis-1,5-cyclooctadiene) -1,1,1,5,5,5-hexafluoroacetylacetonate; Silver diethyldithiocarbamate, silver (I) fluoride, silver (II) fluoride, silver 7,7-dimethyl-1,1,1,2,2,3,3-heptafluoro-4,6-octanedionate , Silver hexafluoroantimonate, silver hexafluoroarsenate, silver hexafluorophosphate, silver iodate, silver iodide, silver isothiocyanate, potassium silver cyanide, silver lactate, silver molybdate, silver nitrate, silver nitrite, silver oxide (I), silver oxide ( I), silver oxalate, silver perchlorate, silver perfluorobutyrate, silver perfluoropropionate, silver permanganate, silver perrhenate, silver phosphate, silver picrate monohydrate, silver propionate, silver selenate , Silver selenide, silver selenite, silver sulfadiazine, silver sulfate, silver sulfide, silver sulfite, silver telluride, silver tetrafluoroborate, silver tetraiodomuccurate, silver tetratungstate, silver thiocyanate, p-toluene Silver sulfonate, silver trifluoromethanesulfonate, silver trifluoroacetate, silver vanadate, etc., silver histidine complex, silver methionine complex, silver cysteine complex, silver aspartate complex, silver pyrrolidonecarboxylate complex, silver oxotetrahydrofurancarboxylate complex And an imidazole silver complex.

  Examples of the carrier supporting silver include zinc calcium phosphate, calcium phosphate, zirconium phosphate, aluminum phosphate, calcium silicate, activated carbon, activated alumina, silica gel, zeolite, hydroxyapatite, zirconium phosphate, titanium phosphate, and titanium. Inorganic compounds such as potassium acid, bismuth hydroxide, zirconium hydroxide and hydrotalcite, and organic compounds such as amino acids capable of forming a chelate complex with silver ions are preferred.

  The mixing ratio of the silver carrier in the viscous antibacterial agent of the present invention is preferably 0.01 to 2.0% by weight, and more preferably 0.05 to 1.5% by weight. When the compounding ratio of the silver carrier is within this range, the silver contained in the silver carrier remains at the body temperature of the user even after the time that the ethanol evaporates after the application to the user's hand or finger. The antibacterial effect can be sustained because it does not volatilize due to heat or outside temperature, and it is used when the silver carrier is uniformly dispersed in the viscous antibacterial agent without aggregation and precipitation. However, a stable antibacterial effect can be achieved. Further, since the silver carrier has little skin irritation, there is almost no risk of irritation or the like even if the user repeatedly applies the viscous antibacterial agent of the present invention to hands or fingers.

  Ethanol in the present invention is an active ingredient that has an antibacterial effect that inhibits the growth of bacteria and kills the bacteria.

  The content of ethanol in the viscous antibacterial agent of the present invention is preferably 30 to 75% by weight, more preferably 55 to 65% by weight. When the content ratio of ethanol is in this range, it has an antibacterial effect such as suppression of growth and death of bacteria and the like, and can uniformly disperse the thickening compound.

  The thickening compound in the present invention is a compound for improving the viscosity of the antibacterial agent. Specifically, it is preferable to use an acrylic acid compound or a polysaccharide. As the acrylic acid compound, a carboxyvinyl polymer, sodium polyacrylate and the like are preferable. Polysaccharides include hydroxyethyl cellulose which is a cellulose derivative having a hydroxyethyl group introduced, hydroxypropyl cellulose which is a cellulose derivative having a hydroxypropyl group introduced, and cellulose having a methyl group introduced among hydroxypropyl and lower alkyl groups. Hydroxypropyl methylcellulose which is a derivative, hydrophobized hydroxypropylmethylcellulose obtained by reacting glycidyl ether having a hydrophobic alkyl group such as stearyl glycidyl ether with hydroxypropylmethylcellulose, cellulose in which hydroxyethyl group and hydroxypropyl group are introduced. Certain hydroxyethyl hydroxypropyl cellulose, carboxymethyl cellulose which is a salt of cellulose having a carboxymethyl group introduced Scan sodium, xanthan gum, and sodium alginate are preferable. In the hydrophobized hydroxypropylmethylcellulose, not only a stearyl group but also a medium-chain or long-chain alkyl group having 6 to 22 carbon atoms can be used. One or more hydroxyethyl groups and hydroxypropyl groups can be added to one hydroxyl group in cellulose, and preferably 1 to 10 are added. In particular, the use of a carboxyvinyl polymer is preferable in that not only can the silver carrier be uniformly dispersed, but also the antibacterial agent can be prevented from discoloring black when stored for a long period of time.

  The content ratio of the thickening compound in the viscous antibacterial agent of the present invention is preferably 0.15 to 2.0% by weight, more preferably 0.2 to 1.5% by weight. When the content of the thickening compound is within this range, the silver carrier can be uniformly dispersed in the antibacterial agent, and the antibacterial agent does not immediately flow off even if the user attaches it to the hand or finger. In addition, it has the effect of making it easy to spread when spreading, and not giving any stickiness.

  Although the viscosity of the antibacterial agent is improved by compounding the thickening compound, the viscosity of the antibacterial agent in the state of mixing and stirring various components to form a uniform white solution is determined by Brookfield described in JIS K7117-1. In a measurement using a rotary viscometer type B (manufactured by Toki Sangyo Co., Ltd., trade name “TVB-10M”), the pressure is preferably 0.05 to 100 Pa · s at 25 ° C., and 50 to 5000 mPa · s. Is more preferable, and most preferably 100 to 3000 mPa · s. When the viscosity is in this range, even if the antibacterial liquid adheres to the skin such as hands, the antibacterial liquid does not run off immediately and is easy to spread when spread.

  In the viscous antibacterial agent of the present invention, water can be blended. The water to be blended is preferably water of the Japanese Pharmacopoeia standard, for example, tap water, ordinary water such as well water, and any of distillation, ion exchange treatment with an ion exchange membrane, and ultrafiltration treatment with an ultrafiltration membrane Alternatively, purified water obtained by treating ordinary water with a combination thereof, and sterilized purified water obtained by sterilizing purified water by heating or the like are preferable. The water content is preferably 20 to 50% by weight.

  The pH of the viscous antibacterial agent of the present invention is preferably 2 to 7 at 25 ° C, more preferably 3 to 6. When the pH of the viscous antibacterial agent of the present invention is within the above range, the viscous antibacterial agent exhibits an antibacterial effect not only on the active ingredients of ethanol and the silver carrier, but also on many bacteria that are not resistant to the acidic region even by liquidity. Can be. When an acrylic acid compound such as a carboxyvinyl polymer or sodium polyacrylate is used as the thickening compound, the molecular chain can be expanded and the viscosity can be increased. In order to adjust the pH of the viscous antibacterial agent of the present invention, a pH adjuster such as citric acid, gluconic acid, succinic acid, potassium carbonate, sodium hydrogencarbonate, and triethanolamine can be added.

  In the viscous antibacterial agent of the present invention, in addition to the above-mentioned components, if necessary, glycerin, propylene glycol, butylene glycol, humectants such as polyhydric alcohols such as sorbit, foaming agents such as carbonates, nonionic A surfactant such as anionic, anionic, or cationic, an antioxidant such as BHT, a buffer, a fragrance, a dye, and the like can also be blended.

  Hereinafter, embodiments of the present invention will be specifically described. The present invention is not limited to the following embodiments. Further, expressions indicating numerical ranges include upper and lower limits.

<Example 1>
To a Griffin beaker having a capacity of 200 ml, 60.7 g of ethanol, 0.1 g of calcium phosphate supporting metallic silver as a silver carrier, 0.6 g of a carboxyvinyl polymer as a thickening compound, and 38.6 g of purified water were added, and a pH adjuster was added. , A small amount of triethanolamine was added dropwise, and the mixture was stirred until a uniform white solution was obtained, thereby obtaining a total of 100 g of an antibacterial agent.

<Example 2>
Example 1 was repeated except that 60.4 g of ethanol, 0.1 g of calcium phosphate supporting metal silver as a silver carrier, 1.1 g of hydroxyethyl cellulose as a thickening compound, 38.4 g of purified water, and an appropriate amount of a pH adjuster were added. A total of 100 g of the antibacterial agent was obtained in the same manner as in the above.

<Example 3>
Example 1 except that 60.7 g of ethanol, 0.1 g of calcium phosphate carrying metal silver as a silver carrier, 0.6 g of hydroxypropyl cellulose as a thickening compound, 38.6 g of purified water, and an appropriate amount of a pH adjuster were added. As in Example 1, a total of 100 g of the antibacterial agent was obtained.

<Example 4>
Example 1 except that 60.7 g of ethanol, 0.1 g of calcium phosphate supporting metal silver as a silver carrier, 0.6 g of hydroxypropylmethylcellulose as a thickening compound, 38.6 g of purified water, and an appropriate amount of a pH adjuster were added. As in Example 1, a total of 100 g of the antibacterial agent was obtained.

<Example 5>
Except for adding 60.7 g of ethanol, 0.1 g of calcium phosphate carrying metal silver as a silver carrier, 0.6 g of hydrophobized hydroxypropylmethylcellulose as a thickening compound, 38.6 g of purified water, and an appropriate amount of a pH adjuster, As in Example 1, a total of 100 g of the antibacterial agent was obtained.

<Example 6>
Except that 60.7 g of ethanol, 0.1 g of calcium phosphate supporting metal silver as a silver carrier, 0.6 g of sodium polyacrylate as a thickening compound, 38.6 g of purified water, and an appropriate amount of a pH adjuster were added. As in Example 1, a total of 100 g of the antibacterial agent was obtained.

<Example 7>
Example 1 except that 60.9 g of ethanol, 0.1 g of calcium phosphate supporting metal silver as a silver carrier, 0.2 g of sodium alginate as a thickening compound, 38.8 g of purified water, and an appropriate amount of a pH adjuster were added. A total of 100 g of the antibacterial agent was obtained in the same manner as in the above.

<Example 8>
Example 1 except that 60.9 g of ethanol, 0.1 g of calcium phosphate supporting metal silver as a silver carrier, 0.2 g of sodium carboxymethylcellulose as a thickening compound, 38.8 g of purified water, and an appropriate amount of a pH adjuster were added. As in Example 1, a total of 100 g of the antibacterial agent was obtained.

<Example 9>
Example 1 was the same as Example 1 except that 60.9 g of ethanol, 0.1 g of calcium phosphate supporting metal silver as a silver carrier, 0.2 g of xanthan gum as a thickening compound, 38.8 g of purified water, and an appropriate amount of a pH adjuster were added. Similarly, a total of 100 g of the antibacterial agent was obtained.

<Comparative Example 1>
A total of 100 g of an antibacterial agent was obtained in the same manner as in Example 1, except that 60.8 g of ethanol, 0.6 g of carboxyvinyl polymer as a thickening compound, 38.7 g of purified water, and an appropriate amount of a pH adjuster were added.

<Comparative Example 2>
A total of 100 g of an antibacterial agent was obtained in the same manner as in Example 1, except that 61.0 g of ethanol, 0.1 g of calcium phosphate carrying metal silver as a silver carrier, 38.8 g of purified water, and an appropriate amount of a pH adjuster were added. .

<Comparative Example 3>
Same as Example 1 except that 60.7 g of ethanol, 0.1 g of benzalkonium chloride, 0.6 g of carboxyvinyl polymer as a thickening compound, 38.6 g of purified water, and an appropriate amount of a pH adjuster were added. A total of 100 g of the antibacterial agent was obtained.

  The evaluation method of the above antibacterial agent was confirmed by the following method.

〔appearance〕
About the appearance, the compounded antibacterial agent was allowed to stand for 24 hours and visually checked. Those with no dark discoloration or sediment were evaluated as ○, when discoloration or sediment was slightly generated, evaluated as Δ, and when discoloration or sediment was largely generated, evaluated as x. Among these, ○ and Δ were judged as good, and × was judged as bad.

[PH]
With respect to pH, a pH 7 (neutral phosphate) standard solution (pH 6.86 at 25 ° C.) was set to zero, and a pH 4 (phthalate) standard solution (pH 4.01 at 25 ° C.) or pH 9 (borate) was used. ) Using a pH measuring device (F-52, manufactured by Horiba, Ltd.) calibrated with a standard solution (pH 9.18 at 25 ° C.), the value was measured as a value corrected to 25 ° C.

〔viscosity〕
The above-mentioned antibacterial agent was put in a container and allowed to stand in a constant temperature bath at 25 ° C., and after the above-mentioned antibacterial agent reached 25 ° C., a Brookfield-type rotational viscometer B type described in JIS K7117-1 (Toki Machine Co., Ltd.) The measurement was performed by attaching a rotor (No. 20) to a trade name “TVB-10M” manufactured by Sangyo Co., Ltd.).

(Usability)
The feeling of use was evaluated based on the organoleptic effect when the compounded antibacterial agent was dropped on the palm and spread. Those that are hard to spill from the palm and do not produce sticky peels or sticky are evaluated as ○, and those that spill slightly from the palm and feel swelling or sticky are evaluated as △, and spilled from the palm Those which were easy and clearly felt stickiness and stickiness were evaluated as x. Among these, ○ and Δ were judged as good, and × was judged as bad. The results are shown in Table 1.

(Persistence of efficacy)
After hand washing with running water, the palm was pressed against a hand-stamp medium (SCD medium) to collect the bacteria before disinfection. Next, about 2 g of the compounded antibacterial agent was rubbed in the hand and dried, and then the palm was pressed against a hand stamp medium to collect the bacteria immediately after application. Then, after 3 hours and 6 hours after the sterilized gloves were attached, the gloves were removed and the palm was pressed against the hand-stamp medium to collect the bacteria. The hand-stamped medium was cultured in a thermostat at about 35 ° C. for about 24 hours or more, and the viable cell count (cfu: colony forming unit) was measured. After 3 hours and 6 hours, the number of bacteria was lower than before the disinfection and the antibacterial effect was maintained, and the sample was evaluated as ○. After 3 hours and 6 hours, the number of bacteria increased compared to before the disinfection and the antibacterial effect was maintained. It was evaluated as x which could not be made. Among these, ○ was judged as good and X was judged as bad. These results are shown in FIGS.

  Table 1 shows the compositions and test results of Examples 1 to 9 and Comparative Examples 1 to 3.

  As shown in Table 1, in the antibacterial agents of Examples 1 to 9, even when a silver carrier was added, the solution became a uniform white liquid without precipitation or discoloration, and hardly spilled from the palm when spread on fingers. A good feeling of use without sticking or sticking as a paste-like peeled product was obtained, and the antibacterial effect could be maintained even after a lapse of a predetermined time. Further, even after the elapse of the predetermined time, no irritation was felt in the spread area.

Claims (5)

A silver carrier;
Ethanol and
A viscous antibacterial agent containing a thickening compound,
A viscous antibacterial agent having a viscosity at 25 ° C. of 0.05 to 100 Pa · s. 0.01 to 2.0% by weight of the silver carrier;
30 to 75% by weight of the ethanol,
The viscous antibacterial agent according to claim 1, wherein the thickening compound is contained in an amount of 0.15 to 2.0% by weight. The viscous antibacterial agent according to claim 1 or 2, wherein the thickening compound is an acrylic acid compound or a polysaccharide. The viscous antibacterial agent according to any one of claims 1 to 3, wherein the thickening compound is a carboxyvinyl polymer. The viscous antibacterial agent according to any one of claims 1 to 4, wherein the silver carrier is calcium phosphate having metallic silver supported on the surface.

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