JP2017121233A5 - - Google Patents
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- Publication number
- JP2017121233A5 JP2017121233A5 JP2016232580A JP2016232580A JP2017121233A5 JP 2017121233 A5 JP2017121233 A5 JP 2017121233A5 JP 2016232580 A JP2016232580 A JP 2016232580A JP 2016232580 A JP2016232580 A JP 2016232580A JP 2017121233 A5 JP2017121233 A5 JP 2017121233A5
- Authority
- JP
- Japan
- Prior art keywords
- tumor
- hsp90 inhibitor
- patient
- hsp90
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000003481 heat shock protein 90 inhibitor Substances 0.000 claims 65
- 206010028980 Neoplasm Diseases 0.000 claims 61
- 238000000034 method Methods 0.000 claims 28
- 238000002560 therapeutic procedure Methods 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 19
- 101710113864 Heat shock protein 90 Proteins 0.000 claims 17
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 15
- 201000011510 cancer Diseases 0.000 claims 12
- 210000004881 tumor cell Anatomy 0.000 claims 10
- 230000002601 intratumoral effect Effects 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 5
- SUPVGFZUWFMATN-UHFFFAOYSA-N zelavespib Chemical compound N1=CN=C2N(CCCNC(C)C)C(SC=3C(=CC=4OCOC=4C=3)I)=NC2=C1N SUPVGFZUWFMATN-UHFFFAOYSA-N 0.000 claims 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 4
- 210000004958 brain cell Anatomy 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- 230000003442 weekly effect Effects 0.000 claims 3
- 238000001574 biopsy Methods 0.000 claims 2
- 230000000977 initiatory effect Effects 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 239000012188 paraffin wax Substances 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- UYODNJZBUUEXPC-UHFFFAOYSA-N 9-[2-(2,2-dimethylpropylamino)ethyl]-8-[(6-iodo-1,3-benzodioxol-5-yl)sulfanyl]purin-6-amine Chemical compound N1=CN=C2N(CCNCC(C)(C)C)C(SC=3C(=CC=4OCOC=4C=3)I)=NC2=C1N UYODNJZBUUEXPC-UHFFFAOYSA-N 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 206010061424 Anal cancer Diseases 0.000 claims 1
- 208000007860 Anus Neoplasms Diseases 0.000 claims 1
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 101710163595 Chaperone protein DnaK Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 101710178376 Heat shock 70 kDa protein Proteins 0.000 claims 1
- 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 claims 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 102000001712 STAT5 Transcription Factor Human genes 0.000 claims 1
- 108010029477 STAT5 Transcription Factor Proteins 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000011165 anus cancer Diseases 0.000 claims 1
- 102000055104 bcl-X Human genes 0.000 claims 1
- 108700000711 bcl-X Proteins 0.000 claims 1
- 230000000711 cancerogenic effect Effects 0.000 claims 1
- 231100000315 carcinogenic Toxicity 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 201000003444 follicular lymphoma Diseases 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 230000004043 responsiveness Effects 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 208000002320 spinal muscular atrophy Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 0 CC(C)(Cc1c2c(*)n[n]1C(/C=C/C(/C(NC)O)=C(\C)/NC(CC1)CCC1[N+]C(Nc1ccc(C(c(c(Oc3c4)c5)ccc5O)(c3ccc4O)O*3=O)c3c1)=S)=C)CC2=O Chemical compound CC(C)(Cc1c2c(*)n[n]1C(/C=C/C(/C(NC)O)=C(\C)/NC(CC1)CCC1[N+]C(Nc1ccc(C(c(c(Oc3c4)c5)ccc5O)(c3ccc4O)O*3=O)c3c1)=S)=C)CC2=O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161506010P | 2011-07-08 | 2011-07-08 | |
| US61/506,010 | 2011-07-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520226A Division JP6054389B2 (ja) | 2011-07-08 | 2012-07-06 | 標識されたｈｓｐ９０阻害剤の使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019125455A Division JP2019194232A (ja) | 2011-07-08 | 2019-07-04 | 標識されたｈｓｐ９０阻害剤の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017121233A JP2017121233A (ja) | 2017-07-13 |
| JP2017121233A5 true JP2017121233A5 (cg-RX-API-DMAC7.html) | 2017-10-12 |
| JP6662759B2 JP6662759B2 (ja) | 2020-03-11 |
Family
ID=47506428
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520226A Expired - Fee Related JP6054389B2 (ja) | 2011-07-08 | 2012-07-06 | 標識されたｈｓｐ９０阻害剤の使用 |
| JP2014520227A Expired - Fee Related JP6218147B2 (ja) | 2011-07-08 | 2012-07-06 | 標識されたｈｓｐ９０阻害剤の使用 |
| JP2016232580A Expired - Fee Related JP6662759B2 (ja) | 2011-07-08 | 2016-11-30 | 標識されたｈｓｐ９０阻害剤の使用 |
| JP2019125455A Pending JP2019194232A (ja) | 2011-07-08 | 2019-07-04 | 標識されたｈｓｐ９０阻害剤の使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520226A Expired - Fee Related JP6054389B2 (ja) | 2011-07-08 | 2012-07-06 | 標識されたｈｓｐ９０阻害剤の使用 |
| JP2014520227A Expired - Fee Related JP6218147B2 (ja) | 2011-07-08 | 2012-07-06 | 標識されたｈｓｐ９０阻害剤の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019125455A Pending JP2019194232A (ja) | 2011-07-08 | 2019-07-04 | 標識されたｈｓｐ９０阻害剤の使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9555137B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2729806B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP6054389B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR102025142B1 (cg-RX-API-DMAC7.html) |
| CN (3) | CN104081206B (cg-RX-API-DMAC7.html) |
| AU (3) | AU2012282905B8 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112014000445A2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2841069C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2729806T3 (cg-RX-API-DMAC7.html) |
| EA (1) | EA201490230A1 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2766623T3 (cg-RX-API-DMAC7.html) |
| MX (2) | MX2014000292A (cg-RX-API-DMAC7.html) |
| WO (2) | WO2013009655A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9403828B2 (en) | 2005-02-01 | 2016-08-02 | Sloan-Kettering Institute For Cancer Research | Small-molecule Hsp90 inhibitors |
| WO2006084030A2 (en) | 2005-02-01 | 2006-08-10 | Sloan-Kettering Institute For Cancer Research | Small-molecule hsp90 inhibitors |
| EP2729806B1 (en) * | 2011-07-08 | 2017-02-22 | Sloan-kettering Institute For Cancer Research | Uses of labeled hsp90 inhibitors |
| HUE040323T2 (hu) | 2012-12-21 | 2019-02-28 | Epizyme Inc | PRMT5-inhibitorok és alkalmazásaik |
| WO2014144715A1 (en) | 2013-03-15 | 2014-09-18 | Memorial Sloan-Kettering Cancer Center | Hsp90-targeted cardiac imaging and therapy |
| CN103279964B (zh) * | 2013-04-23 | 2015-10-28 | 浙江大学 | 一种基于prca的pet图像动态重建方法及系统 |
| EA201690406A1 (ru) * | 2013-08-16 | 2016-08-31 | Мемориал Слоун-Кеттеринг Кэнсэ Сентр | Селективные ингибиторы grp94 и способы их применения |
| EP3035938B1 (en) | 2013-09-10 | 2020-08-19 | Madrigal Pharmaceuticals, Inc. | Targeted therapeutics |
| JP6497767B2 (ja) * | 2013-12-16 | 2019-04-10 | 日本化薬株式会社 | 癌治療におけるｈｓｐ９０阻害剤の抗腫瘍効果を予測する方法 |
| KR102325454B1 (ko) * | 2013-12-23 | 2021-11-16 | 메모리얼 슬로안 케터링 캔서 센터 | 방사성표지화를 위한 방법 및 시약 |
| EP2942629A1 (en) * | 2014-05-08 | 2015-11-11 | Universität Würzburg | Predictive markers for successful cancer immunotherapy |
| KR20170052687A (ko) | 2014-09-17 | 2017-05-12 | 메모리얼 슬로안-케터링 캔서 센터 | Ｈｓｐ90-표적화된 염증 및 감염 영상화 및 치료 |
| WO2017062520A1 (en) | 2015-10-05 | 2017-04-13 | Memorial Sloan Kettering Cancer Center | Rational combination therapy for the treatment of cancer |
| ES2788856T3 (es) | 2017-03-20 | 2020-10-23 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de quinasa de piruvato (PKR) |
| US11680283B2 (en) | 2017-09-22 | 2023-06-20 | University Of Washington | In situ combinatorial labeling of cellular molecules |
| ES2989438T3 (es) | 2018-09-19 | 2024-11-26 | Novo Nordisk Healthcare Ag | Activación de la piruvato cinasa R |
| WO2020061378A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| CA3115315A1 (en) | 2018-10-15 | 2020-04-23 | Anthony A. HYMAN | Compounds for treatment of diseases and methods of screening therefor |
| SG11202106690QA (en) | 2019-02-08 | 2021-07-29 | Dewpoint Therapeutics Inc | Methods of characterizing condensate-associated characteristics of compounds and uses thereof |
| EP3969122A4 (en) * | 2019-05-15 | 2024-01-17 | Whitehead Institute For Biomedical Research | METHODS OF CHARACTERIZATION AND METHODS OF USING AGENT-CONDENSATE INTERACTIONS |
| WO2021055644A1 (en) | 2019-09-18 | 2021-03-25 | Dewpoint Therapeutics, Inc. | Methods of screening for condensate-associated specificity and uses thereof |
| MA57202B1 (fr) | 2019-09-19 | 2025-09-30 | Novo Nordisk Health Care Ag | Compositions d'activation de la pyruvate kinase r (pkr) |
| JP7589935B2 (ja) * | 2019-10-31 | 2024-11-26 | キヤノンメディカルシステムズ株式会社 | 解析装置および解析プログラム |
| US20230357760A1 (en) * | 2020-10-02 | 2023-11-09 | The Trustees Of Dartmouth College | Method and agent for treating/preventing neurodegenerative disease and associated neuroinflammation and for evaluating putative prophylactics/therapeutics for treating/preventing neurodegenerative disease and neuroinflammation |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| CN113025715A (zh) * | 2021-03-23 | 2021-06-25 | 中山大学附属第一医院 | Hop在预测胃癌预后中的应用 |
| AU2024265078A1 (en) | 2023-05-04 | 2025-12-11 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| CN116813622A (zh) * | 2023-05-19 | 2023-09-29 | 中国科学院基础医学与肿瘤研究所(筹) | 一种基于分子伴侣hsp90介导的靶向降解gpx4的嵌合体及其制备方法和应用 |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
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| US7156111B2 (en) * | 2001-07-16 | 2007-01-02 | Akrion Technologies, Inc | Megasonic cleaning using supersaturated cleaning solution |
| EP1519735A4 (en) * | 2001-12-12 | 2006-01-11 | Conforma Therapeutic Corp | ASSAYS AND DEVICES FOR DETERMINING AND MODULATING HSP90 BINDING ACTIVITY |
| US20040121971A1 (en) * | 2002-12-20 | 2004-06-24 | Gang Chen | Therapeutic use of tumor necrosis factor-alpha mutein |
| US7959915B2 (en) * | 2003-03-12 | 2011-06-14 | Tufts University | Inhibitors of extracellular Hsp90 |
| EP1457499A1 (en) | 2003-03-12 | 2004-09-15 | Tufts University School Of Medicine | Inhibitors of extracellular Hsp90 |
| WO2005012482A2 (en) * | 2003-06-30 | 2005-02-10 | Sloan-Kettering Institute For Cancer Research | Assay for identification of bioactive compounds that interact with heat shock protein 90 |
| WO2005021552A1 (en) | 2003-08-29 | 2005-03-10 | Vernalis (Cambridge) Ltd | Pyrimidothiophene compounds |
| GB0323810D0 (en) | 2003-10-10 | 2003-11-12 | Cancer Rec Tech Ltd | Pyridothiophene compounds |
| AU2004286307A1 (en) * | 2003-10-31 | 2005-05-12 | Vitatex, Inc. | Blood test prototypes and methods for the detection of circulating tumor and endothelial cells |
| US9403828B2 (en) | 2005-02-01 | 2016-08-02 | Sloan-Kettering Institute For Cancer Research | Small-molecule Hsp90 inhibitors |
| WO2006084030A2 (en) * | 2005-02-01 | 2006-08-10 | Sloan-Kettering Institute For Cancer Research | Small-molecule hsp90 inhibitors |
| KR20080073711A (ko) * | 2005-10-21 | 2008-08-11 | 바이엘 헬스케어 엘엘씨 | 암의 예측 및 예후 방법, 및 암 치료 모니터링 방법 |
| DE102006023336A1 (de) | 2006-05-18 | 2007-11-22 | Merck Patent Gmbh | 1,5-Diphenyl-pyrazole II |
| US8318790B2 (en) * | 2006-05-25 | 2012-11-27 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate HSP90 activity |
| ES2645095T3 (es) | 2006-06-30 | 2017-12-04 | Sloan-Kettering Institute For Cancer Research | Tratamiento de enfermedades neurodegenerativas a través de la inhibición de Hsp90 |
| WO2008070472A2 (en) | 2006-11-27 | 2008-06-12 | University Of Maryland, Baltimore | Use of plasma hsp90 related to malignancy |
| CN101622349A (zh) * | 2006-12-08 | 2010-01-06 | 奥斯瑞根公司 | 作为治疗性干预靶标的miR-21调节的基因和途径 |
| CA2683822A1 (en) * | 2007-04-13 | 2008-10-23 | Pharmacyclics, Inc. | Calcium flux as a pharmacoefficacy biomarker for inhibitors of histone deacetylase |
| US8466140B2 (en) * | 2007-09-10 | 2013-06-18 | University Of Massachusetts | Mitochondria-targeted anti-tumor agents |
| EP2211913A4 (en) * | 2007-10-12 | 2010-12-22 | Transmolecular Inc | SYSTEMIC ADMINISTRATION OF CHLOROTOXIN AGENTS FOR THE DIAGNOSIS AND TREATMENT OF TUMORS |
| EP2224804A4 (en) * | 2007-12-07 | 2011-06-01 | Bipar Sciences Inc | TREATMENT OF CANCER WITH COMBINATIONS OF TOPOÎSOMERASE INHIBITORS AND PARP INHIBITORS |
| JP2011522515A (ja) * | 2008-04-10 | 2011-08-04 | マサチューセッツ インスティテュート オブ テクノロジー | 癌幹細胞を標的とする薬剤を同定する方法およびその使用 |
| CN102216775B (zh) * | 2008-08-18 | 2014-04-16 | 马克斯·普朗克科学促进协会 | 对hsp90-抑制剂的易感性 |
| CN108752280A (zh) * | 2009-08-17 | 2018-11-06 | 纪念斯隆-凯特琳癌症中心 | 热休克蛋白结合化合物、组合物以及其制备和使用方法 |
| WO2011044394A1 (en) * | 2009-10-07 | 2011-04-14 | Sloan-Kettering Institute For Cancer Research | Purine derivatives useful as hsp90 inhibitors |
| JP2013510585A (ja) | 2009-11-13 | 2013-03-28 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | 癌の同定、評価、予防および治療のための組成物、キットおよび方法 |
| US8710035B2 (en) | 2010-03-24 | 2014-04-29 | The University Of Chicago | Methods and compositions related to glucocorticoid receptor antagonists and breast cancer |
| CA2832530C (en) | 2011-04-05 | 2021-02-16 | Sloan-Kettering Institute For Cancer Research | Hsp90 inhibitors |
| US9546170B2 (en) | 2011-04-05 | 2017-01-17 | Sloan-Kettering Institute For Cancer Research | Hsp90 inhibitors |
| NZ618062A (en) | 2011-04-28 | 2016-04-29 | Sloan Kettering Inst Cancer | Hsp90 combination therapy |
| EP2729806B1 (en) * | 2011-07-08 | 2017-02-22 | Sloan-kettering Institute For Cancer Research | Uses of labeled hsp90 inhibitors |
| WO2014144715A1 (en) | 2013-03-15 | 2014-09-18 | Memorial Sloan-Kettering Cancer Center | Hsp90-targeted cardiac imaging and therapy |
| US10071130B2 (en) | 2013-12-12 | 2018-09-11 | The University Of Chicago | Methods and compositions related to Hsp90 inhibitors and breast cancer |
| KR20170052687A (ko) | 2014-09-17 | 2017-05-12 | 메모리얼 슬로안-케터링 캔서 센터 | Ｈｓｐ90-표적화된 염증 및 감염 영상화 및 치료 |
-
2012
- 2012-07-06 EP EP12811358.6A patent/EP2729806B1/en active Active
- 2012-07-06 WO PCT/US2012/045861 patent/WO2013009655A2/en not_active Ceased
- 2012-07-06 AU AU2012282905A patent/AU2012282905B8/en not_active Ceased
- 2012-07-06 CN CN201280040606.7A patent/CN104081206B/zh not_active Expired - Fee Related
- 2012-07-06 JP JP2014520226A patent/JP6054389B2/ja not_active Expired - Fee Related
- 2012-07-06 EP EP17156149.1A patent/EP3208615B1/en active Active
- 2012-07-06 US US14/131,423 patent/US9555137B2/en active Active
- 2012-07-06 BR BR112014000445A patent/BR112014000445A2/pt not_active Application Discontinuation
- 2012-07-06 JP JP2014520227A patent/JP6218147B2/ja not_active Expired - Fee Related
- 2012-07-06 WO PCT/US2012/045864 patent/WO2013009657A1/en not_active Ceased
- 2012-07-06 MX MX2014000292A patent/MX2014000292A/es unknown
- 2012-07-06 CN CN201280040632.XA patent/CN104081203B/zh not_active Expired - Fee Related
- 2012-07-06 KR KR1020147003357A patent/KR102025142B1/ko not_active Expired - Fee Related
- 2012-07-06 DK DK12811358.6T patent/DK2729806T3/en active
- 2012-07-06 US US14/131,420 patent/US20140294725A1/en not_active Abandoned
- 2012-07-06 CN CN201810715481.2A patent/CN109374889B/zh not_active Expired - Fee Related
- 2012-07-06 MX MX2014000286A patent/MX347607B/es active IP Right Grant
- 2012-07-06 CA CA2841069A patent/CA2841069C/en not_active Expired - Fee Related
- 2012-07-06 EA EA201490230A patent/EA201490230A1/ru unknown
- 2012-07-06 CA CA2841173A patent/CA2841173C/en not_active Expired - Fee Related
- 2012-07-06 AU AU2012282903A patent/AU2012282903A1/en not_active Abandoned
- 2012-07-06 EP EP19202091.5A patent/EP3709022A1/en not_active Withdrawn
- 2012-07-06 KR KR1020177009318A patent/KR102138218B1/ko not_active Expired - Fee Related
- 2012-07-06 ES ES17156149T patent/ES2766623T3/es active Active
- 2012-07-06 ES ES12811358.6T patent/ES2624982T3/es active Active
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2016
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2017
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2019
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2020
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2023
- 2023-01-31 US US18/104,037 patent/US20240058482A1/en active Pending
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