JP2017114818A - Polymer gel formulation for oral use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a polymer gel formulation for oral use which exerts a high stain removing effect in the oral cavity, removing staining even in the gaps between teeth, only by chewing.SOLUTION: This polymer gel formulation for oral use comprises (A) a partially neutralized polyacrylic acid blended with (B) an aluminum compound. Further, the polymer gel formulation for oral use is blended with (C) 10 to 90 mass% of water and/or (D) 10 to 80 mass% of polyhydric alcohol.SELECTED DRAWING: None

Description

  The present invention relates to a polymer gel preparation for oral cavity that exhibits a high dirt removing effect that removes dirt between teeth by simply chewing in the oral cavity.

  In order to prevent dental caries and obtain an aesthetic appearance of the teeth, it is important to remove dirt adhered to the tooth surface such as plaque. In order to remove dirt on the tooth surface, brushing using a dentifrice and mouthwash using a mouthwash are generally performed. However, even with cleaning with a dentifrice, which has a relatively high cleaning effect compared to a mouthwash, there is a problem that sufficient cleaning and removal effects cannot be obtained for dirt that is present in the gap between teeth where the brush is difficult to reach. was there.

In order to overcome this problem, Patent Document 1 (Japanese Patent Application Laid-Open No. 2015-124164) proposes an oral composition containing a granule, but depending on how individuals are polished, it is possible to remove dirt sufficiently. It could be difficult and there was room for further improvement.
Patent Document 2 (Japanese Patent Laid-Open No. 2012-193150) proposes a jelly-like oral composition that is simple and excellent in usability, and has a high cleaning feeling between teeth and tooth surfaces. With regard to, since the dirt is removed when the jelly-like composition for oral cavity passes between the teeth, there is still room for improvement in the dirt removing effect between the teeth.
On the other hand, Patent Document 3 (Japanese Patent Application Laid-Open No. 2012-80898) proposes a stain-removable chewing gum composition containing an anionic surfactant and a nonionic surfactant. The soil removal effect was not sufficient.

Japanese Patent Laying-Open No. 2015-124164 JP2012-193150A JP 2012-80898 A JP 2010-195663 A JP 2014-156497 A

  Therefore, in the preparation for oral cavity, the improvement of the effect of removing dirt between teeth is a technical problem.

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a polymer gel preparation for oral cavity that has a high dirt removing effect that removes dirt between teeth only by chewing in the oral cavity. .

  As a result of intensive studies to achieve the above object, the present inventor has obtained a polyacrylic acid polymer gel preparation containing a partially neutralized polyacrylic acid and an aluminum compound as an oral preparation, with appropriate elasticity. It has been found that it has adhesiveness, and by chewing it, it is excellent in the effect of removing dirt between the teeth and between the teeth, and also in the feeling of use. That is, in the present invention, the oral polymer gel preparation containing (A) a partially neutralized polyacrylic acid and (B) an aluminum compound removes stains between teeth just by chewing in the oral cavity. It has been found that a high dirt removing effect is imparted and a good feeling of use is imparted, and the present invention has been made.

  In the present invention, by blending the components (A) and (B), the polyacrylic acid polymer gel having a stitch structure is formed by chemically crosslinking the component (A) with the aluminum ion of the component (B). A gel, preferably a hydrogel containing a polymer gel and water, as a base for a chewable solid oral preparation, not only contacts and press-contacts the tooth surface by chewing in the oral cavity, but also moderately deforms by chewing Quickly enters the gap between the teeth, and the dirt on the surface and sides of the teeth is peeled off from the teeth by adhering to the gel. Appropriate resilience and stickiness to retreat, thereby providing the excellent soil removal effect. In addition, it is possible to give a feeling of effect that can be felt that the dirt has been removed, and a good feeling of use that is comfortable to bite.

  As shown in Patent Documents 4 and 5 (JP 2010-195663 A, JP 2014-156497 A), it is known that polyacrylic acid polymer gel is used for an external skin patch. Because of its poor fluidity, it has hardly been applied to preparations for use in the oral cavity. In the present invention, by using such a polyacrylic acid polymer gel as a base for a solid oral preparation, it is possible to unexpectedly provide an excellent dirt removing effect that also removes dirt between teeth. It was made.

Accordingly, the present invention provides the following oral polymer gel formulation.
[Claim 1]
(A) A polymer gel preparation for oral cavity comprising a partially neutralized polyacrylic acid and (B) an aluminum compound.
[Claim 2]
The polymer gel preparation for oral cavity according to claim 1, wherein (A) the partially neutralized polyacrylic acid is based on (B) an adhesive polyacrylic acid polymer gel crosslinked with an aluminum compound.
[Claim 3]
The partially neutralized polyacrylic acid component (A) is an acrylic acid / sodium acrylate copolymer having a molar ratio of acrylic acid / sodium acrylate of 20/80 to 70/30. Or the polymer gel formulation for oral cavity of 2.
[Claim 4]
4. The oral polymer gel preparation according to any one of claims 1 to 3, wherein the aluminum compound as component (B) is one or more aluminum ion releasing compounds selected from aluminum lactate, aluminum potassium sulfate and aluminum hydroxide.
[Claim 5]
The polymer gel preparation for oral cavity according to any one of claims 1 to 4, wherein the component (A) is 1 to 15% by mass and the component (B) is 0.009 to 0.1% by mass in terms of aluminum ion.
[Claim 6]
Furthermore, the polymer gel formulation for oral cavity of any one of Claims 1-4 which mix | blended (C) 10-90 mass% of water.
[Claim 7]
Furthermore, the polymer gel formulation for oral cavity of any one of Claims 1-6 which mix | blended 10-80 mass% of (D) polyhydric alcohol.
[Claim 8]
Furthermore, the polymer gel formulation for oral cavity of any one of Claims 2-7 by which the non-adhesive coating was given to the formulation surface.

  According to the present invention, it is possible to provide a polymer gel preparation for oral cavity that exhibits a high dirt removing effect that removes dirt in the gap between teeth just by chewing in the oral cavity and gives a good feeling of use. According to the preparation of the present invention, it is possible to clean teeth easily and effectively.

Hereinafter, the present invention will be described in further detail. The oral polymer gel preparation of the present invention comprises (A) a partially neutralized polyacrylic acid and (B) an aluminum compound. In this case, the polyacrylic acid partial neutralized product of component (A) is a chewable solid polyacrylic acid polymer gel that is crosslinked and adhesive and elastic by the aluminum compound of (B) aluminum compound as a crosslinking agent. Form. In the present invention, such a polyacrylic acid polymer gel is used as a base.
Here, “polymer gel preparation” refers to a preparation comprising a gel formed by crosslinking a polymer compound such as a partially neutralized polyacrylic acid. “Solid” means that the shape of the preparation does not change without fluidity when taken out from a container or the like during use.

(A) The partially neutralized polyacrylic acid is obtained by neutralizing a part of polyacrylic acid with an alkali. Examples of the alkali include alkali metal salts such as sodium hydroxide.
As the partially neutralized polyacrylic acid, an acrylic acid / acrylate copolymer such as acrylic acid / sodium acrylate copolymer can be used.

  The partially neutralized polyacrylic acid component (A) is preferably 20/80 to 70/30, more preferably 20/80 to 70/30, in terms of molar ratio of acrylic acid / acrylic acid salt showing the constituent ratio of acrylic acid and acrylic acid salt. What is 30 / 70-60 / 40 may be used. A gel body can be manufactured more suitably as it is in the said range, and a better usability can be provided. If the constituent ratio of acrylic acid in the partially neutralized polyacrylic acid is lower than 20 mol% and the molar ratio is less than 20/80, it may not be suitable for production of a gel body. On the other hand, when the constituent ratio of acrylic acid is higher than 70 mol% and the molar ratio exceeds 70/30, there is a case where a resilient chewing feeling cannot be obtained and the feeling of use is inferior.

  As such a partially neutralized polyacrylic acid component (A), a commercially available product can be used. Specifically, Sumitomo Seika's ACPERNA AP-40F, ACPERNA AP-50, ACPERNA AP-70, Showa Denko Co., Ltd. Bismecort NP-700, Bismecort NP-600, Toagosei Co., Ltd. Aronbis AH-105X And Aronbis AH-106X.

  (A) As for the compounding quantity of the polyacrylic acid partial neutralized product of a component, 1 to 15% (mass%, the following is similar) of the whole preparation is preferable, More preferably, it is 3 to 10%. Within the above range, a more excellent dirt removal effect and usability can be imparted. If it is less than 1%, gelation does not occur and the effect of removing dirt may be inferior, and the biting feeling may be inferior in elasticity, resulting in poor usability. If it exceeds 15%, it may not be able to be produced properly from the viewpoint of swelling of the partially neutralized polyacrylic acid.

  (B) The aluminum compound is a crosslinking agent and is not particularly limited as long as it is a compound that releases aluminum ions. For example, aluminum chloride, potassium aluminum sulfate (potassium alum), synthetic aluminum silicate, natural aluminum silicate, aluminum oxide And inorganic aluminum compounds such as aluminum hydroxide, and organic aluminum compounds such as aluminum stearate and aluminum lactate. These can be used singly or in combination of two or more. Among them, from the viewpoint of production suitability, potassium aluminum sulfate (potassium alum), aluminum hydroxide, and aluminum lactate are preferable.

  (B) The compounding quantity of an aluminum compound is 0.009 to 0.1% of the whole formulation in conversion of aluminum ion, More preferably, it is 0.02 to 0.09%. Within the above range, a more excellent dirt removal effect and usability can be imparted. If it is less than 0.009%, gelation does not occur and the dirt removal effect and usability may be inferior. If it exceeds 0.1%, gelation does not occur (it is assumed that one of the factors is that the salt concentration increases and the crosslinked structure is broken), and the stain removal effect may be inferior.

The oral polymer gel preparation of the present invention is a solid type polymer gel preparation having elasticity and adhesiveness. The base polymer gel is a polyacrylic acid polymer gel obtained by crosslinking the component (A) with the component (B), which is a hydrophilic polymer gel having elasticity and tackiness. Preferably, the polyacrylic acid polymer gel (matrix) and (C) a hydrogel body containing water.
In this case, (C) water is a dispersion medium, and the amount of water is preferably 10 to 90%, more preferably 20 to 80% of the whole preparation.

In the preparation of the present invention, it is preferable to further blend (D) a polyhydric alcohol as a dispersion medium in view of the effect. When (D) component is mix | blended, the dispersibility of (A) component will improve and it can promote gelatinization more.
Any polyhydric alcohol may be used as long as it can be used in the oral cavity and the component (A) is dispersed. For example, propylene glycol, polyethylene glycol having an average molecular weight of 190 to 420, glycerin and the like can be mentioned, and one kind may be used alone, or two or more kinds may be combined. In addition, the average molecular weight of polyethyleneglycol here is a value measured by the method described in Quasi-drug raw material standard 2006 (the same applies hereinafter).
(D) As for the compounding quantity of the polyhydric alcohol of a component, 10 to 80% of the whole preparation is preferable.

  In addition to the above components, various components that can be blended in the oral preparation can be appropriately blended in the present formulation according to the purpose, dosage form, and the like as long as the effects of the present invention are not impaired. These addition methods can employ ordinary methods. For example, cleaning agents, surfactants, thickeners, wetting agents, sweeteners, fragrances, pH adjusters, preservatives, medicinal ingredients and the like can be mentioned.

As the cleaning agent, water-insoluble powders or granules are particularly preferable from the viewpoint of the cleaning effect.
Examples of the powder include silica compounds such as silica gel, precipitated silica and zirconosilicate, dibasic calcium phosphate dihydrate, dibasic calcium phosphate anhydrate, phosphoric acid compounds such as calcium pyrophosphate, polymethyl methacrylate, Examples thereof include insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, tertiary magnesium phosphate, zirconium silicate, hydroxyapatite, and synthetic resin compounds.

Granules formed by granulating water-insoluble powder, granules obtained by granulating water-insoluble powder with water-insoluble inorganic binder, granules obtained by granulating water-insoluble powder with water-insoluble organic binder However, a granule in which a water-insoluble powder is formed into a granule is particularly preferable.
Specifically, silica-based particles such as silicic anhydride, hydrous silicic acid, titanium silicate, and zirconium silicate, and inorganic compounds such as zeolite, calcium phosphate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, aluminum oxide, and titanium oxide Granules of these components, natural polymer materials such as agar, gelatin, starch, glucomannan, granules made of synthetic polymer materials such as acrylic, polyurethane, polyester, polyamide, nylon, polyvinyl chloride, or these Granules obtained by mixing the components can be used.

  As the silica granule, wet method gel method silica and precipitation method silica are suitably used, and the primary particle diameter is about 3 to 15 nm, preferably 4 to 10 nm. For example, a silica gel mass having a primary particle size grown to about 4 to 10 nm by a gel method is washed, dried and then pulverized to classify into silica granules having an average particle size of 50 to 400 μm. A method of preparing granules by spraying in the air and gelling, a method of preparing by agglomeration while suppressing the growth of primary particles by the precipitation method and then growing the primary particle diameter to about 4 to 10 nm, etc. Silica granules can be prepared by these methods. Among them, a method of pulverizing a mass of silica gel prepared by the gel method is preferable because it is simple in production and easy to control the average particle diameter by classification. By preparing by such a method, a granule having an appropriate average disintegration strength can be obtained.

As such granules, commercially available products can be used. Specifically, as silica granules, SORBOSIL BFG10, SORBOSIL BFG50 from PQ Corporation, NIPGEL AY-001, BY-001, CY-001 from HUSBER, Tosoh Silica Examples thereof include granules such as Zedent 9175, but are not limited thereto.
A cleaning agent can be blended in a combination of one or two or more, and the blending amount is preferably 1 to 60% of the whole preparation.

As the surfactant, an anionic surfactant, an amphoteric surfactant, a nonionic surfactant, and a cationic surfactant can be blended.
Examples of anionic surfactants include alkyl sulfates, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, sodium α-olefin sulfonate, and sodium N-methyl-N-acyl taurate. Examples thereof include amino acid surfactants such as N-acyl taurate and sodium N-acyl-L-glutamate, and acyl sarcosine sodium.
Examples of amphoteric surfactants include amidopropyl betaine type amphoteric surfactants, acetate acetate type amphoteric surfactants, imidazoline type amphoteric surfactants, and amine oxide type amphoteric surfactants.
Nonionic surfactants include polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester, sucrose fatty acid ester, sucrose fatty acid ester such as maltose fatty acid ester, and sugar alcohol fatty acid ester such as maltitol fatty acid ester and lactol fatty acid ester. , Alkylol amide, polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monostearate, fatty acid diethanolamide such as lauric acid mono or diethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene Copolymers, polyoxyethylene polyoxypropylene fatty acid esters, pluronics and the like can be mentioned.
Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts.
These surfactants can be blended singly or in combination of two or more, and the blending amount is preferably 0.1 to 10% of the whole preparation.

  Thickeners include sodium carboxymethylcellulose, xanthan gum, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium hydroxyethylcellulose, sodium alginate, tragacanth gum, karaya gum, arabic gum, locust bean gum, polyvinyl alcohol, sodium polyacrylate, cross-linked sodium polyacrylate Organic binders such as carboxyvinyl polymer, carbopol, bee gum, propylene glycol alginate, and inorganic binders such as thickening silica and aluminum silicate. One or more thickeners can be blended, and the blending amount is desirably 0.1 to 10% of the whole preparation.

  As the wetting agent, one or more sugar alcohols such as sorbitol, erythritol, and reduced starch saccharified product can be blended. The blending amount is preferably 10 to 60% of the whole preparation.

  Examples of the sweetener include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone, perlarthine, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester, acesulfame K and the like. The blending amount of the sweetener is preferably 0.01 to 3% of the entire preparation.

  As the fragrance, known fragrances such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyl linalool, vanillin, thymol, spearmint oil, peppermint oil , Lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, winter green oil, clove oil, eucalyptus oil and the like. The compounding quantity of the fragrance | flavor in a formulation can be 0.001-2%.

Examples of the pH adjuster include organic acids such as citric acid and lactic acid and salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.
Examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.

  Medicinal ingredients include enzymes such as dextranase, amylase, protease, mutanase, tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxy allantoin, azulene, glycyrrhizinate, glycyrrhetinate, sodium chloride, vitamins and other anti-inflammatory agents , Isopropylmethylphenol, copper chlorophyll, copper gluconate, cetylpyridinium chloride, benzalkonium chloride, hinokitiol, lysozyme chloride and other fungicides, pyrophosphates, anticalculus agents such as polyphosphates and zeolites, blood circulation such as vitamin E Accelerators, amino acids such as glycine and proline can be added. In addition, the compounding quantity of a medicinal ingredient can be made into an effective quantity in the range which does not inhibit the effect of this invention.

  In addition, as optional components, inorganic compounds such as hydroxyapatite, mica titanium, titanium oxide, bentonite and the like, granules of cellulose organic powder such as crystalline cellulose, agar, gelatin, starch, gluco Natural polymer compounds such as mannan, synthetic polymer compounds such as polyvinyl acetate, acrylic, polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder and their copolymers, carnauba wax, rosin, rice wax, microcrystalline Wax, beeswax, waxes such as paraffin wax, higher alcohols such as cetanol and stearyl alcohol, latex rubbers such as polyisobutylene, polybutadiene, urethane, silicone, natural rubber, etc. There may be used or lame film those obtained by mixing these materials.

  The oral polymer gel preparation of the present invention can be prepared by employing a conventional gel production method. In this case, the time for swelling and gelation can be appropriately adjusted according to the components used and the concentration thereof. For example, (A) a partially neutralized polyacrylic acid is dispersed in a solvent and stirred for about 3 to 30 minutes. After swelling, the polymer gel can be prepared by adding (B) an aluminum compound and stirring for about 10 to 30 minutes, and preparing it in an appropriate shape. In this case, (C) water and (D) polyhydric alcohol can be used as the solvent.

  Since the polyacrylic acid polymer gel according to the present invention has adhesiveness, a non-adhesive coating such as a powder coating or a water-soluble film coating can be applied to the solid preparation surface.

The preparation of the present invention is used by containing in the oral cavity and chewing. That is, it is preferable that a preparation prepared in an arbitrary shape and size is contained in the oral cavity and used by chewing so that it can be pressed against a tooth for an appropriate time, for example, about 1 to 3 minutes. After chewing, the preparation may be discharged, and the oral cavity may be rinsed with water, wiped with paper or cloth, if necessary, or the teeth may be brushed with a toothbrush or the like.
In addition, the shape of the preparation of the present invention is preferably a rectangular parallelepiped shape, a plate shape or a spherical shape, and the size may be a size suitable for being put in the mouth and chewing, for example, a spherical shape having a diameter or one side of 1 to 2 cm or A rectangular parallelepiped shape is good.

  Since the preparation of the present invention is a chewable solid gel body having moderate elasticity and tackiness, when it is chewed, contact with the teeth, the dirt on the teeth adheres to the gel by pressing, and peels off. Because of its moderate elasticity, it is easy to enter between the teeth, and when chewed, it deforms moderately and quickly enters the gap between the teeth, and dirt on the tooth surface and sides adheres to the gel and peels off. By dropping, the dirt on the teeth can be effectively removed. Furthermore, the gel body loses its shape due to mastication and part or all of it is crushed. After mastication, the gel body is quickly detached from the teeth by brushing or rinsing with water as needed. It can be easily discharged from the oral cavity. The preparation of the present invention has a high soil removal effect as compared with a general tablet, and also has a high soil adhesion as compared with a gum preparation, and an excellent cleaning effect can be expected.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified.

[Examples and Comparative Examples]
Preparations for oral cavity having the compositions shown in Table 1 were prepared and evaluated by the following methods. The results are also shown in Table 1.

<Sample preparation method>
While propylene glycol was stirred with a three-one motor, (A) the partially neutralized polyacrylic acid was added and dispersed. Purified water was added with stirring, and stirring was continued for 20 minutes. Thereafter, (B) propylene glycol in which an aluminum compound was dispersed was added, and stirring was further continued for 10 minutes. Then, the mixture was left at room temperature to obtain an oral polymer gel preparation (hydrogel body) of Examples.
The preparation of the comparative example was prepared according to the above method.

<Evaluation method of dirt removal effect>
Beef tallow was heated to 70 ° C. to dissolve, and Sudan IV was added to 0.01%, and stirred until uniform. Drop 0.01 ml onto an acrylic plate (1 cm x 1 cm x 0.5 cm) whose surface is polished with # 1500 water-resistant abrasive paper, spread it over the entire acrylic plate, and leave it at room temperature until the beef tallow has solidified. did.
After the sample (oral preparation) cut to approximately 2cm square is pressed against the model dirt 10 times, the remaining amount of beef tallow on the acrylic board is visually determined by the degree of redness, and the dirt is stained according to the following evaluation criteria. The removal effect (dirt removal effect) was evaluated.
Judgment criteria ◎: Dirt has become considerably thinner ○: Dirt has become thinner △: Dirt has become slightly thinner ×: No change

<Evaluation method of feeling of use>
The obtained oral preparation was cut into a square of about 2 cm, contained in the oral cavity, and the chewing feeling for 1 minute (effect feeling) when chewed for 1 minute and the chewing comfort of the composition were evaluated as follows. Evaluation was made according to criteria.
Evaluation criteria for the actual feeling that the dirt between the teeth has been removed ◎: There is an actual feeling that the dirt has been removed ○: Feeling that the dirt has been removed ×: No feeling that the dirt has been removed Evaluation criteria for the biting comfort ◎: Chewing Comfort is very good ○: Biting comfort is slightly good ×: Biting comfort is not good

Details of the raw materials used are shown below.
(A) Polyacrylic acid partial neutralized product (1):
Sumitomo Seika Co., Ltd., ACPERNA AP-50 (acrylic acid / sodium acrylate composition ratio = 50/50)
(A) Polyacrylic acid partial neutralized product (2):
Sumitomo Seika Co., Ltd., ACPERNA AP-40F (acrylic acid / sodium acrylate composition ratio = 60/40)
Cross-linked sodium polyacrylate (comparative product): manufactured by Toagosei Co., Ltd., Rheojic 260H
(B) Aluminum lactate: manufactured by Kanto Chemical Co., Inc., aluminum lactate (B) potassium sulfate aluminum: manufactured by Kanto Chemical Co., Ltd., potassium aluminum sulfate / 12 water (D) propylene glycol: manufactured by Dow Chemical Co., propylene glycol

As can be seen from the results shown in Table 1, even when (A) a polyacrylic acid partial neutralized product is contained, and (B) an aluminum compound is not contained, a gel is not formed and a very viscous liquid is formed. The drop effect was inferior, and the feeling of use (feeling that dirt was removed, biting comfort) was also inferior (Comparative Example 1). Moreover, even if it contains (B) an aluminum compound, it does not contain (A) a polyacrylic acid partial neutralized product, and even if it contains a cross-linked sodium polyacrylate (comparative product), The properties were low, and both the dirt removal effect and the feeling of use (feeling that dirt was removed, biting comfort) were inferior (Comparative Example 2).
On the other hand, as shown in the Examples, a chewable solid gel having appropriate tackiness and elasticity by blending (A) a partially neutralized polyacrylic acid and (B) an aluminum compound. When the oral preparation based on this gel body is chewed and chewed, the gel body pressed between the teeth adheres and removes the dirt present between the teeth and the teeth. Removed and excellent dirt removal effect. Further, it was found that the actual feeling that the dirt was removed was excellent as the actual effect, the chewing feeling was good, and the usability was also good.

  Moreover, the polymer gel formulation for oral cavity of the composition shown below was prepared and evaluated by the same method using the same raw material. In the preparation, components other than the surfactant were prepared using a three-one motor, and then the surfactant was mixed with a kneader under reduced pressure (manufactured by Ishiyama Shoten). These were excellent in the dirt removal effect, and the actual feeling that the dirt was removed was high, and the biting comfort was good.

[Prescription Example 1]
(A) Polyacrylic acid partial neutralized product (1) 5.0%
(B) Aluminum lactate 0.3
(Aluminum ion amount: 0.027)
(D) Propylene glycol 8.0
(D) Polyethylene glycol 400 5.0
Saccharin sodium 0.2
Sorbit liquid (70%) 30.0
Sodium lauryl sulfate 1.5
Abrasive silica 12.0
Fragrance ^* 1.0
(C) Purified water balance
Total 100.0%
*; Fragrance composition is shown in Tables 2 and 3 (the same applies hereinafter).

[Prescription Example 2]
(A) Polyacrylic acid partial neutralized product (2) 10.0%
(B) Potassium aluminum sulfate 1.0
(Aluminum ion amount: 0.054)
(D) Propylene glycol 8.0
(D) Concentrated glycerin 20.0
(D) Glycerin (85%) 5.0
(D) Polyethylene glycol 400 17.0
Saccharin sodium 0.2
Sodium lauryl sulfate 1.5
Abrasive silica 12.0
Fragrance ^* 1.0
(C) Purified water balance
Total 100.0%

Claims (8)

  (A) A polymer gel preparation for oral cavity comprising a partially neutralized polyacrylic acid and (B) an aluminum compound.   The polymer gel preparation for oral cavity according to claim 1, wherein (A) the partially neutralized polyacrylic acid is based on (B) an adhesive polyacrylic acid polymer gel crosslinked with an aluminum compound.   The partially neutralized polyacrylic acid component (A) is an acrylic acid / sodium acrylate copolymer having a molar ratio of acrylic acid / sodium acrylate of 20/80 to 70/30. Or the polymer gel formulation for oral cavity of 2.   4. The oral polymer gel preparation according to any one of claims 1 to 3, wherein the aluminum compound as component (B) is one or more aluminum ion releasing compounds selected from aluminum lactate, aluminum potassium sulfate and aluminum hydroxide.   The polymer gel preparation for oral cavity according to any one of claims 1 to 4, wherein the component (A) is 1 to 15% by mass and the component (B) is 0.009 to 0.1% by mass in terms of aluminum ion.   Furthermore, the polymer gel formulation for oral cavity of any one of Claims 1-4 which mix | blended (C) 10-90 mass% of water.   Furthermore, the polymer gel formulation for oral cavity of any one of Claims 1-6 which mix | blended 10-80 mass% of (D) polyhydric alcohol.   Furthermore, the polymer gel formulation for oral cavity of any one of Claims 2-7 by which the non-adhesive coating was given to the formulation surface.