JP2016540778A5 - - Google Patents

Info

Publication number

JP2016540778A5

JP2016540778A5 JP2016536865A JP2016536865A JP2016540778A5 JP 2016540778 A5 JP2016540778 A5 JP 2016540778A5 JP 2016536865 A JP2016536865 A JP 2016536865A JP 2016536865 A JP2016536865 A JP 2016536865A JP 2016540778 A5 JP2016540778 A5 JP 2016540778A5

Authority

JP

Japan

Prior art keywords

nucleic acid

acid molecule

administered

composition formulated

molecule according

Prior art date

2014-12-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108020004707 nucleic acids Proteins 0.000 claims 27
• 102000039446 nucleic acids Human genes 0.000 claims 27
• 150000007523 nucleic acids Chemical class 0.000 claims 27
• 239000000203 mixture Substances 0.000 claims 5
• 230000036573 scar formation Effects 0.000 claims 4
• 102000015225 Connective Tissue Growth Factor Human genes 0.000 claims 3
• 108010039419 Connective Tissue Growth Factor Proteins 0.000 claims 3
• 238000002347 injection Methods 0.000 claims 3
• 239000007924 injection Substances 0.000 claims 3
• 239000002773 nucleotide Substances 0.000 claims 3
• 125000003729 nucleotide group Chemical group 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 102000010907 Cyclooxygenase 2 Human genes 0.000 claims 2
• 108010037462 Cyclooxygenase 2 Proteins 0.000 claims 2
• 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 2
• 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 2
• 102000004079 Prolyl Hydroxylases Human genes 0.000 claims 2
• 108010043005 Prolyl Hydroxylases Proteins 0.000 claims 2
• 102000009738 Ribosomal Protein S6 Kinases Human genes 0.000 claims 2
• 108010034782 Ribosomal Protein S6 Kinases Proteins 0.000 claims 2
• 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims 2
• 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 2
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
• 230000003442 weekly effect Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102100026802 72 kDa type IV collagenase Human genes 0.000 claims 1
• 102000012422 Collagen Type I Human genes 0.000 claims 1
• 108010022452 Collagen Type I Proteins 0.000 claims 1
• 102000010970 Connexin Human genes 0.000 claims 1
• 108050001175 Connexin Proteins 0.000 claims 1
• 102000003834 Histamine H1 Receptors Human genes 0.000 claims 1
• 108090000110 Histamine H1 Receptors Proteins 0.000 claims 1
• 101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 claims 1
• 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims 1
• 108050009527 Hypoxia-inducible factor-1 alpha Proteins 0.000 claims 1
• 108090001005 Interleukin-6 Proteins 0.000 claims 1
• 102000004889 Interleukin-6 Human genes 0.000 claims 1
• 108010016165 Matrix Metalloproteinase 2 Proteins 0.000 claims 1
• 102000000424 Matrix Metalloproteinase 2 Human genes 0.000 claims 1
• 102000004264 Osteopontin Human genes 0.000 claims 1
• 108010081689 Osteopontin Proteins 0.000 claims 1
• 108010050808 Procollagen Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 108700039882 Protein Glutamine gamma Glutamyltransferase 2 Proteins 0.000 claims 1
• 102100038095 Protein-glutamine gamma-glutamyltransferase 2 Human genes 0.000 claims 1
• 108091081021 Sense strand Proteins 0.000 claims 1
• 102000007374 Smad Proteins Human genes 0.000 claims 1
• 108010007945 Smad Proteins Proteins 0.000 claims 1
• 108020004459 Small interfering RNA Proteins 0.000 claims 1
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
• 230000000692 anti-sense effect Effects 0.000 claims 1
• 238000007385 chemical modification Methods 0.000 claims 1
• 125000001153 fluoro group Chemical group F* 0.000 claims 1
• 102000006495 integrins Human genes 0.000 claims 1
• 108010044426 integrins Proteins 0.000 claims 1
• -1 optionally Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 230000037390 scarring Effects 0.000 claims 1
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1