JP2016539995A5 - - Google Patents
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- JP2016539995A5 JP2016539995A5 JP2016538520A JP2016538520A JP2016539995A5 JP 2016539995 A5 JP2016539995 A5 JP 2016539995A5 JP 2016538520 A JP2016538520 A JP 2016538520A JP 2016538520 A JP2016538520 A JP 2016538520A JP 2016539995 A5 JP2016539995 A5 JP 2016539995A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- diseases
- hydrogen
- compounds
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 8
- 229910052739 hydrogen Inorganic materials 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 6
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 5
- 230000011664 signaling Effects 0.000 description 5
- 230000002062 proliferating effect Effects 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 125000001072 heteroaryl group Chemical group 0.000 description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- 206010012689 Diabetic retinopathy Diseases 0.000 description 2
- 206010016654 Fibrosis Diseases 0.000 description 2
- 201000004681 Psoriasis Diseases 0.000 description 2
- 201000002154 Pterygium Diseases 0.000 description 2
- 206010038933 Retinopathy of prematurity Diseases 0.000 description 2
- 206010064930 age-related macular degeneration Diseases 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 208000002780 macular degeneration Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000004770 neurodegeneration Effects 0.000 description 2
- 208000015122 neurodegenerative disease Diseases 0.000 description 2
- 229940002612 prodrug Drugs 0.000 description 2
- 239000000651 prodrug Substances 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108091008606 PDGF receptors Proteins 0.000 description 1
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 description 1
- 241001303601 Rosacea Species 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 108091008605 VEGF receptors Proteins 0.000 description 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 208000002205 allergic conjunctivitis Diseases 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 208000024998 atopic conjunctivitis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 201000005668 blepharoconjunctivitis Diseases 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000002837 carbocyclic group Chemical group 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical group 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 206010023332 keratitis Diseases 0.000 description 1
- 201000010666 keratoconjunctivitis Diseases 0.000 description 1
- 229940043355 kinase inhibitor Drugs 0.000 description 1
- 210000003584 mesangial cell Anatomy 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 201000004700 rosacea Diseases 0.000 description 1
- -1 substituent amines Chemical class 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 125000004385 trihaloalkyl group Chemical group 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361915186P | 2013-12-12 | 2013-12-12 | |
| US201361915209P | 2013-12-12 | 2013-12-12 | |
| US61/915,186 | 2013-12-12 | ||
| US61/915,209 | 2013-12-12 | ||
| PCT/US2014/069601 WO2015089220A1 (en) | 2013-12-12 | 2014-12-10 | Substituted nicotinamide derivatives as kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539995A JP2016539995A (ja) | 2016-12-22 |
| JP2016539995A5 true JP2016539995A5 (enExample) | 2019-04-11 |
| JP6531100B2 JP6531100B2 (ja) | 2019-06-12 |
Family
ID=52118045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016538520A Active JP6531100B2 (ja) | 2013-12-12 | 2014-12-10 | キナーゼ阻害剤としての置換ニコチンアミド誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20150166518A1 (enExample) |
| EP (1) | EP3080084B1 (enExample) |
| JP (1) | JP6531100B2 (enExample) |
| CN (1) | CN105814021B (enExample) |
| AU (1) | AU2014362391B2 (enExample) |
| BR (1) | BR112016013539A2 (enExample) |
| CA (1) | CA2932831A1 (enExample) |
| WO (1) | WO2015089220A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10046649B2 (en) | 2012-06-28 | 2018-08-14 | Midtronics, Inc. | Hybrid and electric vehicle battery pack maintenance device |
| US20110300416A1 (en) | 2010-06-03 | 2011-12-08 | Bertness Kevin I | Battery pack maintenance for electric vehicle |
| US11740294B2 (en) | 2010-06-03 | 2023-08-29 | Midtronics, Inc. | High use battery pack maintenance |
| DE112012004706T5 (de) | 2011-11-10 | 2014-08-21 | Midtronics, Inc. | Batteriepack-Testvorrichtung |
| US11325479B2 (en) | 2012-06-28 | 2022-05-10 | Midtronics, Inc. | Hybrid and electric vehicle battery maintenance device |
| US10843574B2 (en) | 2013-12-12 | 2020-11-24 | Midtronics, Inc. | Calibration and programming of in-vehicle battery sensors |
| US10473555B2 (en) | 2014-07-14 | 2019-11-12 | Midtronics, Inc. | Automotive maintenance system |
| US10317468B2 (en) | 2015-01-26 | 2019-06-11 | Midtronics, Inc. | Alternator tester |
| US10608353B2 (en) | 2016-06-28 | 2020-03-31 | Midtronics, Inc. | Battery clamp |
| US12320857B2 (en) | 2016-10-25 | 2025-06-03 | Midtronics, Inc. | Electrical load for electronic battery tester and electronic battery tester including such electrical load |
| US11054480B2 (en) | 2016-10-25 | 2021-07-06 | Midtronics, Inc. | Electrical load for electronic battery tester and electronic battery tester including such electrical load |
| CN108456163A (zh) | 2017-02-20 | 2018-08-28 | 中国科学院上海药物研究所 | 含邻氨基杂芳环炔基的化合物及其制备方法和用途 |
| US11513160B2 (en) | 2018-11-29 | 2022-11-29 | Midtronics, Inc. | Vehicle battery maintenance device |
| CN111662227B (zh) * | 2019-03-06 | 2022-07-05 | 中国科学院上海药物研究所 | 邻氨基吡啶炔类化合物及其制备方法和用途 |
| US11566972B2 (en) | 2019-07-31 | 2023-01-31 | Midtronics, Inc. | Tire tread gauge using visual indicator |
| US11545839B2 (en) | 2019-11-05 | 2023-01-03 | Midtronics, Inc. | System for charging a series of connected batteries |
| US11668779B2 (en) | 2019-11-11 | 2023-06-06 | Midtronics, Inc. | Hybrid and electric vehicle battery pack maintenance device |
| US11474153B2 (en) | 2019-11-12 | 2022-10-18 | Midtronics, Inc. | Battery pack maintenance system |
| US11973202B2 (en) | 2019-12-31 | 2024-04-30 | Midtronics, Inc. | Intelligent module interface for battery maintenance device |
| DE102020216599A1 (de) | 2019-12-31 | 2021-07-01 | Midtronics, Inc. | Intelligente Modulschnittstelle für eine Batteriewartungsvorrichtung |
| US11486930B2 (en) | 2020-01-23 | 2022-11-01 | Midtronics, Inc. | Electronic battery tester with battery clamp storage holsters |
| US12330513B2 (en) | 2022-02-14 | 2025-06-17 | Midtronics, Inc. | Battery maintenance device with high voltage connector |
| US12392833B2 (en) | 2022-05-09 | 2025-08-19 | Midtronics, Inc. | Electronic battery tester |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7915443B2 (en) * | 2006-11-16 | 2011-03-29 | Allergan, Inc. | Sulfoximines as kinase inhibitors |
| US8558002B2 (en) * | 2006-11-16 | 2013-10-15 | Allergan, Inc. | Sulfoximines as kinase inhibitors |
-
2014
- 2014-12-10 CN CN201480066924.XA patent/CN105814021B/zh not_active Expired - Fee Related
- 2014-12-10 CA CA2932831A patent/CA2932831A1/en not_active Abandoned
- 2014-12-10 WO PCT/US2014/069601 patent/WO2015089220A1/en not_active Ceased
- 2014-12-10 BR BR112016013539-3A patent/BR112016013539A2/pt not_active Application Discontinuation
- 2014-12-10 AU AU2014362391A patent/AU2014362391B2/en not_active Ceased
- 2014-12-10 US US14/565,689 patent/US20150166518A1/en not_active Abandoned
- 2014-12-10 JP JP2016538520A patent/JP6531100B2/ja active Active
- 2014-12-10 EP EP14815201.0A patent/EP3080084B1/en not_active Not-in-force
-
2016
- 2016-03-14 US US15/069,344 patent/US9567324B2/en active Active
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