SG11201900298RA - Heterocyclic compound used as fgfr inhibitor - Google Patents

Heterocyclic compound used as fgfr inhibitor

Info

Publication number
SG11201900298RA
SG11201900298RA SG11201900298RA SG11201900298RA SG11201900298RA SG 11201900298R A SG11201900298R A SG 11201900298RA SG 11201900298R A SG11201900298R A SG 11201900298RA SG 11201900298R A SG11201900298R A SG 11201900298RA SG 11201900298R A SG11201900298R A SG 11201900298RA
Authority
SG
Singapore
Prior art keywords
compound
heterocyclic compound
fgfr
compound used
fgfr inhibitor
Prior art date
Application number
SG11201900298RA
Inventor
Norman Xianglong Kong
Chao Zhou
Zhixiang Zheng
Original Assignee
Nanjing Innocare Pharma Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanjing Innocare Pharma Tech Co Ltd filed Critical Nanjing Innocare Pharma Tech Co Ltd
Publication of SG11201900298RA publication Critical patent/SG11201900298RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

OF THE DISC LOSURE The present invention relates to a heterocyclic compound, a pharmaceutical composition contain ing the same, a preparation method thereof, and use thereof as a fibroblast growth factor receptor (FGFR) inhibitor . T he compound is a heterocyclic compound as shown in Formula I, or a pharmaceutically acceptable salt, prodrug, solvent compound, polymorph , isomer or stable isotopic derivative thereof . T he present invention further relates to use of the compound for t he treatment or prevention of related diseases which are FGFR - mediated such as cancer, and a method for applying the compound to treat said d iseases. (I)
SG11201900298RA 2016-07-13 2017-06-13 Heterocyclic compound used as fgfr inhibitor SG11201900298RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610550151.3A CN107619388A (en) 2016-07-13 2016-07-13 Heterocyclic compound as FGFR inhibitor
PCT/CN2017/088038 WO2018010514A1 (en) 2016-07-13 2017-06-13 Heterocyclic compound used as fgfr inhibitor

Publications (1)

Publication Number Publication Date
SG11201900298RA true SG11201900298RA (en) 2019-02-27

Family

ID=60951887

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201900298RA SG11201900298RA (en) 2016-07-13 2017-06-13 Heterocyclic compound used as fgfr inhibitor
SG10202013038VA SG10202013038VA (en) 2016-07-13 2017-06-13 Heterocyclic compound used as fgfr inhibitor

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10202013038VA SG10202013038VA (en) 2016-07-13 2017-06-13 Heterocyclic compound used as fgfr inhibitor

Country Status (12)

Country Link
US (1) US10590109B2 (en)
EP (1) EP3489223A4 (en)
JP (1) JP6896852B2 (en)
KR (1) KR102386428B1 (en)
CN (2) CN107619388A (en)
AU (1) AU2017295628B2 (en)
CA (1) CA3030070A1 (en)
MX (1) MX2019000451A (en)
PH (1) PH12019500036A1 (en)
RU (1) RU2742485C2 (en)
SG (2) SG11201900298RA (en)
WO (1) WO2018010514A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3069602C (en) * 2017-08-04 2022-12-06 Abbisko Therapeutics Co., Ltd. Formylpyridine derivative having fgfr4 inhibitory activity, preparation method therefor and use thereof
AU2018346597B2 (en) 2017-10-06 2023-07-13 Forma Therapeutics, Inc. Inhibiting Ubiquitin Specific Peptidase 30
CN108129471A (en) * 2018-03-20 2018-06-08 韩邦森 A kind of synthesis technology of thiazole substituted uracil compound
BR112021003620A2 (en) 2018-10-05 2021-05-18 Forma Therapeutics, Inc. Fused pyrrolines that act as specific protease inhibitors for ubiquitin 30 (usp30)
KR20210142154A (en) 2019-03-21 2021-11-24 옹쎄오 DBAIT molecules in combination with kinase inhibitors for the treatment of cancer
CA3159348A1 (en) 2019-11-08 2021-05-14 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
CN111039874B (en) * 2019-12-13 2022-11-04 南开大学 Zero-wastewater preparation method of 2-amino-4-methylpyrimidine compound
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2340605C2 (en) * 2002-06-27 2008-12-10 Ново Нордиск А/С Arylcarbonyl derivatives as therapeutic agents
CN1508130A (en) * 2002-12-18 2004-06-30 中国科学院大连化学物理研究所 N-phenyl-N'-pyrimidinyl-substituted urea derivative synthesizing method
FR2850652B1 (en) * 2003-01-31 2008-05-30 Aventis Pharma Sa NOVEL CYCLIC UREA DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS INHIBITORS OF KINASES
ATE400567T1 (en) * 2004-06-23 2008-07-15 Lilly Co Eli KINASE INHIBITORS
GB0512324D0 (en) * 2005-06-16 2005-07-27 Novartis Ag Organic compounds
FR2889526B1 (en) * 2005-08-04 2012-02-17 Aventis Pharma Sa SUBSTITUTED 7-AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PROCESS FOR PRODUCTION AND USE
EP1790342A1 (en) * 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazine derivatives and their use as signal transduction modulators
US20070173488A1 (en) * 2005-11-16 2007-07-26 Sgx Pharmaceuticals, Inc. Pyrazolothiazole Protein Kinase Modulators
AU2006320440B2 (en) * 2005-12-02 2012-04-05 Bayer Healthcare Llc Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
FR2908409B1 (en) * 2006-11-10 2009-01-09 Sanofi Aventis Sa SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SAME, PROCESS FOR PRODUCTION AND USE
FR2947546B1 (en) * 2009-07-03 2011-07-01 Sanofi Aventis PYRAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
WO2013024427A1 (en) * 2011-08-16 2013-02-21 Glenmark Pharmaceuticals S.A. Novel urea derivatives as tec kinase inhibitors and uses thereof
CA2927252C (en) * 2013-10-25 2021-09-28 Novartis Ag Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors
BR112017016817A2 (en) * 2015-03-25 2018-04-03 Novartis Ag heterocyclic derivatives formulated as fgfr4 inhibitors
US9802917B2 (en) 2015-03-25 2017-10-31 Novartis Ag Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide

Also Published As

Publication number Publication date
RU2019100164A (en) 2020-08-13
CN108349896A (en) 2018-07-31
MX2019000451A (en) 2019-09-27
CA3030070A1 (en) 2018-01-18
AU2017295628B2 (en) 2021-05-13
US10590109B2 (en) 2020-03-17
RU2019100164A3 (en) 2020-08-27
AU2017295628A1 (en) 2019-02-21
KR20190032420A (en) 2019-03-27
KR102386428B1 (en) 2022-04-14
CN108349896B (en) 2021-06-01
EP3489223A1 (en) 2019-05-29
PH12019500036A1 (en) 2019-10-28
EP3489223A4 (en) 2020-01-15
JP6896852B2 (en) 2021-06-30
JP2019522055A (en) 2019-08-08
US20190144427A1 (en) 2019-05-16
WO2018010514A1 (en) 2018-01-18
SG10202013038VA (en) 2021-01-28
CN107619388A (en) 2018-01-23
RU2742485C2 (en) 2021-02-08

Similar Documents

Publication Publication Date Title
SG11201900298RA (en) Heterocyclic compound used as fgfr inhibitor
PH12019500395A1 (en) Amino-pyrrolopyrimidinone compounds and methods of use thereof
PH12018500360A1 (en) Heteroaryl derivatives as parp inhibitors
EA201891191A1 (en) 2-SUBSTITUTED HINAZOLIN COMPOUNDS CONTAINING A SUBSTITUTED HETEROCYCLIC GROUP AND METHODS OF THEIR APPLICATION
EA201992126A1 (en) JAK INHIBITORS CONTAINING 4-MEMBER HETEROCYCLIC AMIDE
MY195427A (en) Jak Kinase Inhibitor Compounds for Treatment of Respiratory Disease
MX2019003143A (en) Alkynyl-substituted heterocyclic compound, preparation method therefor and medical use thereof.
WO2015200481A8 (en) Mnk inhibitors and methods related thereto
WO2015168466A8 (en) Inhibitors of lysine specific demethylase-1
MY197116A (en) Bicyclic heterocyclyl derivatives as irak4 inhibitors
EA202090413A1 (en) Pyrazole and triazobicyclic compounds as inhibitors of JAK kinases
MX2020013694A (en) Heterocyclic compound as trk inhibitor.
EA202190681A1 (en) DIMETHYLAMINOAZETIDINE AMIDES AS JAK INHIBITORS
MY188700A (en) Bicyclic ketone sulfonamide compounds
MX369369B (en) Quinolone derivatives as fibroblast growth factor receptor inhibitors.
MX2016016530A (en) Phosphatidylinositol 3-kinase inhibitors.
PH12021550825A1 (en) Quinoline derivatives as alpha4beta7 integrin inhibitors
WO2015191754A3 (en) Phosphatidylinositol 3-kinase inhibitors
EA202190686A1 (en) 5-7-MEMBER HETEROCYCLIC AMIDES AS JAK INHIBITORS
MX2020001531A (en) Novel heterocyclic compounds as cdk8/19 inhibitors.
EA201991355A1 (en) IMIDAZO [1,5-A] PYRASINE DERIVATIVES AS PI3K DELTA INHIBITORS
SA520411787B1 (en) Benzimidazole derivatives and their uses
EA201990678A1 (en) Heteroarylcarboxamide Compounds as Ripk2 Inhibitors
PH12017500007A1 (en) Quinolizinone derivatives as p13k inhibitors
EP4252856A3 (en) Novel quinazolinones that inhibit the formation of tau oligomers and their method of use