JP2016539929A - 免疫療法のためのポリクローナルγδT細胞 - Google Patents
免疫療法のためのポリクローナルγδT細胞 Download PDFInfo
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- JP2016539929A JP2016539929A JP2016525990A JP2016525990A JP2016539929A JP 2016539929 A JP2016539929 A JP 2016539929A JP 2016525990 A JP2016525990 A JP 2016525990A JP 2016525990 A JP2016525990 A JP 2016525990A JP 2016539929 A JP2016539929 A JP 2016539929A
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N5/0636—T lymphocytes
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/428—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
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- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/54—Pancreas
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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- Developmental Biology & Embryology (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361895626P | 2013-10-25 | 2013-10-25 | |
| US61/895,626 | 2013-10-25 | ||
| PCT/US2014/062191 WO2015061694A2 (en) | 2013-10-25 | 2014-10-24 | Polyclonal gamma delta t cells for immunotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016539929A true JP2016539929A (ja) | 2016-12-22 |
| JP2016539929A5 JP2016539929A5 (https=) | 2017-11-30 |
Family
ID=52993756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016525990A Pending JP2016539929A (ja) | 2013-10-25 | 2014-10-24 | 免疫療法のためのポリクローナルγδT細胞 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9907820B2 (https=) |
| EP (1) | EP3060059A4 (https=) |
| JP (1) | JP2016539929A (https=) |
| KR (1) | KR20160068960A (https=) |
| CN (1) | CN105848484A (https=) |
| AU (2) | AU2014339926B2 (https=) |
| CA (1) | CA2926859A1 (https=) |
| WO (1) | WO2015061694A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022521027A (ja) * | 2019-02-24 | 2022-04-04 | ガミダ セル リミテッド | 治療に使用する細胞組成物を生成するためのガンマ・デルタt細胞のホーミング及び保持の方法 |
| JP2023544240A (ja) * | 2020-08-12 | 2023-10-23 | ユニバーシティ オブ セントラル フロリダ リサーチ ファウンデーション,インコーポレイテッド | ガンマデルタt細胞を刺激するための方法及び組成物 |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1814580B1 (en) | 2004-11-24 | 2016-08-10 | Fred Hutchinson Cancer Research Center | Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens |
| EP3783098A1 (en) | 2013-05-14 | 2021-02-24 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| CA2913052A1 (en) | 2013-05-24 | 2014-11-27 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
| KR102375998B1 (ko) | 2014-02-14 | 2022-03-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키메라 항원 수용체 및 제조방법 |
| GB201506423D0 (en) | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
| CA2964783C (en) | 2014-11-05 | 2024-01-23 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) to selectively target protein complexes |
| IL297773B2 (en) | 2014-11-17 | 2024-07-01 | Adicet Bio Inc | Engineered gamma delta t-cells |
| US20220280564A1 (en) * | 2014-11-21 | 2022-09-08 | Immatics US, Inc. | Methods for expanding t cells for the treatment of cancer and related malignancies |
| US10808230B2 (en) | 2015-02-24 | 2020-10-20 | Board Of Regents, The University Of Texas System | Selection methods for genetically-modified T cells |
| KR102615825B1 (ko) | 2015-03-11 | 2023-12-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 전위효소 폴리펩타이드 및 이의 용도 |
| GB201507368D0 (en) | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
| US11534460B2 (en) * | 2015-05-11 | 2022-12-27 | University Health Network | Method for expansion of double negative regulatory T cells |
| NZ736675A (en) * | 2015-05-12 | 2023-03-31 | Memorial Sloan Kettering Cancer Center | Methods of treating epstein-barr virus-associated lymphoproliferative disorders by t cell therapy |
| AU2016274633B2 (en) * | 2015-06-09 | 2022-04-21 | Gammadelta Therapeutics Ltd | Methods for the production of TCR gamma delta+ T cells |
| DK3307875T3 (da) * | 2015-06-09 | 2022-03-21 | Lymphact Lymphocyte Activation Tech S A | Fremgangsmåder til fremstilling af tcr-gamma-delta+-t-celler |
| CN105112370B (zh) * | 2015-08-25 | 2019-02-05 | 杭州优善生物科技有限公司 | 一种体外刺激外周血γδT细胞高效增殖的方法及其应用 |
| CN108025023A (zh) * | 2015-08-25 | 2018-05-11 | Uab研究基金会 | 用于干细胞移植的方法 |
| HK1258218A1 (zh) | 2015-09-15 | 2019-11-08 | Board Of Regents, The University Of Texas System | T细胞受体(tcr)结合抗体及其应用 |
| CN105624107B (zh) * | 2015-09-21 | 2020-06-12 | 杭州优善生物科技有限公司 | 一种多种淋巴细胞亚群的扩增方法及其应用 |
| EP3368075B1 (en) | 2015-10-27 | 2020-01-29 | Board of Regents, The University of Texas System | Chimeric antigen receptor molecules and uses thereof |
| WO2017072367A1 (en) | 2015-10-30 | 2017-05-04 | Cancer Research Technology Limited | EXPANSION OF NON-HAEMATOPOIETIC TISSUE-RESIDENT γδ T CELLS AND USES OF THESE CELLS |
| US11299708B2 (en) | 2016-05-12 | 2022-04-12 | Adicet Bio, Inc. | Methods for selective expansion of γδ T-cell populations and compositions thereof |
| US20190262400A1 (en) * | 2016-10-31 | 2019-08-29 | H. Lee Moffitt Cancer Center And Research Institure, Inc. | Artificial antigen presenting cells for expanding immune cells for immunotherapy |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| SG10202107136XA (en) * | 2017-02-08 | 2021-07-29 | Agency Science Tech & Res | Gamma delta t cells and a method of augmenting the tumoricidal activity of the same |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| GB201707048D0 (en) * | 2017-05-03 | 2017-06-14 | King S College London | Expansion of gamma delta cells, compositions, and methods of use thereof |
| CN109337872B (zh) * | 2017-07-27 | 2023-06-23 | 上海细胞治疗研究院 | 高效扩增car-t细胞的人工抗原递呈细胞及其用途 |
| EP3681996B1 (en) * | 2017-09-15 | 2024-08-07 | King's College London | Compositions and methods for enhancing gamma delta t cells in the gut |
| CN107794269A (zh) * | 2017-09-30 | 2018-03-13 | 成都美杰赛尔生物科技有限公司 | 促进基因编辑t细胞活化及扩增的生物膜、制法及应用 |
| TWI687227B (zh) * | 2017-10-03 | 2020-03-11 | 生倍科技股份有限公司 | 用於t細胞免疫療法之組合及其用途 |
| CN111479925B (zh) | 2017-10-12 | 2024-03-08 | 麦克马斯特大学 | 具有y182t突变的t细胞-抗原偶联物及其方法和用途 |
| MX2020005005A (es) | 2017-11-15 | 2020-08-27 | Adicet Bio Inc | Métodos para la expansión selectiva de poblaciones de células t gamma delta delta 3 y composiciones de estas. |
| CN108588023B (zh) | 2018-05-09 | 2020-02-14 | 河北森朗生物科技有限公司 | 一种生产嵌合抗原受体修饰的γδT细胞的方法 |
| US10640562B2 (en) | 2018-07-17 | 2020-05-05 | Mcmaster University | T cell-antigen coupler with various construct optimizations |
| AU2019344300A1 (en) * | 2018-09-19 | 2021-04-22 | LAVA Therapeutics N.V. | Dual acting CD1D immunoglobulin |
| CA3114292A1 (en) * | 2018-09-27 | 2020-04-02 | Phosphogam, Inc. | Methods and compositions for the expansion and use of allogeneic gamma/delta-t cells |
| SG11202103234RA (en) * | 2018-10-01 | 2021-04-29 | Adicet Bio Inc | COMPOSITIONS AND METHODS REGARDING ENGINEERED AND NON-ENGINEERED γδ -T CELLS FOR TREATMENT OF SOLID TUMORS |
| US20210388100A1 (en) | 2018-10-01 | 2021-12-16 | Adicet Bio, Inc. | Compositions and methods regarding engineered and non-engineered gamma delta t-cells for treatment of hematological tumors |
| GB201818243D0 (en) | 2018-11-08 | 2018-12-26 | Gammadelta Therapeutics Ltd | Methods for isolating and expanding cells |
| MA55903A (fr) * | 2019-05-08 | 2022-03-16 | Janssen Biotech Inc | Matières et méthodes pour moduler l'immunité médiée par les lymphocytes t |
| WO2021016652A1 (en) * | 2019-07-29 | 2021-02-04 | The University Of Melbourne | METHODS AND COMPOSITIONS FOR MONITORING, TREATING AND PREVENTING CMV INFECTION OR GRAFT REJECTION USING γδ T-CELLS |
| WO2021050789A1 (en) | 2019-09-10 | 2021-03-18 | Obsidian Therapeutics, Inc. | Ca2-il15 fusion proteins for tunable regulation |
| CA3168729A1 (en) * | 2020-02-24 | 2021-09-02 | Melinda MATA | Methods for expanding t cells for the treatment of cancer and related malignancies |
| CN111647070B (zh) * | 2020-06-17 | 2022-06-03 | 深圳豪石生物科技有限公司 | T细胞受体或其抗原结合片段及应用 |
| AU2022283819A1 (en) | 2021-06-01 | 2024-01-04 | Triumvira Immunologics Usa, Inc. | Claudin 18.2 t cell-antigen couplers and uses thereof |
| WO2023069322A1 (en) * | 2021-10-20 | 2023-04-27 | University Of Pittsburgh – Of The Commonwealth System Of Higher Education | Methods and materials for expanding tumor infiltrating gamma-delta t cells |
| EP4433068A4 (en) * | 2021-11-18 | 2025-11-12 | Univ Minnesota | LARGE-SCALE MULTIPLICATION OF MODIFIED HUMAN GAMMA T LYMPHOCYTES |
| EP4183871A1 (en) | 2021-11-23 | 2023-05-24 | Université d'Aix-Marseille | Process for preparing a composition comprising a combined cell population |
| KR20240149401A (ko) | 2022-02-16 | 2024-10-14 | 프리오테라 에스에이에스 | S1p 수용체 조정제와 조합된 car 세포를 이용한 치료 방법 |
| EP4504247A1 (en) * | 2022-04-04 | 2025-02-12 | Gammadelta Therapeutics Ltd | Novel gene armoring |
| CN114645022B (zh) * | 2022-05-13 | 2022-09-02 | 首都医科大学宣武医院 | 靶向CD5的CAR-γ δ T细胞及其制备方法与应用 |
| WO2025046256A1 (en) | 2023-08-31 | 2025-03-06 | Universite D'aix-Marseille | Process for preparing a composition comprising a combined cell population |
| CN118064364B (zh) * | 2024-04-19 | 2024-07-05 | 赛德特生物制药有限公司 | 一种γδT细胞的制备方法 |
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| JP2022521027A (ja) * | 2019-02-24 | 2022-04-04 | ガミダ セル リミテッド | 治療に使用する細胞組成物を生成するためのガンマ・デルタt細胞のホーミング及び保持の方法 |
| JP2024088717A (ja) * | 2019-02-24 | 2024-07-02 | ガミダ セル リミテッド | 治療に使用する細胞組成物を生成するためのガンマ・デルタt細胞のホーミング及び保持の方法 |
| JP7546582B2 (ja) | 2019-02-24 | 2024-09-06 | ガミダ セル リミテッド | 治療に使用する細胞組成物を生成するためのガンマ・デルタt細胞のホーミング及び保持の方法 |
| JP2023544240A (ja) * | 2020-08-12 | 2023-10-23 | ユニバーシティ オブ セントラル フロリダ リサーチ ファウンデーション,インコーポレイテッド | ガンマデルタt細胞を刺激するための方法及び組成物 |
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| Publication number | Publication date |
|---|---|
| US20160256487A1 (en) | 2016-09-08 |
| US20180200299A1 (en) | 2018-07-19 |
| KR20160068960A (ko) | 2016-06-15 |
| WO2015061694A3 (en) | 2015-06-18 |
| AU2014339926B2 (en) | 2018-02-08 |
| EP3060059A4 (en) | 2017-11-01 |
| AU2014339926A1 (en) | 2016-04-28 |
| CN105848484A (zh) | 2016-08-10 |
| WO2015061694A2 (en) | 2015-04-30 |
| EP3060059A2 (en) | 2016-08-31 |
| US9907820B2 (en) | 2018-03-06 |
| AU2018202976A1 (en) | 2018-05-31 |
| CA2926859A1 (en) | 2015-04-30 |
| AU2018202976B2 (en) | 2020-10-29 |
| US20210187028A1 (en) | 2021-06-24 |
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