JP2016539190A5 - - Google Patents
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- Publication number
- JP2016539190A5 JP2016539190A5 JP2016554939A JP2016554939A JP2016539190A5 JP 2016539190 A5 JP2016539190 A5 JP 2016539190A5 JP 2016554939 A JP2016554939 A JP 2016554939A JP 2016554939 A JP2016554939 A JP 2016554939A JP 2016539190 A5 JP2016539190 A5 JP 2016539190A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- formula
- group
- heteroarylene
- alkenylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361909236P | 2013-11-26 | 2013-11-26 | |
| US61/909,236 | 2013-11-26 | ||
| US201462002614P | 2014-05-23 | 2014-05-23 | |
| US62/002,614 | 2014-05-23 | ||
| PCT/IB2014/066300 WO2015079376A1 (en) | 2013-11-26 | 2014-11-24 | Methods for oxime conjugation to ketone-modified polypeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539190A JP2016539190A (ja) | 2016-12-15 |
| JP2016539190A5 true JP2016539190A5 (cg-RX-API-DMAC10.html) | 2018-01-18 |
| JP6609563B2 JP6609563B2 (ja) | 2019-11-20 |
Family
ID=52117931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016554939A Expired - Fee Related JP6609563B2 (ja) | 2013-11-26 | 2014-11-24 | ケトンで修飾されたポリペプチドをオキシム複合化する方法 |
Country Status (15)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013350802B2 (en) | 2012-11-30 | 2016-07-14 | Novartis Ag | Methods for making conjugates from disulfide-containing proteins |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| SG11201701565PA (en) | 2014-09-03 | 2017-03-30 | Immunogen Inc | Conjugates comprising cell-binding agents and cytotoxic agents |
| US20190194315A1 (en) | 2015-06-17 | 2019-06-27 | Novartis Ag | Antibody drug conjugates |
| WO2017051254A1 (en) * | 2015-09-25 | 2017-03-30 | Legochem Biosciences, Inc. | Compositions and methods related to anti-egfr antibody drug conjugates |
| WO2017055582A1 (en) | 2015-10-01 | 2017-04-06 | Novo Nordisk A/S | Protein conjugates |
| CR20180229A (es) | 2015-10-29 | 2018-08-24 | Novartis Ag | Conjugados de anticuerpos que comprenden un agonista del receptor tipo toll |
| HUE067016T2 (hu) | 2015-11-25 | 2024-09-28 | Ligachem Biosciences Inc | Önfeláldozó csoportokat tartalmazó konjugátumok és ezekkel kapcsolos eljárások |
| CN107847605B (zh) | 2015-11-25 | 2021-12-24 | 乐高化学生物科学股份有限公司 | 包含分支接头的抗体-药物缀合物及其相关方法 |
| KR102468989B1 (ko) * | 2016-11-18 | 2022-11-22 | 가고시마 유니버시티 | IgG 결합 펩타이드를 포함하는 고상 담체 및 IgG의 분리 방법 |
| JP7664680B2 (ja) | 2017-03-29 | 2025-04-18 | リガケム バイオサイエンシズ， インク． | ピロロベンゾジアゼピン二量体前駆体及びそのリガンド－リンカーコンジュゲート化合物 |
| AR111651A1 (es) | 2017-04-28 | 2019-08-07 | Novartis Ag | Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación |
| US11827703B2 (en) | 2018-05-09 | 2023-11-28 | Legochem Biosciences, Inc. | Compositions and methods related to anti-CD19 antibody drug conjugates |
| US12391939B2 (en) | 2018-07-23 | 2025-08-19 | The Governors Of The University Of Alberta | Genetically-encoded bicyclic peptide libraries |
| KR20210096115A (ko) * | 2018-11-28 | 2021-08-04 | 더 거버너스 오브 더 유니버시티 오브 알버타 | 약물작용 발생단이 내재된 유전자-암호화된 거대고리형 펩타이드 라이브러리 |
| KR20210028544A (ko) | 2019-09-04 | 2021-03-12 | 주식회사 레고켐 바이오사이언스 | 인간 ror1에 대한 항체를 포함하는 항체 약물 접합체 및 이의 용도 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6239110B1 (en) | 1990-02-22 | 2001-05-29 | W.R. Grace & Co. -Conn. | Synthetic analogs of thrombospondin and therapeutic use thereof |
| WO1999013062A1 (en) | 1997-09-09 | 1999-03-18 | Nycomed Imaging As | Factors vii fragments and analogs thereof and their use in the treatment of blood clotting disorders |
| WO1999013063A1 (en) | 1997-09-09 | 1999-03-18 | Nycomed Imaging As | Factor vii fragments and analogs thereof and their use in the treatment of blood clottng disorders |
| GB0316294D0 (en) * | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| US8673848B2 (en) | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
| WO2008157380A2 (en) | 2007-06-15 | 2008-12-24 | Adherex Technologies Inc. | Chemically modified cyclic peptides containing cell adhesion recognition (car) sequences and uses therefor |
| US20110172126A1 (en) | 2008-09-03 | 2011-07-14 | Xenome Ltd | Libraries of peptide conjugates and methods for making them |
| DK2889624T3 (en) | 2009-08-10 | 2018-12-10 | Ucl Business Plc | Reversible covalent bonding of functional molecules |
| SG11201502757QA (en) | 2012-10-09 | 2015-05-28 | Igenica Biotherapeutics Inc | Anti-c16orf54 antibodies and methods of use thereof |
| WO2014078623A2 (en) | 2012-11-15 | 2014-05-22 | Brandeis University | Tethering cysteine residues using cyclic disulfides |
| AU2013350802B2 (en) * | 2012-11-30 | 2016-07-14 | Novartis Ag | Methods for making conjugates from disulfide-containing proteins |
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2014
- 2014-11-24 ES ES14815051T patent/ES2729643T3/es active Active
- 2014-11-24 EA EA201691075A patent/EA201691075A1/ru unknown
- 2014-11-24 EP EP14815051.9A patent/EP3074048B1/en not_active Not-in-force
- 2014-11-24 AU AU2014356126A patent/AU2014356126B2/en not_active Ceased
- 2014-11-24 CN CN201480064270.7A patent/CN105764530B/zh not_active Expired - Fee Related
- 2014-11-24 US US14/551,187 patent/US10172948B2/en active Active
- 2014-11-24 JP JP2016554939A patent/JP6609563B2/ja not_active Expired - Fee Related
- 2014-11-24 CA CA2928087A patent/CA2928087A1/en not_active Abandoned
- 2014-11-24 WO PCT/IB2014/066300 patent/WO2015079376A1/en not_active Ceased
- 2014-11-24 MX MX2016006674A patent/MX2016006674A/es unknown
- 2014-11-24 KR KR1020167016645A patent/KR20160088429A/ko not_active Withdrawn
- 2014-11-25 UY UY0001035854A patent/UY35854A/es not_active Application Discontinuation
- 2014-11-25 TW TW103140861A patent/TWI572361B/zh not_active IP Right Cessation
-
2016
- 2016-04-15 ZA ZA2016/02603A patent/ZA201602603B/en unknown
- 2016-04-20 IL IL245244A patent/IL245244A0/en unknown