JP2016539179A5 - - Google Patents
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- Publication number
- JP2016539179A5 JP2016539179A5 JP2016546873A JP2016546873A JP2016539179A5 JP 2016539179 A5 JP2016539179 A5 JP 2016539179A5 JP 2016546873 A JP2016546873 A JP 2016546873A JP 2016546873 A JP2016546873 A JP 2016546873A JP 2016539179 A5 JP2016539179 A5 JP 2016539179A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pain
- composition according
- pharmaceutically acceptable
- inflammation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 206010061218 Inflammation Diseases 0.000 claims 6
- 208000002193 Pain Diseases 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 230000004054 inflammatory process Effects 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- DNQQWHOUZPHKMD-OWOJBTEDSA-N (e)-4-bromobut-2-enenitrile Chemical compound BrC\C=C\C#N DNQQWHOUZPHKMD-OWOJBTEDSA-N 0.000 claims 2
- MVQFRIPBGHQHPW-UHFFFAOYSA-N 4-methylsulfonylbut-2-enenitrile Chemical compound CS(=O)(=O)CC=CC#N MVQFRIPBGHQHPW-UHFFFAOYSA-N 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 2
- SJNALLRHIVGIBI-UHFFFAOYSA-N allyl cyanide Chemical compound C=CCC#N SJNALLRHIVGIBI-UHFFFAOYSA-N 0.000 claims 2
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 2
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 206010006811 Bursitis Diseases 0.000 claims 1
- 206010008685 Chondritis Diseases 0.000 claims 1
- 208000034656 Contusions Diseases 0.000 claims 1
- 206010015150 Erythema Diseases 0.000 claims 1
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 206010024453 Ligament sprain Diseases 0.000 claims 1
- 208000021642 Muscular disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010037779 Radiculopathy Diseases 0.000 claims 1
- 208000010040 Sprains and Strains Diseases 0.000 claims 1
- 235000019486 Sunflower oil Nutrition 0.000 claims 1
- 206010042674 Swelling Diseases 0.000 claims 1
- 208000000491 Tendinopathy Diseases 0.000 claims 1
- 208000023835 Tendon disease Diseases 0.000 claims 1
- 206010043255 Tendonitis Diseases 0.000 claims 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000003637 basic solution Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000009519 contusion Effects 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 1
- QQQMUBLXDAFBRH-UHFFFAOYSA-N dodecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)O QQQMUBLXDAFBRH-UHFFFAOYSA-N 0.000 claims 1
- 239000003974 emollient agent Substances 0.000 claims 1
- 210000003195 fascia Anatomy 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 210000003041 ligament Anatomy 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 229960003921 octisalate Drugs 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims 1
- 229960001860 salicylate Drugs 0.000 claims 1
- LYPGDCWPTHTUDO-UHFFFAOYSA-M sodium;methanesulfinate Chemical compound [Na+].CS([O-])=O LYPGDCWPTHTUDO-UHFFFAOYSA-M 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 229940031439 squalene Drugs 0.000 claims 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 1
- 239000002600 sunflower oil Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 201000004415 tendinitis Diseases 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical group CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361887776P | 2013-10-07 | 2013-10-07 | |
| US61/887,776 | 2013-10-07 | ||
| PCT/US2014/058685 WO2015054008A1 (en) | 2013-10-07 | 2014-10-01 | 4-methylsulfonyl-2-butenenitrile and its pharmaceutical use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539179A JP2016539179A (ja) | 2016-12-15 |
| JP2016539179A5 true JP2016539179A5 (https=) | 2017-10-26 |
| JP6426746B2 JP6426746B2 (ja) | 2018-11-21 |
Family
ID=52813515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016546873A Active JP6426746B2 (ja) | 2013-10-07 | 2014-10-01 | ４−メチルスルホニル−２−ブテンニトリル及びその医薬上の使用 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP3055286A4 (https=) |
| JP (1) | JP6426746B2 (https=) |
| CN (1) | CN105683158A (https=) |
| WO (1) | WO2015054008A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015094626A1 (en) * | 2013-12-20 | 2015-06-25 | The Procter & Gamble Company | Diaper with improved cuffs and comfort |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3444175A (en) * | 1966-11-09 | 1969-05-13 | Merck & Co Inc | Certain picolylmethyl sulfones |
| EP2651407B1 (en) * | 2010-12-15 | 2016-12-21 | Olatec Industries LLC | 3-methanesulfonylpropionitrile for treating inflammation and pain |
| JP6151723B2 (ja) * | 2012-02-27 | 2017-06-21 | オラテック セラピューティクス リミティド ライアビリティ カンパニー | ３−メチルスルホニルプロピオニトリルを調製するプロセス |
| WO2014043144A1 (en) * | 2012-09-11 | 2014-03-20 | Olatec Industries Llc | Methods for treating inflammation and pain |
-
2014
- 2014-10-01 EP EP14852179.2A patent/EP3055286A4/en not_active Withdrawn
- 2014-10-01 WO PCT/US2014/058685 patent/WO2015054008A1/en not_active Ceased
- 2014-10-01 JP JP2016546873A patent/JP6426746B2/ja active Active
- 2014-10-01 CN CN201480055104.0A patent/CN105683158A/zh active Pending
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