JP2016533331A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016533331A5 JP2016533331A5 JP2016516948A JP2016516948A JP2016533331A5 JP 2016533331 A5 JP2016533331 A5 JP 2016533331A5 JP 2016516948 A JP2016516948 A JP 2016516948A JP 2016516948 A JP2016516948 A JP 2016516948A JP 2016533331 A5 JP2016533331 A5 JP 2016533331A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- pain
- compound
- inflammation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 208000002193 Pain Diseases 0.000 claims 7
- 206010061218 Inflammation Diseases 0.000 claims 6
- 230000004054 inflammatory process Effects 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- FNONLYYCSYAMJF-UHFFFAOYSA-N 3,4-bis(benzylsulfonyl)butanenitrile Chemical compound C=1C=CC=CC=1CS(=O)(=O)CC(CC#N)S(=O)(=O)CC1=CC=CC=C1 FNONLYYCSYAMJF-UHFFFAOYSA-N 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 201000004624 Dermatitis Diseases 0.000 claims 2
- HQKDGTPKBPLIAK-UHFFFAOYSA-N N#CCC(CSCc1ccccc1)SCc1ccccc1 Chemical compound N#CCC(CSCc1ccccc1)SCc1ccccc1 HQKDGTPKBPLIAK-UHFFFAOYSA-N 0.000 claims 2
- SJNALLRHIVGIBI-UHFFFAOYSA-N allyl cyanide Chemical compound C=CCC#N SJNALLRHIVGIBI-UHFFFAOYSA-N 0.000 claims 2
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 2
- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 1
- DNQQWHOUZPHKMD-OWOJBTEDSA-N (e)-4-bromobut-2-enenitrile Chemical compound BrC\C=C\C#N DNQQWHOUZPHKMD-OWOJBTEDSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 206010006811 Bursitis Diseases 0.000 claims 1
- 206010008685 Chondritis Diseases 0.000 claims 1
- 208000034656 Contusions Diseases 0.000 claims 1
- 206010015150 Erythema Diseases 0.000 claims 1
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 206010024453 Ligament sprain Diseases 0.000 claims 1
- 208000021642 Muscular disease Diseases 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010037779 Radiculopathy Diseases 0.000 claims 1
- 208000010040 Sprains and Strains Diseases 0.000 claims 1
- 235000019486 Sunflower oil Nutrition 0.000 claims 1
- 206010042674 Swelling Diseases 0.000 claims 1
- 208000000491 Tendinopathy Diseases 0.000 claims 1
- 208000023835 Tendon disease Diseases 0.000 claims 1
- 206010043255 Tendonitis Diseases 0.000 claims 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- UENWRTRMUIOCKN-UHFFFAOYSA-N benzyl thiol Chemical compound SCC1=CC=CC=C1 UENWRTRMUIOCKN-UHFFFAOYSA-N 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000009519 contusion Effects 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 1
- QQQMUBLXDAFBRH-UHFFFAOYSA-N dodecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)O QQQMUBLXDAFBRH-UHFFFAOYSA-N 0.000 claims 1
- 239000003974 emollient agent Substances 0.000 claims 1
- 210000003195 fascia Anatomy 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 210000001503 joint Anatomy 0.000 claims 1
- 150000003903 lactic acid esters Chemical class 0.000 claims 1
- 210000003041 ligament Anatomy 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 229960003921 octisalate Drugs 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 150000002978 peroxides Chemical class 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims 1
- 229960001860 salicylate Drugs 0.000 claims 1
- -1 salts compound Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 229940031439 squalene Drugs 0.000 claims 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 1
- 239000002600 sunflower oil Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 201000004415 tendinitis Diseases 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical group CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361883129P | 2013-09-26 | 2013-09-26 | |
| US61/883,129 | 2013-09-26 | ||
| PCT/US2014/057521 WO2015048328A1 (en) | 2013-09-26 | 2014-09-25 | 3, 4-bis-benzylsulfonylbutanenitrile and its pharmaceutical use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016533331A JP2016533331A (ja) | 2016-10-27 |
| JP2016533331A5 true JP2016533331A5 (https=) | 2017-10-26 |
| JP6360163B2 JP6360163B2 (ja) | 2018-07-18 |
Family
ID=52744469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016516948A Active JP6360163B2 (ja) | 2013-09-26 | 2014-09-25 | ３，４−ビス−ベンジルスルホニルブタンニトリル及びその医薬上の使用 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP3048886B1 (https=) |
| JP (1) | JP6360163B2 (https=) |
| WO (1) | WO2015048328A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2948859B2 (ja) | 1990-04-11 | 1999-09-13 | 財団法人鉄道総合技術研究所 | 高速立体分岐装置 |
| CN106902105A (zh) * | 2017-03-13 | 2017-06-30 | 牡丹江医学院 | 一种用于运动损伤保护的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3166582A (en) * | 1961-07-24 | 1965-01-19 | Du Pont | 3-amino-2, 4 bis sulfonyl-crotononitriles and production thereof |
| US3792093A (en) * | 1972-04-21 | 1974-02-12 | Du Pont | Nitro ethyl sulfones |
| US5180852A (en) * | 1991-09-30 | 1993-01-19 | Phillips Petroleum Company | Preparation of bis(organothio) alkanes |
| KR0174117B1 (ko) * | 1995-12-28 | 1999-02-01 | 윤원영 | 새로운 세팔로스포린 유도체 및 그 제조방법 |
| EP2651407B1 (en) * | 2010-12-15 | 2016-12-21 | Olatec Industries LLC | 3-methanesulfonylpropionitrile for treating inflammation and pain |
-
2014
- 2014-09-25 WO PCT/US2014/057521 patent/WO2015048328A1/en not_active Ceased
- 2014-09-25 JP JP2016516948A patent/JP6360163B2/ja active Active
- 2014-09-25 EP EP14847818.3A patent/EP3048886B1/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014503533A5 (https=) | ||
| MA37762A1 (fr) | Composés n-aryltriazole utilisés comme antagonistes de lpar | |
| MA37764A1 (fr) | Composés n-alkyltriazole utilisés comme antagonistes de lpar | |
| JP2014114305A5 (https=) | ||
| EA201270824A1 (ru) | Соединения для уменьшения продукции бета-амилоида | |
| PH12017501029B1 (en) | Biaryl derivative as gpr120 agonist | |
| MX355742B (es) | Análogos deuterados del ácido 4-hidroxibutírico. | |
| JP2011509303A5 (https=) | ||
| EA201071298A1 (ru) | Соединение 3-аминокарбазола, фармацевтическая композиция, его содержащая, и способ их получения | |
| JP2015529657A5 (https=) | ||
| JP2016511753A5 (https=) | ||
| HRP20171587T1 (hr) | Spojevi, pripravci i postupci pogodni za mobilizaciju kolesterola | |
| JP2018537513A5 (https=) | ||
| JP2017222722A5 (https=) | ||
| CY1124710T1 (el) | Κετυλιωμενα λιπαρα οξεα, συστημα για την παρασκευη αυτων και χρηση αυτων | |
| MX2015016543A (es) | Derivados de biarilo como agonistas de gpr120. | |
| BR112013030264A2 (pt) | ácidos acéticos de benzociclohepteno | |
| JP2013523623A5 (https=) | ||
| BR112013018298A2 (pt) | compostos para a redução da produção de beta-amiloides | |
| RU2015130602A (ru) | Соли и кристаллические формы | |
| JP2016533331A5 (https=) | ||
| JP2016539179A5 (https=) | ||
| JP2016531878A5 (https=) | ||
| Ahmadi et al. | Synthesis and pharmacological evaluation of new chemical entities based on paracetamol and their ibuprofen conjugates as novel and superior analgesic and anti-inflammatory candidates | |
| AR101487A1 (es) | Formas cristalinas de un modulador de receptor de estrógeno |