JP2016539149A5 - - Google Patents
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- Publication number
- JP2016539149A5 JP2016539149A5 JP2016536539A JP2016536539A JP2016539149A5 JP 2016539149 A5 JP2016539149 A5 JP 2016539149A5 JP 2016536539 A JP2016536539 A JP 2016536539A JP 2016536539 A JP2016536539 A JP 2016536539A JP 2016539149 A5 JP2016539149 A5 JP 2016539149A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pharmaceutically acceptable
- compound
- acceptable salt
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 16
- 150000003839 salts Chemical class 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 238000004820 blood count Methods 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000000144 pharmacologic effect Effects 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 206010002388 Angina unstable Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010048610 Cardiotoxicity Diseases 0.000 claims 1
- 208000034656 Contusions Diseases 0.000 claims 1
- 208000012609 Cowden disease Diseases 0.000 claims 1
- 201000002847 Cowden syndrome Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 208000010201 Exanthema Diseases 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010028116 Mucosal inflammation Diseases 0.000 claims 1
- 201000010927 Mucositis Diseases 0.000 claims 1
- 208000008770 Multiple Hamartoma Syndrome Diseases 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 206010033733 Papule Diseases 0.000 claims 1
- 206010034972 Photosensitivity reaction Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000025371 Taste disease Diseases 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 208000034526 bruise Diseases 0.000 claims 1
- 231100000259 cardiotoxicity Toxicity 0.000 claims 1
- 201000002758 colorectal adenoma Diseases 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000006549 dyspepsia Diseases 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 206010016256 fatigue Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 230000009610 hypersensitivity Effects 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 230000005976 liver dysfunction Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000004235 neutropenia Diseases 0.000 claims 1
- 201000000235 ovarian squamous cell carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000036211 photosensitivity Effects 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 230000001953 sensory effect Effects 0.000 claims 1
- 201000010700 sporadic breast cancer Diseases 0.000 claims 1
- 208000003265 stomatitis Diseases 0.000 claims 1
- 235000019669 taste disorders Nutrition 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13306679 | 2013-12-06 | ||
| EP13306679.5 | 2013-12-06 | ||
| PCT/IB2014/066558 WO2015083101A1 (en) | 2013-12-06 | 2014-12-03 | Dosage regimen for an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016539149A JP2016539149A (ja) | 2016-12-15 |
| JP2016539149A5 true JP2016539149A5 (OSRAM) | 2017-12-28 |
Family
ID=49876516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536539A Pending JP2016539149A (ja) | 2013-12-06 | 2014-12-03 | アルファ−アイソフォーム選択的ホスファチジルイノシトール３−キナーゼ阻害剤の投薬レジメン |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20170000778A1 (OSRAM) |
| EP (2) | EP4000619A1 (OSRAM) |
| JP (1) | JP2016539149A (OSRAM) |
| KR (1) | KR20160095035A (OSRAM) |
| CN (1) | CN105979947A (OSRAM) |
| AU (2) | AU2014358773A1 (OSRAM) |
| BR (1) | BR112016011811A2 (OSRAM) |
| CA (1) | CA2930359C (OSRAM) |
| CL (1) | CL2016001361A1 (OSRAM) |
| DK (1) | DK3076969T3 (OSRAM) |
| ES (1) | ES2899167T3 (OSRAM) |
| HU (1) | HUE057092T2 (OSRAM) |
| IL (1) | IL245709B (OSRAM) |
| MX (1) | MX378409B (OSRAM) |
| PH (1) | PH12016501026A1 (OSRAM) |
| PL (1) | PL3076969T3 (OSRAM) |
| PT (1) | PT3076969T (OSRAM) |
| RU (1) | RU2680246C1 (OSRAM) |
| SI (1) | SI3076969T1 (OSRAM) |
| TN (1) | TN2016000179A1 (OSRAM) |
| TW (1) | TWI666019B (OSRAM) |
| WO (1) | WO2015083101A1 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018005298A (es) * | 2015-11-02 | 2018-06-22 | Novartis Ag | Regimen de dosificacion para un inhibidor de fosfatidilinositol 3-quinasa. |
| WO2018060833A1 (en) * | 2016-09-27 | 2018-04-05 | Novartis Ag | Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib |
| GB202010627D0 (en) * | 2020-07-10 | 2020-08-26 | Qbd (Qs-Ip) Ltd | Blocking method |
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| JPS6041077B2 (ja) | 1976-09-06 | 1985-09-13 | 喜徳 喜谷 | １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体 |
| US4323581A (en) | 1978-07-31 | 1982-04-06 | Johnson & Johnson | Method of treating carcinogenesis |
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| US4929624A (en) | 1989-03-23 | 1990-05-29 | Minnesota Mining And Manufacturing Company | Olefinic 1H-imidazo(4,5-c)quinolin-4-amines |
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| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
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| US5621100A (en) | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
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| ATE280180T1 (de) | 1992-08-31 | 2004-11-15 | Ludwig Inst Cancer Res | Vom mage-3-gen abgeleitetes und von hla-a1 präsentiertes, isoliertes nonapeptid und dessen anwendungen |
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| CN103285395A (zh) * | 2005-02-18 | 2013-09-11 | 阿布拉科斯生物科学有限公司 | 治疗剂的组合和给予方式以及联合治疗 |
| UA104147C2 (uk) * | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| CN105412105A (zh) * | 2010-11-08 | 2016-03-23 | 诺华有限公司 | 2-甲酰胺环氨基尿素衍生物在治疗egfr依赖性疾病或对靶向egfr家族成员的药剂有获得性耐受性的疾病中的应用 |
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| EP2601965A1 (en) * | 2011-12-06 | 2013-06-12 | Apeiron Biologics AG | Compositions for preventing or treating adverse reactions of EGFR inhibition |
| SG10201608469RA (en) * | 2012-05-16 | 2016-11-29 | Novartis Ag | Dosage regimen for a pi-3 kinase inhibitor |
-
2014
- 2014-12-03 PL PL14812658T patent/PL3076969T3/pl unknown
- 2014-12-03 JP JP2016536539A patent/JP2016539149A/ja active Pending
- 2014-12-03 CA CA2930359A patent/CA2930359C/en active Active
- 2014-12-03 CN CN201480074816.7A patent/CN105979947A/zh active Pending
- 2014-12-03 ES ES14812658T patent/ES2899167T3/es active Active
- 2014-12-03 BR BR112016011811A patent/BR112016011811A2/pt not_active Application Discontinuation
- 2014-12-03 EP EP21193406.2A patent/EP4000619A1/en not_active Withdrawn
- 2014-12-03 RU RU2016126716A patent/RU2680246C1/ru active
- 2014-12-03 TN TN2016000179A patent/TN2016000179A1/en unknown
- 2014-12-03 PT PT148126584T patent/PT3076969T/pt unknown
- 2014-12-03 KR KR1020167017707A patent/KR20160095035A/ko not_active Ceased
- 2014-12-03 US US15/101,155 patent/US20170000778A1/en not_active Abandoned
- 2014-12-03 MX MX2016007376A patent/MX378409B/es unknown
- 2014-12-03 SI SI201431901T patent/SI3076969T1/sl unknown
- 2014-12-03 HU HUE14812658A patent/HUE057092T2/hu unknown
- 2014-12-03 DK DK14812658.4T patent/DK3076969T3/da active
- 2014-12-03 EP EP14812658.4A patent/EP3076969B1/en not_active Revoked
- 2014-12-03 AU AU2014358773A patent/AU2014358773A1/en not_active Abandoned
- 2014-12-03 WO PCT/IB2014/066558 patent/WO2015083101A1/en not_active Ceased
- 2014-12-05 TW TW103142503A patent/TWI666019B/zh not_active IP Right Cessation
-
2016
- 2016-05-18 IL IL245709A patent/IL245709B/en active IP Right Grant
- 2016-05-31 PH PH12016501026A patent/PH12016501026A1/en unknown
- 2016-06-03 CL CL2016001361A patent/CL2016001361A1/es unknown
-
2017
- 2017-09-29 US US15/719,636 patent/US10434092B2/en not_active Expired - Fee Related
- 2017-10-09 AU AU2017245292A patent/AU2017245292B2/en not_active Ceased
-
2019
- 2019-08-29 US US16/556,111 patent/US20200069670A1/en not_active Abandoned
-
2020
- 2020-11-25 US US17/105,453 patent/US20210196696A1/en not_active Abandoned
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