JP2016538307A - チエノトリアゾロジアゼピン化合物を含む医薬製剤を使用する非小細胞肺癌の治療方法 - Google Patents

チエノトリアゾロジアゼピン化合物を含む医薬製剤を使用する非小細胞肺癌の治療方法 Download PDF

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JP2016538307A
JP2016538307A JP2016534953A JP2016534953A JP2016538307A JP 2016538307 A JP2016538307 A JP 2016538307A JP 2016534953 A JP2016534953 A JP 2016534953A JP 2016534953 A JP2016534953 A JP 2016534953A JP 2016538307 A JP2016538307 A JP 2016538307A
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compound
carbon atoms
solid dispersion
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thienotriazolodiazepine compound
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JP2016538307A5 (enExample
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イー． リベイロ、マリア
イー． リベイロ、マリア
レイモンド、エリック
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オンコエシックス ゲーエムベーハー
オンコエシックス ゲーエムベーハー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
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    • A61K9/1605—Excipients; Inactive ingredients
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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    • A61K9/4841—Filling excipients; Inactive ingredients
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    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
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  • Bioinformatics & Cheminformatics (AREA)
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  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016534953A 2013-11-27 2014-11-26 チエノトリアゾロジアゼピン化合物を含む医薬製剤を使用する非小細胞肺癌の治療方法 Pending JP2016538307A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361909599P 2013-11-27 2013-11-27
US61/909,599 2013-11-27
US201462012042P 2014-06-13 2014-06-13
US62/012,042 2014-06-13
US201462080779P 2014-11-17 2014-11-17
US62/080,779 2014-11-17
PCT/EP2014/075707 WO2015078928A1 (en) 2013-11-27 2014-11-26 Method of treating non-small-cell lung cancer using pharmaceutical formulation containing thienotriazolodiazepine compounds

Publications (2)

Publication Number Publication Date
JP2016538307A true JP2016538307A (ja) 2016-12-08
JP2016538307A5 JP2016538307A5 (enExample) 2018-01-11

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JP2016534953A Pending JP2016538307A (ja) 2013-11-27 2014-11-26 チエノトリアゾロジアゼピン化合物を含む医薬製剤を使用する非小細胞肺癌の治療方法

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US (1) US9820992B2 (enExample)
EP (1) EP3074019A1 (enExample)
JP (1) JP2016538307A (enExample)
KR (1) KR20160079822A (enExample)
CN (1) CN105813643A (enExample)
WO (1) WO2015078928A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018221679A1 (ja) * 2017-05-31 2018-12-06 あゆみ製薬株式会社 ６Ｈ－チエノ［２，３－ｅ］［１，２，４］トリアゾロ［３，４－ｃ］［１，２，４］トリアゼピン誘導体

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JP2017514907A (ja) * 2014-05-02 2017-06-08 オンコエシックス ゲーエムベーハー チエノトリアゾロジアゼピン化合物を用いる耐性非ホジキンリンパ腫、髄芽腫及び／又はａｌｋ＋非小細胞肺癌の治療方法
CA2951211A1 (en) 2014-06-13 2015-12-17 Oncoethix Gmbh Method of treating non-small cell lung cancer and/or small cell lung cancer using thienotriazolodiazepine compounds
EP4351560A4 (en) 2021-06-08 2025-06-04 The Regents of the University of California ANTI-CANCER COMPOUNDS
US12527741B2 (en) 2021-06-17 2026-01-20 Wisconsin Alumni Research Foundation Modular dendron micelles for treatment of pulmonary diseases related to fibrosis and viral infection including COVID-19

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WO2009084693A1 (ja) * 2007-12-28 2009-07-09 Mitsubishi Tanabe Pharma Corporation 抗癌剤
JP4875277B2 (ja) * 2000-06-16 2012-02-15 田辺三菱製薬株式会社 放出ｐＨ域及び／又は速度制御組成物
WO2012068339A2 (en) * 2010-11-17 2012-05-24 Glaxosmithkline Llc Methods of treating cancer
WO2013074518A1 (en) * 2011-11-14 2013-05-23 Tesaro, Inc. Modulating certain tyrosine kinases

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DE102011082013A1 (de) 2011-09-01 2013-03-07 Bayer Pharma AG 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
WO2013071056A2 (en) 2011-11-11 2013-05-16 Duke University Combination drug therapy for the treatment of solid tumors
EP2620140A1 (en) * 2012-01-26 2013-07-31 ratiopharm GmbH Crizotinib containing compositions
CN103305625B (zh) * 2013-07-08 2014-06-25 广东省人民医院 检测非小细胞肺癌驱动基因突变谱的方法及试剂盒与应用

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JP4875277B2 (ja) * 2000-06-16 2012-02-15 田辺三菱製薬株式会社 放出ｐＨ域及び／又は速度制御組成物
WO2009084693A1 (ja) * 2007-12-28 2009-07-09 Mitsubishi Tanabe Pharma Corporation 抗癌剤
WO2012068339A2 (en) * 2010-11-17 2012-05-24 Glaxosmithkline Llc Methods of treating cancer
WO2013074518A1 (en) * 2011-11-14 2013-05-23 Tesaro, Inc. Modulating certain tyrosine kinases

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HUM. MUTAT., vol. Vol.30(8), JPN6018028548, 2009, pages 1199 - 1206, ISSN: 0004195554 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018221679A1 (ja) * 2017-05-31 2018-12-06 あゆみ製薬株式会社 ６Ｈ－チエノ［２，３－ｅ］［１，２，４］トリアゾロ［３，４－ｃ］［１，２，４］トリアゼピン誘導体
JP6494886B1 (ja) * 2017-05-31 2019-04-03 あゆみ製薬株式会社 ６Ｈ−チエノ［２，３−ｅ］［１，２，４］トリアゾロ［３，４−ｃ］［１，２，４］トリアゼピン誘導体
US11186588B2 (en) 2017-05-31 2021-11-30 Ayumi Pharmaceutical Corporation 6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivative

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EP3074019A1 (en) 2016-10-05
KR20160079822A (ko) 2016-07-06
CN105813643A (zh) 2016-07-27
US9820992B2 (en) 2017-11-21
US20160375032A1 (en) 2016-12-29
WO2015078928A1 (en) 2015-06-04

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