JP2016538306A - 複素環化合物及びその使用方法 - Google Patents

複素環化合物及びその使用方法 Download PDF

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JP2016538306A
JP2016538306A JP2016534890A JP2016534890A JP2016538306A JP 2016538306 A JP2016538306 A JP 2016538306A JP 2016534890 A JP2016534890 A JP 2016534890A JP 2016534890 A JP2016534890 A JP 2016534890A JP 2016538306 A JP2016538306 A JP 2016538306A
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aryl
alkyl
compound
stereoisomer
independently
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JP2016538306A5 (enExample
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ジェイク リャン、ツァンヤン
ジェイク リャン、ツァンヤン
フェレール、マーク
ヘ、シャンシャン
フ、シン
フ、ゾンイ
ホセ マルガン、ファン
ホセ マルガン、ファン
テレンス サウソール、ノエル
テレンス サウソール、ノエル
シャオ、ジンボ
チェン、ウェイ
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Government of the United States of America
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Publication of JP2016538306A publication Critical patent/JP2016538306A/ja
Publication of JP2016538306A5 publication Critical patent/JP2016538306A5/ja
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200094141A (ko) * 2017-10-27 2020-08-06 트랜스퓨전 헬스, 엘엘씨 플루오렌의 유도체를 이용하여 증대된 조혈 줄기 세포를 제조하는 조성물 및 방법

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3150616T1 (sl) * 2012-11-16 2017-08-31 University College Cardiff Consultants Limited Mešanica rp/sp gemcitabin-(fenil-(benziloksi-l-alaninil))-fosfata
CN106727574B (zh) * 2016-12-28 2019-05-03 中国科学院武汉病毒研究所 马尼地平在制备治疗黄病毒科病毒感染药物中的应用
US12187687B2 (en) 2017-06-26 2025-01-07 University Of Virginia Patent Foundation Compositions and uses thereof
CN113549092B (zh) * 2020-04-23 2022-10-18 山东轩竹医药科技有限公司 三并环类激酶抑制剂
CN116023395B (zh) * 2021-10-25 2025-07-15 山东轩竹医药科技有限公司 三环类激酶抑制剂的晶型
WO2023122260A2 (en) * 2021-12-22 2023-06-29 The Texas A&M University System Inhibitors of sars-cov-2

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154078C (da) * 1981-02-06 1989-05-22 Ucb Sa Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf
GB8914040D0 (en) * 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
EP0979231B1 (en) * 1997-04-25 2004-11-24 Takeda Chemical Industries, Ltd. Condensed pyridazine derivatives, their production and use
MXPA02008770A (es) * 2000-03-06 2004-09-10 Acadia Pharm Inc Compuestos azaciclicos para uso en el tratamiento de enfermedades relacionadas con la serotonina.
US6977301B1 (en) * 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
TW200831105A (en) * 2006-12-14 2008-08-01 Astrazeneca Ab Novel compounds
AU2008226791B2 (en) * 2007-03-12 2014-01-16 Nektar Therapeutics Oligomer-antihistamine conjugates
US20110172425A1 (en) * 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
WO2010101649A2 (en) * 2009-03-05 2010-09-10 Pablo Gastaminza Sigma 1 receptor inhibition as a novel therapeutical approach against hepatitis c virus infection
CA2874998A1 (en) * 2011-05-27 2012-12-06 Cytocure Llc Methods, compositions, and kits for the treatment of cancer
SG11201506385WA (en) * 2013-03-18 2015-10-29 Genoscience Pharma Quinolines derivatives as novel anticancer agents

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200094141A (ko) * 2017-10-27 2020-08-06 트랜스퓨전 헬스, 엘엘씨 플루오렌의 유도체를 이용하여 증대된 조혈 줄기 세포를 제조하는 조성물 및 방법
JP2021501198A (ja) * 2017-10-27 2021-01-14 トランスフュージョン ヘルス，リミティド ライアビリティ カンパニー フルオレンの誘導体を用いて造血幹細胞を増殖する組成物および方法
KR102770289B1 (ko) * 2017-10-27 2025-02-19 이뮨브리지 인코포레이티드 플루오렌의 유도체를 이용하여 증대된 조혈 줄기 세포를 제조하는 조성물 및 방법
AU2018354418B2 (en) * 2017-10-27 2025-09-11 Immunebridge Inc. Compositions and methods of making expanded hematopoietic stem cells using derivatives of fluorene

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CN106029060A (zh) 2016-10-12
CA2931804A1 (en) 2015-06-04
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