JP2016537414A - 心臓神経堤細胞、及びその使用方法 - Google Patents
心臓神経堤細胞、及びその使用方法 Download PDFInfo
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- JP2016537414A JP2016537414A JP2016552222A JP2016552222A JP2016537414A JP 2016537414 A JP2016537414 A JP 2016537414A JP 2016552222 A JP2016552222 A JP 2016552222A JP 2016552222 A JP2016552222 A JP 2016552222A JP 2016537414 A JP2016537414 A JP 2016537414A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
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- C12N2500/00—Specific components of cell culture medium
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- C12N2500/38—Vitamins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1329—Cardiomyocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Developmental Biology & Embryology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361896945P | 2013-10-29 | 2013-10-29 | |
| US61/896,945 | 2013-10-29 | ||
| PCT/US2014/062939 WO2015066197A2 (en) | 2013-10-29 | 2014-10-29 | Cardiac neural crest cells and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019000020A Division JP6832049B2 (ja) | 2013-10-29 | 2019-01-04 | 心臓神経堤細胞、及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016537414A true JP2016537414A (ja) | 2016-12-01 |
| JP2016537414A5 JP2016537414A5 (enExample) | 2017-12-14 |
Family
ID=53005371
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552222A Pending JP2016537414A (ja) | 2013-10-29 | 2014-10-29 | 心臓神経堤細胞、及びその使用方法 |
| JP2019000020A Expired - Fee Related JP6832049B2 (ja) | 2013-10-29 | 2019-01-04 | 心臓神経堤細胞、及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019000020A Expired - Fee Related JP6832049B2 (ja) | 2013-10-29 | 2019-01-04 | 心臓神経堤細胞、及びその使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US10786536B2 (enExample) |
| EP (1) | EP3063267A4 (enExample) |
| JP (2) | JP2016537414A (enExample) |
| WO (1) | WO2015066197A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019049957A1 (ja) * | 2017-09-08 | 2019-03-14 | 株式会社大塚製薬工場 | 幼若ブタ由来幹細胞およびその調製方法 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9962409B2 (en) | 2007-10-01 | 2018-05-08 | Vestion, Inc. | Therapy using cardiac stem cells and mesenchymal stem cells |
| US10653650B2 (en) | 2011-12-13 | 2020-05-19 | Io Therapeutics, Inc. | Treatment of diseases by concurrently eliciting remyelination effects and immunomodulatory effects using selective RXR agonists |
| CN104114171A (zh) | 2011-12-13 | 2014-10-22 | Io治疗公司 | 使用rxr激动剂的自身免疫紊乱的治疗 |
| ES2824165T3 (es) | 2012-11-30 | 2021-05-11 | Vestion Inc | Células madre cardíacas y métodos de identificación y uso de las mismas |
| EP3426302B1 (en) | 2016-03-10 | 2022-12-14 | IO Therapeutics, Inc. | Treatment of autoimmune diseases with combinations of rxr agonists and thyroid hormones |
| DK3426303T3 (da) * | 2016-03-10 | 2022-09-19 | Io Therapeutics Inc | Behandling af muskellidelser med kombinationer af rxr-agonister og thyroideahormoner |
| EP3684348A4 (en) | 2017-09-20 | 2021-08-18 | IO Therapeutics, Inc. | TREATMENT OF DISEASE WITH SELECTIVE RXR AGONIST ESTERS |
| BR112020010539A2 (pt) | 2017-11-30 | 2020-11-17 | Kyoto University | métodos para produção e para proliferação de células da crista neural, para produção de células nervosas, células da glia, células estromais mesenquimais, células ósseas, condrócitos, células da córnea ou células pigmentares e para cultivar células da crista neural, meio, estoque congelado, e, uso de um meio |
| CN108300722A (zh) * | 2018-02-11 | 2018-07-20 | 南京市妇幼保健院 | 用于检测先天性心脏病的基因panel及应用 |
| CN110652515A (zh) * | 2018-06-29 | 2020-01-07 | 中国科学院深圳先进技术研究院 | AMPK抑制剂Compound C在治疗肿瘤药物中的应用 |
| WO2022020794A1 (en) * | 2020-07-24 | 2022-01-27 | The Scripps Research Institute | Compositions comprising neural crest cell derivatives and uses thereof |
| JP2024543621A (ja) | 2021-12-07 | 2024-11-21 | アイオー セラピューティクス インコーポレイテッド | Her2+がんの治療におけるrxrアゴニストおよびタキサンの使用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005033298A1 (ja) * | 2003-10-03 | 2005-04-14 | Keiichi Fukuda | 幹細胞から心筋細胞を分化誘導する方法 |
| US20120034595A1 (en) * | 2006-11-07 | 2012-02-09 | Keck Graduate Institute | Enriched stem cell and progenitor cell populations, and methods of producing and using such populations |
| JP2013531497A (ja) * | 2010-06-13 | 2013-08-08 | インスティチュート・オブ・バイオフィジックス,チャイニーズ・アカデミー・オブ・サイエンシズ | 幹細胞から心筋細胞を調製するための方法および組成物ならびにその使用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1007631T4 (da) | 1997-07-14 | 2009-04-27 | Osiris Therapeutics Inc | Hjertemuskelregeneration ved anvendelse af mesenkymale stamceller |
| US6821740B2 (en) | 1998-02-25 | 2004-11-23 | Becton, Dickinson And Company | Flow cytometric methods for the concurrent detection of discrete functional conformations of PRB in single cells |
| AU5545499A (en) | 1998-07-31 | 2000-02-21 | Genzyme Corporation | Improvement of cardiac function by mesenchymal stem cell transplantation |
| US8075881B2 (en) | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
| US7547674B2 (en) | 2001-06-06 | 2009-06-16 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US6930222B2 (en) | 2000-08-22 | 2005-08-16 | The Scripps Research Institute | In vivo animal model of human leukemia |
| AU2003270051A1 (en) | 2002-08-29 | 2004-03-19 | Baylor College Of Medicine | Heart derived cells for cardiac repair |
| CA2528869A1 (en) | 2003-06-12 | 2004-12-23 | Regents Of The University Of Minnesota | Directing cells to target tissues or organs |
| US7082573B2 (en) | 2003-07-30 | 2006-07-25 | America Online, Inc. | Method and system for managing digital assets |
| DE602004024125D1 (de) | 2003-12-25 | 2009-12-24 | Kanazawa University Technology | Induktion einer myokardzelle unter verwendung einer säuger-knochenmarkzelle oder aus nabelschnurblut stammenden zelle und fettgewebe |
| WO2006039630A2 (en) | 2004-10-02 | 2006-04-13 | Indiana University Research & Technology Corporation | Materials and methods for identifying compounds that modulate the cell cycle |
| WO2008054819A2 (en) | 2006-11-02 | 2008-05-08 | The General Hospital Corporation | Cardiovascular stem cells, methods for stem cell isolation, and uses thereof |
| US9962409B2 (en) | 2007-10-01 | 2018-05-08 | Vestion, Inc. | Therapy using cardiac stem cells and mesenchymal stem cells |
| WO2009073618A2 (en) * | 2007-11-30 | 2009-06-11 | New York Medical College | Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure |
| US8512696B2 (en) | 2007-11-30 | 2013-08-20 | Autologous, Llc | Methods of isolating non-senescent cardiac stem cells and uses thereof |
| EP3399026B1 (en) * | 2010-06-14 | 2024-06-26 | The Scripps Research Institute | Reprogramming of cells to a new fate |
| EP2750509B1 (en) * | 2011-08-30 | 2016-12-28 | The J. David Gladstone Institutes | Methods for generating cardiomyocytes |
| US20140162366A1 (en) * | 2012-08-31 | 2014-06-12 | Salk Institute For Biological Studies | Generation of vascular progenitor cells |
| ES2824165T3 (es) | 2012-11-30 | 2021-05-11 | Vestion Inc | Células madre cardíacas y métodos de identificación y uso de las mismas |
| US11377639B2 (en) * | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
-
2014
- 2014-10-29 EP EP14858818.9A patent/EP3063267A4/en not_active Ceased
- 2014-10-29 US US15/032,965 patent/US10786536B2/en active Active - Reinstated
- 2014-10-29 JP JP2016552222A patent/JP2016537414A/ja active Pending
- 2014-10-29 WO PCT/US2014/062939 patent/WO2015066197A2/en not_active Ceased
-
2019
- 2019-01-04 JP JP2019000020A patent/JP6832049B2/ja not_active Expired - Fee Related
-
2020
- 2020-09-28 US US17/034,883 patent/US20210260133A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005033298A1 (ja) * | 2003-10-03 | 2005-04-14 | Keiichi Fukuda | 幹細胞から心筋細胞を分化誘導する方法 |
| US20120034595A1 (en) * | 2006-11-07 | 2012-02-09 | Keck Graduate Institute | Enriched stem cell and progenitor cell populations, and methods of producing and using such populations |
| JP2013531497A (ja) * | 2010-06-13 | 2013-08-08 | インスティチュート・オブ・バイオフィジックス,チャイニーズ・アカデミー・オブ・サイエンシズ | 幹細胞から心筋細胞を調製するための方法および組成物ならびにその使用 |
Non-Patent Citations (5)
| Title |
|---|
| ARTERIOSCLER. THROMB. VASC. BIOL., vol. 31, JPN6018024316, 2011, pages 582 - 589, ISSN: 0003991827 * |
| J. CELL BIOL., vol. 170, no. 7, JPN6018024321, 2005, pages 1135 - 1146, ISSN: 0003991830 * |
| NATURE PROTOCOLS, vol. 5, no. 4, JPN6018024323, 2010, pages 688 - 701, ISSN: 0003991831 * |
| STEM CELLS TRANSL. MED., vol. 1, JPN6018024318, 2012, pages 116 - 124, ISSN: 0003991828 * |
| 田村 雄一 YUICHI TAMURA: "心臓の再生 The review of basic studies abollt the cardiac stem cell and regenerative medicine", 日本臨牀, vol. 66, no. 5, JPN6018024319, 2008, pages 908 - 914, ISSN: 0003991829 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019049957A1 (ja) * | 2017-09-08 | 2019-03-14 | 株式会社大塚製薬工場 | 幼若ブタ由来幹細胞およびその調製方法 |
| JPWO2019049957A1 (ja) * | 2017-09-08 | 2020-10-15 | 株式会社大塚製薬工場 | 幼若ブタ由来幹細胞およびその調製方法 |
| JP7628691B2 (ja) | 2017-09-08 | 2025-02-12 | 株式会社大塚製薬工場 | 幼若ブタ由来幹細胞およびその調製方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6832049B2 (ja) | 2021-02-24 |
| WO2015066197A3 (en) | 2015-09-11 |
| US10786536B2 (en) | 2020-09-29 |
| US20210260133A1 (en) | 2021-08-26 |
| EP3063267A4 (en) | 2017-10-18 |
| EP3063267A2 (en) | 2016-09-07 |
| JP2019077701A (ja) | 2019-05-23 |
| WO2015066197A2 (en) | 2015-05-07 |
| US20160250261A1 (en) | 2016-09-01 |
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