JP2016535758A5 - - Google Patents
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- Publication number
- JP2016535758A5 JP2016535758A5 JP2016534884A JP2016534884A JP2016535758A5 JP 2016535758 A5 JP2016535758 A5 JP 2016535758A5 JP 2016534884 A JP2016534884 A JP 2016534884A JP 2016534884 A JP2016534884 A JP 2016534884A JP 2016535758 A5 JP2016535758 A5 JP 2016535758A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- conh
- haloalkyl
- con
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 46
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 239000001257 hydrogen Substances 0.000 claims 23
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 19
- 229910052736 halogen Inorganic materials 0.000 claims 19
- 150000002367 halogens Chemical class 0.000 claims 19
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 16
- 125000001072 heteroaryl group Chemical group 0.000 claims 15
- 125000000623 heterocyclic group Chemical group 0.000 claims 13
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- -1 4 , 4-difluoro-3-hydroxy-1- (hydroxyamino) -2,3-dimethyl-1-oxobutan-2-yl Chemical group 0.000 claims 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 3
- 241001673062 Achromobacter xylosoxidans Species 0.000 claims 2
- 241000589291 Acinetobacter Species 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 241000589513 Burkholderia cepacia Species 0.000 claims 2
- 241000607473 Edwardsiella <enterobacteria> Species 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 2
- 241000122973 Stenotrophomonas maltophilia Species 0.000 claims 2
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims 2
- 208000027096 gram-negative bacterial infections Diseases 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 241001453380 Burkholderia Species 0.000 claims 1
- 241000722910 Burkholderia mallei Species 0.000 claims 1
- 241001136175 Burkholderia pseudomallei Species 0.000 claims 1
- 241000589875 Campylobacter jejuni Species 0.000 claims 1
- 241000606161 Chlamydia Species 0.000 claims 1
- 241000606153 Chlamydia trachomatis Species 0.000 claims 1
- 241000588923 Citrobacter Species 0.000 claims 1
- 241000606678 Coxiella burnetii Species 0.000 claims 1
- 241000588914 Enterobacter Species 0.000 claims 1
- 241000588697 Enterobacter cloacae Species 0.000 claims 1
- 241000305071 Enterobacterales Species 0.000 claims 1
- 241000588921 Enterobacteriaceae Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000589602 Francisella tularensis Species 0.000 claims 1
- 241000606790 Haemophilus Species 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 241000588915 Klebsiella aerogenes Species 0.000 claims 1
- 241000588655 Moraxella catarrhalis Species 0.000 claims 1
- 241000588771 Morganella <proteobacterium> Species 0.000 claims 1
- 241000588653 Neisseria Species 0.000 claims 1
- 241000282376 Panthera tigris Species 0.000 claims 1
- 241000588769 Proteus <enterobacteria> Species 0.000 claims 1
- 241000588768 Providencia Species 0.000 claims 1
- 241000606697 Rickettsia prowazekii Species 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000607720 Serratia Species 0.000 claims 1
- 241000607768 Shigella Species 0.000 claims 1
- 241000607479 Yersinia pestis Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 229940074375 burkholderia mallei Drugs 0.000 claims 1
- 229940038705 chlamydia trachomatis Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940092559 enterobacter aerogenes Drugs 0.000 claims 1
- 229940118764 francisella tularensis Drugs 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940046939 rickettsia prowazekii Drugs 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 0 *C(*)(C(*=*ICC#C*I)=**)N(*)* Chemical compound *C(*)(C(*=*ICC#C*I)=**)N(*)* 0.000 description 1
- VHZYAZSJQQFLNK-UHFFFAOYSA-N CC(C(C)(C)C(NO)=O)O Chemical compound CC(C(C)(C)C(NO)=O)O VHZYAZSJQQFLNK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361866823P | 2013-08-16 | 2013-08-16 | |
| US61/866,823 | 2013-08-16 | ||
| US201361867933P | 2013-08-20 | 2013-08-20 | |
| US61/867,933 | 2013-08-20 | ||
| PCT/US2014/051459 WO2015024010A2 (en) | 2013-08-16 | 2014-08-18 | Substituted hydroxamic acid compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018224004A Division JP2019077688A (ja) | 2013-08-16 | 2018-11-29 | 置換されたヒドロキサム酸化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016535758A JP2016535758A (ja) | 2016-11-17 |
| JP2016535758A5 true JP2016535758A5 (OSRAM) | 2017-09-28 |
| JP6458270B2 JP6458270B2 (ja) | 2019-01-30 |
Family
ID=52468825
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016534884A Expired - Fee Related JP6458270B2 (ja) | 2013-08-16 | 2014-08-18 | 置換されたヒドロキサム酸化合物 |
| JP2018224004A Pending JP2019077688A (ja) | 2013-08-16 | 2018-11-29 | 置換されたヒドロキサム酸化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018224004A Pending JP2019077688A (ja) | 2013-08-16 | 2018-11-29 | 置換されたヒドロキサム酸化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10647664B2 (OSRAM) |
| EP (1) | EP3041354A4 (OSRAM) |
| JP (2) | JP6458270B2 (OSRAM) |
| AU (1) | AU2014306451B2 (OSRAM) |
| CA (1) | CA2921427A1 (OSRAM) |
| WO (1) | WO2015024010A2 (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014306451B2 (en) * | 2013-08-16 | 2019-01-17 | Duke University | Substituted hydroxamic acid compounds |
| KR20170005105A (ko) | 2014-05-16 | 2017-01-11 | 액테리온 파마슈티칼 리미티드 | 항균성 퀴나졸린-４(３ｈ)-온 유도체 |
| EP3374350B1 (en) | 2015-11-09 | 2022-01-05 | Forge Therapeutics, Inc. | Hydroxypyridinone and hydroxypyrimidinone based compounds for treating bacterial infections |
| EP3374355A4 (en) | 2015-11-09 | 2019-04-17 | Forge Therapeutics, Inc. | COMPOUNDS BASED ON PYRONE AND METHOD FOR THE TREATMENT OF BACTERIAL INFECTIONS |
| WO2017189586A1 (en) * | 2016-04-25 | 2017-11-02 | Duke University | Benzoylglycine derivatives and methods of making and using same |
| JP7471820B2 (ja) * | 2016-12-23 | 2024-04-22 | インターベット インターナショナル ベー． フェー． | マンヘミア・ヘモリチカ感染症又はヒストフィルス・ソムニ感染症を治療するのに有用な化合物 |
| EP3621962A4 (en) | 2017-05-10 | 2020-12-09 | Forge Therapeutics, Inc. | ANTIBACTERIAL COMPOUNDS |
| CN112074507B (zh) * | 2018-02-10 | 2023-09-05 | 山东亨利医药科技有限责任公司 | 作为抗菌素的化合物 |
| IL281614B2 (en) * | 2018-09-20 | 2024-12-01 | Blacksmith Medicines Inc | Antibacterial compounds |
| US11731962B2 (en) | 2020-03-25 | 2023-08-22 | Blacksmith Medicines, Inc. | LpxC inhibitor and methods of making |
| ES3040117T3 (en) | 2020-09-09 | 2025-10-28 | Crinetics Pharmaceuticals Inc | Formulations of a somatostatin modulator |
| IL311588A (en) | 2021-09-28 | 2024-05-01 | Blacksmith Medicines Inc | LPXC inhibitors and their uses |
| WO2024077160A2 (en) * | 2022-10-05 | 2024-04-11 | Duke University | Compositions comprising prodrugs of hydroxyamate-based compounds and methods of making and using same |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3351293A (en) | 1992-01-21 | 1993-08-03 | Glaxo Group Limited | Piperidineacetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation |
| TW448172B (en) | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| US5925659A (en) | 1996-05-07 | 1999-07-20 | Merck & Co., Inc. | Antibacterial agents |
| GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
| JP2000344752A (ja) * | 1999-04-01 | 2000-12-12 | Sumitomo Pharmaceut Co Ltd | 点眼剤 |
| US6511993B1 (en) | 1999-06-03 | 2003-01-28 | Kevin Neil Dack | Metalloprotease inhibitors |
| EP1470102B1 (en) * | 2002-01-29 | 2011-05-25 | Merck Serono SA | Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases (ptps) |
| AU2003221786A1 (en) | 2002-04-25 | 2003-11-10 | Pharmacia Corporation | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
| WO2004007444A2 (en) | 2002-07-11 | 2004-01-22 | Vicuron Pharmaceuticals, Inc. | N-hydroxyamide derivatives possessing antibacterial activity |
| SG2012000667A (en) * | 2003-01-08 | 2015-03-30 | Univ Washington | Antibacterial agents |
| US20050154022A1 (en) | 2004-01-14 | 2005-07-14 | H. Lundbeck A/S | 4-aryl piperidines |
| US7638513B2 (en) | 2004-06-02 | 2009-12-29 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
| AT502219B1 (de) | 2005-08-04 | 2007-04-15 | Sanochemia Pharmazeutika Ag | Verfahren zur reindarstellung von 5-substituierten tetrazolen |
| US7553864B2 (en) | 2005-12-01 | 2009-06-30 | Schering Corporation | Compounds for the treatment of inflammatory disorders and microbial diseases |
| JP2010502617A (ja) | 2006-08-31 | 2010-01-28 | シェーリング コーポレイション | 抗菌物質として有用なヒダントイン誘導体 |
| JP5227304B2 (ja) | 2007-02-28 | 2013-07-03 | 大正製薬株式会社 | 新規なヒドロキサム酸誘導体 |
| TW201716375A (zh) | 2007-06-12 | 2017-05-16 | Achaogen Inc | 抗菌劑 |
| WO2009158369A1 (en) | 2008-06-25 | 2009-12-30 | Schering Corporation | Synthesis and use of heterocyclic antibacterial agents |
| CA2732045A1 (en) | 2008-08-04 | 2010-02-11 | Schering Corporation | Urea derivatives as antibacterial agents |
| WO2010024356A1 (ja) | 2008-08-27 | 2010-03-04 | 大正製薬株式会社 | ナフチリジン－ｎ－オキシドを有する新規ヒドロキサム酸誘導体 |
| US8372885B2 (en) * | 2008-09-17 | 2013-02-12 | Novartis Ag | Organic compounds and their uses |
| WO2010100475A1 (en) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
| WO2011005355A1 (en) | 2009-05-07 | 2011-01-13 | Achaogen, Inc. | Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria |
| JP5671545B2 (ja) * | 2009-10-13 | 2015-02-18 | ファイザー・インク | 抗菌薬として有用なｃ結合ヒドロキサム酸誘導体 |
| US8389536B2 (en) | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
| JP5793766B2 (ja) | 2009-12-16 | 2015-10-14 | ファイザー・インク | 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体 |
| HUE044575T2 (hu) * | 2010-04-20 | 2019-11-28 | Fujifilm Toyama Chemical Co Ltd | Hidroxámsav-származék |
| US9738604B2 (en) * | 2010-09-03 | 2017-08-22 | Duke University | Ethynylbenzene derivatives |
| US8772300B2 (en) * | 2011-04-19 | 2014-07-08 | Hoffmann-La Roche Inc. | Phenyl or pyridinyl-ethynyl derivatives |
| WO2013049255A1 (en) * | 2011-09-26 | 2013-04-04 | Vanderbilt University | Substitued 5-(prop-1-yn-1-yl)picolinamide analogs as allosteric modulators of mglur5 receptors |
| JP6006609B2 (ja) * | 2011-10-19 | 2016-10-12 | 大正製薬株式会社 | 新規なヒドロキサム酸誘導体を含有する医薬 |
| EP2847168A1 (en) * | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| CA2905248A1 (en) * | 2013-03-15 | 2014-09-18 | Muneo Shoji | Novel hydroxamic acid derivative or salt thereof |
| AU2014306451B2 (en) * | 2013-08-16 | 2019-01-17 | Duke University | Substituted hydroxamic acid compounds |
-
2014
- 2014-08-18 AU AU2014306451A patent/AU2014306451B2/en not_active Ceased
- 2014-08-18 JP JP2016534884A patent/JP6458270B2/ja not_active Expired - Fee Related
- 2014-08-18 WO PCT/US2014/051459 patent/WO2015024010A2/en not_active Ceased
- 2014-08-18 US US14/912,134 patent/US10647664B2/en not_active Expired - Fee Related
- 2014-08-18 EP EP14836244.5A patent/EP3041354A4/en not_active Withdrawn
- 2014-08-18 CA CA2921427A patent/CA2921427A1/en not_active Abandoned
-
2018
- 2018-11-29 JP JP2018224004A patent/JP2019077688A/ja active Pending