JP2016535741A5 - - Google Patents
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- Publication number
- JP2016535741A5 JP2016535741A5 JP2016526141A JP2016526141A JP2016535741A5 JP 2016535741 A5 JP2016535741 A5 JP 2016535741A5 JP 2016526141 A JP2016526141 A JP 2016526141A JP 2016526141 A JP2016526141 A JP 2016526141A JP 2016535741 A5 JP2016535741 A5 JP 2016535741A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- amino acids
- seq
- endoglin polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- 102100037241 Endoglin Human genes 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 108010036395 Endoglin Proteins 0.000 claims 19
- 150000001413 amino acids Chemical class 0.000 claims 19
- 229920001184 polypeptide Polymers 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 238000010494 dissociation reaction Methods 0.000 claims 8
- 230000005593 dissociations Effects 0.000 claims 8
- 208000019425 cirrhosis of liver Diseases 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 101000695367 Homo sapiens Bone morphogenetic protein 10 Proteins 0.000 claims 2
- 101000893585 Homo sapiens Growth/differentiation factor 2 Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000003176 fibrotic effect Effects 0.000 claims 2
- 102000052974 human BMP10 Human genes 0.000 claims 2
- 102000046041 human GDF2 Human genes 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000002458 infectious effect Effects 0.000 claims 2
- 206010003827 Autoimmune hepatitis Diseases 0.000 claims 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
- 206010010356 Congenital anomaly Diseases 0.000 claims 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 101001052035 Homo sapiens Fibroblast growth factor 2 Proteins 0.000 claims 1
- 101500025614 Homo sapiens Transforming growth factor beta-1 Proteins 0.000 claims 1
- 101500026551 Homo sapiens Transforming growth factor beta-3 Proteins 0.000 claims 1
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 claims 1
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 210000000013 bile duct Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 230000009918 complex formation Effects 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940126864 fibroblast growth factor Drugs 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 102000058223 human VEGFA Human genes 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 238000001361 intraarterial administration Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 125000003473 lipid group Chemical group 0.000 claims 1
- 230000004807 localization Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361896002P | 2013-10-25 | 2013-10-25 | |
| US61/896,002 | 2013-10-25 | ||
| PCT/US2014/062147 WO2015061666A1 (en) | 2013-10-25 | 2014-10-24 | Endoglin peptides to treat fibrotic diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019115063A Division JP6994481B2 (ja) | 2013-10-25 | 2019-06-21 | 線維性疾患を処置するためのエンドグリンポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016535741A JP2016535741A (ja) | 2016-11-17 |
| JP2016535741A5 true JP2016535741A5 (cg-RX-API-DMAC7.html) | 2017-11-30 |
| JP6546587B2 JP6546587B2 (ja) | 2019-07-17 |
Family
ID=51894230
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016526141A Expired - Fee Related JP6546587B2 (ja) | 2013-10-25 | 2014-10-24 | 線維性疾患を処置するためのエンドグリンポリペプチド |
| JP2019115063A Expired - Fee Related JP6994481B2 (ja) | 2013-10-25 | 2019-06-21 | 線維性疾患を処置するためのエンドグリンポリペプチド |
| JP2021201819A Pending JP2022058352A (ja) | 2013-10-25 | 2021-12-13 | 線維性疾患を処置するためのエンドグリンポリペプチド |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019115063A Expired - Fee Related JP6994481B2 (ja) | 2013-10-25 | 2019-06-21 | 線維性疾患を処置するためのエンドグリンポリペプチド |
| JP2021201819A Pending JP2022058352A (ja) | 2013-10-25 | 2021-12-13 | 線維性疾患を処置するためのエンドグリンポリペプチド |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20150202260A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3851118A1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6546587B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR20220013459A (cg-RX-API-DMAC7.html) |
| CN (1) | CN105899225A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2014339898B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2928708A1 (cg-RX-API-DMAC7.html) |
| EA (2) | EA202090707A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015061666A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8642031B2 (en) | 2006-11-02 | 2014-02-04 | Acceleron Pharma, Inc. | Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses thereof |
| AU2012245439B2 (en) | 2011-04-20 | 2017-04-06 | Acceleron Pharma, Inc. | Endoglin polypeptides and uses thereof |
| CN105899225A (zh) | 2013-10-25 | 2016-08-24 | 阿塞勒隆制药公司 | 用于治疗纤维化疾病的内皮联蛋白肽 |
| WO2016193872A2 (en) * | 2015-06-05 | 2016-12-08 | Novartis Ag | Antibodies targeting bone morphogenetic protein 9 (bmp9) and methods therefor |
| WO2018009624A1 (en) * | 2016-07-07 | 2018-01-11 | Acceleron Pharma Inc. | Tgf-beta superfamily heteromultimers and uses thereof |
| CN106994181A (zh) * | 2017-03-10 | 2017-08-01 | 上海交通大学医学院附属第九人民医院 | Bmp9在制备延缓肝纤维化药物中的应用 |
| WO2020022438A1 (ja) * | 2018-07-26 | 2020-01-30 | 参天製薬株式会社 | 網膜線維化を伴う眼疾患の処置剤 |
| CN114630662B (zh) * | 2020-10-08 | 2025-04-04 | 科罗姆生物科技有限公司 | 包含β-拉帕醌作为有效成分的用于预防或治疗胆汁淤积性肝病的药学组合物 |
| KR20240167591A (ko) * | 2023-05-18 | 2024-11-27 | 한국과학기술연구원 | 항-엔도글린 항체 및 이의 용도 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8529014D0 (en) | 1985-11-25 | 1986-01-02 | Biogen Nv | Enhanced secretion of heterologous proteins |
| WO1987005330A1 (en) | 1986-03-07 | 1987-09-11 | Michel Louis Eugene Bergh | Method for enhancing glycoprotein stability |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5462990A (en) | 1990-10-15 | 1995-10-31 | Board Of Regents, The University Of Texas System | Multifunctional organic polymers |
| US20030206899A1 (en) | 1991-03-29 | 2003-11-06 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
| US6582959B2 (en) | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
| WO1994010202A1 (en) | 1992-10-28 | 1994-05-11 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
| AU5541094A (en) | 1992-10-30 | 1994-05-24 | Consejo Superior De Investigaciones Cientificas | Compositions and methods for modifying the regulatory activity of tgf-beta |
| US5830847A (en) * | 1992-10-30 | 1998-11-03 | Hsc Research & Development Limited Partnership | Soluble TGF-β-binding endoglin polypeptides and homodimers |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| CA2163345A1 (en) | 1993-06-16 | 1994-12-22 | Susan Adrienne Morgan | Antibodies |
| US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
| US6423501B2 (en) | 1996-12-13 | 2002-07-23 | Beth Israel Deaconess Medical Center | Calcium-independent negative regulation by CD81 of receptor signaling |
| MX9701946A (es) | 1997-03-14 | 1998-04-30 | Arturo Jimenez Bayardo | Solucion oftalmica transportadora. |
| SI1325932T1 (cg-RX-API-DMAC7.html) | 1997-04-07 | 2005-08-31 | Genentech Inc | |
| US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| EP1695985B1 (en) | 1997-04-07 | 2011-03-09 | Genentech, Inc. | Methods for forming humanised antibodies by random mutagenesis |
| US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
| AU7467898A (en) | 1997-04-21 | 1998-11-13 | Arch Development Corporation | Fc receptor non-binding anti-cd3 monoclonal antibodies deliver a partial cr signal and induce clonal anergy |
| EP1068241B1 (en) | 1998-04-02 | 2007-10-10 | Genentech, Inc. | Antibody variants and fragments thereof |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| US6703020B1 (en) | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| KR20080068151A (ko) | 2000-06-23 | 2008-07-22 | 바이엘 쉐링 파마 악티엔게젤샤프트 | ＶＥＧＦ/ＶＥＧＦ 수용체 및 안지오포이에틴/Ｔｉｅ수용체의 기능을 방해하는 조합 제제 및 조성물과 이들의용도 (Ⅱ) |
| US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| EP1638941B1 (en) | 2003-05-22 | 2010-06-02 | Abbott Laboratories | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors |
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| WO2005044853A2 (en) | 2003-11-01 | 2005-05-19 | Genentech, Inc. | Anti-vegf antibodies |
| US20090170767A1 (en) | 2006-05-31 | 2009-07-02 | Beth Israel Deaconess Medical Center | Soluble Endoglin Compounds for the Treatment and Prevention of Cancer |
| US20090286271A1 (en) | 2006-05-31 | 2009-11-19 | Karumanchi Ananth S | Methods of Diagnosing and Treating Complications of Pregnancy |
| EP3181580A1 (en) | 2006-11-02 | 2017-06-21 | Acceleron Pharma Inc. | Alk1 receptor and ligand antagonists and uses thereof |
| WO2008151078A1 (en) | 2007-06-01 | 2008-12-11 | Wyeth | Methods and compositions for modulating bmp-10 activity |
| US20100210713A1 (en) * | 2009-01-16 | 2010-08-19 | The General Hospital Corporation | Regeneration and survival of cardiac progenitors and cardiomyocytes with a stretch activated transcription factor |
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| EP3384964B1 (en) * | 2009-03-30 | 2020-03-25 | Acceleron Pharma Inc. | Bmp-alk3 antagonists and uses for promoting bone growth |
| WO2010128158A1 (en) | 2009-05-08 | 2010-11-11 | Novartis Ag | Diagnostic biomarkers for fibrotic disorders |
| US8795663B2 (en) | 2010-01-12 | 2014-08-05 | Beth Israel Deaconess Medical Center, Inc. | Soluble endoglin and uses thereof |
| AU2012245439B2 (en) | 2011-04-20 | 2017-04-06 | Acceleron Pharma, Inc. | Endoglin polypeptides and uses thereof |
| WO2013019805A1 (en) * | 2011-08-01 | 2013-02-07 | Tufts Medical Center, Inc. | Treatment of heart failure and related conditions |
| CA2962277C (en) * | 2013-09-20 | 2021-12-07 | Tufts Medical Center, Inc. | Methods and compositions for reducing cardiac damage and other conditions |
| CN105899225A (zh) | 2013-10-25 | 2016-08-24 | 阿塞勒隆制药公司 | 用于治疗纤维化疾病的内皮联蛋白肽 |
| WO2016077451A1 (en) | 2014-11-12 | 2016-05-19 | Tracon Pharmaceuticals, Inc. | Anti-endoglin antibodies and uses thereof |
-
2014
- 2014-10-24 CN CN201480070781.XA patent/CN105899225A/zh active Pending
- 2014-10-24 WO PCT/US2014/062147 patent/WO2015061666A1/en not_active Ceased
- 2014-10-24 KR KR1020227001830A patent/KR20220013459A/ko not_active Ceased
- 2014-10-24 AU AU2014339898A patent/AU2014339898B2/en not_active Ceased
- 2014-10-24 CA CA2928708A patent/CA2928708A1/en not_active Abandoned
- 2014-10-24 EA EA202090707A patent/EA202090707A1/ru unknown
- 2014-10-24 US US14/522,891 patent/US20150202260A1/en not_active Abandoned
- 2014-10-24 JP JP2016526141A patent/JP6546587B2/ja not_active Expired - Fee Related
- 2014-10-24 EA EA201690855A patent/EA035481B1/ru not_active IP Right Cessation
- 2014-10-24 KR KR1020167013678A patent/KR102354787B1/ko not_active Expired - Fee Related
- 2014-10-24 EP EP20201627.5A patent/EP3851118A1/en not_active Withdrawn
- 2014-10-24 EP EP14796626.1A patent/EP3060235B1/en active Active
-
2019
- 2019-06-21 JP JP2019115063A patent/JP6994481B2/ja not_active Expired - Fee Related
- 2019-09-05 US US16/561,991 patent/US11590201B2/en active Active
-
2020
- 2020-09-30 AU AU2020244463A patent/AU2020244463A1/en not_active Abandoned
-
2021
- 2021-12-13 JP JP2021201819A patent/JP2022058352A/ja active Pending