JP2016535282A5 - - Google Patents

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Publication number
JP2016535282A5
JP2016535282A5 JP2016549647A JP2016549647A JP2016535282A5 JP 2016535282 A5 JP2016535282 A5 JP 2016535282A5 JP 2016549647 A JP2016549647 A JP 2016549647A JP 2016549647 A JP2016549647 A JP 2016549647A JP 2016535282 A5 JP2016535282 A5 JP 2016535282A5
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JP
Japan
Prior art keywords
cleavage
molecule
site
bromomethyl
indicator molecule
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JP2016549647A
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English (en)
Japanese (ja)
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JP2016535282A (ja
JP6496322B2 (ja
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Priority claimed from GB201318728A external-priority patent/GB201318728D0/en
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Publication of JP2016535282A5 publication Critical patent/JP2016535282A5/ja
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JP2016549647A 2013-10-23 2014-10-23 酵素の切断活性の検出 Active JP6496322B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1318728.1 2013-10-23
GB201318728A GB201318728D0 (en) 2013-10-23 2013-10-23 Detection of cleavage activity of an enzyme
PCT/GB2014/053171 WO2015059487A2 (en) 2013-10-23 2014-10-23 Detection of cleavage activity of an enzyme

Publications (3)

Publication Number Publication Date
JP2016535282A JP2016535282A (ja) 2016-11-10
JP2016535282A5 true JP2016535282A5 (https=) 2017-11-30
JP6496322B2 JP6496322B2 (ja) 2019-04-03

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ID=49727217

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016549647A Active JP6496322B2 (ja) 2013-10-23 2014-10-23 酵素の切断活性の検出

Country Status (11)

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US (2) US10866236B2 (https=)
EP (1) EP3060915B1 (https=)
JP (1) JP6496322B2 (https=)
CN (1) CN105940304B (https=)
AU (1) AU2014338709B2 (https=)
BR (1) BR112016008956A2 (https=)
CA (1) CA2928308C (https=)
GB (1) GB201318728D0 (https=)
MX (1) MX371379B (https=)
RU (1) RU2016119422A (https=)
WO (1) WO2015059487A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201605110D0 (en) 2016-03-24 2016-05-11 Mologic Ltd Detecting sepsis
EP3440113A1 (en) * 2016-04-08 2019-02-13 Gilead Sciences, Inc. Compositions and methods for treating cancer, inflammatory diseases and autoimmune diseases
US20190360019A1 (en) * 2016-11-16 2019-11-28 Universal Biosensors Pty Ltd Cleavage event transduction methods and products
ES2931536T3 (es) * 2017-08-31 2022-12-30 Somaprobes Sl Ensayo de flujo lateral para detectar la presencia de una célula de mamífero o bacterias específicas en una muestra biológica
CN111630162A (zh) * 2017-10-04 2020-09-04 博德研究所 基于crispr效应系统的诊断
US11732009B2 (en) * 2018-06-08 2023-08-22 Glympse Bio, Inc. Activity sensor with tunable analyte
GB201812331D0 (en) * 2018-07-27 2018-09-12 Mologic Ltd Bacterial vaginosis diagnostic
JP2022515728A (ja) * 2018-12-20 2022-02-22 武田薬品工業株式会社 好中球エラスターゼの新規な活性ベースのプローブおよびその使用
JP2023542867A (ja) 2020-09-11 2023-10-12 グリンプス バイオ， インコーポレイテッド 疾患の検出／診断、病期分類、モニタリング及び処置のための生体外でのプロテアーゼ活性検出

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795702A (en) 1986-02-05 1989-01-03 Immunogon Associates Diagnostic method for gonorrhea by assay of IgA1 fragments
WO2003102544A2 (en) 2002-05-31 2003-12-11 Cognosci, Inc. Assays for measuring matrix metalloproteinase activities
EP1452868A2 (en) * 2003-02-27 2004-09-01 Pepscan Systems B.V. Method for selecting a candidate drug compound
WO2004099784A2 (en) 2003-05-06 2004-11-18 Anamar Medical Ab Method for determining a tissue degradation process by detection of fibromodulin neoepitopes
GB0311961D0 (en) * 2003-05-23 2003-06-25 Health Prot Agency Mass-based toxin assay and substrates therefor
US20050079566A1 (en) * 2003-09-10 2005-04-14 Caterer Nigel Robert Analytical methods for determination of proteolytic cleavage at specific sites
ATE488766T1 (de) * 2004-06-21 2010-12-15 Progenra Inc Diagnostik und screening-methode und kit in verbindung mit proteolytischer aktivität
EP1889919A4 (en) 2005-05-20 2009-04-15 Mitsubishi Kagaku Iatron Inc PROCESS FOR ENZYMANALYSIS
GB2435511A (en) * 2006-02-23 2007-08-29 Mologic Ltd Protease detection
GB2437311A (en) 2006-04-07 2007-10-24 Mologic Ltd A protease detection product
US7897360B2 (en) * 2006-12-15 2011-03-01 Kimberly-Clark Worldwide, Inc. Enzyme detection techniques
WO2012154272A1 (en) * 2011-02-25 2012-11-15 Wellstat Diagnostics, Llc Assays for detecting enzymatic activity
WO2013116791A1 (en) 2012-02-02 2013-08-08 Mosaic Biosciences, Inc. Biomaterials for delivery of blood extracts and methods of using same
GB201206976D0 (en) 2012-04-20 2012-06-06 Mologic Ltd An enzyme detection device

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