JP2016535082A5 - - Google Patents
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- Publication number
- JP2016535082A5 JP2016535082A5 JP2016548443A JP2016548443A JP2016535082A5 JP 2016535082 A5 JP2016535082 A5 JP 2016535082A5 JP 2016548443 A JP2016548443 A JP 2016548443A JP 2016548443 A JP2016548443 A JP 2016548443A JP 2016535082 A5 JP2016535082 A5 JP 2016535082A5
- Authority
- JP
- Japan
- Prior art keywords
- steatohepatitis
- pyrazino
- octahydro
- quinolin
- dioxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000004930 Fatty Liver Diseases 0.000 claims 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- KLGHKOORFHZFGO-AZXNYEMZSA-N (6s,9s,9as)-n-benzyl-6-[(4-hydroxyphenyl)methyl]-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazine-1-carboxamide Chemical compound C([C@@H]1N2[C@@H](N(N(C)CC2=O)C(=O)NCC=2C=CC=CC=2)[C@@H](N(C1=O)CC=1C2=NC=CC=C2C=CC=1)C)C1=CC=C(O)C=C1 KLGHKOORFHZFGO-AZXNYEMZSA-N 0.000 claims 1
- VHOZWHQPEJGPCC-AZXNYEMZSA-N [4-[[(6s,9s,9as)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazin-6-yl]methyl]phenyl] dihydrogen phosphate Chemical compound C([C@@H]1N2[C@@H](N(N(C)CC2=O)C(=O)NCC=2C=CC=CC=2)[C@@H](N(C1=O)CC=1C2=NC=CC=C2C=CC=1)C)C1=CC=C(OP(O)(O)=O)C=C1 VHOZWHQPEJGPCC-AZXNYEMZSA-N 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361892606P | 2013-10-18 | 2013-10-18 | |
| US61/892,606 | 2013-10-18 | ||
| PCT/IB2014/002846 WO2015056104A2 (en) | 2013-10-18 | 2014-10-17 | Treatment of hepatic fibrosis using an inhibitor of cbp/catenin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016535082A JP2016535082A (ja) | 2016-11-10 |
| JP2016535082A5 true JP2016535082A5 (enExample) | 2017-12-28 |
| JP6507336B2 JP6507336B2 (ja) | 2019-05-08 |
Family
ID=52828810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016548443A Active JP6507336B2 (ja) | 2013-10-18 | 2014-10-17 | Ｃｂｐ／カテニン阻害剤を用いる肝線維症の治療 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20160263131A1 (enExample) |
| EP (1) | EP3057590B1 (enExample) |
| JP (1) | JP6507336B2 (enExample) |
| CN (1) | CN105899211A (enExample) |
| WO (1) | WO2015056104A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6303112B2 (ja) | 2012-12-12 | 2018-04-04 | 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ | 肝線維症の予防または治療剤 |
| CN110156774A (zh) * | 2016-07-29 | 2019-08-23 | 新波制药有限公司 | 用于治疗hbv感染的新颖治疗剂 |
| KR20180045213A (ko) * | 2016-10-25 | 2018-05-04 | 경상대학교산학협력단 | Icg-001을 함유하는 섬유증의 예방 또는 치료용 약학 조성물 |
| JPWO2020122022A1 (ja) * | 2018-12-10 | 2021-10-28 | 東京都 | 肝機能改善剤 |
| ES2993261T3 (en) * | 2020-02-11 | 2024-12-26 | Ospedale San Raffaele Srl | Spirocyclic inhibitors of hepatitis b virus |
| KR20210153908A (ko) * | 2020-06-11 | 2021-12-20 | 제이더블유중외제약 주식회사 | 코로나바이러스감염증-19(covid-19) 치료용 조성물 |
| CN113730403A (zh) * | 2021-09-26 | 2021-12-03 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 化合物kya1797k制备抗hbv病毒药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0573608A1 (en) | 1991-02-07 | 1993-12-15 | Molecumetics, Ltd. | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
| WO1994003494A1 (en) | 1992-08-06 | 1994-02-17 | The Board Of Trustees Of The University Of Illinois | Conformationally restricted mimetics of reverse turns and peptides containing the same |
| US6184223B1 (en) | 1995-10-27 | 2001-02-06 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US6013458A (en) | 1995-10-27 | 2000-01-11 | Molecumetics, Ltd. | Reverse-turn mimetics and methods relating thereto |
| US5929237A (en) | 1995-10-27 | 1999-07-27 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US6294525B1 (en) | 1999-09-01 | 2001-09-25 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US7566711B2 (en) * | 2001-10-12 | 2009-07-28 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| AU2006227776A1 (en) * | 2005-03-18 | 2006-09-28 | Institute For Chemical Genomics | Alpha-helix mimetics and methods relating to the treatment of fibrosis |
| JP5536336B2 (ja) | 2005-11-08 | 2014-07-02 | チョンウェ ファーマ コーポレイション | α−ヘリックス類似体および癌幹細胞の治療に関する方法 |
| WO2007056513A1 (en) | 2005-11-08 | 2007-05-18 | Institute For Chemical Genomics | α-HELIX MIMETICS AND METHODS RELATING TO THE TREATMENT OF FIBROTIC DISORDERS |
| BRPI0911383B1 (pt) * | 2008-06-06 | 2021-08-31 | Prism Biolab Corporation | Composto, composição farmacêutica, uso do referido composto, agentes para tratar ou prevenir câncer, fibrose, restenose associada com angioplastia, doença renal policística, doença de angiogênese aberrante, complexo de esclerose tuberosa (tsc) tumor associado com kshv, perda de cabelo, e doença de alzheimer, e processo para preparar o referido composto |
| US8691819B2 (en) | 2008-10-14 | 2014-04-08 | Prism Biolab Corporation | Alpha helix mimetic compositions for treating cancer and other CBP/catenin-mediated diseases and conditions |
| JP5768239B2 (ja) | 2009-05-07 | 2015-08-26 | 株式会社 ＰＲＩＳＭ ＢｉｏＬａｂ | アルファへリックスミメティック及び関連の方法 |
| US20130274215A1 (en) * | 2010-04-08 | 2013-10-17 | Fate Therapeutics, Inc. | Pharmaceutical compositions to treat fibrosis |
| EP2678341A1 (en) * | 2011-02-25 | 2014-01-01 | PRISM Pharma Co., Ltd. | Alpha helix mimetics and methods relating thereto |
| JP6303112B2 (ja) * | 2012-12-12 | 2018-04-04 | 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ | 肝線維症の予防または治療剤 |
-
2014
- 2014-10-17 US US15/030,095 patent/US20160263131A1/en not_active Abandoned
- 2014-10-17 CN CN201480057194.7A patent/CN105899211A/zh active Pending
- 2014-10-17 EP EP14853712.9A patent/EP3057590B1/en active Active
- 2014-10-17 JP JP2016548443A patent/JP6507336B2/ja active Active
- 2014-10-17 WO PCT/IB2014/002846 patent/WO2015056104A2/en not_active Ceased
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