JP2016535082A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016535082A5 JP2016535082A5 JP2016548443A JP2016548443A JP2016535082A5 JP 2016535082 A5 JP2016535082 A5 JP 2016535082A5 JP 2016548443 A JP2016548443 A JP 2016548443A JP 2016548443 A JP2016548443 A JP 2016548443A JP 2016535082 A5 JP2016535082 A5 JP 2016535082A5
- Authority
- JP
- Japan
- Prior art keywords
- steatohepatitis
- pyrazino
- octahydro
- quinolin
- dioxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000004930 Fatty Liver Diseases 0.000 claims 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- KLGHKOORFHZFGO-AZXNYEMZSA-N (6s,9s,9as)-n-benzyl-6-[(4-hydroxyphenyl)methyl]-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazine-1-carboxamide Chemical compound C([C@@H]1N2[C@@H](N(N(C)CC2=O)C(=O)NCC=2C=CC=CC=2)[C@@H](N(C1=O)CC=1C2=NC=CC=C2C=CC=1)C)C1=CC=C(O)C=C1 KLGHKOORFHZFGO-AZXNYEMZSA-N 0.000 claims 1
- VHOZWHQPEJGPCC-AZXNYEMZSA-N [4-[[(6s,9s,9as)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazin-6-yl]methyl]phenyl] dihydrogen phosphate Chemical compound C([C@@H]1N2[C@@H](N(N(C)CC2=O)C(=O)NCC=2C=CC=CC=2)[C@@H](N(C1=O)CC=1C2=NC=CC=C2C=CC=1)C)C1=CC=C(OP(O)(O)=O)C=C1 VHOZWHQPEJGPCC-AZXNYEMZSA-N 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361892606P | 2013-10-18 | 2013-10-18 | |
| US61/892,606 | 2013-10-18 | ||
| PCT/IB2014/002846 WO2015056104A2 (en) | 2013-10-18 | 2014-10-17 | Treatment of hepatic fibrosis using an inhibitor of cbp/catenin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016535082A JP2016535082A (ja) | 2016-11-10 |
| JP2016535082A5 true JP2016535082A5 (enExample) | 2017-12-28 |
| JP6507336B2 JP6507336B2 (ja) | 2019-05-08 |
Family
ID=52828810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016548443A Active JP6507336B2 (ja) | 2013-10-18 | 2014-10-17 | Ｃｂｐ／カテニン阻害剤を用いる肝線維症の治療 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20160263131A1 (enExample) |
| EP (1) | EP3057590B1 (enExample) |
| JP (1) | JP6507336B2 (enExample) |
| CN (1) | CN105899211A (enExample) |
| WO (1) | WO2015056104A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9700569B2 (en) * | 2012-12-12 | 2017-07-11 | Prism Pharma Co., Ltd. | Prevention or treatment agent for hepatic fibrosis |
| CA3031063A1 (en) * | 2016-07-29 | 2018-02-01 | Newave Pharmaceutical Inc. | Benzo-quinolizin-2oxo carboxylic acid derivatives for the treatment of hbv infection |
| KR20180045213A (ko) * | 2016-10-25 | 2018-05-04 | 경상대학교산학협력단 | Icg-001을 함유하는 섬유증의 예방 또는 치료용 약학 조성물 |
| CN118084813A (zh) * | 2017-03-15 | 2024-05-28 | 诺和诺德牛津研究中心有限公司 | 大环化合物 |
| JPWO2020122022A1 (ja) * | 2018-12-10 | 2021-10-28 | 東京都 | 肝機能改善剤 |
| CN115551870B (zh) * | 2020-02-11 | 2025-08-08 | 圣拉斐尔医院有限公司 | 乙型肝炎病毒的螺环抑制剂 |
| KR20210153908A (ko) * | 2020-06-11 | 2021-12-20 | 제이더블유중외제약 주식회사 | 코로나바이러스감염증-19(covid-19) 치료용 조성물 |
| CN113730403A (zh) * | 2021-09-26 | 2021-12-03 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 化合物kya1797k制备抗hbv病毒药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0573608A1 (en) | 1991-02-07 | 1993-12-15 | Molecumetics, Ltd. | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
| AU679460B2 (en) | 1992-08-06 | 1997-07-03 | Molecumetics, Ltd. | Conformationally restricted mimetics of reverse turns and peptides containing the same |
| US5929237A (en) | 1995-10-27 | 1999-07-27 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US6013458A (en) | 1995-10-27 | 2000-01-11 | Molecumetics, Ltd. | Reverse-turn mimetics and methods relating thereto |
| US6184223B1 (en) | 1995-10-27 | 2001-02-06 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US6294525B1 (en) | 1999-09-01 | 2001-09-25 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US7566711B2 (en) * | 2001-10-12 | 2009-07-28 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| AU2006227776A1 (en) * | 2005-03-18 | 2006-09-28 | Institute For Chemical Genomics | Alpha-helix mimetics and methods relating to the treatment of fibrosis |
| US20080009500A1 (en) | 2005-11-08 | 2008-01-10 | Michael Kahn | Alpha-helix mimetics and methods relating to the treatment of fibrotic disorders |
| US20070129353A1 (en) | 2005-11-08 | 2007-06-07 | Michael Kahn | Alpha-helix mimetics and method relating to the treatment of cancer stem cells |
| RU2512538C2 (ru) | 2008-06-06 | 2014-04-10 | Присм Байолэб Корпорейшн | Альфа-спиральные миметики и способы, связанные с ними |
| US8691819B2 (en) | 2008-10-14 | 2014-04-08 | Prism Biolab Corporation | Alpha helix mimetic compositions for treating cancer and other CBP/catenin-mediated diseases and conditions |
| EP2427451B1 (en) | 2009-05-07 | 2019-03-20 | PRISM BioLab Co., Ltd. | Alpha helix mimetics and methods relating thereto |
| US20130274215A1 (en) * | 2010-04-08 | 2013-10-17 | Fate Therapeutics, Inc. | Pharmaceutical compositions to treat fibrosis |
| JP2014509298A (ja) * | 2011-02-25 | 2014-04-17 | 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ | アルファへリックスミメティック及びその関連の方法 |
| US9700569B2 (en) * | 2012-12-12 | 2017-07-11 | Prism Pharma Co., Ltd. | Prevention or treatment agent for hepatic fibrosis |
-
2014
- 2014-10-17 CN CN201480057194.7A patent/CN105899211A/zh active Pending
- 2014-10-17 EP EP14853712.9A patent/EP3057590B1/en active Active
- 2014-10-17 JP JP2016548443A patent/JP6507336B2/ja active Active
- 2014-10-17 US US15/030,095 patent/US20160263131A1/en not_active Abandoned
- 2014-10-17 WO PCT/IB2014/002846 patent/WO2015056104A2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3400285A4 (en) | METHOD FOR IMPROVING MILK PRODUCTION BY ADMINISTERING MICROBIAL CONSORTIA | |
| JP2015528502A5 (enExample) | ||
| EA201790661A2 (ru) | Ингибиторы вируса гепатита c | |
| MX2018000688A (es) | Triciclicos sustituidos y metodo para usarlos. | |
| EA201490228A1 (ru) | Новые производные трифторметилоксадиазола и их применение для лечения заболевания | |
| EA201491060A1 (ru) | Новые производные трифторметилоксадиазола и их применение для лечения заболевания | |
| CN103717571B8 (zh) | 9‑氨基甲基取代的四环素类化合物 | |
| SG10201805231WA (en) | 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof | |
| EA201600622A1 (ru) | Бициклические анелированные гетероарильные или арильные соединения и их применение в качестве ингибиторов irak4 | |
| EA201491028A8 (ru) | Способ получения замещенных 5-фтор-1н-пиразолопиридинов | |
| EA201500298A1 (ru) | Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы | |
| UA109868C2 (ru) | Соединения n-алкилтриазола как антагонисты лизофосфатидной кислоты (lpar) | |
| CN109843873A (zh) | 炔代杂环化合物、其制备方法及其在医药学上的应用 | |
| HK1200812A1 (en) | Rod -like hepatitis c virus inhibitors containing the fragement {2- [4- (bi phenyl - 4 - yl) - 1h - imidazo - 2 - yl] pyrrolidine - 1 - carbonlymethyl} amine | |
| CY1124251T1 (el) | Παραγωγα καρβοξαμιδιου | |
| EA201692542A1 (ru) | Индановые и индолиновые производные и их применение в качестве активаторов растворимой гуанилатциклазы | |
| MX377202B (es) | Derivado basado en 1,2-naftoquinona y metodo de preparacion del mismo. | |
| EA201990095A1 (ru) | КОНДЕНСИРОВАННЫЕ ТИОФЕНОВЫЕ ПРОИЗВОДНЫЕ, ПРИЕМЛЕМЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ NAPI-IIb | |
| WO2014036502A3 (en) | Tetracycline compounds | |
| PH12017500558A1 (en) | 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication | |
| WO2012137227A3 (en) | Solid forms of antiretroviral compounds and anti-oxidative acids, processes for preparation and pharmaceutical compositions thereof | |
| PH12015502717B1 (en) | Anti-fibrogenic compounds, methods and uses thereof | |
| MX2015013224A (es) | Inhibidores macrociclicos y biciclicos del virus de la hepatitis c. | |
| EA201692298A1 (ru) | Производные карбоксамидов | |
| WO2015052568A3 (en) | Solid forms of curcumin and derivatives thereof |