JP2016535082A5 - - Google Patents
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- Publication number
- JP2016535082A5 JP2016535082A5 JP2016548443A JP2016548443A JP2016535082A5 JP 2016535082 A5 JP2016535082 A5 JP 2016535082A5 JP 2016548443 A JP2016548443 A JP 2016548443A JP 2016548443 A JP2016548443 A JP 2016548443A JP 2016535082 A5 JP2016535082 A5 JP 2016535082A5
- Authority
- JP
- Japan
- Prior art keywords
- steatohepatitis
- pyrazino
- octahydro
- quinolin
- dioxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000004930 Fatty Liver Diseases 0.000 claims 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- KLGHKOORFHZFGO-AZXNYEMZSA-N (6s,9s,9as)-n-benzyl-6-[(4-hydroxyphenyl)methyl]-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazine-1-carboxamide Chemical compound C([C@@H]1N2[C@@H](N(N(C)CC2=O)C(=O)NCC=2C=CC=CC=2)[C@@H](N(C1=O)CC=1C2=NC=CC=C2C=CC=1)C)C1=CC=C(O)C=C1 KLGHKOORFHZFGO-AZXNYEMZSA-N 0.000 claims 1
- VHOZWHQPEJGPCC-AZXNYEMZSA-N [4-[[(6s,9s,9as)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazin-6-yl]methyl]phenyl] dihydrogen phosphate Chemical compound C([C@@H]1N2[C@@H](N(N(C)CC2=O)C(=O)NCC=2C=CC=CC=2)[C@@H](N(C1=O)CC=1C2=NC=CC=C2C=CC=1)C)C1=CC=C(OP(O)(O)=O)C=C1 VHOZWHQPEJGPCC-AZXNYEMZSA-N 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361892606P | 2013-10-18 | 2013-10-18 | |
| US61/892,606 | 2013-10-18 | ||
| PCT/IB2014/002846 WO2015056104A2 (en) | 2013-10-18 | 2014-10-17 | Treatment of hepatic fibrosis using an inhibitor of cbp/catenin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016535082A JP2016535082A (ja) | 2016-11-10 |
| JP2016535082A5 true JP2016535082A5 (OSRAM) | 2017-12-28 |
| JP6507336B2 JP6507336B2 (ja) | 2019-05-08 |
Family
ID=52828810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016548443A Active JP6507336B2 (ja) | 2013-10-18 | 2014-10-17 | Ｃｂｐ／カテニン阻害剤を用いる肝線維症の治療 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20160263131A1 (OSRAM) |
| EP (1) | EP3057590B1 (OSRAM) |
| JP (1) | JP6507336B2 (OSRAM) |
| CN (1) | CN105899211A (OSRAM) |
| WO (1) | WO2015056104A2 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014092154A1 (ja) | 2012-12-12 | 2014-06-19 | 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ | 肝線維症の予防または治療剤 |
| EP3490987B1 (en) * | 2016-07-29 | 2022-09-21 | Guangzhou Lupeng Pharmaceutical Company Ltd. | Novel therapeutic agents for the treatment of hbv infection |
| KR20180045213A (ko) * | 2016-10-25 | 2018-05-04 | 경상대학교산학협력단 | Icg-001을 함유하는 섬유증의 예방 또는 치료용 약학 조성물 |
| EP3596055A1 (en) * | 2017-03-15 | 2020-01-22 | Ziylo Limited | Macrocyclic compounds |
| JPWO2020122022A1 (ja) * | 2018-12-10 | 2021-10-28 | 東京都 | 肝機能改善剤 |
| WO2021160617A1 (en) * | 2020-02-11 | 2021-08-19 | Irbm S.P.A. | Spirocyclic inhibitors of hepatitis b virus |
| KR20210153908A (ko) * | 2020-06-11 | 2021-12-20 | 제이더블유중외제약 주식회사 | 코로나바이러스감염증-19(covid-19) 치료용 조성물 |
| CN113730403A (zh) * | 2021-09-26 | 2021-12-03 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 化合物kya1797k制备抗hbv病毒药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06505486A (ja) | 1991-02-07 | 1994-06-23 | モレキュメティクス，リミティド | βターンおよびβバルジのコンフォメーション的に制限された模倣物およびそれらを含有するペプチド |
| JPH07509723A (ja) | 1992-08-06 | 1995-10-26 | モレキュメティクス，リミティド | 反転型ターンの立体配座的に拘束されたミメティックスと前者を含有するペプチド |
| US6184223B1 (en) | 1995-10-27 | 2001-02-06 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US5929237A (en) | 1995-10-27 | 1999-07-27 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US6013458A (en) * | 1995-10-27 | 2000-01-11 | Molecumetics, Ltd. | Reverse-turn mimetics and methods relating thereto |
| US6294525B1 (en) | 1999-09-01 | 2001-09-25 | Molecumetics Ltd. | Reverse-turn mimetics and methods relating thereto |
| US7566711B2 (en) * | 2001-10-12 | 2009-07-28 | Choongwae Pharma Corporation | Reverse-turn mimetics and method relating thereto |
| AU2006227776A1 (en) * | 2005-03-18 | 2006-09-28 | Institute For Chemical Genomics | Alpha-helix mimetics and methods relating to the treatment of fibrosis |
| US20070129353A1 (en) | 2005-11-08 | 2007-06-07 | Michael Kahn | Alpha-helix mimetics and method relating to the treatment of cancer stem cells |
| WO2007056513A1 (en) | 2005-11-08 | 2007-05-18 | Institute For Chemical Genomics | α-HELIX MIMETICS AND METHODS RELATING TO THE TREATMENT OF FIBROTIC DISORDERS |
| KR101671535B1 (ko) | 2008-06-06 | 2016-11-01 | 가부시키가이샤 프리즘 파마 | 알파 나선 모방체 및 이와 관련된 방법 |
| WO2010044485A1 (en) | 2008-10-14 | 2010-04-22 | Prism Biolab Corporation | Alpha helix mimetics in the treatment of cancer |
| WO2010128685A1 (en) | 2009-05-07 | 2010-11-11 | Prism Biolab Corporation | Alpha helix mimetics and methods relating thereto |
| US20130274215A1 (en) * | 2010-04-08 | 2013-10-17 | Fate Therapeutics, Inc. | Pharmaceutical compositions to treat fibrosis |
| JP2014509298A (ja) * | 2011-02-25 | 2014-04-17 | 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ | アルファへリックスミメティック及びその関連の方法 |
| WO2014092154A1 (ja) * | 2012-12-12 | 2014-06-19 | 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ | 肝線維症の予防または治療剤 |
-
2014
- 2014-10-17 EP EP14853712.9A patent/EP3057590B1/en active Active
- 2014-10-17 CN CN201480057194.7A patent/CN105899211A/zh active Pending
- 2014-10-17 JP JP2016548443A patent/JP6507336B2/ja active Active
- 2014-10-17 WO PCT/IB2014/002846 patent/WO2015056104A2/en not_active Ceased
- 2014-10-17 US US15/030,095 patent/US20160263131A1/en not_active Abandoned
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