JP2016535009A - 抗体依存性エキソソーム治療の方法 - Google Patents

抗体依存性エキソソーム治療の方法 Download PDF

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JP2016535009A
JP2016535009A JP2016524060A JP2016524060A JP2016535009A JP 2016535009 A JP2016535009 A JP 2016535009A JP 2016524060 A JP2016524060 A JP 2016524060A JP 2016524060 A JP2016524060 A JP 2016524060A JP 2016535009 A JP2016535009 A JP 2016535009A
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cancer
cells
exosome
exosomes
composition
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JP2016535009A5 (show.php
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ロバート シー． シーガー
ロバート シー． シーガー
ミュラー ファッブリ
ミュラー ファッブリ
アンブローズ ジョン
アンブローズ ジョン
アラン エス． ウェイン
アラン エス． ウェイン
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チルドレンズ ホスピタル ロサンゼルス
チルドレンズ ホスピタル ロサンゼルス
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JP2016524060A 2013-10-17 2014-10-17 抗体依存性エキソソーム治療の方法 Pending JP2016535009A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361892352P 2013-10-17 2013-10-17
US61/892,352 2013-10-17
US201462038734P 2014-08-18 2014-08-18
US62/038,734 2014-08-18
PCT/US2014/061245 WO2015058148A1 (en) 2013-10-17 2014-10-17 Antibody dependent exosome therapy

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JP2016535009A true JP2016535009A (ja) 2016-11-10
JP2016535009A5 JP2016535009A5 (show.php) 2017-11-09

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US (1) US20160243192A1 (show.php)
EP (1) EP3057662A4 (show.php)
JP (1) JP2016535009A (show.php)
WO (1) WO2015058148A1 (show.php)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023536665A (ja) * 2020-08-05 2023-08-28 オハイオ・ステイト・イノベーション・ファウンデーション アダプターポリペプチドおよびその使用方法

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011097480A1 (en) 2010-02-05 2011-08-11 University Of Louisville Research Foundation, Inc. Exosomal compositions and methods for the treatment of disease
US20140308212A1 (en) 2011-11-07 2014-10-16 University Of Louisville Research Foundation, Inc. Edible plant-derived microvesicle compositions for diagnosis and treatment of disease
ES2775451T3 (es) 2014-04-11 2020-07-27 Univ Louisville Res Found Inc Composiciones de microvesículas recubiertas derivadas de plantas comestibles y procedimientos para la utilización de las mismas
CN107920995A (zh) * 2015-07-02 2018-04-17 路易斯威尔大学研究基金会 用于递送miRNA的源自可食用植物的微囊泡组合物和用于治疗癌症的方法
US11993787B2 (en) 2015-11-18 2024-05-28 University Of Georgia Research Foundation, Inc. Neural cell extracellular vesicles
WO2017087685A1 (en) 2015-11-20 2017-05-26 The Regents Of The University Of California Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
GB2552473A (en) * 2016-07-21 2018-01-31 Evox Therapeutics Ltd Surface decoration of extracellular vesicles
WO2018187240A1 (en) 2017-04-03 2018-10-11 The Regents Of The University Of California Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
US10815520B2 (en) 2017-04-07 2020-10-27 University Of Louisville Research Foundation, Inc. Nanovesicles, methods, and systems for diagnosis and prognosis of cancer
EP3438250B1 (en) 2017-07-31 2022-12-07 Rheinische Friedrich-Wilhelms-Universität Bonn Cell derived extracellular vesicles for the treatment of diseases
US12036262B2 (en) 2017-11-22 2024-07-16 University Of Louisville Research Foundation, Inc. Edible plant-derived nanoparticles for regulation of gut microbiota
CN110951729B (zh) * 2017-12-11 2021-01-12 浙江大学 一种hsa-miR-10029 miRNA序列在抗肿瘤中的应用
EP4663245A2 (en) * 2018-02-12 2025-12-17 Lonza Sales AG Methods and compositions for macrophage polarization
IL266153A (en) * 2019-04-18 2019-07-31 Aharon Anat Extracellular vesicles derived from t cells containing a chimeric antigen receptor
CN113924126A (zh) 2019-05-06 2022-01-11 托马斯·马尔科姆 为癌症肿瘤定制的低免疫纳米囊泡递送系统
US11607428B2 (en) 2019-06-06 2023-03-21 Spiritus Therapeutics, Inc. Mesenchymal stem cell-derived extracellular vesicles and uses thereof for treating and diagnosing fibrotic diseases
WO2020247675A1 (en) * 2019-06-06 2020-12-10 Spiritus Therapeutics, Inc. Methods for attenuating viral infection and for treating lung injury
US12097222B2 (en) 2019-06-06 2024-09-24 Spiritus Therapeutics, Inc. Methods for attenuating viral infection and for treating lung injury
US20210130782A1 (en) * 2019-10-28 2021-05-06 Augusta University Research Institute, Inc. Engineered Exosomes to Detect and Deplete Pro-Tumorigenic Macrophages
WO2021092080A1 (en) * 2019-11-04 2021-05-14 Aruna Bio, Inc. Extracellular vesicles and uses thereof for antibody delivery
CN111450249A (zh) * 2020-03-09 2020-07-28 杨静悦 miRNA-320a的表达促进物在制备抑制肿瘤细胞药物中的应用
WO2022149779A1 (ko) * 2021-01-11 2022-07-14 주식회사 엑소코바이오 과발현된 Fc 수용체 또는 이의 일부를 포함하는 엑소좀 및 이의 제조방법
WO2022158836A1 (ko) * 2021-01-21 2022-07-28 주식회사 엑소코바이오 목적 단백질 또는 펩타이드가 융합가능한 Fc 수용체 또는 이의 일부를 포함하는 재조합 엑소좀 및 이의 용도
US20230144704A1 (en) * 2021-11-05 2023-05-11 Thomas Malcolm Tailored hypoimmune nanovesicular delivery systems for cancer tumors, hereditary and infectious diseases
CN115887491A (zh) * 2022-11-10 2023-04-04 中国药科大学 一种具有骨髓靶向功能的工程化双特异性外泌体/囊泡制剂及其制备方法和应用
US20240318185A1 (en) * 2023-03-20 2024-09-26 MAM Holdings of West Florida, L.L.C. Mesenchymal stem cell-derived microribonucleic acid-mediated treatments for the prevention and targeted treatment of cancer and other disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002331244B2 (en) * 2001-08-17 2007-02-15 Exothera L.L.C. Methods and compounds for the targeting of protein to exosomes
EP1599572A4 (en) * 2003-02-14 2007-06-13 Univ Southern California COMPOSITIONS AND METHODS FOR CANCER IMMUNOTHERAPY
IL161899A0 (en) * 2004-05-10 2005-11-20 Hoffman Arnold Kit for treatment of cancer
MX363905B (es) * 2006-06-12 2019-04-08 Aptevo Res & Development Llc Proteinas de union multivalentes monocatenarias con funcion efectora.
WO2011097480A1 (en) * 2010-02-05 2011-08-11 University Of Louisville Research Foundation, Inc. Exosomal compositions and methods for the treatment of disease

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CLIN. CANCER RES, vol. 19, no. 8, JPN6018021559, 15 April 2013 (2013-04-15), pages 2132 - 2143, ISSN: 0003965760 *
ONCOIMMUNOLOGY, vol. 2, no. 1, JPN6018021560, 1 January 2013 (2013-01-01), pages 22337 - 3, ISSN: 0003815160 *
THE JOURNAL OF IMMUNOLOGY, vol. 189, JPN6018021558, 2012, pages 2833 - 2842, ISSN: 0003965759 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023536665A (ja) * 2020-08-05 2023-08-28 オハイオ・ステイト・イノベーション・ファウンデーション アダプターポリペプチドおよびその使用方法

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