JP2016534714A - 全血凝固のリアルタイムの臨床モニタリングおよび定量的評価 - Google Patents

全血凝固のリアルタイムの臨床モニタリングおよび定量的評価 Download PDF

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JP2016534714A
JP2016534714A JP2016524024A JP2016524024A JP2016534714A JP 2016534714 A JP2016534714 A JP 2016534714A JP 2016524024 A JP2016524024 A JP 2016524024A JP 2016524024 A JP2016524024 A JP 2016524024A JP 2016534714 A JP2016534714 A JP 2016534714A
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microchannels
blood sample
time
blood
coagulation
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JP2016534714A5 (enExample
Inventor
ジャイン，アビシェーク
ウォーターハウス，アナ
スーパー，マイク
イングバー，ドナルド・イー
レスリー，ダニエル・シィ
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Harvard University
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Harvard University
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/146—Employing pressure sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Ecology (AREA)
  • Data Mining & Analysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioethics (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
JP2016524024A 2013-10-16 2014-10-16 全血凝固のリアルタイムの臨床モニタリングおよび定量的評価 Pending JP2016534714A (ja)

Applications Claiming Priority (3)

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US201361891732P 2013-10-16 2013-10-16
US61/891,732 2013-10-16
PCT/US2014/060956 WO2015102726A2 (en) 2013-10-16 2014-10-16 A microfluidic device for real-time clinical monitoring and quantitative assessment of whole blood coagulation

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JP2016534714A true JP2016534714A (ja) 2016-11-10
JP2016534714A5 JP2016534714A5 (enExample) 2017-11-30

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US (3) US9562914B2 (enExample)
EP (1) EP3058367B1 (enExample)
JP (1) JP2016534714A (enExample)
WO (1) WO2015102726A2 (enExample)

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JP2020527718A (ja) * 2017-07-20 2020-09-10 ザ ユニバーシティ オブ ブリストル マイクロ流体分析システム
JP2020529593A (ja) * 2017-07-28 2020-10-08 マサチューセッツ インスティテュート オブ テクノロジー 血漿および全血中の抗凝固薬の検出のための方法ならびにデバイス
JPWO2019069378A1 (ja) * 2017-10-03 2020-11-05 オリンパス株式会社 培養情報処理装置

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US11112400B2 (en) 2016-01-16 2021-09-07 Hewlett-Packard Development Company, L.P. Blood characteristic measurement
JP6941061B2 (ja) * 2016-02-17 2021-09-29 ソニーグループ株式会社 血小板凝集能解析装置、血小板凝集能解析システム、血小板凝集能解析用プログラム及び血小板凝集能の解析方法
US9892225B2 (en) * 2016-04-01 2018-02-13 International Business Machines Corporation Method for optimizing the design of micro-fluidic devices
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CN106744626A (zh) * 2016-12-13 2017-05-31 浙江微兰环境科技有限公司 一种单定量环系统
CN106841640A (zh) * 2016-12-20 2017-06-13 柳州秦华科技有限公司 一种由医护平台监测老年人血栓的系统
CN109655383A (zh) * 2017-10-11 2019-04-19 南京大学 一种基于血小板投影成像的检测装置及其方法
CN109839349B (zh) * 2017-11-28 2021-12-07 北京碧澄生物科技有限公司 检测液体相变的装置和方法
US10596311B2 (en) * 2018-05-25 2020-03-24 Fresenius Medical Care Holdings, Inc. Fiber-optic clot detector with an ultrasonic clot neutralizer
WO2020027741A1 (en) * 2018-07-29 2020-02-06 Koc Universitesi Microfluidic thromboelastometry instrument
WO2020207456A1 (en) * 2019-04-11 2020-10-15 The Chinese University Of Hong Kong Systems and methods for controlled membrane disruption
CN111855732B (zh) * 2019-04-28 2023-07-04 北京碧澄生物科技有限公司 检测液体相变的装置和方法
US20210354135A1 (en) * 2020-05-13 2021-11-18 The Texas A&M University System Systems and methods for evaluating an ability of a blood sample to coagulate, clot, and/or occlude
US20210394177A1 (en) * 2020-06-19 2021-12-23 The Texas A&M University System Systems and methods for mimicking a blood vessel of a patient
CN116368212A (zh) * 2020-10-19 2023-06-30 金玟墉 具有细胞活化部的血液分离管
US20230414123A1 (en) * 2020-11-17 2023-12-28 Case Western Reserve University System and method for measuring blood flow velocity on a microfluidic chip
CN113116348B (zh) * 2021-03-02 2022-09-27 天津大学 一种连续动脉血液检测装置
CN115166224B (zh) * 2021-04-06 2024-01-02 清华大学 微流控芯片、血小板功能检测装置及方法
WO2024229114A1 (en) * 2023-05-01 2024-11-07 Georgia Tech Research Corporation Point-of-care assay for occlusive platelet thrombosis
CN120532566B (zh) * 2025-07-28 2025-10-17 集美大学 一种微血管脉动血流多参数同步调控的微流控平台及方法

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Cited By (7)

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Publication number Priority date Publication date Assignee Title
JP2020527718A (ja) * 2017-07-20 2020-09-10 ザ ユニバーシティ オブ ブリストル マイクロ流体分析システム
JP7268945B2 (ja) 2017-07-20 2023-05-08 ザ ユニバーシティ オブ ブリストル マイクロ流体分析システム
JP2020529593A (ja) * 2017-07-28 2020-10-08 マサチューセッツ インスティテュート オブ テクノロジー 血漿および全血中の抗凝固薬の検出のための方法ならびにデバイス
JP7214712B2 (ja) 2017-07-28 2023-01-30 マサチューセッツ インスティテュート オブ テクノロジー 血漿および全血中の抗凝固薬の検出のための方法ならびにデバイス
JPWO2019069378A1 (ja) * 2017-10-03 2020-11-05 オリンパス株式会社 培養情報処理装置
JP7018955B2 (ja) 2017-10-03 2022-02-14 オリンパス株式会社 培養情報処理装置
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US20170100714A1 (en) 2017-04-13
EP3058367A2 (en) 2016-08-24
WO2015102726A3 (en) 2015-10-29
WO2015102726A2 (en) 2015-07-09
US9562914B2 (en) 2017-02-07
EP3058367A4 (en) 2017-01-11
EP3058367B1 (en) 2019-01-09
US20180185839A1 (en) 2018-07-05
US20160258968A1 (en) 2016-09-08

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