JP2016533344A5 - - Google Patents

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JP2016533344A5
JP2016533344A5 JP2016517553A JP2016517553A JP2016533344A5 JP 2016533344 A5 JP2016533344 A5 JP 2016533344A5 JP 2016517553 A JP2016517553 A JP 2016517553A JP 2016517553 A JP2016517553 A JP 2016517553A JP 2016533344 A5 JP2016533344 A5 JP 2016533344A5
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composition
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protein
cancer
polymer
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JP2016517553A
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JP7097667B2 (ja
JP2016533344A (ja
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Priority claimed from PCT/US2014/057789 external-priority patent/WO2015048498A2/en
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JP2016517553A 2013-09-27 2014-09-26 無担体生物活性タンパク質ナノ構造体 Expired - Fee Related JP7097667B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361883503P 2013-09-27 2013-09-27
US61/883,503 2013-09-27
PCT/US2014/057789 WO2015048498A2 (en) 2013-09-27 2014-09-26 Carrier-free biologically-active protein nanostructures

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JP2020109309A Division JP7272664B2 (ja) 2013-09-27 2020-06-25 無担体生物活性タンパク質ナノ構造体

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JP2016533344A JP2016533344A (ja) 2016-10-27
JP2016533344A5 true JP2016533344A5 (enExample) 2017-11-09
JP7097667B2 JP7097667B2 (ja) 2022-07-08

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JP2016517553A Expired - Fee Related JP7097667B2 (ja) 2013-09-27 2014-09-26 無担体生物活性タンパク質ナノ構造体
JP2020109309A Active JP7272664B2 (ja) 2013-09-27 2020-06-25 無担体生物活性タンパク質ナノ構造体
JP2023069170A Pending JP2023103260A (ja) 2013-09-27 2023-04-20 無担体生物活性タンパク質ナノ構造体

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JP2023069170A Pending JP2023103260A (ja) 2013-09-27 2023-04-20 無担体生物活性タンパク質ナノ構造体

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US (6) US9603944B2 (enExample)
EP (2) EP3049114B1 (enExample)
JP (3) JP7097667B2 (enExample)
CA (2) CA3191031A1 (enExample)
ES (1) ES2904276T3 (enExample)
WO (1) WO2015048498A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3191031A1 (en) 2013-09-27 2015-04-02 Massachusetts Institute Of Technology Carrier-free biologically-active protein nanostructures
AU2016305087B2 (en) * 2015-08-12 2022-01-20 Massachusetts Institute Of Technology Cell surface coupling of nanoparticles
CN109715196A (zh) * 2016-06-13 2019-05-03 转矩医疗股份有限公司 用于促进免疫细胞功能的组合物和方法
US11123441B2 (en) * 2016-10-04 2021-09-21 The Trustees Of The University Of Pennsylvania Methods and compositions for drug delivery
US20200306301A1 (en) 2017-07-03 2020-10-01 Torque Therapeutics, Inc. Polynucleotides Encoding Immunostimulatory Fusion Molecules and Uses Thereof
CA3074826A1 (en) * 2017-09-05 2019-03-14 Torque Therapeutics, Inc. Therapeutic protein compositions and methods of making and using the same
EP3678704A4 (en) * 2017-09-05 2021-09-01 Torque Therapeutics, Inc. REVERSIBLE LINKS AND THEIR USE
JP2022500034A (ja) 2018-09-10 2022-01-04 トルク セラピューティクス， インコーポレイテッド 抗原特異的ｔリンパ球ならびに抗原特異的ｔリンパ球を作製および使用する方法
AU2020253356A1 (en) * 2019-03-29 2021-10-28 Torque Therapeutics, Inc. Immunotherapeutic compositions and use thereof
FR3099052B1 (fr) * 2019-07-23 2022-03-25 Univ Franche Comte Structures particulaires à base de nanoparticules d’or, leurs procédés de préparation et leurs utilisations dans le traitement des tumeurs solides
EP3795172A1 (en) 2019-09-20 2021-03-24 Ecole Polytechnique Federale De Lausanne (EPFL) EPFL-TTO Polymer or polycondensate based on peptide, linker and optionally other monomers and method for preparing the same
CN113121670B (zh) * 2020-01-15 2022-11-22 天津键凯科技有限公司 二取代peg化白细胞介素2及其制备方法、应用
CN112125832B (zh) * 2020-08-12 2022-09-20 北京大学 刺突蛋白受体结合结构域纳米凝胶及其制备方法与应用
CA3206549A1 (en) 2021-01-29 2022-08-04 Frederick G. Vogt Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy
CN112891556B (zh) * 2021-02-01 2023-03-03 浙江大学医学院附属第一医院 一种单抗类药物口服纳米凝胶及其制备方法
EP4469065A1 (en) 2022-01-28 2024-12-04 Iovance Biotherapeutics, Inc. Cytokine associated tumor infiltrating lymphocytes compositions and methods
CN115746044A (zh) * 2022-09-27 2023-03-07 大连理工大学 一类含有链中柔性链段和脲键的硅烷偶联剂及其制备方法及其制备方法
US20260234258A1 (en) 2022-10-20 2026-08-13 Repertoire Immune Medicines, Inc. Cd8 t cell targeted il2
EP4634216A1 (en) 2022-12-16 2025-10-22 Repertoire Immune Medicines, Inc. T cell receptors binding hpv-16 epitopes

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE147633T1 (de) 1988-10-27 1997-02-15 Univ Minnesota Immunhilfsmittel aus liposome enthaltend lymphokin il -2
JPH03244601A (ja) 1990-02-22 1991-10-31 Masuko Suzuki マンナンと癌細胞分化誘導体の複合体、その製法及び抗癌剤
US5453491A (en) * 1990-09-11 1995-09-26 Kiyoshi Takatsu Murine interleukin-5 receptor
CA2065658A1 (en) 1991-04-19 1992-10-20 Tse-Wen Chang Conjugates of liposomes or microbeads and antibodies specific for t lymphocytes and their use in vivo immune modulators
US6197298B1 (en) 1991-04-19 2001-03-06 Tanox, Inc. Modified binding molecules specific for T lymphocytes and their use as in vivo immune modulators in animals
US5753261A (en) 1993-02-12 1998-05-19 Access Pharmaceuticals, Inc. Lipid-coated condensed-phase microparticle composition
US6180134B1 (en) 1993-03-23 2001-01-30 Sequus Pharmaceuticals, Inc. Enhanced ciruclation effector composition and method
US5464629A (en) 1993-11-16 1995-11-07 Georgetown University Method of forming hydrogel particles having a controlled size using liposomes
AU713040B2 (en) 1994-07-15 1999-11-18 University Of Iowa Research Foundation, The Immunomodulatory oligonucleotides
US6056973A (en) 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
IN184589B (enExample) 1996-10-16 2000-09-09 Alza Corp
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
IN190388B (enExample) 1997-10-01 2003-07-26 Biomira Usa Inc
US6787132B1 (en) 1997-12-04 2004-09-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combined chemo-immunotherapy with liposomal drugs and cytokines
US6693086B1 (en) 1998-06-25 2004-02-17 National Jewish Medical And Research Center Systemic immune activation method using nucleic acid-lipid complexes
US6319715B1 (en) 2000-04-21 2001-11-20 Cornell Research Foundation, Inc. Method of enhancing the delivery of nucleic acids using silica nanoparticles
US20020151004A1 (en) 2000-07-24 2002-10-17 Roger Craig Delivery vehicles and methods for using the same
HUP0303616A3 (en) 2001-03-26 2006-07-28 Alza Corp Mountain View Liposome composition for improved intracellular delivery of a therapeutic agent
US20030235619A1 (en) 2001-12-21 2003-12-25 Christine Allen Polymer-lipid delivery vehicles
JP5014573B2 (ja) 2002-05-09 2012-08-29 オンコサイレオン インコーポレーテッド 脂質ａおよび他の炭水化物リガンド類似体
AU2003300043A1 (en) 2002-10-10 2004-05-04 Elizabeth Chambers Carriers attached to blood cells
US8192485B2 (en) * 2002-11-13 2012-06-05 The United States of America, as represented by the Department of Veterens Affairs Reversible hydrogel systems and methods therefor
US7435592B2 (en) 2003-05-13 2008-10-14 Immunovative Therapies, Ltd. Compositions for allogeneic cell therapy
US7402431B2 (en) 2004-03-01 2008-07-22 Immunovative Therapies, Ltd. T-cell therapy formulation
US20040247624A1 (en) 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US7223544B2 (en) 2003-06-27 2007-05-29 Cornell Research Foundation, Inc. Nucleic acid-engineered materials
US20050042298A1 (en) 2003-08-20 2005-02-24 Pardridge William M. Immunonanoparticles
EP1550458A1 (en) 2003-12-23 2005-07-06 Vectron Therapeutics AG Synergistic liposomal adjuvants
ES2367027T3 (es) 2004-02-27 2011-10-27 Inserm (Institut National De La Santé Et De La Recherche Medicale) Sitio de unión de la il-15 para il-15ralfa y mutantes específicos de il-15 que tienen actividad agonista/antagonista.
JP2007526322A (ja) 2004-03-02 2007-09-13 マサチューセッツ インスティテュート オブ テクノロジー ナノセル薬物送達系
WO2006080951A2 (en) 2004-07-01 2006-08-03 Yale University Targeted and high density drug loaded polymeric materials
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
DE102004054536A1 (de) 2004-11-06 2006-05-11 Capsulution Nanoscience Ag Multimodal veränderte Zellen als zellulare Darreichungsformen für aktive Substanzen und als diagnostische Zellpartikel
US8246995B2 (en) 2005-05-10 2012-08-21 The Board Of Trustees Of The Leland Stanford Junior University Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells
WO2007001677A2 (en) 2005-05-17 2007-01-04 University Of Connecticut Compositions and methods for immunomodulation in an organism
US20070148246A1 (en) 2005-08-11 2007-06-28 Dan Luo Nucleic Acid-Based Matrixes
WO2007022152A2 (en) 2005-08-15 2007-02-22 The Research Foundation Of State University Of New York Lipid nano particulates containing antigens as cancer vaccines
JP2009508936A (ja) 2005-09-20 2009-03-05 イッサム リサーチ ディベロップメント カンパニー 活性物質の標的化送達用ナノ粒子
JP2007131568A (ja) * 2005-11-09 2007-05-31 Nippon Seiyaku Kogyo Kk 免疫賦活剤及びこれを含有する免疫賦活性飲食物
CA2633399C (en) 2005-12-12 2016-01-26 Ac Immune S.A. Therapeutic vaccine
CA2601803A1 (en) 2006-01-13 2007-07-19 Riken Preventive or therapeutic agent and method for immune disease
CA2643826A1 (en) 2006-02-27 2008-06-12 Paul A. Wender Compositions and methods for transport of molecules with enhanced release properties across biological barriers
JP2009542592A (ja) 2006-07-06 2009-12-03 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｉｌ−２媒介性免疫応答の有効性を高める組成物および方法
US8367051B2 (en) * 2006-10-09 2013-02-05 Carnegie Mellon University Preparation of functional gel particles with a dual crosslink network
CA2705797A1 (en) 2007-11-14 2009-05-22 The Regents Of The University Of California Sterol-modified amphiphilic lipids
JP2009149526A (ja) 2007-12-18 2009-07-09 Tokyo Medical & Dental Univ サイトカイン−ナノゲル複合体を含む皮下注射又は筋肉内注射徐放製剤
WO2009134866A2 (en) 2008-04-29 2009-11-05 The Brigham And Women's Hospital, Inc. Cell membrane engineering
WO2010059253A2 (en) 2008-11-24 2010-05-27 Massachusets Institute Of Technology Methods and compositions for localized agent delivery
EP2406173A4 (en) 2009-03-09 2016-04-06 Univ California SINGLE PROTEIN NANOCAPSULES FOR PROTEIN RELIEF WITH LONG-TERM EFFECT
CA2754896C (en) 2009-03-09 2017-11-28 Molecular Express, Inc. Methods and compositions for liposomal formulation of antigens and uses thereof
WO2010138193A2 (en) 2009-05-27 2010-12-02 Selecta Biosciences, Inc. Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents
US20100324124A1 (en) 2009-06-17 2010-12-23 Massachusetts Institute Of Technology Compositions and methods relating to DNA-based particles
US20100323018A1 (en) 2009-06-17 2010-12-23 Massachusetts Institute Of Technology Branched DNA/RNA monomers and uses thereof
CA2780645C (en) 2009-11-18 2018-01-16 Nektar Therapeutics Salt form of a multi-arm polymer-drug conjugate
SG184127A1 (en) 2010-03-19 2012-10-30 Massachusetts Inst Technology Lipid vesicle compositions and methods of use
US9149432B2 (en) 2010-03-19 2015-10-06 Massachusetts Institute Of Technology Lipid vesicle compositions and methods of use
US20110229556A1 (en) 2010-03-19 2011-09-22 Massachusetts Institute Of Technology Lipid-coated polymer particles for immune stimulation
WO2012024396A2 (en) 2010-08-17 2012-02-23 Rutgers, The State University Of New Jersey Compositions and methods for delivering nucleic acid molecules and treating cancer
EP2616103A1 (en) 2010-09-16 2013-07-24 The University of North Carolina At Chapel Hill Asymmetric bifunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents
JP6251570B2 (ja) 2010-09-21 2017-12-20 アルター・バイオサイエンス・コーポレーション 多量体ｉｌ−１５可溶性融合分子並びにその製造及び使用方法
US20140081012A1 (en) 2011-02-15 2014-03-20 The University Of North Carolina At Chapel Hill Nanoparticle, liposomes, polymers, agents and proteins modified with reversible linkers
WO2012142410A2 (en) 2011-04-15 2012-10-18 The Regents Of The University Of California Redox responsive polymeric nanocapsules for protein delivery
WO2013033430A1 (en) * 2011-09-02 2013-03-07 Wake Forest School Of Medicine Targeted delivery and prodrug designs for platinum-acridine anti-cancer compounds and methods thereof
JP2013173689A (ja) 2012-02-24 2013-09-05 Univ Of Tsukuba 高分子化ニトロキシドラジカル化合物と非ステロイド性抗炎症薬の複合体
US20130337471A1 (en) 2012-06-14 2013-12-19 Emory University Cell identification with nanoparticles, compositions and methods related thereto
US9149535B2 (en) * 2012-06-28 2015-10-06 University Of South Carolina Polymers and the preparation of nanogel drug cocktails
FR3004106B1 (fr) 2013-04-05 2016-08-05 Oreal Composition contenant des particules composites filtrant les radiations uv de taille moyenne superieure a 0,1μm et des particules d'aerogel de silice hydrophobes
EP3650038A1 (en) 2013-06-19 2020-05-13 Massachusetts Institute of Technology In vivo targeting of cells with ligand-conjugated particles
CA3191031A1 (en) 2013-09-27 2015-04-02 Massachusetts Institute Of Technology Carrier-free biologically-active protein nanostructures
AU2016305087B2 (en) * 2015-08-12 2022-01-20 Massachusetts Institute Of Technology Cell surface coupling of nanoparticles
CN109715196A (zh) 2016-06-13 2019-05-03 转矩医疗股份有限公司 用于促进免疫细胞功能的组合物和方法
US10933660B2 (en) 2017-02-01 2021-03-02 Hewlett-Packard Development Company, L.P. Output tension zones

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