JP2016533344A5 - - Google Patents
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- JP2016533344A5 JP2016533344A5 JP2016517553A JP2016517553A JP2016533344A5 JP 2016533344 A5 JP2016533344 A5 JP 2016533344A5 JP 2016517553 A JP2016517553 A JP 2016517553A JP 2016517553 A JP2016517553 A JP 2016517553A JP 2016533344 A5 JP2016533344 A5 JP 2016533344A5
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- 102000004169 proteins and genes Human genes 0.000 claims description 74
- 108090000623 proteins and genes Proteins 0.000 claims description 74
- 229920000642 polymer Polymers 0.000 claims description 54
- 239000000203 mixture Substances 0.000 claims description 45
- 230000000975 bioactive effect Effects 0.000 claims description 31
- 108090000695 Cytokines Proteins 0.000 claims description 23
- 102000004127 Cytokines Human genes 0.000 claims description 23
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 19
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 229920001477 hydrophilic polymer Polymers 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 238000001727 in vivo Methods 0.000 claims description 4
- 208000023275 Autoimmune disease Diseases 0.000 claims description 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 3
- 206010012601 diabetes mellitus Diseases 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 238000011467 adoptive cell therapy Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 230000002483 superagonistic effect Effects 0.000 claims 2
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000002699 Digestive System Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 201000010918 connective tissue cancer Diseases 0.000 claims 1
- 208000024558 digestive system cancer Diseases 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 208000024519 eye neoplasm Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010231 gastrointestinal system cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000008106 ocular cancer Diseases 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 54
- 239000002086 nanomaterial Substances 0.000 description 28
- 125000000524 functional group Chemical group 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 8
- 108010002350 Interleukin-2 Proteins 0.000 description 7
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical group [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 6
- 229910000077 silane Inorganic materials 0.000 description 6
- 239000000427 antigen Substances 0.000 description 5
- 102000036639 antigens Human genes 0.000 description 5
- 108091007433 antigens Proteins 0.000 description 5
- 239000012062 aqueous buffer Substances 0.000 description 5
- 239000003102 growth factor Substances 0.000 description 5
- 239000002245 particle Substances 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 3
- 229920000747 poly(lactic acid) Polymers 0.000 description 3
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 3
- 239000004626 polylactic acid Substances 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 210000000581 natural killer T-cell Anatomy 0.000 description 2
- 210000000822 natural killer cell Anatomy 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 230000004962 physiological condition Effects 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical group [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361883503P | 2013-09-27 | 2013-09-27 | |
| US61/883,503 | 2013-09-27 | ||
| PCT/US2014/057789 WO2015048498A2 (en) | 2013-09-27 | 2014-09-26 | Carrier-free biologically-active protein nanostructures |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020109309A Division JP7272664B2 (ja) | 2013-09-27 | 2020-06-25 | 無担体生物活性タンパク質ナノ構造体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016533344A JP2016533344A (ja) | 2016-10-27 |
| JP2016533344A5 true JP2016533344A5 (enExample) | 2017-11-09 |
| JP7097667B2 JP7097667B2 (ja) | 2022-07-08 |
Family
ID=51795741
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016517553A Active JP7097667B2 (ja) | 2013-09-27 | 2014-09-26 | 無担体生物活性タンパク質ナノ構造体 |
| JP2020109309A Active JP7272664B2 (ja) | 2013-09-27 | 2020-06-25 | 無担体生物活性タンパク質ナノ構造体 |
| JP2023069170A Pending JP2023103260A (ja) | 2013-09-27 | 2023-04-20 | 無担体生物活性タンパク質ナノ構造体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020109309A Active JP7272664B2 (ja) | 2013-09-27 | 2020-06-25 | 無担体生物活性タンパク質ナノ構造体 |
| JP2023069170A Pending JP2023103260A (ja) | 2013-09-27 | 2023-04-20 | 無担体生物活性タンパク質ナノ構造体 |
Country Status (6)
| Country | Link |
|---|---|
| US (6) | US9603944B2 (enExample) |
| EP (2) | EP3049114B1 (enExample) |
| JP (3) | JP7097667B2 (enExample) |
| CA (2) | CA3191031A1 (enExample) |
| ES (1) | ES2904276T3 (enExample) |
| WO (1) | WO2015048498A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3049114B1 (en) * | 2013-09-27 | 2021-11-10 | Massachusetts Institute of Technology | Carrier-free biologically-active protein nanostructures |
| US11034752B2 (en) | 2015-08-12 | 2021-06-15 | Massachusetts Institute Of Technology | Cell surface coupling of nanoparticles |
| CA3029813A1 (en) * | 2016-06-13 | 2017-12-21 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
| US11123441B2 (en) * | 2016-10-04 | 2021-09-21 | The Trustees Of The University Of Pennsylvania | Methods and compositions for drug delivery |
| EP3648786A4 (en) | 2017-07-03 | 2021-12-15 | Torque Therapeutics, Inc. | FUSION MOLECULES TARGETING IMMUNE REGULATORY CELLS AND THEIR USES |
| CA3075027A1 (en) * | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | Reversible linkers and use thereof |
| WO2019050978A1 (en) * | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | THERAPEUTIC PROTEIN COMPOSITIONS AND METHODS OF PREPARATION AND USE THEREOF |
| US20220033766A1 (en) | 2018-09-10 | 2022-02-03 | Torque Therapeutics, Inc. | Antigen-specific t lymphocytes and methods of making and using the same |
| MX2021011653A (es) * | 2019-03-29 | 2021-10-22 | Torque Therapeutics Inc | Composiciones inmunoterapeuticas y uso de las mismas. |
| FR3099052B1 (fr) * | 2019-07-23 | 2022-03-25 | Univ Franche Comte | Structures particulaires à base de nanoparticules d’or, leurs procédés de préparation et leurs utilisations dans le traitement des tumeurs solides |
| EP3795172A1 (en) | 2019-09-20 | 2021-03-24 | Ecole Polytechnique Federale De Lausanne (EPFL) EPFL-TTO | Polymer or polycondensate based on peptide, linker and optionally other monomers and method for preparing the same |
| CN113121670B (zh) * | 2020-01-15 | 2022-11-22 | 天津键凯科技有限公司 | 二取代peg化白细胞介素2及其制备方法、应用 |
| CN112125832B (zh) * | 2020-08-12 | 2022-09-20 | 北京大学 | 刺突蛋白受体结合结构域纳米凝胶及其制备方法与应用 |
| CA3206549A1 (en) | 2021-01-29 | 2022-08-04 | Frederick G. Vogt | Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy |
| CN112891556B (zh) * | 2021-02-01 | 2023-03-03 | 浙江大学医学院附属第一医院 | 一种单抗类药物口服纳米凝胶及其制备方法 |
| WO2023147488A1 (en) | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | Cytokine associated tumor infiltrating lymphocytes compositions and methods |
| CN115746044A (zh) * | 2022-09-27 | 2023-03-07 | 大连理工大学 | 一类含有链中柔性链段和脲键的硅烷偶联剂及其制备方法及其制备方法 |
| WO2024086827A2 (en) | 2022-10-20 | 2024-04-25 | Repertoire Immune Medicines, Inc. | Cd8 t cell targeted il2 |
| AU2023395989A1 (en) | 2022-12-16 | 2025-07-24 | Repertoire Immune Medicines, Inc. | T cell receptors binding hpv-16 epitopes |
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| EP3049114B1 (en) | 2013-09-27 | 2021-11-10 | Massachusetts Institute of Technology | Carrier-free biologically-active protein nanostructures |
| US11034752B2 (en) * | 2015-08-12 | 2021-06-15 | Massachusetts Institute Of Technology | Cell surface coupling of nanoparticles |
| CA3029813A1 (en) | 2016-06-13 | 2017-12-21 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
| US10933660B2 (en) | 2017-02-01 | 2021-03-02 | Hewlett-Packard Development Company, L.P. | Output tension zones |
-
2014
- 2014-09-26 EP EP14789653.4A patent/EP3049114B1/en active Active
- 2014-09-26 CA CA3191031A patent/CA3191031A1/en active Pending
- 2014-09-26 WO PCT/US2014/057789 patent/WO2015048498A2/en not_active Ceased
- 2014-09-26 CA CA2925304A patent/CA2925304C/en active Active
- 2014-09-26 US US14/498,386 patent/US9603944B2/en active Active
- 2014-09-26 JP JP2016517553A patent/JP7097667B2/ja active Active
- 2014-09-26 ES ES14789653T patent/ES2904276T3/es active Active
- 2014-09-26 EP EP21207101.3A patent/EP4043036A1/en not_active Withdrawn
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2017
- 2017-03-27 US US15/470,169 patent/US10226510B2/en active Active
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2018
- 2018-11-19 US US16/195,128 patent/US10357544B2/en active Active
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2019
- 2019-06-25 US US16/451,996 patent/US10588942B2/en active Active
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2020
- 2020-02-19 US US16/795,286 patent/US11529392B2/en active Active
- 2020-06-25 JP JP2020109309A patent/JP7272664B2/ja active Active
-
2022
- 2022-11-11 US US17/985,817 patent/US20230277626A1/en not_active Abandoned
-
2023
- 2023-04-20 JP JP2023069170A patent/JP2023103260A/ja active Pending
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