JP2016533235A - 物体の屈折率のインサイチュー算定 - Google Patents
物体の屈折率のインサイチュー算定 Download PDFInfo
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Abstract
Description
本願は、2013年7月25日に出願された米国特許仮出願第61/858,445号の優先権主張出願であり、この米国特許仮出願は、2008年3月3日に出願された米国特許出願第12/048,182号(発明の名称:METHOD AND APPARATUS FOR CREATING INCISIONS TO IMPROVE INTRAOCULAR LENS PLACEMENT )、2008年3月13日に出願された米国特許出願第12/048,186号(発明の名称:METHOD AND APPARATUS FOR CREATING OCULAR SURGICAL AND RELAXING INCISIONS)、及び、2012年11月2日に出願された米国特許出願第61/722,064号(発明の名称:LASER EYE SURGERY SYSTEM CALIBRATION)に関連し、これら出願を参照により引用し、これらの記載内容を本明細書の一部とする。ここに、パリ条約上の優先権の全てを明示的に保持する。
Claims (28)
- 物体の屈折率を算定する方法であって、
光を、ビーム経路に沿って、前記物体内の所在位置を有する焦点に集束させるステップと、
前記物体内の前記焦点の前記所在位置に応じて、前記物体の前記屈折率を算定するステップと、
を備えたことを特徴とする方法。 - 前記物体は、第2の屈折率を有する第2の物体に隣接して位置する表面を有しており、
前記第1の屈折率は、前記第2の屈折率とは異なっており、
前記ビーム経路は、前記表面から前記焦点までの距離にわたって延びており、
前記屈折率は、前記表面から前記焦点までの前記距離に応じて算定される
ことを特徴とする請求項1記載の方法。 - 前記物体は、標的物体から成り、
当該方法は、前記ビーム経路の所在位置を前記集束光の光学干渉信号によって算定するステップを更に備え、
前記所在位置は、前記光学干渉信号のピーク強度の所在位置に応じて求められる
ことを特徴とする請求項2記載の方法。 - 前記標的物体は、患者の眼の光学的に透過性の組織構造体を有する
ことを特徴とする請求項3記載の方法。 - 前記眼の前記光学的に透過性の組織構造体は、涙液膜、角膜、眼房水、水晶体、前水晶体曩、水晶体皮質、水晶体皮質の前方部分、水晶体皮質の後方部分、水晶体核、後水晶体曩、及び、硝子体液、のうちの1つ又は2つ以上を含み、
第2の組織構造体が、前記第2の物体を有しており、
前記第2の組織構造体は、前記光学的に透過性の組織構造体の前方に位置しており、
前記表面は、両者の間に配置されている
ことを特徴とする請求項4記載の方法。 - 前記光学的に透過性の組織構造体の前記屈折率を算定するために、前記ビーム経路に沿う複数の焦点の複数の所在位置を決定するステップ
を更に備えたことを特徴とする請求項4記載の方法。 - 前記複数の所在位置は、第1の焦点の第1の所在位置及び第2の焦点の第2の所在位置を含み、
前記屈折率は、前記第1の焦点と前記第2の焦点との間の前記物体の平均屈折率に対応している
ことを特徴とする請求項6記載の方法。 - 前記第1の所在位置は、前記眼の水晶体の前方部分の前方所在位置を有しており、
前記第2の所在位置は、前記眼の後方部分の後方所在位置を有しており、
前記屈折率は、前記水晶体の前記前方部分と前記水晶体の前記後方部分との間の平均屈折率に対応している、請求項7記載の方法。 - 前記平均屈折率は、前記水晶体の後水晶体曩の近くへの治療ビームの位置決めを決定するために、前記前方所在位置と前記後方所在位置との間の光路長に沿う屈折率の積分に対応している、請求項8記載の方法。
- 複数の集束レーザビームパルスを前記水晶体の後方部分に方向付けて前記水晶体の当該後方部分を切開するステップ
を更に備えたことを特徴とする請求項8記載の方法。 - 複数の集束レーザビームパルスを前記水晶体の後水晶体曩に方向付けて前記平均屈折率に応じて前記水晶体の前記後水晶体曩を切開するステップ
を更に備え、
前記集束ビームは、前記集束レーザビームとは異なる1つ又は2つ以上の光の波長を有する、請求項8記載の方法。 - 前記組織構造体の前記屈折率を前記ビーム経路に沿う前記複数の焦点の前記複数の所在位置に応じてマッピングするステップと、
前記複数の所在位置の各々について前記標的物体の前記屈折率を算定するために、前記複数の焦点の各々について前記集束ステップ及び前記算定ステップを繰り返すステップと、
を更に備えたことを特徴とする請求項6記載の方法。 - 前記複数の所在位置は、前記眼の前記水晶体の複数の所在位置を含み、
前記眼の前記水晶体の勾配屈折率プロフィールが、前記眼の前記水晶体内の前記複数の焦点の前記複数の所在位置に応じて求められる
ことを特徴とする請求項12記載の方法。 - 光源は、トモグラフィーシステムの光源を有し、
当該トモグラフィーシステムは、光干渉トモグラフィーシステム、スペクトル光干渉トモグラフィーシステム、時間領域光干渉トモグラフィーシステム、シャインプルーク画像化トモグラフィーシステム、共焦点トモグラフィーシステム、及び、低コヒーレンス反射光測定システムのうちの1つ又は2つ以上を含み、
前記焦点の前記所在位置は、当該トモグラフィーシステムにより決定される
ことを特徴とする請求項3記載の方法。 - 前記標的物体の前記屈折率は、所定の屈折率に応じて算定される
ことを特徴とする請求項3記載の方法。 - 前記所定の屈折率は、患者インターフェース光学部品、水、生理的食塩水、角膜、及び、眼房水、のうちの1つ又は2つ以上の屈折率を有する
ことを特徴とする請求項15記載の方法。 - 前記屈折率を算定するステップは、前記所定の屈折率に、前記標的物体の表面と前記所定のビーム経路所在位置との間の距離を前記標的物体の前記表面と意図した焦点との間の距離で除算して得られる値の平方根を乗算するステップを含む
ことを特徴とする請求項15記載の方法。 - 眼の構造体を治療する方法であって、
前記構造体中で所在位置を有する焦点に光源を集束させるステップと、
前記焦点の所在位置を光学干渉信号に応じて識別するステップと、
前記物体の屈折率を前記焦点の前記所在位置に応じて算定するステップと、
前記屈折率を前記構造体にマッピングするステップと、
前記構造体のプロフィールを前記マッピングに応じて求めるステップと、
前記構造体の前記プロフィールに応じて当該構造体を切開するステップと、
を備えたことを特徴とする方法。 - 前記眼の前記構造体は、涙液膜、角膜、眼防水、水晶体、前水晶体曩、後水晶体曩、水晶体皮質、水晶体核、及び、硝子体液、のうちの1つ又は2つ以上を含む
ことを特徴とする請求項18記載の方法。 - 物体の屈折率を算定する装置であって、
光のビームを発生させる光源を含むトモグラフィーシステムと、
画像化システムに結合されると共に前記トモグラフィーシステムからデータを受け取るように構成された有体的媒体を含むプロセッサと、
を備え、
前記有体的媒体は、前記ビームの焦点の所在位置に応じて物体の屈折率を算定するよう、命令を具体化する
ことを特徴とする装置。 - 前記有体的媒体は、
前記物質中で意図した所在位置を有する意図した焦点に前記光ビームを集束させ、
前記集束させた光の干渉信号の所在位置を識別し、
前記意図した焦点所在位置及び前記求めた干渉パターン所在位置に応じて前記標的物体の屈折率を算定し、
前記算定された屈折率を前記物体の所在位置にマッピングする、
という命令を具体化する
ことを特徴とする請求項20記載の装置。 - 前記物体を切開するためにパルス化レーザビームを発生させるパルスレーザと、
前記レーザビーム、前記トモグラフィーシステム、及び前記プロセッサに結合された光学的送出システムと、
を更に備え、
前記有体的媒体は、前記屈折率に応じて治療プロフィールを決定する命令を含む
ことを特徴とする請求項20記載の装置。 - 前記パルスレーザは、第1の1つ又は2つ以上の波長を有しており、
第2のレーザは、前記第1の1つ又は2つ以上の波長とは異なる第2の1つ又は2つ以上の波長を有しており、
前記プロセッサは、前記第1の1つ又は2つ以上の波長の前記屈折率に応じて、前記第2の1つ又は2つ以上の波長を有する前記パルス化レーザビームの複数の焦点位置を求める命令を含む
ことを特徴とする請求項22記載の装置。 - 前記有体的媒体は、前記マッピングに応じて前記物体のプロフィールを求めて当該プロフィールに応じて前記物体を前記レーザによって切開する命令を更に具体化する
ことを特徴とする請求項22記載の装置。 - 前記プロセッサは、前記物体の前記屈折率に応じて、前記物体の後方に位置する第2の構造体の切開プロフィールの命令を決定する命令を具体化する
ことを特徴とする請求項22記載の装置。 - 前記有体的媒体は、眼の標的組織構造体までの光路に沿う眼の複数の組織構造体の複数の屈折率を算定する命令を具体化し、
前記有体的媒体は、前記光路に沿う前記複数の屈折率に応じて、組織を切開するためにパルス化レーザビームの焦点位置を求める命令を具体化し、
前記複数の組織構造体は、前記眼の涙液膜、角膜、眼房水、水晶体、前水晶体曩、前水晶体皮質、水晶体核、後水晶体皮質、後水晶体曩、及び、硝子体液、のうちの1つ又は2つ以上を含む
ことを特徴とする請求項20記載の装置。 - 前記有体的媒体は、請求項1〜19のうちいずれか一に記載のステップのうちの任意の1つ又は2つ以上を実施する命令を具体化する
ことを特徴とする請求項20記載の装置。 - 前記トモグラフィーシステムは、光干渉トモグラフィーシステム、スペクトル光干渉トモグラフィーシステム、時間領域光干渉トモグラフィーシステム、シャインプルーク画像化トモグラフィーシステム、共焦点トモグラフィーシステム、及び、低コヒーレンス反射光測定システムのうちの1つ又は2つ以上を含み、
前記焦点の前記所在位置は、当該トモグラフィーシステムにより決定される
ことを特徴とする請求項20記載の装置。
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US11672419B2 (en) | 2023-06-13 |
JP6434015B2 (ja) | 2018-12-05 |
AU2014293542A1 (en) | 2015-12-24 |
WO2015013044A1 (en) | 2015-01-29 |
AU2019203837A1 (en) | 2019-06-20 |
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AU2014293542B2 (en) | 2019-03-14 |
CA2935721A1 (en) | 2015-01-29 |
US20200268245A1 (en) | 2020-08-27 |
CN105530853A (zh) | 2016-04-27 |
CN105530853B (zh) | 2018-12-04 |
US10849789B2 (en) | 2020-12-01 |
AU2019203837B2 (en) | 2021-06-17 |
EP3024376B1 (en) | 2019-03-20 |
EP3646774A1 (en) | 2020-05-06 |
US20150032090A1 (en) | 2015-01-29 |
US20240172937A1 (en) | 2024-05-30 |
US11911104B2 (en) | 2024-02-27 |
US20170189233A1 (en) | 2017-07-06 |
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