JP2016531846A5 - - Google Patents
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- Publication number
- JP2016531846A5 JP2016531846A5 JP2016515427A JP2016515427A JP2016531846A5 JP 2016531846 A5 JP2016531846 A5 JP 2016531846A5 JP 2016515427 A JP2016515427 A JP 2016515427A JP 2016515427 A JP2016515427 A JP 2016515427A JP 2016531846 A5 JP2016531846 A5 JP 2016531846A5
- Authority
- JP
- Japan
- Prior art keywords
- stereoisomer
- acceptable salt
- pharmaceutically acceptable
- fibrosis
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 206010016654 Fibrosis Diseases 0.000 claims 10
- 230000004761 fibrosis Effects 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 206010020772 Hypertension Diseases 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 238000011282 treatment Methods 0.000 claims 5
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 206010065918 Prehypertension Diseases 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 206010028594 Myocardial fibrosis Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 201000002793 renal fibrosis Diseases 0.000 claims 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- -1 hydroxy, amino Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 201000011461 pre-eclampsia Diseases 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2013903571A AU2013903571A0 (en) | 2013-09-17 | Compositions for the treatment of hypertension and/or fibrosis | |
| AU2013903571 | 2013-09-17 | ||
| AU2013903572A AU2013903572A0 (en) | 2013-09-17 | Compositions for the treatment of hypertension and/or fibrosis | |
| AU2013903572 | 2013-09-17 | ||
| PCT/AU2014/000922 WO2015039172A1 (en) | 2013-09-17 | 2014-09-17 | Compositions for the treatment of hypertension and/or fibrosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531846A JP2016531846A (ja) | 2016-10-13 |
| JP2016531846A5 true JP2016531846A5 (https=) | 2017-10-05 |
| JP6293266B2 JP6293266B2 (ja) | 2018-03-14 |
Family
ID=52687997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016515427A Active JP6293266B2 (ja) | 2013-09-17 | 2014-09-17 | 高血圧及び／又は線維症の処置用組成物 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9630935B2 (https=) |
| EP (1) | EP3046902B1 (https=) |
| JP (1) | JP6293266B2 (https=) |
| KR (1) | KR101863708B1 (https=) |
| CN (1) | CN105683153B (https=) |
| AP (1) | AP2016009080A0 (https=) |
| AU (1) | AU2014324075B2 (https=) |
| BR (1) | BR112016005606B1 (https=) |
| CA (1) | CA2924353C (https=) |
| DK (1) | DK3046902T3 (https=) |
| ES (1) | ES2694375T3 (https=) |
| IL (1) | IL244622A0 (https=) |
| MX (1) | MX368011B (https=) |
| MY (1) | MY191337A (https=) |
| NZ (1) | NZ717930A (https=) |
| PH (1) | PH12016500495B1 (https=) |
| RU (1) | RU2661878C2 (https=) |
| SG (1) | SG11201601641VA (https=) |
| UA (1) | UA117254C2 (https=) |
| WO (1) | WO2015039172A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO3046901T3 (https=) * | 2013-09-17 | 2018-03-17 | ||
| MX376504B (es) | 2015-03-18 | 2025-03-07 | Vectus Biosystems Ltd | Composiciones para el tratamiento de enfermedades renales y/o hepaticas. |
| DK3271320T3 (da) | 2015-03-18 | 2020-02-03 | Vectus Biosystems Ltd | Sammensætninger til behandling af fibrose og fibroserelaterede tilstande |
| BR112019001510B1 (pt) * | 2016-07-28 | 2022-11-08 | Vectus Biosystems Limited | Composto, e, uso de um composto para manufatura de um medicamento para tratar profilática ou terapeuticamente fibrose pulmonar, ou uma enfermidade relacionada em um indivíduo com fibrose pulmonar ou em risco de desenvolver fibrose pulmonar |
| JP2019534266A (ja) | 2016-10-14 | 2019-11-28 | 江蘇恒瑞医薬股▲ふん▼有限公司 | ５員ヘテロアリール環の架橋した環誘導体、その製造方法およびその医学的使用 |
| ES2971497T3 (es) | 2017-10-06 | 2024-06-05 | Takeda Pharmaceuticals Co | Compuestos heterocíclicos |
| JP2023526521A (ja) * | 2020-05-21 | 2023-06-21 | ステムシナジー セラピューティクス， インク． | Ｎｏｔｃｈ阻害剤及びそれらの使用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EE200300360A (et) * | 2001-01-31 | 2003-12-15 | Pfizer Products Inc. | PDE4 isosüümide inhibiitoritena kasutatavad nikotiinamiidi biarüülderivaadid |
| KR20040054729A (ko) * | 2001-10-18 | 2004-06-25 | 브리스톨-마이어스 스큅 컴퍼니 | 인간 글루카곤-유사-펩티드-1 모방체, 및 당뇨병 및 이와관련된 증상의 치료에 있어서 이의 용도 |
| US20030162824A1 (en) * | 2001-11-12 | 2003-08-28 | Krul Elaine S. | Methods of treating or preventing a cardiovascular condition using a cyclooxygenase-1 inhibitor |
| ATE356808T1 (de) * | 2002-06-25 | 2007-04-15 | Merck Frosst Canada Ltd | 8-(biaryl)chinolin-pde4-inhibitoren |
| SE0301010D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| ES2523659T3 (es) * | 2004-06-11 | 2014-11-28 | Vectus Biosystems Limited | Composiciones y procedimientos para el tratamiento de enfermedades cardiovasculares |
| ATE413167T1 (de) * | 2004-08-17 | 2008-11-15 | Galderma Res & Dev | Neuartige biaromatische ppar-rezeptoren aktivierende zusammensetzungen und ihre verwendung in kosmetischen oder pharmazeutischen zusammensetzungen |
| TW200831080A (en) * | 2006-12-15 | 2008-08-01 | Irm Llc | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity |
| WO2009003921A1 (en) * | 2007-07-04 | 2009-01-08 | Neurosearch A/S | Novel pyrazole derivatives useful as potassium channel modulators |
| TW201021797A (en) * | 2008-12-04 | 2010-06-16 | Nat Univ Tsing Hua | 1,2,3-triazole derivatives as new cannabinoid-1 receptor antagonists |
| CA2752190A1 (en) | 2009-02-13 | 2010-08-19 | Jerini Ag | Small molecule bradykinin b1 receptor antagonists |
| SG176009A1 (en) * | 2009-05-28 | 2011-12-29 | Novartis Ag | Substituted aminopropionic derivatives as neprilysin inhibitors |
| US20120088737A2 (en) * | 2009-10-02 | 2012-04-12 | Ajinomoto Co., Inc | Novel acyl guanidine derivatives |
-
2014
- 2014-09-17 JP JP2016515427A patent/JP6293266B2/ja active Active
- 2014-09-17 EP EP14845828.4A patent/EP3046902B1/en active Active
- 2014-09-17 CN CN201480050947.1A patent/CN105683153B/zh active Active
- 2014-09-17 AU AU2014324075A patent/AU2014324075B2/en active Active
- 2014-09-17 UA UAA201602269A patent/UA117254C2/uk unknown
- 2014-09-17 KR KR1020167009836A patent/KR101863708B1/ko active Active
- 2014-09-17 CA CA2924353A patent/CA2924353C/en active Active
- 2014-09-17 DK DK14845828.4T patent/DK3046902T3/en active
- 2014-09-17 ES ES14845828.4T patent/ES2694375T3/es active Active
- 2014-09-17 AP AP2016009080A patent/AP2016009080A0/xx unknown
- 2014-09-17 BR BR112016005606-0A patent/BR112016005606B1/pt active IP Right Grant
- 2014-09-17 US US15/022,264 patent/US9630935B2/en active Active
- 2014-09-17 SG SG11201601641VA patent/SG11201601641VA/en unknown
- 2014-09-17 MY MYPI2016000481A patent/MY191337A/en unknown
- 2014-09-17 WO PCT/AU2014/000922 patent/WO2015039172A1/en not_active Ceased
- 2014-09-17 NZ NZ717930A patent/NZ717930A/en unknown
- 2014-09-17 RU RU2016112053A patent/RU2661878C2/ru active
- 2014-09-17 MX MX2016003372A patent/MX368011B/es active IP Right Grant
-
2016
- 2016-03-14 PH PH12016500495A patent/PH12016500495B1/en unknown
- 2016-03-16 IL IL244622A patent/IL244622A0/en active IP Right Grant
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