JP2016530316A5 - - Google Patents
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- Publication number
- JP2016530316A5 JP2016530316A5 JP2016542091A JP2016542091A JP2016530316A5 JP 2016530316 A5 JP2016530316 A5 JP 2016530316A5 JP 2016542091 A JP2016542091 A JP 2016542091A JP 2016542091 A JP2016542091 A JP 2016542091A JP 2016530316 A5 JP2016530316 A5 JP 2016530316A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- liquid pharmaceutical
- composition according
- water
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 7
- 239000004094 surface-active agent Substances 0.000 claims 7
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 6
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 6
- 229960000502 poloxamer Drugs 0.000 claims 6
- 229920001983 poloxamer Polymers 0.000 claims 6
- -1 Oxo-1 ′, 2 ′, 5,7-tetrahydrospiro [cyclopenta [b] pyridine-6,3′-pyrrolo [2,3-b] pyridine] -3-carboxamide trihydrate Chemical compound 0.000 claims 5
- DDOOFTLHJSMHLN-ZQHRPCGSSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=CC=CC=C1 DDOOFTLHJSMHLN-ZQHRPCGSSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- 229920001213 Polysorbate 20 Polymers 0.000 claims 3
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 3
- 229920000053 polysorbate 80 Polymers 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 235000011067 sorbitan monolaureate Nutrition 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000012052 hydrophilic carrier Substances 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical group CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 1
- 235000006679 Mentha X verticillata Nutrition 0.000 claims 1
- 235000002899 Mentha suaveolens Nutrition 0.000 claims 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 239000004376 Sucralose Substances 0.000 claims 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 1
- 230000002821 anti-nucleating effect Effects 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 150000002314 glycerols Chemical class 0.000 claims 1
- 239000001087 glyceryl triacetate Substances 0.000 claims 1
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- 229940041616 menthol Drugs 0.000 claims 1
- 239000008368 mint flavor Substances 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 239000007967 peppermint flavor Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229940069328 povidone Drugs 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims 1
- 235000019408 sucralose Nutrition 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 229960002622 triacetin Drugs 0.000 claims 1
- 239000001069 triethyl citrate Substances 0.000 claims 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 1
- 235000013769 triethyl citrate Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361878183P | 2013-09-16 | 2013-09-16 | |
| US61/878,183 | 2013-09-16 | ||
| PCT/US2014/055132 WO2015038736A2 (en) | 2013-09-16 | 2014-09-11 | Formulations for cgrp receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016530316A JP2016530316A (ja) | 2016-09-29 |
| JP2016530316A5 true JP2016530316A5 (enExample) | 2017-10-19 |
| JP6612234B2 JP6612234B2 (ja) | 2019-11-27 |
Family
ID=52666511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016542091A Active JP6612234B2 (ja) | 2013-09-16 | 2014-09-11 | Ｃｇｒｐ受容体アンタゴニストのための製剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20160220552A1 (enExample) |
| EP (2) | EP3915561A1 (enExample) |
| JP (1) | JP6612234B2 (enExample) |
| KR (3) | KR20220108207A (enExample) |
| CN (2) | CN112545981A (enExample) |
| AU (1) | AU2014318741B2 (enExample) |
| BR (1) | BR112016005589B8 (enExample) |
| CA (1) | CA2923426A1 (enExample) |
| IL (1) | IL244356B (enExample) |
| MX (1) | MX384611B (enExample) |
| RU (1) | RU2690006C2 (enExample) |
| SA (1) | SA516370737B1 (enExample) |
| WO (1) | WO2015038736A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI487706B (zh) * | 2010-11-12 | 2015-06-11 | Merck Sharp & Dohme | 六氫吡啶酮甲醯胺氮雜茚滿ｃｇｒｐ受體拮抗劑 |
| KR20230107902A (ko) | 2014-02-05 | 2023-07-18 | 머크 샤프 앤드 돔 엘엘씨 | Cgrp-활성 화합물에 대한 정제 제제 |
| US12168004B2 (en) | 2014-02-05 | 2024-12-17 | Merck Sharp & Dohme Llc | Treatment of migraine |
| US12383545B1 (en) | 2018-06-08 | 2025-08-12 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| WO2021005497A1 (en) * | 2019-07-05 | 2021-01-14 | Allergan Pharmaceuticals International Limited | Cgrp antagonists and clostridial derivatives for the treatment of cortical spreading depression associated disorders |
| AU2021319090A1 (en) | 2020-07-29 | 2023-03-02 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| WO2022140537A1 (en) | 2020-12-22 | 2022-06-30 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| JP2024533756A (ja) | 2021-09-27 | 2024-09-12 | アラガン ファーマスーティカルズ インターナショナル リミテッド | アトゲパントを含む片頭痛の併用療法 |
| CN119350337A (zh) * | 2024-12-24 | 2025-01-24 | 药康众拓(北京)医药科技有限公司 | 一类氘代哌啶酮酸酰胺氮杂茚满类cgrp抑制剂药物及用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU739393B2 (en) * | 1998-03-19 | 2001-10-11 | Merck Sharp & Dohme Corp. | Sulfurpenta fluorophenyl pyrazoles for controlling ectoparasitic infestations |
| GB9815801D0 (en) * | 1998-07-21 | 1998-09-16 | Merck & Co Inc | Liquid polymeric compositions for controlled released bioactive substances |
| ITRM20020357A1 (it) * | 2002-07-03 | 2004-01-05 | Foscama Biomed Chim Farma | Composizione liquida per la somministrazione orale di lorazepam. |
| US7390798B2 (en) * | 2004-09-13 | 2008-06-24 | Merck & Co., Inc. | Carboxamide spirolactam CGRP receptor antagonists |
| AU2007293032A1 (en) * | 2006-09-08 | 2008-03-13 | Merck Sharp & Dohme Corp. | Liquid pharmaceutical formulations for oral administration of a CGRP antagonist |
| US8715715B2 (en) * | 2008-11-03 | 2014-05-06 | Nal Pharmaceuticals Ltd. | Dosage form for insertion into the mouth |
| TWI487706B (zh) | 2010-11-12 | 2015-06-11 | Merck Sharp & Dohme | 六氫吡啶酮甲醯胺氮雜茚滿ｃｇｒｐ受體拮抗劑 |
-
2014
- 2014-09-11 KR KR1020227025748A patent/KR20220108207A/ko not_active Ceased
- 2014-09-11 KR KR1020167006505A patent/KR102337994B1/ko active Active
- 2014-09-11 KR KR1020217040059A patent/KR20210153745A/ko not_active Ceased
- 2014-09-11 RU RU2016114537A patent/RU2690006C2/ru active
- 2014-09-11 EP EP21171525.5A patent/EP3915561A1/en active Pending
- 2014-09-11 EP EP14844555.4A patent/EP3046923A4/en not_active Withdrawn
- 2014-09-11 BR BR112016005589A patent/BR112016005589B8/pt active IP Right Grant
- 2014-09-11 CN CN202011381004.0A patent/CN112545981A/zh active Pending
- 2014-09-11 AU AU2014318741A patent/AU2014318741B2/en active Active
- 2014-09-11 CA CA2923426A patent/CA2923426A1/en active Pending
- 2014-09-11 WO PCT/US2014/055132 patent/WO2015038736A2/en not_active Ceased
- 2014-09-11 US US15/021,471 patent/US20160220552A1/en not_active Abandoned
- 2014-09-11 MX MX2016003394A patent/MX384611B/es unknown
- 2014-09-11 CN CN201480050553.6A patent/CN105531275B/zh not_active Expired - Fee Related
- 2014-09-11 JP JP2016542091A patent/JP6612234B2/ja active Active
-
2016
- 2016-02-29 IL IL244356A patent/IL244356B/en active IP Right Grant
- 2016-03-14 SA SA516370737A patent/SA516370737B1/ar unknown
-
2018
- 2018-09-10 US US16/125,924 patent/US20190070161A1/en not_active Abandoned
-
2020
- 2020-12-07 US US17/114,169 patent/US20210330660A1/en not_active Abandoned
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