JP2016527302A - 接着トローチでの唾液刺激による睡眠中の逆流抑制 - Google Patents
接着トローチでの唾液刺激による睡眠中の逆流抑制 Download PDFInfo
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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Abstract
Description
徐々に溶解する基材及び唾液分泌を刺激する成分を有するトローチは、乾燥した複数の顆粒状粉末物を混合させることにより製造できる。前記基材は、イヌリン、ポリデキストロース又はポリオール等の炭水化物のように、唾液中に徐々に溶解又は浸食される少なくとも1種の粉末を含んでいる。
Claims (25)
- 治療が必要な人物において、睡眠中の胃から口内への逆流を減少させる方法であって、この方法は、
a.前記人物に接着性の二層トローチを提供することと、
b.前記人物に、就寝前に1以上のトローチを口内に接着するように指示することと、含み、これにより睡眠中に刺激された唾液を頻繁に嚥下させることで、結果として胃からの逆流を減少させ、
前記トローチは、
i.接着性粉末を含む第1の層と、
ii.唾液内で徐々に溶解又は浸食される基材及び放出される成分を含む第2の層と、を含み、前記成分は口内の唾液産生を促す、方法。 - 前記唾液産生を促す成分は風味分子を含む、請求項1記載の方法。
- 前記風味分子は甘味ポリオールを含む、請求項2記載の方法。
- 前記甘味ポリオールは、キシリトール、ソルビトール、マルチトール、エリトリトール及びマンニトールからなる群から選択される、請求項3記載の方法。
- 前記風味分子は合成甘味剤を含む、請求項2記載の方法。
- 前記合成甘味剤の分子は、スクラロース、ネオテーム、アスパルテーム、アセスルファムカリウム及びサッカリンからなる群から選択される、請求項5記載の方法。
- 前記風味分子はステビアを含む、請求項2記載の方法。
- 前記トローチは、二方向の寸法のそれぞれが約5mmから約18mmである、請求項1記載の方法。
- 前記人物は、臼歯の外側又は臼歯の外側に隣接する歯茎に前記トローチを接着するように指示される、請求項1記載の方法。
- 睡眠中の胃から口内への逆流を減少させる方法であって、
就寝前に口内に、睡眠中に溶解して睡眠中の唾液産生を促す成分を放出し、徐々に溶解する接着性の二層トローチを接着することを含み、これによって刺激された唾液の頻繁な嚥下を引き起こし、胃からの逆流を減少させ、
前記トローチは、
i.接着性粉末を含む第1の層と、
ii.唾液内で徐々に溶解又は浸食される基材及び放出される成分を含んだ第2の層と、を含み、前記成分は口内の唾液産生を促すことを特徴とする方法。 - 前記成分は風味分子を含む、請求項10記載の方法。
- 前記風味分子は甘味ポリオールを含む、請求項11記載の方法。
- 前記甘味ポリオールは、キシリトール、ソルビトール、マルチトール、エリトリトール及びマンニトールからなる群から選択される、請求項12記載の方法。
- 前記風味分子は合成甘味剤を含む、請求項11記載の方法。
- 前記合成甘味剤分子は、スクラロース、ネオテーム、アスパルテーム、アセスルファムカリウム及びサッカリンからなる群から選択される、請求項14記載の方法。
- 前記風味分子はステビアを含む、請求項11記載の方法。
- 前記トローチは、二方向の寸法のそれぞれが約5mmから約18mmである、請求項10記載の方法。
- 前記接着性トローチは、臼歯の外側又は臼歯の外側に隣接する歯茎に接着される、請求項10記載の方法。
- (a)二層の接着性トローチと、(b)就寝前に口内に1以上の前記トローチを接着させるよう指示する説明書と、を含み、
前記トローチは、
i.接着性粉末を含む第1の層と、
ii.唾液内で徐々に溶解又は浸食される基材及び放出される成分を含む第2の層と、を含み、前記成分は、口内での唾液の産生を促して、刺激された唾液の頻繁な嚥下を引き起こし、胃からの逆流を減少させる、キット。 - 前記トローチは、二方向の寸法のそれぞれが約5mmから約18mmである、請求項19記載のキット。
- 前記接着性粉末は、少なくとも80%のアカシアガムを含む、請求項19記載のキット。
- 前記成分は風味分子を含む、請求項19記載のキット。
- 前記風味分子は、キシリトール、ソルビトール、マルチトール、エリトリトール及びマンニトールからなる群から選択される甘味ポリオールを含む、請求項22記載のキット。
- 前記風味分子は、スクラロース、ネオテーム、アスパルテーム、アセスルファムカリウム及びサッカリンからなる群から選択される合成甘味剤を含む、請求項22記載のキット。
- 前記風味分子はステビアを含む、請求項22記載のキット。
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