JP2016526908A5 - - Google Patents
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- Publication number
- JP2016526908A5 JP2016526908A5 JP2016531859A JP2016531859A JP2016526908A5 JP 2016526908 A5 JP2016526908 A5 JP 2016526908A5 JP 2016531859 A JP2016531859 A JP 2016531859A JP 2016531859 A JP2016531859 A JP 2016531859A JP 2016526908 A5 JP2016526908 A5 JP 2016526908A5
- Authority
- JP
- Japan
- Prior art keywords
- signature
- pathway
- cto
- pharmacodynamic
- response
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000090 biomarker Substances 0.000 claims 30
- 230000037361 pathway Effects 0.000 claims 30
- 230000003285 pharmacodynamic effect Effects 0.000 claims 30
- 108090000623 proteins and genes Proteins 0.000 claims 24
- 238000000034 method Methods 0.000 claims 17
- 230000004044 response Effects 0.000 claims 17
- 230000028956 calcium-mediated signaling Effects 0.000 claims 13
- 108020004999 messenger RNA Proteins 0.000 claims 6
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims 5
- 108700005081 Overlapping Genes Proteins 0.000 claims 4
- 230000001419 dependent effect Effects 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 102100032249 Dystonin Human genes 0.000 claims 3
- 108010013976 Dystonin Proteins 0.000 claims 3
- 102100023226 Early growth response protein 1 Human genes 0.000 claims 3
- 101001049697 Homo sapiens Early growth response protein 1 Proteins 0.000 claims 3
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 3
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 3
- 239000002299 complementary DNA Substances 0.000 claims 3
- 238000003068 pathway analysis Methods 0.000 claims 3
- 230000002103 transcriptional effect Effects 0.000 claims 3
- -1 CEACAMI Proteins 0.000 claims 2
- 101710113864 Heat shock protein 90 Proteins 0.000 claims 2
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 claims 2
- 102000003964 Histone deacetylase Human genes 0.000 claims 2
- 108090000353 Histone deacetylase Proteins 0.000 claims 2
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 2
- 229960005010 orotic acid Drugs 0.000 claims 2
- 101100243447 Arabidopsis thaliana PER53 gene Proteins 0.000 claims 1
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 1
- 230000005723 MEK inhibition Effects 0.000 claims 1
- 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 claims 1
- 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 claims 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 1
- 101150040459 RAS gene Proteins 0.000 claims 1
- 101150076031 RAS1 gene Proteins 0.000 claims 1
- 101150080074 TP53 gene Proteins 0.000 claims 1
- 229940125374 mitogen-activated extracellular signal-regulated kinase inhibitor Drugs 0.000 claims 1
- 102000016914 ras Proteins Human genes 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/957,720 | 2013-08-02 | ||
| US13/957,720 US10378059B2 (en) | 2013-08-02 | 2013-08-02 | Methods and molecular pharmacodynamic biomarkers for multiple signaling pathways in response to carboxyamidotriazole orotate |
| PCT/US2014/048905 WO2015017545A1 (en) | 2013-08-02 | 2014-07-30 | Methods and molecular pharmacodynamic biomarkers for multiple signaling pathways in response to carboxyamidotriazole orotate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016526908A JP2016526908A (ja) | 2016-09-08 |
| JP2016526908A5 true JP2016526908A5 (enExample) | 2019-02-14 |
| JP6913459B2 JP6913459B2 (ja) | 2021-08-04 |
Family
ID=52428197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016531859A Active JP6913459B2 (ja) | 2013-08-02 | 2014-07-30 | オロト酸カルボキシアミドトリアゾール応答における多種多様なシグナリング経路に関する方法及び分子薬力学バイオマーカー |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10378059B2 (enExample) |
| EP (1) | EP3027776B1 (enExample) |
| JP (1) | JP6913459B2 (enExample) |
| KR (1) | KR102389934B1 (enExample) |
| CN (1) | CN105531380B (enExample) |
| AU (1) | AU2014296212B2 (enExample) |
| CA (1) | CA2919690C (enExample) |
| IL (1) | IL243894B (enExample) |
| WO (1) | WO2015017545A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3423452B1 (en) | 2016-03-01 | 2025-05-07 | University of Maryland, Baltimore | Wnt signaling pathway inhibitors for treatments of disease |
| JP6889009B2 (ja) * | 2017-04-13 | 2021-06-18 | 浜松ホトニクス株式会社 | 画像取得システム及び画像取得方法 |
| US20220168276A1 (en) * | 2020-08-05 | 2022-06-02 | Tactical Therapeotics Inc. | Mehods and Compositions for Treating SARS-CoV-2 Infection using Carboxyamidotriazole Orotate |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2227205C (en) * | 1995-07-21 | 2007-05-01 | Constantia Gruppe | Treatment and prevention of neoplasms with salts of aminoimidazole carboxamide and 5-amino or substituted amino 1,2,3-triazoles |
| US20030170720A1 (en) * | 2001-01-23 | 2003-09-11 | Van Der Kuyl Antoinette Cornelia | Means and methods for treatment evaluation |
| SI1504126T1 (sl) | 2002-05-03 | 2014-08-29 | Duke University Office Of Science And Technology | Postopek regulacije izraĹľanja genov |
| WO2008021115A2 (en) | 2006-08-14 | 2008-02-21 | The Brigham And Women's Hospital, Inc. | Diagnostic tests using gene expression ratios |
| US7750018B2 (en) * | 2006-12-06 | 2010-07-06 | Tactical Therapeutics, Inc | Use of carboxiamidotriazole (CAI) orotate in macular degeneration |
| AU2008232732A1 (en) | 2007-03-28 | 2008-10-09 | Medarex, Inc. | Methods of gene amplification and expression |
| JP2011515088A (ja) * | 2008-03-22 | 2011-05-19 | メルク・シャープ・エンド・ドーム・コーポレイション | 増殖因子シグナル伝達経路レギュレーション状態を評価するための方法及び遺伝子発現サイン |
| KR101597338B1 (ko) * | 2009-09-04 | 2016-02-24 | 탁티칼 떼라페우틱스 인크. | 5-아미노 또는 치환된 아미노 1,2,3-트리아졸 화합물 및 이의 오로트산염 제형들의 신규한 조성물들 및 이의 제조방법 |
| US8877785B2 (en) * | 2009-09-04 | 2014-11-04 | Tactical Therapeutics Inc | Methods and compositions for enhancing sensitivity of cytotoxic drugs with timely combinatorial therapy with carboxyamidotriazole orotate |
| JP6355555B2 (ja) * | 2011-04-01 | 2018-07-11 | キアゲン | Ｗｎｔ／ｂ−カテニンシグナル伝達経路に関する遺伝子発現シグネチャーおよびその使用 |
-
2013
- 2013-08-02 US US13/957,720 patent/US10378059B2/en active Active
-
2014
- 2014-07-30 CN CN201480050189.3A patent/CN105531380B/zh active Active
- 2014-07-30 CA CA2919690A patent/CA2919690C/en active Active
- 2014-07-30 AU AU2014296212A patent/AU2014296212B2/en active Active
- 2014-07-30 KR KR1020167002926A patent/KR102389934B1/ko active Active
- 2014-07-30 WO PCT/US2014/048905 patent/WO2015017545A1/en not_active Ceased
- 2014-07-30 EP EP14832909.7A patent/EP3027776B1/en active Active
- 2014-07-30 JP JP2016531859A patent/JP6913459B2/ja active Active
-
2016
- 2016-02-01 IL IL243894A patent/IL243894B/en active IP Right Grant
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