KR102389934B1 - 카르복시아미도트리아졸 오로트산에 반응한 다중 신호화 경로에 대한 방법과 분자의 약역학 바이오마커 - Google Patents

카르복시아미도트리아졸 오로트산에 반응한 다중 신호화 경로에 대한 방법과 분자의 약역학 바이오마커 Download PDF

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KR102389934B1
KR102389934B1 KR1020167002926A KR20167002926A KR102389934B1 KR 102389934 B1 KR102389934 B1 KR 102389934B1 KR 1020167002926 A KR1020167002926 A KR 1020167002926A KR 20167002926 A KR20167002926 A KR 20167002926A KR 102389934 B1 KR102389934 B1 KR 102389934B1
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라지다 에이. 카말리
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탁티칼 떼라페우틱스 인크.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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KR1020167002926A 2013-08-02 2014-07-30 카르복시아미도트리아졸 오로트산에 반응한 다중 신호화 경로에 대한 방법과 분자의 약역학 바이오마커 Active KR102389934B1 (ko)

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Application Number Priority Date Filing Date Title
US13/957,720 2013-08-02
US13/957,720 US10378059B2 (en) 2013-08-02 2013-08-02 Methods and molecular pharmacodynamic biomarkers for multiple signaling pathways in response to carboxyamidotriazole orotate
PCT/US2014/048905 WO2015017545A1 (en) 2013-08-02 2014-07-30 Methods and molecular pharmacodynamic biomarkers for multiple signaling pathways in response to carboxyamidotriazole orotate

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KR20160030535A KR20160030535A (ko) 2016-03-18
KR102389934B1 true KR102389934B1 (ko) 2022-04-21

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US (1) US10378059B2 (enExample)
EP (1) EP3027776B1 (enExample)
JP (1) JP6913459B2 (enExample)
KR (1) KR102389934B1 (enExample)
CN (1) CN105531380B (enExample)
AU (1) AU2014296212B2 (enExample)
CA (1) CA2919690C (enExample)
IL (1) IL243894B (enExample)
WO (1) WO2015017545A1 (enExample)

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EP3423452B1 (en) 2016-03-01 2025-05-07 University of Maryland, Baltimore Wnt signaling pathway inhibitors for treatments of disease
JP6889009B2 (ja) * 2017-04-13 2021-06-18 浜松ホトニクス株式会社 画像取得システム及び画像取得方法
US20220168276A1 (en) * 2020-08-05 2022-06-02 Tactical Therapeotics Inc. Mehods and Compositions for Treating SARS-CoV-2 Infection using Carboxyamidotriazole Orotate

Citations (1)

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US20120202760A1 (en) 2009-09-04 2012-08-09 Rashida A. Karmali Methods and compositions for enhancing sensitivity of cytotoxic drugs with timely combinatorial therapy with carboxyamidotriazole orotate

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CA2227205C (en) * 1995-07-21 2007-05-01 Constantia Gruppe Treatment and prevention of neoplasms with salts of aminoimidazole carboxamide and 5-amino or substituted amino 1,2,3-triazoles
US20030170720A1 (en) * 2001-01-23 2003-09-11 Van Der Kuyl Antoinette Cornelia Means and methods for treatment evaluation
SI1504126T1 (sl) 2002-05-03 2014-08-29 Duke University Office Of Science And Technology Postopek regulacije izraĹľanja genov
WO2008021115A2 (en) 2006-08-14 2008-02-21 The Brigham And Women's Hospital, Inc. Diagnostic tests using gene expression ratios
US7750018B2 (en) * 2006-12-06 2010-07-06 Tactical Therapeutics, Inc Use of carboxiamidotriazole (CAI) orotate in macular degeneration
AU2008232732A1 (en) 2007-03-28 2008-10-09 Medarex, Inc. Methods of gene amplification and expression
JP2011515088A (ja) * 2008-03-22 2011-05-19 メルク・シャープ・エンド・ドーム・コーポレイション 増殖因子シグナル伝達経路レギュレーション状態を評価するための方法及び遺伝子発現サイン
KR101597338B1 (ko) * 2009-09-04 2016-02-24 탁티칼 떼라페우틱스 인크. 5-아미노 또는 치환된 아미노 1,2,3-트리아졸 화합물 및 이의 오로트산염 제형들의 신규한 조성물들 및 이의 제조방법
JP6355555B2 (ja) * 2011-04-01 2018-07-11 キアゲン Ｗｎｔ／ｂ−カテニンシグナル伝達経路に関する遺伝子発現シグネチャーおよびその使用

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Publication number Priority date Publication date Assignee Title
US20120202760A1 (en) 2009-09-04 2012-08-09 Rashida A. Karmali Methods and compositions for enhancing sensitivity of cytotoxic drugs with timely combinatorial therapy with carboxyamidotriazole orotate

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KR20160030535A (ko) 2016-03-18
WO2015017545A1 (en) 2015-02-05
JP6913459B2 (ja) 2021-08-04
CN105531380A (zh) 2016-04-27
US20150038349A1 (en) 2015-02-05
US10378059B2 (en) 2019-08-13
AU2014296212A1 (en) 2016-02-25
EP3027776C0 (en) 2024-02-07
EP3027776B1 (en) 2024-02-07
IL243894B (en) 2020-06-30
CA2919690A1 (en) 2015-02-05
JP2016526908A (ja) 2016-09-08
IL243894A0 (en) 2016-04-21
AU2014296212B2 (en) 2020-10-22
CA2919690C (en) 2021-11-02
EP3027776A4 (en) 2017-03-08
HK1220493A1 (en) 2017-05-05
EP3027776A1 (en) 2016-06-08
CN105531380B (zh) 2021-07-13

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