JP2016526689A - 液体検査用低コントラストの標準として使用される粒子懸濁液 - Google Patents
液体検査用低コントラストの標準として使用される粒子懸濁液 Download PDFInfo
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Abstract
Description
本特許は2013年7月10日に出願された米国仮特許出願第61/844,662号の優先権を主張し、当該出願の全内容は引用することにより本明細書に組み込まれている。
Claims (21)
- 人による目視検査及び/又は光学分析機器で使用するための標準粒子懸濁液であって、
溶液と、
前記溶液中に懸濁された1つ又は複数の標準粒子と、を備え、各複数の標準粒子は限定された粒度分布及び形状分布を有し、及び前記標準粒子は生物学的粒子に実質的に類似する限定された屈折率及び浮揚性を有する、標準粒子懸濁液。 - 前記標準粒子の前記屈折率は、前記標準粒子を溶液中で透明にする値から、溶液中で不透明にする値の範囲である、請求項1記載の懸濁液。
- 前記標準粒子は、選択された粒子径近傍の限定された粒度分布を有する、請求項1記載の懸濁液。
- 前記選択された標準粒子径は約1ナノメータから約1ミリメータの範囲である、請求項1記載の懸濁液。
- 前記標準粒子は、PTFE、ETFE、PDMS、及びFEPからなる群から選択されるポリマー材料を含む、請求項1記載の懸濁液。
- 前記溶液中に1つ又は複数の添加剤を更に含み、前記添加剤は、前記溶液中の前記標準粒子の前記屈折率差を調整し、前記生物学的粒子及びそれらの原溶液との前記屈折率差が実質的に同じになる、請求項1記載の懸濁液。
- 前記標準粒子の少なくとも1つは、1つ又は複数のパターンを含む、請求項1記載の懸濁液。
- 前記パターンの少なくとも1つは、前記標準粒子の前記長さに沿って幅及び分離を変えるストライプ含む、請求項7記載の懸濁液。
- 前記懸濁液は、光学分析機器の較正及び/又は検証のために使用される、請求項1記載の懸濁液。
- 生物学的粒子を使用する光学分析機器を較正する及び/又は検証する方法であって、前記方法は、
前記光学分析機器を用いて標準粒子懸濁液を検査する工程を含み、前記標準粒子懸濁液は、限定された粒度分布及び形状分布を有する各標準粒子集団の溶液中に懸濁された1つ又は複数の既知濃度の標準粒子集団を含み、各標準粒子集団は限定された屈折率を有し、前記方法は、更に
前記検査から前記標準粒子懸濁液中の各標準粒子集団の濃度を評価する工程と、
標準粒子集団の各評価濃度と各標準粒子集団の前記既知濃度との間の差を評価する工程と、
各前記濃度間の前記評価された差に基づいて、前記光学分析機器の1つ又は複数のパラメータを変更する工程と、
各標準粒子集団の各前記濃度と前記既知濃度との間の前記評価された比に基づいて、前記光学分析機器の検出効率を評価する工程と、を含む、方法。 - 前記光学分析機器の前記パラメータの少なくとも1つは、閾値コントラストレベルを含む、請求項10記載の方法。
- 前記光学分析機器の前記パラメータの少なくとも1つは、画像処理パラメータを含む、請求項10記載の方法。
- 前記標準粒子の少なくともいくつかは、1つ又は複数のMTF(変調伝達関数)テストパターンを含み、及び前記方法は、前記MTFテストパターンを用いて前記光学分析機器の光学性能を評価する工程と、前記評価に基づいて1つ又は複数のパラメータを修正する工程と、を更に含む、請求項10記載の方法。
- 前記検査から前記標準粒子懸濁液中の前記標準粒子の粒度分布を評価する工程を更に含む、請求項10記載の方法。
- 前記検査から前記標準粒子懸濁液中の前記標準粒子の形状分布を評価する工程を更に含む、請求項10記載の方法。
- 請求項10記載の方法であって、前記方法は、
標準粒子懸濁液中の濃度変化を評価する内部標準を確立する工程を更に備え、標準粒子懸濁液は、それぞれが限定された濃度及び異なった屈折率を有する標準粒子の2つ以上の集団を備え、前記方法は、更に
前記光学分析機器で高い検出率を有する少なくとも1つの不透明な集団を提供する工程と、
前記1つ又は複数の不透明な集団の前記濃度変化を評価する工程、及び前記1つ又は複数のほぼ透明な標準粒子集団の前記出発濃度を修正するために、このような測定された変化を適用する工程と、を更に含む、請求項10記載の方法。 - 標準粒子懸濁液を形成する方法であって、前記方法は
ポリマー材料から複数の標準粒子を形成する工程と、
同様なサイズ及び形状の標準粒子を選択し、同様なサイズ及び形状を有する複数の標準粒子を提供する工程と、
溶液中に前記標準粒子を配置する工程と、を備え、前記溶液中の前記標準粒子及び前記溶液はそれぞれが既知の屈折率を有し、前記方法は、更に
前記溶液中の前記標準粒子の濃度を評価する工程を含む、方法。 - リソグラフィプロセスを用いて前記標準粒子を形成する工程を更に含む、請求項17記載の方法。
- 濾過工程を用いて同様なサイズ及び形状の前記標準粒子を選択する工程を更に含む、請求項17記載の方法。
- 溶液中の前記標準粒子の前記屈折率は、前記標準粒子を溶液中で透明にする値から溶液中で不透明にする値までの範囲である、請求項17記載の方法。
- 前記溶液中の前記標準粒子の粒度分布及び/又は形状分布を評価する工程を更に含む、請求項17記載の方法。
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US201361844662P | 2013-07-10 | 2013-07-10 | |
US61/844,662 | 2013-07-10 | ||
US14/324,872 US9562846B2 (en) | 2013-07-10 | 2014-07-07 | Particle suspensions used as low-contrast standards for inspection of liquids |
US14/324,872 | 2014-07-07 | ||
PCT/US2014/046096 WO2015006532A1 (en) | 2013-07-10 | 2014-07-10 | Particle suspensions used as low-contrast standards for inspection of liquids |
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EP3919912A4 (en) * | 2019-03-20 | 2023-04-12 | Biosquare Inc. | COMPOSITION OF STANDARD MATERIAL FOR VERIFYING A BIOANALYZER AND STANDARD STRIP USING IT |
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US9562846B2 (en) | 2017-02-07 |
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US20150015872A1 (en) | 2015-01-15 |
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