JP2016523849A5 - - Google Patents
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- Publication number
- JP2016523849A5 JP2016523849A5 JP2016518420A JP2016518420A JP2016523849A5 JP 2016523849 A5 JP2016523849 A5 JP 2016523849A5 JP 2016518420 A JP2016518420 A JP 2016518420A JP 2016518420 A JP2016518420 A JP 2016518420A JP 2016523849 A5 JP2016523849 A5 JP 2016523849A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- prostate cancer
- composition
- effective amount
- preparation according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 206010060862 Prostate cancer Diseases 0.000 claims 8
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 8
- 241000196324 Embryophyta Species 0.000 claims 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims 7
- 239000000284 extract Substances 0.000 claims 6
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 5
- 229960003668 docetaxel Drugs 0.000 claims 5
- 235000014113 dietary fatty acids Nutrition 0.000 claims 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 4
- 229930195729 fatty acid Natural products 0.000 claims 4
- 239000000194 fatty acid Substances 0.000 claims 4
- -1 polyoxyethylene glycerin Polymers 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- 240000008397 Ganoderma lucidum Species 0.000 claims 3
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims 3
- 150000004665 fatty acids Chemical group 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 102000007066 Prostate-Specific Antigen Human genes 0.000 claims 2
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 2
- 241001072909 Salvia Species 0.000 claims 2
- 235000017276 Salvia Nutrition 0.000 claims 2
- 241000304195 Salvia miltiorrhiza Species 0.000 claims 2
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims 2
- 241000915604 Scutellaria barbata Species 0.000 claims 2
- 239000003098 androgen Substances 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 235000006708 antioxidants Nutrition 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 2
- 239000008389 polyethoxylated castor oil Substances 0.000 claims 2
- 208000023958 prostate neoplasm Diseases 0.000 claims 2
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 claims 1
- 239000008565 Scutellaria barbata extract Substances 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 229940087168 alpha tocopherol Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- LDVVMCZRFWMZSG-UHFFFAOYSA-N captan Chemical compound C1C=CCC2C(=O)N(SC(Cl)(Cl)Cl)C(=O)C21 LDVVMCZRFWMZSG-UHFFFAOYSA-N 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-M decanoate Chemical compound CCCCCCCCCC([O-])=O GHVNFZFCNZKVNT-UHFFFAOYSA-M 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 229940087068 glyceryl caprylate Drugs 0.000 claims 1
- 239000001087 glyceryl triacetate Substances 0.000 claims 1
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 1
- 150000002334 glycols Chemical class 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000003549 soybean oil Substances 0.000 claims 1
- 235000012424 soybean oil Nutrition 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 238000011287 therapeutic dose Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 229960000984 tocofersolan Drugs 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 229960002622 triacetin Drugs 0.000 claims 1
- 239000002076 α-tocopherol Substances 0.000 claims 1
- 235000004835 α-tocopherol Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361830626P | 2013-06-03 | 2013-06-03 | |
| US61/830,626 | 2013-06-03 | ||
| PCT/US2014/040769 WO2014197519A1 (en) | 2013-06-03 | 2014-06-03 | Combination therapy for prostate cancer using botanical compositions and docetaxel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016523849A JP2016523849A (ja) | 2016-08-12 |
| JP2016523849A5 true JP2016523849A5 (cg-RX-API-DMAC7.html) | 2017-07-13 |
Family
ID=52008544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016518420A Pending JP2016523849A (ja) | 2013-06-03 | 2014-06-03 | 植物組成物とドセタキセルを使用する前立腺癌用併用療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20160143971A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3003490B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2016523849A (cg-RX-API-DMAC7.html) |
| CN (1) | CN105636647A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2951110A1 (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201510802QA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014197519A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3630090A4 (en) * | 2017-05-26 | 2021-04-07 | Genyous Biomed International | CANCER POLYTHERAPY USING PLANT COMPOSITIONS AND ENZALUTAMIDE |
| US10835538B2 (en) * | 2018-03-28 | 2020-11-17 | Nymox Corporation | Method of treating benign prostatic hyperlasia with antibiotics |
| CN108836994B (zh) * | 2018-07-25 | 2021-06-18 | 南京林业大学 | 一种人工林树皮皂苷类活性成分的提取方法 |
| WO2025003967A1 (en) * | 2023-06-30 | 2025-01-02 | Future Biome Corporation | Polysaccharide mixture obtainable by fermentation of ganoderma sessile followed by ultrafiltration and uses of this mixture |
| CN117064899B (zh) * | 2023-10-13 | 2024-01-23 | 暨南大学附属第一医院（广州华侨医院） | 灵芝酸a在制备治疗去势抵抗性前列腺癌的药物中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6395770B1 (en) * | 1995-10-26 | 2002-05-28 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for administering taxanes orally to human patients |
| US5910308A (en) | 1997-03-19 | 1999-06-08 | Sante International Inc. | Herbal extract composition containing gynostemma pentaphyllum, crataegus pinnatifida and camellia sinensis |
| US6168795B1 (en) | 1998-06-09 | 2001-01-02 | Sant{acute over (e)} International Inc. | Method for anticancer therapy using an herbal extract composition |
| AU2004287358A1 (en) * | 2003-09-08 | 2005-05-19 | Genyous Biomed International Inc. | Compositions of botanical extracts for cancer therapy |
| RU2006113703A (ru) * | 2003-09-22 | 2007-11-10 | Джиниус Байомед Интернэшнл Инк. (Us) | Композиции hippophae rhamnoides для терапии рака |
| US20050196409A1 (en) * | 2003-09-24 | 2005-09-08 | James Dao | Compositions of botanical extracts for treating malignancy-associated changes |
| WO2008127302A2 (en) * | 2006-10-27 | 2008-10-23 | Genyous BioMed International, Inc. | Compositions for treatment and inhibition of pain |
| CN103327994B (zh) * | 2010-11-04 | 2016-06-01 | 盖尼奥斯生物医学国际公司 | 一种组合物在制备用于治疗或降低受试者体内的前列腺癌的严重性的药物中的应用 |
-
2014
- 2014-06-03 JP JP2016518420A patent/JP2016523849A/ja active Pending
- 2014-06-03 EP EP14807920.5A patent/EP3003490B1/en active Active
- 2014-06-03 US US14/392,117 patent/US20160143971A1/en not_active Abandoned
- 2014-06-03 SG SG11201510802QA patent/SG11201510802QA/en unknown
- 2014-06-03 CA CA2951110A patent/CA2951110A1/en not_active Abandoned
- 2014-06-03 CN CN201480042054.2A patent/CN105636647A/zh active Pending
- 2014-06-03 WO PCT/US2014/040769 patent/WO2014197519A1/en not_active Ceased
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