|
US3998834A
(en)
*
|
1975-03-14 |
1976-12-21 |
Janssen Pharmaceutica N.V. |
N-(4-piperidinyl)-n-phenylamides and -carbamates
|
|
US4179569A
(en)
*
|
1975-03-14 |
1979-12-18 |
Janssen Pharmaceutica N.V. |
N-(4-piperidinyl)-N-phenylamides
|
|
US4270537A
(en)
|
1979-11-19 |
1981-06-02 |
Romaine Richard A |
Automatic hypodermic syringe
|
|
US4584303A
(en)
*
|
1984-04-09 |
1986-04-22 |
The Boc Group, Inc. |
N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
|
|
ZA852315B
(en)
*
|
1984-04-09 |
1985-11-27 |
Boc Inc |
N-aryl-n-(4-piperindinyl)amides and pharmaceutical compositions and methods employing such compounds
|
|
US4596556A
(en)
|
1985-03-25 |
1986-06-24 |
Bioject, Inc. |
Hypodermic injection apparatus
|
|
US4730006A
(en)
|
1986-01-27 |
1988-03-08 |
Merrell Dow Pharmaceuticals Inc. |
Derivatives of 2,6-diamino-3-haloheptanedioic acid
|
|
US4886499A
(en)
|
1986-12-18 |
1989-12-12 |
Hoffmann-La Roche Inc. |
Portable injection appliance
|
|
GB8704027D0
(en)
|
1987-02-20 |
1987-03-25 |
Owen Mumford Ltd |
Syringe needle combination
|
|
US4940460A
(en)
|
1987-06-19 |
1990-07-10 |
Bioject, Inc. |
Patient-fillable and non-invasive hypodermic injection device assembly
|
|
US4941880A
(en)
|
1987-06-19 |
1990-07-17 |
Bioject, Inc. |
Pre-filled ampule and non-invasive hypodermic injection device assembly
|
|
US4790824A
(en)
|
1987-06-19 |
1988-12-13 |
Bioject, Inc. |
Non-invasive hypodermic injection device
|
|
US5339163A
(en)
|
1988-03-16 |
1994-08-16 |
Canon Kabushiki Kaisha |
Automatic exposure control device using plural image plane detection areas
|
|
FR2638359A1
(fr)
|
1988-11-03 |
1990-05-04 |
Tino Dalto |
Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau
|
|
US5120859A
(en)
|
1989-09-22 |
1992-06-09 |
Genentech, Inc. |
Chimeric amino acid analogues
|
|
US5712418A
(en)
|
1989-10-23 |
1998-01-27 |
Research Corporation Technologies, Inc. |
Synthesis and use of amino acid fluorides as peptide coupling reagents
|
|
US5312335A
(en)
|
1989-11-09 |
1994-05-17 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
US5064413A
(en)
|
1989-11-09 |
1991-11-12 |
Bioject, Inc. |
Needleless hypodermic injection device
|
|
US5190521A
(en)
|
1990-08-22 |
1993-03-02 |
Tecnol Medical Products, Inc. |
Apparatus and method for raising a skin wheal and anesthetizing skin
|
|
US5527288A
(en)
|
1990-12-13 |
1996-06-18 |
Elan Medical Technologies Limited |
Intradermal drug delivery device and method for intradermal delivery of drugs
|
|
US5364851A
(en)
|
1991-06-14 |
1994-11-15 |
International Synthecon, Llc |
Conformationally restricted biologically active peptides, methods for their production and uses thereof
|
|
GB9118204D0
(en)
|
1991-08-23 |
1991-10-09 |
Weston Terence E |
Needle-less injector
|
|
SE9102652D0
(sv)
|
1991-09-13 |
1991-09-13 |
Kabi Pharmacia Ab |
Injection needle arrangement
|
|
US5328483A
(en)
|
1992-02-27 |
1994-07-12 |
Jacoby Richard M |
Intradermal injection device with medication and needle guard
|
|
WO1996004289A1
(en)
|
1992-04-03 |
1996-02-15 |
California Institute Of Technology |
High activity ruthenium or osmium metal carbene complexes for olefin metathesis reactions and synthesis thereof
|
|
US5411860A
(en)
|
1992-04-07 |
1995-05-02 |
The Johns Hopkins University |
Amplification of human MDM2 gene in human tumors
|
|
US5383851A
(en)
|
1992-07-24 |
1995-01-24 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
US5569189A
(en)
|
1992-09-28 |
1996-10-29 |
Equidyne Systems, Inc. |
hypodermic jet injector
|
|
US5334144A
(en)
|
1992-10-30 |
1994-08-02 |
Becton, Dickinson And Company |
Single use disposable needleless injector
|
|
US5446128A
(en)
|
1993-06-18 |
1995-08-29 |
The Board Of Trustees Of The University Of Illinois |
Alpha-helix mimetics and methods relating thereto
|
|
US5622852A
(en)
|
1994-10-31 |
1997-04-22 |
Washington University |
Bcl-x/Bcl-2 associated cell death regulator
|
|
WO1995024176A1
(en)
|
1994-03-07 |
1995-09-14 |
Bioject, Inc. |
Ampule filling device
|
|
US5466220A
(en)
|
1994-03-08 |
1995-11-14 |
Bioject, Inc. |
Drug vial mixing and transfer device
|
|
US5824483A
(en)
|
1994-05-18 |
1998-10-20 |
Pence Inc. |
Conformationally-restricted combinatiorial library composition and method
|
|
IL109943A
(en)
|
1994-06-08 |
2006-08-01 |
Develogen Israel Ltd |
Conformationally constrained backbone cyclized peptide analogs
|
|
US6407059B1
(en)
|
1994-06-08 |
2002-06-18 |
Peptor Limited |
Conformationally constrained backbone cyclized peptide analogs
|
|
US5770377A
(en)
|
1994-07-20 |
1998-06-23 |
University Of Dundee |
Interruption of binding of MDM2 and P53 protein and therapeutic application thereof
|
|
WO1996020951A1
(en)
|
1994-12-29 |
1996-07-11 |
Massachusetts Institute Of Technology |
Chimeric dna-binding proteins
|
|
US5599302A
(en)
|
1995-01-09 |
1997-02-04 |
Medi-Ject Corporation |
Medical injection system and method, gas spring thereof and launching device using gas spring
|
|
US6184344B1
(en)
|
1995-05-04 |
2001-02-06 |
The Scripps Research Institute |
Synthesis of proteins by native chemical ligation
|
|
DE69521815T2
(de)
|
1995-05-04 |
2002-04-04 |
The Scripps Research Institute, La Jolla |
Proteinsynthese mittels nativer chemischer ligation (07.01.97)
|
|
US5730723A
(en)
|
1995-10-10 |
1998-03-24 |
Visionary Medical Products Corporation, Inc. |
Gas pressured needle-less injection device and method
|
|
US6051554A
(en)
|
1995-06-07 |
2000-04-18 |
Peptor Limited |
Conformationally constrained backbone cyclized somatostatin analogs
|
|
US5811515A
(en)
|
1995-06-12 |
1998-09-22 |
California Institute Of Technology |
Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis
|
|
US5808146A
(en)
*
|
1995-11-09 |
1998-09-15 |
Emory University |
Amino acid analogs for tumor imaging
|
|
US5893397A
(en)
|
1996-01-12 |
1999-04-13 |
Bioject Inc. |
Medication vial/syringe liquid-transfer apparatus
|
|
EP0880357A4
(en)
*
|
1996-01-17 |
1999-05-12 |
California Inst Of Techn |
SYNTHESIS OF CONFORMATORICALLY RESTRICTED AMINO ACIDS, PEPTIDES AND PEPTIDOMIMETIC COMPOUNDS BY CATALYTIC RINGCLOSE METATHESIS
|
|
GB9607549D0
(en)
|
1996-04-11 |
1996-06-12 |
Weston Medical Ltd |
Spring-powered dispensing device
|
|
US5663316A
(en)
|
1996-06-18 |
1997-09-02 |
Clontech Laboratories, Inc. |
BBC6 gene for regulation of cell death
|
|
US7083983B2
(en)
|
1996-07-05 |
2006-08-01 |
Cancer Research Campaign Technology Limited |
Inhibitors of the interaction between P53 and MDM2
|
|
US5955593A
(en)
|
1996-09-09 |
1999-09-21 |
Washington University |
BH3 interacting domain death agonist
|
|
US20020064546A1
(en)
|
1996-09-13 |
2002-05-30 |
J. Milton Harris |
Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
|
|
US5965703A
(en)
|
1996-09-20 |
1999-10-12 |
Idun Pharmaceuticals |
Human bad polypeptides, encoding nucleic acids and methods of use
|
|
US5856445A
(en)
|
1996-10-18 |
1999-01-05 |
Washington University |
Serine substituted mutants of BCL-XL /BCL-2 associated cell death regulator
|
|
US6271198B1
(en)
|
1996-11-06 |
2001-08-07 |
Genentech, Inc. |
Constrained helical peptides and methods of making same
|
|
WO1998022122A1
(en)
|
1996-11-21 |
1998-05-28 |
Promega Corporation |
Alkyl peptide amides and applications
|
|
US6849428B1
(en)
|
1997-03-05 |
2005-02-01 |
New England Biolabs, Inc. |
Intein-mediated protein ligation of expressed proteins
|
|
US5993412A
(en)
|
1997-05-19 |
1999-11-30 |
Bioject, Inc. |
Injection apparatus
|
|
US7064193B1
(en)
|
1997-09-17 |
2006-06-20 |
The Walter And Eliza Hall Institute Of Medical Research |
Therapeutic molecules
|
|
US6165732A
(en)
|
1997-10-14 |
2000-12-26 |
Washington University |
Method for identifying apoptosis modulating compounds
|
|
US6875594B2
(en)
|
1997-11-13 |
2005-04-05 |
The Rockefeller University |
Methods of ligating expressed proteins
|
|
EP1053019B1
(en)
|
1998-01-07 |
2003-12-03 |
Debio Recherche Pharmaceutique S.A. |
Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom
|
|
IT1298087B1
(it)
|
1998-01-08 |
1999-12-20 |
Fiderm S R L |
Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
|
|
US20030190368A1
(en)
|
1998-03-11 |
2003-10-09 |
Roland Stoughton |
Methods of diagnosis and triage using cell activation measures
|
|
AU767185B2
(en)
|
1998-03-23 |
2003-11-06 |
President And Fellows Of Harvard College |
Synthesis of compounds and libraries of compounds
|
|
US6326354B1
(en)
|
1998-08-19 |
2001-12-04 |
Washington University |
Modulation of apoptosis with bid
|
|
US7173005B2
(en)
|
1998-09-02 |
2007-02-06 |
Antyra Inc. |
Insulin and IGF-1 receptor agonists and antagonists
|
|
TR200102765T2
(tr)
|
1999-03-29 |
2002-05-21 |
The Procter & Gamble Company |
Melanokortin reseptör ligandları
|
|
US6444425B1
(en)
|
1999-04-02 |
2002-09-03 |
Corixa Corporation |
Compounds for therapy and diagnosis of lung cancer and methods for their use
|
|
US6713280B1
(en)
|
1999-04-07 |
2004-03-30 |
Thomas Jefferson University |
Enhancement of peptide cellular uptake
|
|
US7192713B1
(en)
*
|
1999-05-18 |
2007-03-20 |
President And Fellows Of Harvard College |
Stabilized compounds having secondary structure motifs
|
|
US6348558B1
(en)
|
1999-12-10 |
2002-02-19 |
Shearwater Corporation |
Hydrolytically degradable polymers and hydrogels made therefrom
|
|
DE60118935D1
(de)
|
2000-04-24 |
2006-05-24 |
Univ Yale New Haven |
Dna & protein bindende miniatur proteine
|
|
AU2001276406A1
(en)
|
2000-07-14 |
2002-01-30 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Apoptosis-inducing dna sequences
|
|
US7049290B2
(en)
|
2000-07-28 |
2006-05-23 |
Universität Zürich |
Essential downstream component of the wingless signaling pathway and therapeutic and diagnostic applications based thereon
|
|
WO2002013833A2
(en)
|
2000-08-16 |
2002-02-21 |
Georgetown University Medical Center |
SMALL MOLECULE INHIBITORS TARGETED AT Bcl-2
|
|
EP1343884A2
(en)
|
2000-12-19 |
2003-09-17 |
The Johns Hopkins University |
Jfy1 protein induces rapid apoptosis
|
|
US6822073B2
(en)
|
2001-12-20 |
2004-11-23 |
Kimberly-Clark Worldwide, Inc. |
Modular peptide-based reagent
|
|
US7247700B2
(en)
|
2001-12-31 |
2007-07-24 |
Dana Farber Cancer Institute, Inc. |
BID polypeptides and methods of inducing apoptosis
|
|
ATE394674T1
(de)
|
2002-04-22 |
2008-05-15 |
Univ Florida |
Funktionalisierte nanopartikel und verwendungsverfahren
|
|
SE0201863D0
(en)
|
2002-06-18 |
2002-06-18 |
Cepep Ab |
Cell penetrating peptides
|
|
JP2006516383A
(ja)
|
2002-09-09 |
2006-07-06 |
デイナ−ファーバー キャンサー インスティチュート，インコーポレイテッド |
Ｂｈ３ペプチドおよびその使用方法
|
|
EP1572203B1
(en)
|
2002-11-08 |
2007-11-07 |
F. Hoffmann-La Roche Ag |
Substituted 4-alkoxyoxazol derivatives as ppar agonists
|
|
WO2004058804A1
(en)
|
2002-12-24 |
2004-07-15 |
Walter And Eliza Hall Institute Of Medical Research |
Peptides and therapeutic uses thereof
|
|
AU2004231987C1
(en)
*
|
2003-04-18 |
2010-09-30 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
|
|
US7348434B2
(en)
|
2003-08-08 |
2008-03-25 |
Antony Bigot |
4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
|
|
JP2007537989A
(ja)
|
2003-10-16 |
2007-12-27 |
アプラーゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング |
安定化ペプチド
|
|
ITMI20032102A1
(it)
|
2003-10-30 |
2005-04-30 |
Univ Degli Studi Milano |
Composti peptidomimetici, procedimento stereoselettivo per la loro preparazione, loro uso come intermedi di sintesi di derivati biologicamente attivi.
|
|
CA2830063C
(en)
|
2003-11-05 |
2017-10-31 |
Dana-Farber Cancer Institute, Inc. |
Stabilized alpha helical peptides and uses thereof
|
|
GB0404731D0
(en)
|
2004-03-03 |
2004-04-07 |
Indp Administrative Inst Nims |
Method and products for the selective degradation of proteins
|
|
EP1737884B1
(en)
*
|
2004-03-19 |
2016-10-19 |
The University Of Queensland |
Alpha helical mimics, their uses and methods for their production
|
|
US7407929B2
(en)
|
2004-05-07 |
2008-08-05 |
Boston Biomedical Research Institute |
Leptin peptide antagonists
|
|
WO2005118620A2
(en)
|
2004-05-27 |
2005-12-15 |
New York University |
Methods for preparing internally constraied peptides and peptidomimetics
|
|
WO2005118634A2
(en)
|
2004-06-04 |
2005-12-15 |
The Brigham And Women's Hospital, Inc. |
Helical peptidomimetics with enhanced activity against beta-amyloid production
|
|
EP1793841B1
(en)
|
2004-08-20 |
2013-04-03 |
Phylogica Limited |
Peptide inhibitors of c-jun dimerization and uses thereof
|
|
WO2006069001A2
(en)
|
2004-12-20 |
2006-06-29 |
Baylor College Of Medicine |
Structural requirements for stat3 binding and recruitment to phosphototyrosine ligands
|
|
WO2006103666A2
(en)
|
2005-03-28 |
2006-10-05 |
Yeda Research And Development Co. Ltd. |
Isolated bid polypeptides, polynucleotides encoding same and antibodies directed thereagainst and methods of using same for inducing cell cycle arrest or apoptosis
|
|
WO2007013050A1
(en)
|
2005-07-25 |
2007-02-01 |
Hadasit Medical Research Services & Development Ltd. |
Heparanase-derived peptide dimers and their uses as inhibitors of heparanase
|
|
US7538190B2
(en)
|
2006-02-17 |
2009-05-26 |
Polychip Pharmaceuticals Pty Ltd |
Methods for the synthesis of two or more dicarba bridges in organic compounds
|
|
US7745573B2
(en)
|
2006-02-17 |
2010-06-29 |
Polychip Pharmaceuticals Pty Ltd. |
Conotoxin analogues and methods for synthesis of intramolecular dicarba bridge-containing peptides
|
|
GB0611405D0
(en)
|
2006-06-09 |
2006-07-19 |
Univ Belfast |
FKBP-L: A novel inhibitor of angiogenesis
|
|
AU2007319193A1
(en)
*
|
2006-11-15 |
2008-05-22 |
Dana-Farber Cancer Institute, Inc. |
Stabilized MAML peptides and uses thereof
|
|
JP5227803B2
(ja)
*
|
2006-11-24 |
2013-07-03 |
ハイクス ラボラトリーズ合同会社 |
スピロキノン化合物及び医薬組成物
|
|
US7981998B2
(en)
|
2006-12-14 |
2011-07-19 |
Aileron Therapeutics, Inc. |
Bis-sulfhydryl macrocyclization systems
|
|
BRPI0720306A2
(pt)
|
2006-12-14 |
2014-02-04 |
Aileron Therapeutics Inc |
Sistemas de macrociclização da bis-sufidrila
|
|
CA2677045C
(en)
|
2007-01-31 |
2016-10-18 |
Dana-Farber Cancer Institute, Inc. |
Stabilized p53 peptides and uses thereof
|
|
CA2678941C
(en)
|
2007-02-23 |
2018-11-27 |
Aileron Therapeutics, Inc. |
Triazole macrocycle systems
|
|
KR20160061439A
(ko)
|
2007-03-28 |
2016-05-31 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
스티칭된 폴리펩티드
|
|
KR20100038417A
(ko)
*
|
2007-06-29 |
2010-04-14 |
길리애드 사이언시즈, 인코포레이티드 |
항바이러스 화합물
|
|
WO2009020477A1
(en)
|
2007-08-06 |
2009-02-12 |
Yale University |
Modified miniature proteins
|
|
WO2009042237A2
(en)
|
2007-09-26 |
2009-04-02 |
Dana Farber Cancer Institute |
Methods and compositions for modulating bcl-2 family polypeptides
|
|
CN102099055A
(zh)
|
2007-10-04 |
2011-06-15 |
津莫吉尼蒂克斯公司 |
B7家族成员zB7H6及相关的组合物和方法
|
|
US20110144303A1
(en)
|
2008-04-08 |
2011-06-16 |
Aileron Therapeutics, Inc. |
Biologically Active Peptidomimetic Macrocycles
|
|
WO2009126292A2
(en)
|
2008-04-08 |
2009-10-15 |
Aileron Therapeutics, Inc. |
Biologically active peptidomimetic macrocycles
|
|
US20110144306A1
(en)
|
2008-07-23 |
2011-06-16 |
President And Fellows Of Harvard College |
Ligation of stapled polypeptides
|
|
EP2331567A1
(en)
|
2008-09-22 |
2011-06-15 |
Aileron Therapeutics, Inc. |
Peptidomimetic macrocycles
|
|
WO2010034034A1
(en)
|
2008-09-22 |
2010-03-25 |
Aileron Therapeutics, Inc. |
Peptidomimetic macrocycles
|
|
BRPI0920899A2
(pt)
|
2008-11-24 |
2016-04-26 |
Aileron Therapeutics Inc |
macrociclos peptidomiméticos com propriedades melhoradas
|
|
WO2010068684A2
(en)
*
|
2008-12-09 |
2010-06-17 |
Dana Farber Cancer Institute, Inc. |
Methods and compositions for specific modulation of mcl-1
|
|
NZ592705A
(en)
*
|
2008-12-10 |
2013-02-22 |
Achillion Pharmaceuticals Inc |
4-amino-4-oxobutanoyl peptide cyclic analogues, inhibitors of viral replication
|
|
DE102009032902A1
(de)
|
2009-07-10 |
2011-01-13 |
Forschungsverbund Berlin E.V. |
Induktion von α-Helix-Konformationen in Proteinen und Peptiden
|
|
JP2012532929A
(ja)
*
|
2009-07-13 |
2012-12-20 |
プレジデント アンド フェロウズ オブ ハーバード カレッジ |
二機能性のステープリングされたポリペプチドおよびそれらの使用
|
|
US20110223149A1
(en)
|
2009-10-14 |
2011-09-15 |
Aileron Therapeutics, Inc. |
Peptidomimetic macrocycles
|
|
CA2785738A1
(en)
|
2009-12-30 |
2011-07-07 |
Avila Therapeutics, Inc. |
Ligand-directed covalent modification of protein
|
|
EP2576588A4
(en)
|
2010-05-25 |
2014-07-09 |
Syngene Ltd |
METHODS FOR SYNTHESIZING DICARBA BRIDGES CONTAINING ALKYNES IN PEPTIDES
|
|
WO2011156686A2
(en)
*
|
2010-06-11 |
2011-12-15 |
The Regents Of The University Of Colorado, A Body Corporate |
Method for synthesizing a cyclic multivalent peptide using a thiol-mediated reaction
|
|
WO2011163423A2
(en)
|
2010-06-22 |
2011-12-29 |
University Of Central Florida Research Foundation, Inc. |
Methods and compositions for cell permeable stat3 inhibitor
|
|
US8957026B2
(en)
|
2010-09-22 |
2015-02-17 |
President And Fellows Of Harvard College |
Beta-catenin targeting peptides and uses thereof
|
|
US10822374B2
(en)
*
|
2010-11-12 |
2020-11-03 |
Dana-Farber Cancer Institute, Inc. |
Cancer therapies and diagnostics
|
|
WO2012174423A1
(en)
|
2011-06-17 |
2012-12-20 |
President And Fellows Of Harvard College |
Stabilized polypeptides as regulators of rab gtpase function
|
|
EP2721061A4
(en)
|
2011-06-17 |
2014-11-05 |
Harvard College |
VARIANT STABILIZED MAML-PEPTIDES AND USES THEREOF
|
|
DK2920197T3
(da)
|
2012-09-26 |
2021-05-31 |
Harvard College |
Prolinlåste sammenhæftede peptider og anvendelser deraf
|
|
US20150225471A1
(en)
|
2012-10-01 |
2015-08-13 |
President And Fellows Of Harvard College |
Stabilized polypeptide insulin receptor modulators
|
|
US9493510B2
(en)
*
|
2013-01-10 |
2016-11-15 |
Noliva Therapeutics Llc |
Peptidomimetic compounds
|
|
BR112015022872A2
(pt)
|
2013-03-13 |
2017-11-07 |
Harvard College |
polipeptídeos grampeados e costurados, seu uso, seu método de preparação, composição que os compreende e aminoácido
|