JP2016518834A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016518834A5 JP2016518834A5 JP2016509140A JP2016509140A JP2016518834A5 JP 2016518834 A5 JP2016518834 A5 JP 2016518834A5 JP 2016509140 A JP2016509140 A JP 2016509140A JP 2016509140 A JP2016509140 A JP 2016509140A JP 2016518834 A5 JP2016518834 A5 JP 2016518834A5
- Authority
- JP
- Japan
- Prior art keywords
- volumes
- substrate
- sample
- cells
- defined volumes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 101
- 239000000758 substrate Substances 0.000 claims description 74
- 238000004458 analytical method Methods 0.000 claims description 27
- 238000003556 assay Methods 0.000 claims description 5
- 238000002825 functional assay Methods 0.000 claims description 5
- 239000003349 gelling agent Substances 0.000 claims description 5
- 230000002068 genetic effect Effects 0.000 claims description 5
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 239000002246 antineoplastic agent Substances 0.000 claims description 4
- 230000003115 biocidal effect Effects 0.000 claims description 4
- 229940127089 cytotoxic agent Drugs 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims description 4
- 239000003112 inhibitor Substances 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 241000700605 Viruses Species 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 239000001963 growth medium Substances 0.000 claims description 2
- 238000005086 pumping Methods 0.000 claims description 2
- 241000894007 species Species 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims 1
- 230000001066 destructive effect Effects 0.000 claims 1
- 238000003672 processing method Methods 0.000 claims 1
- 239000012530 fluid Substances 0.000 description 17
- 238000001514 detection method Methods 0.000 description 8
- 239000007788 liquid Substances 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 239000006041 probiotic Substances 0.000 description 2
- 235000018291 probiotics Nutrition 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361814090P | 2013-04-19 | 2013-04-19 | |
| US61/814,090 | 2013-04-19 | ||
| US201361903156P | 2013-11-12 | 2013-11-12 | |
| US61/903,156 | 2013-11-12 | ||
| PCT/US2014/034728 WO2014172688A1 (en) | 2013-04-19 | 2014-04-18 | Parallelized sample handling |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518834A JP2016518834A (ja) | 2016-06-30 |
| JP2016518834A5 true JP2016518834A5 (enExample) | 2017-06-29 |
| JP6533516B2 JP6533516B2 (ja) | 2019-06-19 |
Family
ID=51731892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016509140A Expired - Fee Related JP6533516B2 (ja) | 2013-04-19 | 2014-04-18 | 並行化サンプル取り扱い |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20160114322A1 (enExample) |
| EP (1) | EP2986554A4 (enExample) |
| JP (1) | JP6533516B2 (enExample) |
| KR (1) | KR20160087749A (enExample) |
| CN (1) | CN105745172B (enExample) |
| AU (1) | AU2014253749B2 (enExample) |
| CA (1) | CA2918388A1 (enExample) |
| SG (2) | SG10201800317PA (enExample) |
| WO (1) | WO2014172688A1 (enExample) |
| ZA (1) | ZA201508323B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10039777B2 (en) | 2012-03-20 | 2018-08-07 | Neuro-Lm Sas | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
| US10196684B2 (en) | 2013-10-18 | 2019-02-05 | California Institute Of Technology | Enhanced nucleic acid identification and detection |
| CN113943773A (zh) * | 2014-11-05 | 2022-01-18 | 加州理工学院 | 生物体对药物的响应的微流体测量 |
| WO2016138290A1 (en) | 2015-02-25 | 2016-09-01 | The Broad Institute, Inc. | Reaction circuit design in microfluidic circuits |
| EP3481553B1 (en) | 2016-07-07 | 2024-04-10 | Onexio Biosystems Llc | Use of a cell co-culture device in high throughput screening and a corresponding method |
| US11959125B2 (en) * | 2016-09-15 | 2024-04-16 | Sun Genomics, Inc. | Universal method for extracting nucleic acid molecules from a diverse population of one or more types of microbes in a sample |
| WO2018058078A1 (en) | 2016-09-23 | 2018-03-29 | California Institute Of Technology | Digital quantification of dna replication and/or chromosome segregation based determination of antimicrobial susceptibility |
| WO2019060914A2 (en) * | 2017-09-25 | 2019-03-28 | California Institute Of Technology | METHODS AND SYSTEMS FOR PERFORMING THE ANALYSIS OF A SINGLE CELL OF MOLECULAR MOLECULES AND MOLECULAR COMPLEXES |
| US11827944B2 (en) | 2017-10-11 | 2023-11-28 | California Institute Of Technology | Antibiotic susceptibility of microorganisms and related compositions, methods and systems |
| US12448655B2 (en) | 2017-10-11 | 2025-10-21 | California Institute Of Technology | Antibiotic susceptibility of microorganisms and related methods and systems |
| US11890620B2 (en) | 2017-10-13 | 2024-02-06 | The Charles Stark Draper Laboratory, Inc. | Miniaturized DNA microarray for small-volume sample processing |
| WO2019133098A2 (en) * | 2017-10-20 | 2019-07-04 | President And Fellows Of Harvard College | Microfluidic platform for time-resolved tissue and organism analysis |
| US12186750B2 (en) * | 2018-02-23 | 2025-01-07 | University Of Virginia Patent Foundation | Slipchip device for on-chip dilution and size-based extraction of protein labeling reagents |
| CN113373104B (zh) * | 2020-03-09 | 2022-11-18 | 浙江大学 | 一种用于稀有细胞高纯度分选的装置及方法 |
| WO2022035382A1 (en) * | 2020-08-14 | 2022-02-17 | Lucence Life Sciences Pte. Ltd. | Automated sample pre-processing system and method |
| CN113008973A (zh) * | 2021-01-29 | 2021-06-22 | 融智生物科技（青岛）有限公司 | 一种适用于低丰度蛋白检测的蛋白芯片及其制备方法和应用 |
| US20240182946A1 (en) * | 2021-04-01 | 2024-06-06 | Centre National De La Recherche Scientifique | Methods for counting the number of living microorganisms contained in a specimen sample and apparatuses for implementing such methods |
| US20240218419A1 (en) * | 2021-05-05 | 2024-07-04 | The University Of Chicago | Rapid enumeration of microorganisms |
| WO2023055790A1 (en) * | 2021-09-29 | 2023-04-06 | Battelle Memorial Institute | Apparatus and methods for performing multiple omics analysis and processing analyte mixtures |
| US20240287571A1 (en) * | 2023-02-28 | 2024-08-29 | Applied Food Diagnostics, Inc. | Methods and kits for detecting cross-contamination in foodborne and environmental pathogen testing |
| WO2024243045A1 (en) * | 2023-05-25 | 2024-11-28 | California Institute Of Technology | Instructional point of care device for sample handling |
| EP4471785A1 (fr) * | 2023-05-31 | 2024-12-04 | Biomérieux | Procede et systeme de typage probabiliste de souches microbiennes |
| EP4471784A1 (fr) * | 2023-05-31 | 2024-12-04 | Biomérieux | Procede et systeme de typage probabiliste de souches microbiennes |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3584990B2 (ja) * | 1994-05-09 | 2004-11-04 | タカラバイオ株式会社 | 抗ヒトインフルエンザウイルス抗体 |
| EP1330306A2 (en) * | 2000-10-10 | 2003-07-30 | BioTrove, Inc. | Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof |
| JP2004344084A (ja) * | 2003-05-23 | 2004-12-09 | Japan Science & Technology Agency | アルコール発酵性酵母 |
| JP2011239784A (ja) * | 2003-12-04 | 2011-12-01 | Perseus Proteomics Inc | 細胞表面抗原に対する抗体取得とその抗原同定 |
| US9447461B2 (en) * | 2009-03-24 | 2016-09-20 | California Institute Of Technology | Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes |
| WO2010111265A1 (en) * | 2009-03-24 | 2010-09-30 | University Of Chicago | Slip chip device and methods |
| US9464319B2 (en) * | 2009-03-24 | 2016-10-11 | California Institute Of Technology | Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes |
| JP5686361B2 (ja) * | 2010-01-28 | 2015-03-18 | 国立大学法人 筑波大学 | 可溶型ｃｄ１５５タンパク質を用いた癌の検出方法 |
| US9481945B2 (en) * | 2011-08-30 | 2016-11-01 | The Royal Institution For The Advancement Of Learning / Mcgill University | Methods and devices for multiplexed microarray microfluidic analysis of biomolecules |
-
2014
- 2014-04-18 CN CN201480034616.9A patent/CN105745172B/zh not_active Expired - Fee Related
- 2014-04-18 AU AU2014253749A patent/AU2014253749B2/en not_active Ceased
- 2014-04-18 US US14/785,480 patent/US20160114322A1/en not_active Abandoned
- 2014-04-18 KR KR1020157032933A patent/KR20160087749A/ko not_active Ceased
- 2014-04-18 EP EP14785518.3A patent/EP2986554A4/en not_active Withdrawn
- 2014-04-18 SG SG10201800317PA patent/SG10201800317PA/en unknown
- 2014-04-18 WO PCT/US2014/034728 patent/WO2014172688A1/en not_active Ceased
- 2014-04-18 SG SG11201508618RA patent/SG11201508618RA/en unknown
- 2014-04-18 JP JP2016509140A patent/JP6533516B2/ja not_active Expired - Fee Related
- 2014-04-18 CA CA2918388A patent/CA2918388A1/en not_active Abandoned
-
2015
- 2015-11-11 ZA ZA2015/08323A patent/ZA201508323B/en unknown
-
2019
- 2019-03-27 US US16/367,036 patent/US20190336969A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016518834A5 (enExample) | ||
| US11066699B2 (en) | Microfluidic process for treating and analysing a solution containing a biological material and corresponding microfluidic circuit | |
| US10252261B2 (en) | Handling liquid samples | |
| Zhang et al. | Development of a facile droplet-based single-cell isolation platform for cultivation and genomic analysis in microorganisms | |
| Hu et al. | One cell at a time: droplet-based microbial cultivation, screening and sequencing | |
| EP3710820B1 (en) | Devices for sample analysis using epitachophoresis | |
| Sjostrom et al. | High-throughput screening for industrial enzyme production hosts by droplet microfluidics | |
| US10947587B2 (en) | Single-cell forensic short tandem repeat typing within microfluidic droplets | |
| KR101796906B1 (ko) | 반응을 수행하기 위한 방법 | |
| US6423536B1 (en) | Low volume chemical and biochemical reaction system | |
| Konry et al. | Innovative tools and technology for analysis of single cells and cell–cell interaction | |
| CN114868006A (zh) | 用于液滴操控的方法和系统 | |
| Ding et al. | From single-molecule detection to next-generation sequencing: microfluidic droplets for high-throughput nucleic acid analysis | |
| US11426729B2 (en) | Systems and methods for whole cell analysis | |
| Xu et al. | Forming a large-scale droplet array in a microcage array chip for high-throughput screening | |
| US20220041967A1 (en) | Real-time monitoring of single cell or events | |
| CN103269787A (zh) | 用于在管内操作对象成分的器件和方法 | |
| Li et al. | Centrifugal-driven droplet generation method with minimal waste for single-cell whole genome amplification | |
| Li et al. | Microfluidics cell loading‐dock system: ordered cellular array for dynamic lymphocyte‐communication study | |
| Bai et al. | Interfacing picoliter droplet microfluidics with addressable microliter compartments using fluorescence activated cell sorting | |
| JP2024512325A (ja) | 液滴操作のための方法およびシステム | |
| Cui et al. | A facile and rapid route to self-digitization of samples into a high density microwell array for digital bioassays | |
| Diao et al. | Artificial intelligence‐assisted automatic and index‐based microbial single‐cell sorting system for One‐Cell‐One‐Tube | |
| Zimny et al. | Hydrogel droplet single-cell processing: DNA purification, handling, release, and on-chip linearization | |
| Li et al. | Integrated Addressable Dynamic Droplet Array (aDDA) as Sub‐Nanoliter Reactors for High‐Coverage Genome Sequencing of Single Yeast Cells |