JP2016518411A5 - - Google Patents
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- JP2016518411A5 JP2016518411A5 JP2016512995A JP2016512995A JP2016518411A5 JP 2016518411 A5 JP2016518411 A5 JP 2016518411A5 JP 2016512995 A JP2016512995 A JP 2016512995A JP 2016512995 A JP2016512995 A JP 2016512995A JP 2016518411 A5 JP2016518411 A5 JP 2016518411A5
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- JP
- Japan
- Prior art keywords
- subject
- amount
- pooled human
- mmse
- score
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940027941 immunoglobulin g Drugs 0.000 claims description 122
- 208000024827 Alzheimer disease Diseases 0.000 claims description 104
- 238000011282 treatment Methods 0.000 claims description 87
- 230000037396 body weight Effects 0.000 claims description 67
- 230000006996 mental state Effects 0.000 claims description 64
- 238000011269 treatment regimen Methods 0.000 claims description 50
- 239000000203 mixture Substances 0.000 claims description 47
- 108700028369 Alleles Proteins 0.000 claims description 44
- 229940098197 human immunoglobulin g Drugs 0.000 claims description 43
- 230000000977 initiatory effect Effects 0.000 claims description 43
- 238000007920 subcutaneous administration Methods 0.000 claims description 11
- 238000007918 intramuscular administration Methods 0.000 claims description 4
- 238000007912 intraperitoneal administration Methods 0.000 claims description 4
- 238000001990 intravenous administration Methods 0.000 claims description 4
- 230000003442 weekly effect Effects 0.000 claims description 4
- 238000007914 intraventricular administration Methods 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 239000000969 carrier Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 216
- 210000003169 central nervous system Anatomy 0.000 description 18
- 108010003272 Hyaluronate lyase Proteins 0.000 description 6
- 102000001974 Hyaluronidases Human genes 0.000 description 6
- 229960002773 hyaluronidase Drugs 0.000 description 6
- 102100021102 Hyaluronidase PH-20 Human genes 0.000 description 3
- 101150055528 SPAM1 gene Proteins 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000000185 intracerebroventricular administration Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361855062P | 2013-05-06 | 2013-05-06 | |
| US61/855,062 | 2013-05-06 | ||
| US201361833447P | 2013-06-10 | 2013-06-10 | |
| US61/833,447 | 2013-06-10 | ||
| US201361844732P | 2013-07-10 | 2013-07-10 | |
| US61/844,732 | 2013-07-10 | ||
| US201361886464P | 2013-10-03 | 2013-10-03 | |
| US61/886,464 | 2013-10-03 | ||
| PCT/US2014/036848 WO2014182631A1 (en) | 2013-05-06 | 2014-05-05 | Treatment of alzheimer's disease subpopulations with pooled immunoglobulin g |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016518411A JP2016518411A (ja) | 2016-06-23 |
| JP2016518411A5 true JP2016518411A5 (https=) | 2017-06-15 |
| JP6424210B2 JP6424210B2 (ja) | 2018-11-14 |
Family
ID=50943566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016512995A Active JP6424210B2 (ja) | 2013-05-06 | 2014-05-05 | プールされた免疫グロブリンｇを用いたアルツハイマー病の亜集団の治療 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20140328856A1 (https=) |
| EP (2) | EP2994160B1 (https=) |
| JP (1) | JP6424210B2 (https=) |
| AU (4) | AU2014262890B2 (https=) |
| DK (1) | DK2994160T3 (https=) |
| ES (1) | ES2740127T3 (https=) |
| HR (1) | HRP20191383T1 (https=) |
| HU (1) | HUE044737T2 (https=) |
| LT (1) | LT2994160T (https=) |
| PL (1) | PL2994160T3 (https=) |
| PT (1) | PT2994160T (https=) |
| WO (1) | WO2014182631A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102645633B1 (ko) | 2014-03-21 | 2024-03-11 | 알제온, 인크. | 신경학적 장애를 치료하는 방법 |
| WO2016033382A1 (en) * | 2014-08-27 | 2016-03-03 | Capnia, Inc. | Methods for immune globulin administration |
| MA41115A (fr) * | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| EP4275750B1 (en) * | 2015-09-10 | 2026-05-06 | Alzheon, Inc. | Treatment of alzheimer's disease in a particular patient population |
| US20190016791A1 (en) * | 2016-01-20 | 2019-01-17 | Genentech, Inc. | High dose treatments for alzheimer's disease |
| LT3484502T (lt) * | 2016-08-18 | 2021-12-10 | Alkahest, Inc. | Kraujo plazmos frakcijos, kaip su senėjimu susijusio pažinimo sutrikimo gydymo priemonė |
| MX2019012795A (es) * | 2017-04-26 | 2020-02-13 | Alkahest Inc | Régimen de dosificación para el tratamiento de deterioros cognitivos y motores con plasma de sangre y productos de plasma de sangre. |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| CN118370815A (zh) | 2017-08-22 | 2024-07-23 | 渤健马萨诸塞州股份有限公司 | 含有抗β淀粉样蛋白抗体的药物组合物 |
| FI128916B (en) * | 2018-02-05 | 2021-03-15 | Vetcare Oy | Health-promoting composition and method for its preparation |
| WO2020160156A2 (en) | 2019-01-30 | 2020-08-06 | Immutics, Inc. | Anti-gal3 antibodies and uses thereof |
| KR102276545B1 (ko) * | 2019-09-05 | 2021-07-15 | 고려대학교 산학협력단 | Ct 영상 기반 부위별 대뇌 피질 수축율 예측 방법 및 장치 |
| NL2024431B1 (en) | 2019-12-11 | 2021-09-07 | Sulfateq Bv | Compounds for treatment of alzheimer’s disease |
| EP4157338A4 (en) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING |
| US20240018231A1 (en) * | 2020-10-30 | 2024-01-18 | Rush University Medical Center | Intranasal immunotherapt for the treatment of alzheimer's disease |
| CA3243602A1 (en) * | 2022-02-03 | 2023-08-10 | Eli Lilly And Company | Regional Tau Imaging for the Diagnosis and Treatment of Alzheimer's Disease |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE348942B (https=) | 1970-06-02 | 1972-09-18 | Statens Bakteriologiska Labor | |
| US5624898A (en) | 1989-12-05 | 1997-04-29 | Ramsey Foundation | Method for administering neurologic agents to the brain |
| US6585957B1 (en) | 2000-01-25 | 2003-07-01 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| EP1463527A4 (en) | 2001-10-04 | 2005-05-11 | Protein Therapeutics Inc | USE OF GAMMAGLOBULIN FOR THE TREATMENT OF IMMUNE-MEDIATED DISEASES |
| US20060188496A1 (en) | 2005-02-23 | 2006-08-24 | Hanne Bentz | Intranasal administration of active agents to the central nervous system |
| US20090136505A1 (en) | 2005-02-23 | 2009-05-28 | Johanna Bentz | Intranasal Administration of Active Agents to the Central Nervous System |
| US8852585B2 (en) * | 2006-01-30 | 2014-10-07 | Grifols Therapeutics Inc. | Method of treatment and prophylaxis of diseases related to amyloid deposition using IgM |
| JO3076B1 (ar) * | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| TWI489994B (zh) | 2008-03-17 | 2015-07-01 | Baxter Healthcare Sa | 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法 |
| HUE028832T2 (en) | 2009-09-17 | 2017-01-30 | Baxalta Inc | Stable co-formulation of hyaluronidase and immunoglobulin, as well as a process for its preparation |
| US8622993B2 (en) | 2009-12-18 | 2014-01-07 | Healthpartners Research Foundation | Device and method for delivering therapeutic substances to the maxillary sinus of a patient |
| CN102946799A (zh) * | 2010-04-13 | 2013-02-27 | 巴克斯特国际公司 | 脑室增大率在阿尔茨海默病的静脉内免疫球蛋白治疗中的应用 |
| JP2013526518A (ja) * | 2010-05-13 | 2013-06-24 | ザ ユニバーシティ オブ ケンタッキー リサーチ ファウンデーション | Ｍｃｉおよびアルツハイマー病の処置 |
| US20120076779A1 (en) * | 2010-09-17 | 2012-03-29 | Baxter Healthcare S.A. | STABILIZATION OF IMMUNOGLOBULINS AND OTHER PROTEINS THROUGH AQUEOUS FORMULATIONS WITH SODIUM CHLORIDE AT WEAK ACIDIC TO NEUTRAL ph |
| JP2014507649A (ja) * | 2011-01-18 | 2014-03-27 | バクスター・インターナショナル・インコーポレイテッド | ヒト血液中の抗βアミロイド抗体の測定 |
| US20120251524A1 (en) * | 2011-04-01 | 2012-10-04 | Baxter Healthcare S.A. | Use of cytokine levels in intravenous immunoglobulin treatment of alzheimer's disease |
| KR101956585B1 (ko) * | 2011-09-24 | 2019-03-11 | 체에스엘 베링 게엠베하 | 면역글로불린과 ｃ1-억제제를 사용하는 병용 치료요법 |
-
2014
- 2014-05-05 HU HUE14730660 patent/HUE044737T2/hu unknown
- 2014-05-05 EP EP14730660.9A patent/EP2994160B1/en active Active
- 2014-05-05 AU AU2014262890A patent/AU2014262890B2/en active Active
- 2014-05-05 JP JP2016512995A patent/JP6424210B2/ja active Active
- 2014-05-05 WO PCT/US2014/036848 patent/WO2014182631A1/en not_active Ceased
- 2014-05-05 DK DK14730660.9T patent/DK2994160T3/da active
- 2014-05-05 LT LTEP14730660.9T patent/LT2994160T/lt unknown
- 2014-05-05 PT PT14730660T patent/PT2994160T/pt unknown
- 2014-05-05 PL PL14730660T patent/PL2994160T3/pl unknown
- 2014-05-05 ES ES14730660T patent/ES2740127T3/es active Active
- 2014-05-05 EP EP19175106.4A patent/EP3552624A1/en not_active Withdrawn
- 2014-05-05 US US14/270,192 patent/US20140328856A1/en not_active Abandoned
- 2014-05-05 HR HRP20191383TT patent/HRP20191383T1/hr unknown
-
2019
- 2019-01-14 US US16/247,141 patent/US20190144530A1/en not_active Abandoned
- 2019-04-09 AU AU2019202459A patent/AU2019202459B2/en active Active
-
2020
- 2020-10-19 AU AU2020257034A patent/AU2020257034A1/en not_active Abandoned
-
2021
- 2021-04-19 US US17/234,658 patent/US20210238267A1/en not_active Abandoned
-
2024
- 2024-02-19 AU AU2024201051A patent/AU2024201051A1/en active Pending
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