JP2016516780A5 - - Google Patents
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- Publication number
- JP2016516780A5 JP2016516780A5 JP2016507662A JP2016507662A JP2016516780A5 JP 2016516780 A5 JP2016516780 A5 JP 2016516780A5 JP 2016507662 A JP2016507662 A JP 2016507662A JP 2016507662 A JP2016507662 A JP 2016507662A JP 2016516780 A5 JP2016516780 A5 JP 2016516780A5
- Authority
- JP
- Japan
- Prior art keywords
- chemotherapeutic agent
- paclitaxel
- therapeutically effective
- effective amount
- tissue site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 22
- 239000002246 antineoplastic agent Substances 0.000 claims 21
- 229940127089 cytotoxic agent Drugs 0.000 claims 20
- 229960001592 paclitaxel Drugs 0.000 claims 16
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 16
- 229930012538 Paclitaxel Natural products 0.000 claims 14
- 229940079593 drug Drugs 0.000 claims 11
- 229920006237 degradable polymer Polymers 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 230000015556 catabolic process Effects 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 238000006731 degradation reaction Methods 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 229920001577 copolymer Polymers 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 108010058566 130-nm albumin-bound paclitaxel Proteins 0.000 claims 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 2
- 210000000013 bile duct Anatomy 0.000 claims 2
- 210000003445 biliary tract Anatomy 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 claims 2
- 229960002949 fluorouracil Drugs 0.000 claims 2
- 210000000232 gallbladder Anatomy 0.000 claims 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
- 229960005277 gemcitabine Drugs 0.000 claims 2
- 229960004768 irinotecan Drugs 0.000 claims 2
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 2
- 229960001756 oxaliplatin Drugs 0.000 claims 2
- 210000000277 pancreatic duct Anatomy 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 210000000813 small intestine Anatomy 0.000 claims 2
- 229910000684 Cobalt-chrome Inorganic materials 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 229910001260 Pt alloy Inorganic materials 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 229910001069 Ti alloy Inorganic materials 0.000 claims 1
- 229910045601 alloy Inorganic materials 0.000 claims 1
- 239000000956 alloy Substances 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 229910010293 ceramic material Inorganic materials 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 239000010952 cobalt-chrome Substances 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910001000 nickel titanium Inorganic materials 0.000 claims 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- -1 polyethylene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229910001256 stainless steel alloy Inorganic materials 0.000 claims 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361810543P | 2013-04-10 | 2013-04-10 | |
| US61/810,543 | 2013-04-10 | ||
| PCT/US2014/033671 WO2014169137A1 (en) | 2013-04-10 | 2014-04-10 | Local drug delivery devices and methods for treating cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018207608A Division JP2019034962A (ja) | 2013-04-10 | 2018-11-02 | 癌治療のための薬物局所送達装置及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016516780A JP2016516780A (ja) | 2016-06-09 |
| JP2016516780A5 true JP2016516780A5 (enExample) | 2017-06-08 |
| JP6431528B2 JP6431528B2 (ja) | 2018-11-28 |
Family
ID=50841949
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016507662A Active JP6431528B2 (ja) | 2013-04-10 | 2014-04-10 | 癌治療のための薬物局所送達装置及び方法 |
| JP2018207608A Pending JP2019034962A (ja) | 2013-04-10 | 2018-11-02 | 癌治療のための薬物局所送達装置及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018207608A Pending JP2019034962A (ja) | 2013-04-10 | 2018-11-02 | 癌治療のための薬物局所送達装置及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US9301926B2 (enExample) |
| EP (1) | EP2983730B1 (enExample) |
| JP (2) | JP6431528B2 (enExample) |
| CA (1) | CA2944480C (enExample) |
| ES (1) | ES2762555T3 (enExample) |
| WO (1) | WO2014169137A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015004110A2 (pt) | 2012-08-31 | 2017-07-04 | Taris Biomedical Llc | sistemas e métodos de distribuição de drogas para tratamento de próstata |
| CA2944480C (en) * | 2013-04-10 | 2021-05-18 | Massachusetts Institute Of Technology | Local drug delivery devices and methods for treating cancer |
| US20150250717A1 (en) | 2014-03-06 | 2015-09-10 | Taris Biomedical Llc | Drug delivery systems and methods for treatment of bladder cancer with gemcitabine |
| BR112016030310A2 (pt) | 2014-06-23 | 2017-08-22 | Placon Therapeutics Inc | Compostos de platina, composições e seus usos |
| JP6758325B2 (ja) | 2015-06-04 | 2020-09-23 | クリティテック・インコーポレイテッド | タキサン粒子およびその使用 |
| CA2990521C (en) | 2015-07-07 | 2023-10-10 | H. Lundbeck A/S | Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases |
| CN114767860A (zh) | 2016-04-04 | 2022-07-22 | 克里蒂泰克公司 | 实体肿瘤治疗方法 |
| IL295973A (en) | 2016-07-06 | 2022-10-01 | H Lundbeck As | pde9 inhibitors for the treatment of peripheral diseases |
| US11207272B2 (en) | 2017-05-17 | 2021-12-28 | Massachusetts Institute Of Technology | Tissue anchoring articles |
| HUE065158T2 (hu) | 2017-05-26 | 2024-05-28 | Cardurion Pharmaceuticals Inc | PDE9 gátlószereinek elõállítására és alkalmazására szolgáló eljárások |
| CA3063420A1 (en) | 2017-06-09 | 2018-12-13 | Crititech, Inc. | Treatment of epithelial cysts by intracystic injection of antineoplastic particles |
| AU2018284247B2 (en) | 2017-06-14 | 2020-04-30 | Crititech Inc. | Methods for treating lung disorders |
| US10857173B2 (en) | 2017-07-25 | 2020-12-08 | Taris Biomedical Llc | Methods of treating tumor metastasis |
| CA3076919A1 (en) | 2017-10-03 | 2019-04-11 | Crititech, Inc. | Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer |
| JOP20200124A1 (ar) | 2017-11-08 | 2020-05-20 | Taris Biomedical Llc | طُرق لعلاج سرطان المثانة باستخدام جيمسيتابين وعلاج مدوامة لذلك |
| CA3098243A1 (en) * | 2017-11-30 | 2019-06-06 | Anatoli D. Dosta | Method of local exposure to biological tissues, tissue-substitute applicator and use of porous polytetrafluoroethylene |
| US11202903B2 (en) | 2018-05-17 | 2021-12-21 | Massachusetts Institute Of Technology | Systems for electrical stimulation |
| CA3087238A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
| CN111989068B (zh) | 2018-05-24 | 2024-10-25 | 塞拉尼斯伊娃高性能聚合物公司 | 用于持续释放大分子药物化合物的可植入器件 |
| EP3803866A4 (en) | 2018-05-24 | 2022-03-16 | Nureva Inc. | METHOD, APPARATUS, AND COMPUTER READABLE MATERIALS FOR MANAGING SEMI-CONSTANT (PERSISTENT) SOUND SOURCES IN MICROPHONE CATCH/HOME AREAS |
| BR112020024019A2 (pt) | 2018-05-25 | 2021-02-23 | Imara Inc. | monoidrato e formas cristalinas de 6-[(3s,4s)-4-metil-1-(pirimidin-2-ilmetil)pirrolidin-3-il]-3-tetra-hidropiran-4-il-7h-imidazo[1,5-a]pirazin-8-ona |
| KR20250108770A (ko) | 2018-08-31 | 2025-07-15 | 카듀리온 파마슈티칼스, 인크. | 겸상 세포 질환의 치료를 위한 pde9 억제제 |
| EP4329734A4 (en) | 2021-04-26 | 2025-04-02 | Celanese EVA Performance Polymers LLC | Implantable device for the delayed release of a macromolecular drug compound |
| EP4433038A1 (en) * | 2021-11-17 | 2024-09-25 | Panther Therapeutics, Inc. | Implantable and biodegradable drug delivery devices and methods of use thereof |
| CA3262806A1 (en) * | 2022-07-22 | 2024-02-01 | PanTher Therapeutics, Inc. | BIODEGRADABLE AND TISSUE-PENETRATING DRUG DELIVERY DEVICES AND THEIR METHODS OF USE |
| JP2025538459A (ja) * | 2022-11-17 | 2025-11-28 | パンサー セラピューティクス，インコーポレイティド | 膵臓がんを治療する方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994341A (en) * | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
| US20050271701A1 (en) | 2000-03-15 | 2005-12-08 | Orbus Medical Technologies, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
| US9216239B2 (en) | 2001-06-08 | 2015-12-22 | Leo Rubin | Medical device for intra-lumenal delivery of pharmaceutical agents |
| JP2005160600A (ja) * | 2003-12-01 | 2005-06-23 | Ir:Kk | 液含浸性ステント及び薬液含浸ステント |
| JP5028605B2 (ja) * | 2004-11-22 | 2012-09-19 | 国立大学法人九州大学 | バイオフィルム形成阻害剤及び治療用器具 |
| US20110118827A1 (en) | 2005-06-06 | 2011-05-19 | Dr. Tim Wu | Biodegradable stent formed with polymer-bioceramic nanoparticle composite and method of making the same |
| US20070178138A1 (en) | 2006-02-01 | 2007-08-02 | Allergan, Inc. | Biodegradable non-opthalmic implants and related methods |
| EP2019649A4 (en) * | 2006-04-27 | 2012-09-19 | Narmada R Shenoy | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING BODILUM DISORDER DISORDERS |
| JP2007313009A (ja) * | 2006-05-25 | 2007-12-06 | Terumo Corp | ステント |
| US9474833B2 (en) * | 2006-12-18 | 2016-10-25 | Cook Medical Technologies Llc | Stent graft with releasable therapeutic agent and soluble coating |
| KR100904207B1 (ko) | 2007-06-01 | 2009-06-25 | (주) 태웅메디칼 | 스텐트용 약물 방출 코팅제, 그의 제조방법 및 이 코팅제로 코팅된 약물 방출 스텐트 |
| AU2008202283B2 (en) | 2007-06-01 | 2011-01-20 | Kyong-Min Shin | Coating agent for drug releasing stent, preparation method thereof and drug releasing stent coated therewith |
| KR100988816B1 (ko) | 2008-01-29 | 2010-10-20 | 신경민 | 담즙관용 이중 피막형 스텐트 |
| AU2009324464B2 (en) * | 2008-12-11 | 2016-05-05 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| US20110045055A1 (en) * | 2009-08-21 | 2011-02-24 | Boston Scientific Scimed, Inc. | Medical devices containing therapeutic agents |
| WO2011133655A1 (en) | 2010-04-22 | 2011-10-27 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
| US20120150282A1 (en) | 2010-12-10 | 2012-06-14 | Biotronik Ag | Implant having a paclitaxel-releasing coating |
| US20120323311A1 (en) | 2011-04-13 | 2012-12-20 | Micell Technologies, Inc. | Stents having controlled elution |
| EP2725103A3 (en) | 2011-11-14 | 2016-01-06 | Silenseed Ltd | Methods and compositions for treating prostate cancer |
| CN102727944A (zh) * | 2011-11-14 | 2012-10-17 | 上海市第一人民医院 | 抗胆管良、恶性狭窄的药物涂层支架及制备方法 |
| US8834902B2 (en) * | 2012-03-09 | 2014-09-16 | Q3 Medical Devices Limited | Biodegradable supporting device |
| CA2944480C (en) * | 2013-04-10 | 2021-05-18 | Massachusetts Institute Of Technology | Local drug delivery devices and methods for treating cancer |
-
2014
- 2014-04-10 CA CA2944480A patent/CA2944480C/en active Active
- 2014-04-10 US US14/250,025 patent/US9301926B2/en active Active
- 2014-04-10 ES ES14727109T patent/ES2762555T3/es active Active
- 2014-04-10 JP JP2016507662A patent/JP6431528B2/ja active Active
- 2014-04-10 EP EP14727109.2A patent/EP2983730B1/en active Active
- 2014-04-10 WO PCT/US2014/033671 patent/WO2014169137A1/en not_active Ceased
-
2016
- 2016-02-26 US US15/055,012 patent/US11167066B2/en active Active
-
2018
- 2018-11-02 JP JP2018207608A patent/JP2019034962A/ja active Pending
-
2021
- 2021-11-08 US US17/520,891 patent/US20220054719A1/en active Pending
-
2024
- 2024-03-29 US US18/621,669 patent/US12611492B2/en active Active
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