JP2016516728A5

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Publication number: JP2016516728A5
Authority: JP; Japan
Prior art keywords: patent document; insulin; international publication; international; publication
Prior art date: 2014-03-17
Legal status : Pending

Application number

JP2016503388A

Other languages

English (en)

Japanese (ja)

Other versions

JP2016516728A (ja

Filing date

2014-03-17

Publication date

2017-03-30

2014-03-17 Application filed filed Critical

2014-03-17 Priority claimed from PCT/US2014/030387 external-priority patent/WO2014145593A2/en

2016-06-09 Publication of JP2016516728A publication Critical patent/JP2016516728A/ja

2017-03-30 Publication of JP2016516728A5 publication Critical patent/JP2016516728A5/ja

Status Pending legal-status Critical Current

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NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 12
102000004877 Insulin Human genes 0.000 description 4
108090001061 Insulin Proteins 0.000 description 4
229940125396 insulin Drugs 0.000 description 4
230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
235000018102 proteins Nutrition 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
230000011664 signaling Effects 0.000 description 2
208000013016 Hypoglycemia Diseases 0.000 description 1
230000001133 acceleration Effects 0.000 description 1
238000012867 alanine scanning Methods 0.000 description 1
230000004075 alteration Effects 0.000 description 1
230000004791 biological behavior Effects 0.000 description 1
230000005754 cellular signaling Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
108091008039 hormone receptors Proteins 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1

JP2016503388A 2013-03-15 2014-03-17 第２部位インスリン類似体 Pending JP2016516728A (ja)