JP2016516428A5 - - Google Patents
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- JP2016516428A5 JP2016516428A5 JP2016509098A JP2016509098A JP2016516428A5 JP 2016516428 A5 JP2016516428 A5 JP 2016516428A5 JP 2016509098 A JP2016509098 A JP 2016509098A JP 2016509098 A JP2016509098 A JP 2016509098A JP 2016516428 A5 JP2016516428 A5 JP 2016516428A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- engineered polypeptide
- pal
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000000694 effects Effects 0.000 claims description 16
- 230000002378 acidificating effect Effects 0.000 claims description 5
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 4
- 241000078013 Trichormus variabilis Species 0.000 claims description 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 230000002496 gastric effect Effects 0.000 claims description 2
- 102200091761 rs33926449 Human genes 0.000 claims 128
- 229920001184 polypeptide Polymers 0.000 claims 50
- 102000004196 processed proteins & peptides Human genes 0.000 claims 50
- 108090000765 processed proteins & peptides Proteins 0.000 claims 50
- 108700023158 Phenylalanine ammonia-lyases Proteins 0.000 claims 37
- 238000006467 substitution reaction Methods 0.000 claims 19
- 125000000539 amino acid group Chemical group 0.000 claims 17
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 239000012634 fragment Substances 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 230000017854 proteolysis Effects 0.000 claims 6
- 102220626287 RUN domain-containing protein 3B_L47M_mutation Human genes 0.000 claims 4
- 230000035945 sensitivity Effects 0.000 claims 4
- 201000011252 Phenylketonuria Diseases 0.000 claims 3
- 238000004220 aggregation Methods 0.000 claims 3
- 230000002776 aggregation Effects 0.000 claims 3
- 102200047300 c.127C>A Human genes 0.000 claims 3
- 230000003197 catalytic effect Effects 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 230000005847 immunogenicity Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229940088598 enzyme Drugs 0.000 claims 2
- 239000007897 gelcap Substances 0.000 claims 2
- 239000006187 pill Substances 0.000 claims 2
- 102220214356 rs1060501305 Human genes 0.000 claims 2
- 102220232156 rs370120266 Human genes 0.000 claims 2
- 102220062177 rs786202861 Human genes 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 102220546945 ASNSD1 upstream open reading frame protein_Q39A_mutation Human genes 0.000 claims 1
- 108090000673 Ammonia-Lyases Proteins 0.000 claims 1
- 102000004118 Ammonia-Lyases Human genes 0.000 claims 1
- 102000005367 Carboxypeptidases Human genes 0.000 claims 1
- 108010006303 Carboxypeptidases Proteins 0.000 claims 1
- 108090000317 Chymotrypsin Proteins 0.000 claims 1
- 102220473686 DNA repair protein RAD50_G45D_mutation Human genes 0.000 claims 1
- 102220595765 Glutathione peroxidase 6_Q58H_mutation Human genes 0.000 claims 1
- 102220511169 HMG box-containing protein 1_G20S_mutation Human genes 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 108010067372 Pancreatic elastase Proteins 0.000 claims 1
- 102000016387 Pancreatic elastase Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 102200108120 c.116C>T Human genes 0.000 claims 1
- 239000001110 calcium chloride Substances 0.000 claims 1
- 229960002376 chymotrypsin Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000037213 diet Effects 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000002702 enteric coating Substances 0.000 claims 1
- 238000009505 enteric coating Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000012054 meals Nutrition 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002797 proteolythic effect Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 102200050840 rs11568438 Human genes 0.000 claims 1
- 102220029635 rs146867923 Human genes 0.000 claims 1
- 102200153342 rs1555937077 Human genes 0.000 claims 1
- 102220223774 rs375605948 Human genes 0.000 claims 1
- 102220023192 rs387907509 Human genes 0.000 claims 1
- 102220277622 rs550945533 Human genes 0.000 claims 1
- 102220014966 rs61732490 Human genes 0.000 claims 1
- 102220032317 rs76914224 Human genes 0.000 claims 1
- 102200042086 rs8192687 Human genes 0.000 claims 1
- 102220125344 rs886043940 Human genes 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 239000002478 γ-tocopherol Substances 0.000 claims 1
- 102100029989 SHC SH2 domain-binding protein 1 Human genes 0.000 description 5
- 102000030789 Histidine Ammonia-Lyase Human genes 0.000 description 4
- 108700006308 Histidine ammonia-lyases Proteins 0.000 description 4
- 102000057297 Pepsin A Human genes 0.000 description 3
- 108090000284 Pepsin A Proteins 0.000 description 3
- 239000006166 lysate Substances 0.000 description 3
- 229940111202 pepsin Drugs 0.000 description 3
- 101900027613 Nostoc punctiforme Phenylalanine ammonia-lyase Proteins 0.000 description 2
- 241000192520 Oscillatoria sp. Species 0.000 description 2
- 241001575211 Rivularia <snail> Species 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361813586P | 2013-04-18 | 2013-04-18 | |
| US61/813,586 | 2013-04-18 | ||
| US201361897932P | 2013-10-31 | 2013-10-31 | |
| US61/897,932 | 2013-10-31 | ||
| PCT/US2014/034500 WO2014172541A2 (en) | 2013-04-18 | 2014-04-17 | Engineered phenylalanine ammonia lyase polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018149210A Division JP2018166524A (ja) | 2013-04-18 | 2018-08-08 | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016516428A JP2016516428A (ja) | 2016-06-09 |
| JP2016516428A5 true JP2016516428A5 (https=) | 2017-11-30 |
| JP6637410B2 JP6637410B2 (ja) | 2020-01-29 |
Family
ID=51729192
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016509098A Expired - Fee Related JP6637410B2 (ja) | 2013-04-18 | 2014-04-17 | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
| JP2018149210A Withdrawn JP2018166524A (ja) | 2013-04-18 | 2018-08-08 | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
| JP2020138454A Withdrawn JP2020185017A (ja) | 2013-04-18 | 2020-08-19 | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
| JP2020138453A Active JP7129715B2 (ja) | 2013-04-18 | 2020-08-19 | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
| JP2022169038A Pending JP2022183356A (ja) | 2013-04-18 | 2022-10-21 | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018149210A Withdrawn JP2018166524A (ja) | 2013-04-18 | 2018-08-08 | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
| JP2020138454A Withdrawn JP2020185017A (ja) | 2013-04-18 | 2020-08-19 | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
| JP2020138453A Active JP7129715B2 (ja) | 2013-04-18 | 2020-08-19 | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
| JP2022169038A Pending JP2022183356A (ja) | 2013-04-18 | 2022-10-21 | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
Country Status (27)
| Country | Link |
|---|---|
| US (17) | US9611468B2 (https=) |
| EP (3) | EP3971288A1 (https=) |
| JP (5) | JP6637410B2 (https=) |
| KR (1) | KR102218930B1 (https=) |
| CN (2) | CN105324483B (https=) |
| AU (2) | AU2014253900C1 (https=) |
| CA (1) | CA2909719C (https=) |
| CY (1) | CY1121891T1 (https=) |
| DK (2) | DK3521423T3 (https=) |
| EA (1) | EA034034B1 (https=) |
| ES (2) | ES2890955T3 (https=) |
| HR (1) | HRP20190928T1 (https=) |
| HU (2) | HUE055899T2 (https=) |
| IL (1) | IL242067B (https=) |
| LT (1) | LT2986722T (https=) |
| MX (1) | MX366196B (https=) |
| MY (1) | MY193198A (https=) |
| NZ (1) | NZ713396A (https=) |
| PE (1) | PE20151775A1 (https=) |
| PH (1) | PH12015502412A1 (https=) |
| PL (1) | PL2986722T3 (https=) |
| PT (1) | PT2986722T (https=) |
| RS (1) | RS58802B1 (https=) |
| SG (1) | SG11201508598YA (https=) |
| SI (1) | SI2986722T1 (https=) |
| SM (1) | SMT201900315T1 (https=) |
| WO (1) | WO2014172541A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ713396A (en) | 2013-04-18 | 2020-06-26 | Codexis Inc | Engineered phenylalanine ammonia lyase polypeptides |
| WO2015161019A1 (en) | 2014-04-16 | 2015-10-22 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| ES2881384T3 (es) | 2015-05-13 | 2021-11-29 | Synlogic Operating Co Inc | Bacterias manipuladas para reducir la hiperfenilalaninemia |
| CN106636048A (zh) * | 2016-12-14 | 2017-05-10 | 江南大学 | 一株酶活提高的苯丙氨酸脱氨酶突变体 |
| CN106755160B (zh) * | 2017-01-17 | 2019-08-02 | 湖州颐辉生物科技有限公司 | 一种组氨酸解氨酶及其用途 |
| MX2019009615A (es) | 2017-02-13 | 2019-10-14 | Codexis Inc | Polipeptidos dise?ados de fenilalanina amonio liasa. |
| CN110914288B (zh) * | 2017-05-27 | 2023-05-05 | 宁波酶赛生物工程有限公司 | 工程化醛缩酶多肽及其应用 |
| CN111655841A (zh) | 2017-06-21 | 2020-09-11 | 同生运营公司 | 用于治疗紊乱的细菌 |
| US10900055B2 (en) * | 2018-06-12 | 2021-01-26 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| JP2021531749A (ja) * | 2018-07-12 | 2021-11-25 | コデクシス， インコーポレイテッド | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
| AU2019373208A1 (en) * | 2018-10-29 | 2021-05-13 | Codexis, Inc. | Engineered DNA polymerase variants |
| CA3122524A1 (en) | 2018-12-14 | 2020-06-18 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| WO2021168060A1 (en) * | 2020-02-19 | 2021-08-26 | Trustees Of Tufts College | Methods for engineering amino acid ammonia lyase enzymes and enzymes thereby obtained |
| BR112022018571A2 (pt) * | 2020-03-20 | 2022-11-01 | Synlogic Operating Co Inc | Microrganismos manipulados para reduzir a hiperfenilalaninemia |
| CN116847860A (zh) * | 2020-12-31 | 2023-10-03 | 同生运营公司 | 经工程化以减轻高苯丙氨酸血症的微生物 |
| CA3220735A1 (en) * | 2021-05-21 | 2022-11-24 | Codexis, Inc. | Engineered methionine gamma lyase variants |
| CN114015636B (zh) * | 2021-12-08 | 2023-09-29 | 天地壹号饮料股份有限公司 | 重组醋酸菌及其制备方法和应用 |
| CN114457151B (zh) * | 2022-01-27 | 2024-06-11 | 宁夏医科大学总医院 | 一种用于检测苯丙氨酸羟化酶基因突变的检测试剂盒及其检测方法 |
| CN117417925A (zh) * | 2022-07-18 | 2024-01-19 | 浙江泽科塔生物医药有限公司 | Pal变体、包含该pal变体的药物组合物以及用于制备该pal变体的方法 |
| CN115518691B (zh) * | 2022-10-14 | 2023-11-21 | 天津大学 | 一种具有类漆酶活性的人工酶及制备方法和应用 |
| CN115873837A (zh) * | 2022-11-18 | 2023-03-31 | 安徽盈科生物科技有限公司 | 高表达的新型的苯丙氨酸解氨酶 |
| CN116478975B (zh) * | 2023-06-16 | 2023-09-01 | 苏州优信合生技术有限公司 | 高活性苯丙氨酸解氨酶突变体及其表达菌株 |
| TW202519654A (zh) * | 2023-09-19 | 2025-05-16 | 日商積水化學工業股份有限公司 | 解氨酶及其用途 |
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