JP2016513953A5 - - Google Patents

Info

Publication number

JP2016513953A5

JP2016513953A5 JP2015556448A JP2015556448A JP2016513953A5 JP 2016513953 A5 JP2016513953 A5 JP 2016513953A5 JP 2015556448 A JP2015556448 A JP 2015556448A JP 2015556448 A JP2015556448 A JP 2015556448A JP 2016513953 A5 JP2016513953 A5 JP 2016513953A5

Authority

JP

Japan

Prior art keywords

idc

antigen

cells

vector

cytokine

Prior art date

2014-01-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 210000004443 dendritic cell Anatomy 0.000 claims 19
• 102000004127 Cytokines Human genes 0.000 claims 9
• 108090000695 Cytokines Proteins 0.000 claims 9
• 239000000427 antigen Substances 0.000 claims 9
• 102000036639 antigens Human genes 0.000 claims 9
• 108091007433 antigens Proteins 0.000 claims 9
• 206010061598 Immunodeficiency Diseases 0.000 claims 5
• 208000029462 Immunodeficiency disease Diseases 0.000 claims 5
• 230000007813 immunodeficiency Effects 0.000 claims 5
• 210000000130 stem cell Anatomy 0.000 claims 5
• 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims 4
• 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims 4
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 4
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 4
• 102000006992 Interferon-alpha Human genes 0.000 claims 4
• 108010047761 Interferon-alpha Proteins 0.000 claims 4
• 230000004069 differentiation Effects 0.000 claims 4
• 210000003958 hematopoietic stem cell Anatomy 0.000 claims 4
• OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 claims 4
• 210000000987 immune system Anatomy 0.000 claims 3
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
• 108010029697 CD40 Ligand Proteins 0.000 claims 2
• 102100032937 CD40 ligand Human genes 0.000 claims 2
• 102100034343 Integrase Human genes 0.000 claims 2
• 108010061833 Integrases Proteins 0.000 claims 2
• 102000003812 Interleukin-15 Human genes 0.000 claims 2
• 108090000172 Interleukin-15 Proteins 0.000 claims 2
• 108010002386 Interleukin-3 Proteins 0.000 claims 2
• 102100039064 Interleukin-3 Human genes 0.000 claims 2
• 210000001744 T-lymphocyte Anatomy 0.000 claims 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
• 230000002950 deficient Effects 0.000 claims 2
• 244000052769 pathogen Species 0.000 claims 2
• 208000028529 primary immunodeficiency disease Diseases 0.000 claims 2
• 241000282412 Homo Species 0.000 claims 1
• 102000004388 Interleukin-4 Human genes 0.000 claims 1
• 108090000978 Interleukin-4 Proteins 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• -1 TGF-B Proteins 0.000 claims 1
• 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
• 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
• 210000005006 adaptive immune system Anatomy 0.000 claims 1
• 230000005784 autoimmunity Effects 0.000 claims 1
• 210000003719 b-lymphocyte Anatomy 0.000 claims 1
• 210000001124 body fluid Anatomy 0.000 claims 1
• 239000010839 body fluid Substances 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 230000003013 cytotoxicity Effects 0.000 claims 1
• 231100000135 cytotoxicity Toxicity 0.000 claims 1
• 230000007812 deficiency Effects 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 239000007943 implant Substances 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 230000005865 ionizing radiation Effects 0.000 claims 1
• 230000007257 malfunction Effects 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 230000001717 pathogenic effect Effects 0.000 claims 1
• 239000002243 precursor Substances 0.000 claims 1
• 230000001172 regenerating effect Effects 0.000 claims 1
• ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims 1
• 238000002054 transplantation Methods 0.000 claims 1