RU2016144509A - Новые производные сатн2 - Google Patents
Новые производные сатн2 Download PDFInfo
- Publication number
- RU2016144509A RU2016144509A RU2016144509A RU2016144509A RU2016144509A RU 2016144509 A RU2016144509 A RU 2016144509A RU 2016144509 A RU2016144509 A RU 2016144509A RU 2016144509 A RU2016144509 A RU 2016144509A RU 2016144509 A RU2016144509 A RU 2016144509A
- Authority
- RU
- Russia
- Prior art keywords
- smap27
- derivative
- derivatives
- inverse
- terminus
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (10)
1. Усеченное с N-конца производное СМАР27.
2. Инверсное и ретро-инверсное производное СМАР27.
3. Способ in ovo вакцинации домашней птицы, предпочтительно куриц, включающий введение производного СМАР27, где указанное производное СМАР27 выбрано из группы усеченных с С-конца производных СМАР27, усеченных с N-конца производных СМАР27, D-аминокислотных производных СМАР27, циклических производных СМАР27, инверсных и ретро-инверсных производных СМАР27.
4. Способ активации иммунного ответа животного или человека, включающий введение указанному животному или человеку производного СМАР27, где указанное производное выбрано из группы усеченных с С-конца производных СМАР27, усеченных с N-конца производных СМАР27, D-аминокислотных производных СМАР27, циклических производных СМАР27, инверсных и ретро-инверсных производных СМАР27.
5. Способ по п. 4, в котором активация иммунного ответа выбрана из усиленной активации Толл-подобного рецептора путем увеличения захвата ДНК, нейтрализации эндотоксина, стимуляции производства иммунными клетками цитокинов/хемокинов, прямого хемотаксиса, усиленного фагоцитоза и стимуляции пролиферации и дифференцировки иммунных клеток.
6. Иммунологическая композиция, содержащая производное СМАР27 по любому из пп. 1-2.
7. Применение производного СМАР27 по любому из пп. 1-2 для приготовления лекарственного средства для лечения инфекционного заболевания или для приготовления вакцины.
8. Производное СМАР27 по п. 1 или 2 для применения в качестве антибиотика.
9. Производное СМАР27 по п. 1 или 2 для применения для увеличения массы животных.
10. Способ увеличения массы домашней птицы путем in ovo вакцинации яиц указанных видов домашней птицы производным СМАР27, где указанное производное СМАР27 выбрано из группы усеченных с С-конца производных СМАР27, усеченных с N-конца производных СМАР27, D-аминокислотных производных СМАР27, циклических производных СМАР27, инверсных и ретро-инверсных производных СМАР27.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14167718 | 2014-05-09 | ||
| EP14167718.7 | 2014-05-09 | ||
| PCT/NL2015/050323 WO2015170984A1 (en) | 2014-05-09 | 2015-05-08 | New cath2 derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016144509A true RU2016144509A (ru) | 2018-06-13 |
| RU2016144509A3 RU2016144509A3 (ru) | 2019-02-05 |
| RU2726124C2 RU2726124C2 (ru) | 2020-07-09 |
Family
ID=50685785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016144509A RU2726124C2 (ru) | 2014-05-09 | 2015-05-08 | Новые производные сатн2 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10829524B2 (ru) |
| EP (2) | EP4434535A2 (ru) |
| JP (2) | JP6676544B2 (ru) |
| CN (1) | CN106488929B (ru) |
| AU (2) | AU2015256729B2 (ru) |
| CA (2) | CA2948455C (ru) |
| MX (1) | MX2016014633A (ru) |
| NZ (2) | NZ764154A (ru) |
| RU (1) | RU2726124C2 (ru) |
| WO (1) | WO2015170984A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6676544B2 (ja) * | 2014-05-09 | 2020-04-08 | ユニベルシテイト、ユトレヒト、ホールディング ベスローテン、フェンノートシャップＵｎｉｖｅｒｓｉｔｅｉｔ Ｕｔｒｅｃｈｔ Ｈｏｌｄｉｎｇ Ｂ．Ｖ． | 新しいｃａｔｈ２誘導体。 |
| CN109535227B (zh) * | 2018-12-18 | 2020-10-02 | 西安市儿童医院 | 抗菌肽、抗菌肽制备方法、抗菌组合物、抗菌方法和应用 |
| CN110128544B (zh) * | 2019-04-03 | 2020-12-01 | 中国农业大学 | 一种具有免疫调节和抗炎功能的杂合肽及其制备方法与应用 |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| WO2022131922A1 (en) | 2020-12-18 | 2022-06-23 | Universiteit Utrecht Holding B.V. | Cath2 derivatives for stimulating innate immune memory |
| KR20230146035A (ko) * | 2021-02-05 | 2023-10-18 | 유니버시테이트 우트레크트 홀딩 비.브이. | 스트렙토코커스 수이스를 억제하는 cath2 및 유도체 |
| WO2023015274A1 (en) * | 2021-08-05 | 2023-02-09 | Zoetis Services Llc | Compositions and methods for treating mastitis |
| EP4448104A1 (en) * | 2021-12-15 | 2024-10-23 | Zoetis Services LLC | Compositions and methods for activating innate immunity |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4040388A (en) | 1976-02-27 | 1977-08-09 | Agrimatic Corporation | Method and apparatus for automatic egg injection |
| US4593646A (en) | 1982-06-01 | 1986-06-10 | Agrimatic Corporation | Egg injection method and apparatus |
| US4469047A (en) | 1983-10-25 | 1984-09-04 | Miller Gary E | Apparatus and method for injecting eggs |
| US4681063A (en) | 1986-07-02 | 1987-07-21 | Embrex Inc. | High speed automated injection system for avian embryos |
| SK282436B6 (sk) | 1995-06-07 | 2002-02-05 | Pfizer Inc. | Živé sporocysty alebo oocysty Eimeria alebo ich zmesi na výrobu očkovacej látky |
| CA2290646C (en) | 1997-05-20 | 2008-03-11 | Galenica Pharmaceuticals, Inc. | Triterpene saponin analogs having adjuvant and immunostimulatory activity |
| CN1309418C (zh) | 2000-06-08 | 2007-04-11 | 英特塞尔生物医药研究发展股份公司 | 免疫刺激性寡脱氧核苷酸 |
| WO2002013857A2 (en) * | 2000-08-17 | 2002-02-21 | Intercell Biomedizinische Forschungs- Und Entwicklungs Ag | A vaccine which comprises at least one antigen and a cathelididin derived antimicrobial peptide or a derivative thereof |
| JP4602347B2 (ja) * | 2003-12-03 | 2010-12-22 | ファイザー・プロダクツ・インク | 鳥類におけるカンピロバクターの卵内接種 |
| US20080119405A1 (en) * | 2005-12-02 | 2008-05-22 | The Board Of Regents For Oklahoma State University | Fowlicidins and Methods of Their Use |
| AU2008251748B2 (en) * | 2007-01-16 | 2014-02-27 | C3 Jian, Inc. | Novel antimicrobial peptides |
| JP2010533705A (ja) | 2007-07-15 | 2010-10-28 | ヒルマン，イチャク | 抗菌ペプチドまたはその阻害剤を用いた疾病治療 |
| EP2396345B1 (en) | 2009-02-13 | 2016-11-09 | Universiteit Utrecht Holding B.V. | Antimicrobial peptides based on cmap27 |
| RU2458526C1 (ru) | 2011-03-28 | 2012-08-20 | Общество с ограниченной ответственностью "Поливит" (ООО "Поливит") | Пробиотическая кормовая добавка для сельскохозяйственных птиц и пушных зверей |
| JP6676544B2 (ja) * | 2014-05-09 | 2020-04-08 | ユニベルシテイト、ユトレヒト、ホールディング ベスローテン、フェンノートシャップＵｎｉｖｅｒｓｉｔｅｉｔ Ｕｔｒｅｃｈｔ Ｈｏｌｄｉｎｇ Ｂ．Ｖ． | 新しいｃａｔｈ２誘導体。 |
-
2015
- 2015-05-08 JP JP2016567361A patent/JP6676544B2/ja active Active
- 2015-05-08 CA CA2948455A patent/CA2948455C/en active Active
- 2015-05-08 WO PCT/NL2015/050323 patent/WO2015170984A1/en active Application Filing
- 2015-05-08 CA CA3207425A patent/CA3207425A1/en active Pending
- 2015-05-08 EP EP24183144.5A patent/EP4434535A2/en active Pending
- 2015-05-08 MX MX2016014633A patent/MX2016014633A/es unknown
- 2015-05-08 NZ NZ764154A patent/NZ764154A/en unknown
- 2015-05-08 US US15/310,034 patent/US10829524B2/en active Active
- 2015-05-08 RU RU2016144509A patent/RU2726124C2/ru active
- 2015-05-08 EP EP15731134.1A patent/EP3140315B1/en active Active
- 2015-05-08 AU AU2015256729A patent/AU2015256729B2/en active Active
- 2015-05-08 CN CN201580036371.8A patent/CN106488929B/zh active Active
- 2015-05-08 NZ NZ726972A patent/NZ726972A/en unknown
-
2019
- 2019-12-19 AU AU2019283922A patent/AU2019283922A1/en not_active Abandoned
-
2020
- 2020-03-11 JP JP2020042476A patent/JP2020109109A/ja not_active Abandoned
- 2020-10-13 US US17/069,127 patent/US11603391B2/en active Active
-
2023
- 2023-02-08 US US18/166,117 patent/US20230382961A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3140315C0 (en) | 2024-07-24 |
| US20210246177A1 (en) | 2021-08-12 |
| JP2017518976A (ja) | 2017-07-13 |
| AU2015256729A1 (en) | 2016-11-24 |
| MX2016014633A (es) | 2017-04-27 |
| JP6676544B2 (ja) | 2020-04-08 |
| EP3140315B1 (en) | 2024-07-24 |
| US10829524B2 (en) | 2020-11-10 |
| US11603391B2 (en) | 2023-03-14 |
| JP2020109109A (ja) | 2020-07-16 |
| NZ726972A (en) | 2024-07-05 |
| CN106488929A (zh) | 2017-03-08 |
| CN106488929B (zh) | 2021-08-24 |
| CA3207425A1 (en) | 2015-11-12 |
| US20230382961A1 (en) | 2023-11-30 |
| WO2015170984A1 (en) | 2015-11-12 |
| RU2016144509A3 (ru) | 2019-02-05 |
| CA2948455C (en) | 2023-09-19 |
| NZ764154A (en) | 2024-07-05 |
| EP3140315A1 (en) | 2017-03-15 |
| CA2948455A1 (en) | 2015-11-12 |
| AU2015256729B2 (en) | 2019-09-19 |
| AU2019283922A1 (en) | 2020-01-30 |
| RU2726124C2 (ru) | 2020-07-09 |
| US20170145065A1 (en) | 2017-05-25 |
| EP4434535A2 (en) | 2024-09-25 |
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